CA2866889C - Stabilizing composition for biological materials - Google Patents
Stabilizing composition for biological materials Download PDFInfo
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- CA2866889C CA2866889C CA2866889A CA2866889A CA2866889C CA 2866889 C CA2866889 C CA 2866889C CA 2866889 A CA2866889 A CA 2866889A CA 2866889 A CA2866889 A CA 2866889A CA 2866889 C CA2866889 C CA 2866889C
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| US10766799B2 (en) | 2014-05-23 | 2020-09-08 | Nch Corporation | Method for improving quality of aquaculture pond water using a nutrient germinant composition and spore incubation method |
| MX384826B (es) * | 2015-02-11 | 2025-03-14 | Evah Nutrition Inc | Matriz seca mejorada para incrustar escherichia coli viable, metodo para hacer la misma y uso de la misma. |
| PT3328215T (pt) | 2015-07-29 | 2021-08-03 | Advanced Bionutrition Corp | Composições probióticas estáveis secas para utilizações dietéticas especiais |
| KR102754888B1 (ko) * | 2015-12-04 | 2025-01-13 | 어드밴스드 바이오뉴트리션 코프. | 당을 전혀 또는 거의 함유하지 않은 안정한 건조 조성물 |
| BR112018011352B1 (pt) * | 2015-12-18 | 2023-01-10 | Société des Produits Nestlé S.A. | Composição e aditivo de hidratação |
| FR3045384B1 (fr) | 2015-12-18 | 2020-02-07 | Institut National De La Recherche Agronomique | Composition lyophilisee pour la conservation de microbiote dans son ecosysteme |
| CN105504050A (zh) * | 2016-03-03 | 2016-04-20 | 河南欧普生物科技有限公司 | 一种抗安卡拉病毒鸡卵黄抗体的制备方法 |
| WO2017176872A1 (en) | 2016-04-05 | 2017-10-12 | Nch Corporation | Nutrient rich germinant composition and spore incubation method |
| US10897922B2 (en) | 2016-04-05 | 2021-01-26 | Nch Corporation | Composition and method for germinative compounds in probiotic food and beverage products for human consumption |
| US12097226B2 (en) | 2016-04-05 | 2024-09-24 | Nch Corporation | System and method for using a single-serve nutrient spore composition for small scale farm applications |
| WO2017214727A1 (en) * | 2016-06-14 | 2017-12-21 | Prevtec Microbia Inc. | Animal feed pellets including a feed additive, method of making and of using same |
| ES2978987T3 (es) | 2016-06-24 | 2024-09-23 | Yessinergy Holding S/A | Composición inmunomoduladora y promotora del crecimiento que controla la población de bacterias indeseables en la microbiota intestinal |
| KR101766430B1 (ko) * | 2016-10-28 | 2017-08-08 | 주식회사 삼양사 | 올리고당을 함유하는 알룰로오스 시럽 및 그 제조방법 |
| CN106819418A (zh) * | 2017-03-27 | 2017-06-13 | 张军军 | 一种超高脂饲料及其制备方法 |
| US10323226B2 (en) * | 2017-03-30 | 2019-06-18 | Nch Corporation | Feed material for biomass generator |
| GB201708932D0 (en) * | 2017-06-05 | 2017-07-19 | Probi Ab | Microbial compositions |
| KR102862883B1 (ko) * | 2018-07-04 | 2025-09-23 | 시에이치알. 한센 에이/에스 | 생존 가능한 프로바이오틱 박테리아를 포함하는 수성 국소 조성물 |
| WO2020007931A1 (en) | 2018-07-04 | 2020-01-09 | Chr. Hansen A/S | Topical compositions comprising viable probiotic bacteria |
| US11401500B2 (en) | 2018-08-29 | 2022-08-02 | Nch Corporation | System, method, and composition for incubating spores for use in aquaculture, agriculture, wastewater, and environmental remediation applications |
| MX2021004771A (es) * | 2018-10-26 | 2021-07-15 | Danisco Us Inc | Composicion microbiana estable y proceso de secado. |
| KR20210113179A (ko) * | 2018-12-07 | 2021-09-15 | 피벗 바이오, 인크. | 질소 고정 미생물 제품을 위한 안정성이 개선된 중합체 조성물 |
| WO2020130770A1 (es) * | 2018-12-19 | 2020-06-25 | Ajtzakbio S.A.P.I. De C.V. | Composición probiótica de alto valor sin necesidad de cadena de frio, desarrollada para reducir el impacto ambiental, aumentar la producción y mejorar la supervivencia de larvas de camarón |
| JP2022549133A (ja) * | 2019-09-16 | 2022-11-24 | ヴェダンタ バイオサイエンシーズ インコーポレーテッド | 細菌を保存するための方法および組成物 |
| CN114845549B (zh) * | 2019-10-22 | 2024-07-09 | 麻省理工学院 | 递送促进植物生长的微生物的基于生物材料的组合物 |
| CN110923145B (zh) * | 2019-12-16 | 2021-07-20 | 天康制药(苏州)有限公司 | 支原体的冻干保护剂与冻干支原体及其制备方法 |
| WO2021159068A1 (en) | 2020-02-06 | 2021-08-12 | Nch Corportion | Composition and method of using germinative compounds in probiotics for inflammation reduction in humans |
| US20230080017A1 (en) * | 2020-02-19 | 2023-03-16 | Zantebio Limited | Coated microcapsules and methods for the production thereof |
| RU2746022C1 (ru) * | 2020-04-03 | 2021-04-06 | Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации | Способ стабилизации бактериальных клеток чумного микроба перед сублимационным высушиванием |
| RU2736064C1 (ru) * | 2020-04-03 | 2020-11-11 | Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации | Защитная среда для стабилизации клеток возбудителя туляремии в процессе приготовления и хранения сухих препаратов |
| WO2021222643A1 (en) | 2020-05-01 | 2021-11-04 | Pivot Bio, Inc. | Stable liquid formulations for nitrogen-fixing microorganisms |
| JP2022102198A (ja) * | 2020-12-25 | 2022-07-07 | ライオン株式会社 | 内服固形剤 |
| MX2023007685A (es) * | 2020-12-25 | 2023-11-22 | Hayashibara Co | Método para mejorar la productividad en ganado y aves de corral y método para mejorar la flora intestinal en ganado y/o aves de corral. |
| US20240090550A1 (en) * | 2021-02-10 | 2024-03-21 | Dsm Ip Assets B.V. | Powderous composition(ii) |
| EP4291046A1 (en) * | 2021-02-10 | 2023-12-20 | DSM IP Assets B.V. | Powderous composition (i) |
| CN112843328B (zh) * | 2021-02-25 | 2022-05-13 | 山东大学 | 一种具有抑菌作用的鲍鱼壳粉/ZnO复合材料掺杂的智能水凝胶伤口敷料的制备方法 |
| CN113621519B (zh) * | 2021-08-11 | 2023-07-18 | 河南农业大学 | 一种复合酵母冻干保护剂 |
| EP4392070A4 (en) * | 2021-08-25 | 2025-06-11 | Zvinavashe, Augustine, T. | Microbiome delivery platform |
| US20240131108A1 (en) * | 2021-09-29 | 2024-04-25 | Institute of Process Engineering, Chinese Academy of Science | Amino acid-based glass, preparation method and use thereof |
| CN114196579A (zh) * | 2021-12-13 | 2022-03-18 | 张峰 | 一种建筑通风工程用的甲醛微生物净化器 |
| WO2023204734A1 (ru) * | 2022-04-21 | 2023-10-26 | Общество С Ограниченной Ответственностью "Кинетик-Фарм" | Средство для интравагинальной доставки активного компонента, способ получения и применения средства |
| CN116040604B (zh) * | 2022-12-21 | 2025-04-29 | 天津华电南疆热电有限公司 | 一种用于微生物培养的碳源材料及其制备方法 |
| CN116694581A (zh) * | 2023-05-24 | 2023-09-05 | 华南农业大学 | 哈维氏弧菌噬菌体v-ydf132的冻干保护剂及其保藏方法 |
| CN117256857B (zh) * | 2023-07-24 | 2025-12-02 | 浙江大学 | 一种用于制备鱼油微胶囊的复合壁材及其制备方法与应用 |
| WO2025055959A1 (en) * | 2023-09-12 | 2025-03-20 | Bing Biotech Limited | Encapsulation of dual-enzyme composition for preventing, treating and/or alleviating veisalgia and symptoms associated therewith |
| CN117247305A (zh) * | 2023-09-16 | 2023-12-19 | 鲁东大学 | 一种促进植物根系生长的水凝胶及制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1047696A1 (zh) * | 1999-08-24 | 2003-03-07 | Teva Pharmaceutical Industries, Ltd. | 疫苗组合物及其使用方法 |
| ES2162746B1 (es) * | 1999-10-21 | 2003-02-16 | Lipotec Sa | Microcapsulas para la estabilizacion de productos cosmeticos, farmaceuticos o de alimentacion. |
| IL153282A0 (en) | 2000-06-27 | 2003-07-06 | Hoffmann La Roche | Method for preparing a pharmaceutical composition |
| US20020044988A1 (en) * | 2000-08-22 | 2002-04-18 | Fuchs Eileen C. | Nutritional composition and method for improving protein deposition |
| AU2003247337B2 (en) * | 2002-04-11 | 2007-09-06 | Medimmune, Llc | Preservation of bioactive materials by freeze dried foam |
| WO2004024177A1 (en) * | 2002-09-16 | 2004-03-25 | Quest International Services B.V. | Method of treating or preventing obeisity and lipid metabolism disorders and compositions for use therein |
| US8871266B2 (en) * | 2003-10-01 | 2014-10-28 | Commonwealth Scientific & Industrial Research Organisation | Probiotic storage and delivery |
| EP1616486A1 (en) * | 2004-07-13 | 2006-01-18 | Friesland Brands B.V. | Powdered compositions containing an edible oil and their use in food products |
| WO2007079147A2 (en) * | 2005-12-28 | 2007-07-12 | Advanced Bionutrition Corporation | A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
| CA2673120C (en) * | 2006-12-18 | 2012-08-07 | Advanced Bionutrition Corporation | A dry food product containing live probiotic |
| AU2008343689A1 (en) * | 2007-12-20 | 2009-07-09 | Abbott Laboratories | Stable nutritional powder |
| RU2521642C2 (ru) * | 2008-10-20 | 2014-07-10 | Нестек С.А. | Питательная композиция с противосрыгивающими свойствами |
| TWI468157B (zh) * | 2009-04-29 | 2015-01-11 | Intervet Int Bv | 形成錠劑的方法，進行該方法的系統及包含該錠劑的包裝物 |
| US20110070334A1 (en) * | 2009-09-20 | 2011-03-24 | Nagendra Rangavajla | Probiotic Stabilization |
| PH12013500272B1 (en) * | 2010-08-13 | 2019-07-03 | Advanced Bionutrition Corp | Dry storage stabilizing composition for biological materials |
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|---|---|
| KR20140135845A (ko) | 2014-11-26 |
| MX356072B (es) | 2018-05-14 |
| AR093204A1 (es) | 2015-05-27 |
| BR112014023234B1 (pt) | 2020-12-08 |
| PH12014502092A1 (en) | 2014-11-24 |
| JP2015517985A (ja) | 2015-06-25 |
| KR102062645B1 (ko) | 2020-01-06 |
| AU2013234931A2 (en) | 2014-12-04 |
| BR112014023234A8 (pt) | 2018-01-16 |
| EP2827905A4 (en) | 2015-05-06 |
| CN104244985A (zh) | 2014-12-24 |
| AU2013234931A1 (en) | 2014-09-18 |
| RU2014136089A (ru) | 2016-05-20 |
| JP6229188B2 (ja) | 2017-11-15 |
| MY178686A (en) | 2020-10-20 |
| EP2827905A1 (en) | 2015-01-28 |
| RU2666601C2 (ru) | 2018-09-11 |
| EP2827905C0 (en) | 2025-03-12 |
| MX2014011122A (es) | 2014-12-05 |
| ES3016483T3 (en) | 2025-05-09 |
| SG11201405478VA (en) | 2014-11-27 |
| EP2827905B1 (en) | 2025-03-12 |
| CL2014002506A1 (es) | 2015-01-09 |
| CN114601849A (zh) | 2022-06-10 |
| AU2013234931B2 (en) | 2017-12-07 |
| NZ628912A (en) | 2016-06-24 |
| CA2866889A1 (en) | 2013-09-26 |
| IN2014DN08599A (OSRAM) | 2015-05-22 |
| PH12014502092B1 (en) | 2019-11-20 |
| WO2013142792A1 (en) | 2013-09-26 |
| BR112014023234A2 (pt) | 2017-06-20 |
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