CA2864864C - Pharmaceutical composition for treatment and/or prevention of cancer - Google Patents

Pharmaceutical composition for treatment and/or prevention of cancer Download PDF

Info

Publication number
CA2864864C
CA2864864C CA2864864A CA2864864A CA2864864C CA 2864864 C CA2864864 C CA 2864864C CA 2864864 A CA2864864 A CA 2864864A CA 2864864 A CA2864864 A CA 2864864A CA 2864864 C CA2864864 C CA 2864864C
Authority
CA
Canada
Prior art keywords
antibody
cancer
caprin
seq
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2864864A
Other languages
English (en)
French (fr)
Other versions
CA2864864A1 (en
Inventor
Shinichi Kobayashi
Fumiyoshi Okano
Takanori Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of CA2864864A1 publication Critical patent/CA2864864A1/en
Application granted granted Critical
Publication of CA2864864C publication Critical patent/CA2864864C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2864864A 2012-02-21 2013-02-21 Pharmaceutical composition for treatment and/or prevention of cancer Active CA2864864C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-035484 2012-02-21
JP2012035484 2012-02-21
PCT/JP2013/054337 WO2013125636A1 (ja) 2012-02-21 2013-02-21 癌の治療及び/又は予防用医薬組成物

Publications (2)

Publication Number Publication Date
CA2864864A1 CA2864864A1 (en) 2013-08-29
CA2864864C true CA2864864C (en) 2020-05-12

Family

ID=49005813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2864864A Active CA2864864C (en) 2012-02-21 2013-02-21 Pharmaceutical composition for treatment and/or prevention of cancer

Country Status (16)

Country Link
US (1) US9273130B2 (Direct)
EP (1) EP2818482B1 (Direct)
JP (1) JP6187255B2 (Direct)
KR (1) KR102009238B1 (Direct)
CN (1) CN104169303B (Direct)
AU (1) AU2013223143B2 (Direct)
CA (1) CA2864864C (Direct)
DK (1) DK2818482T3 (Direct)
ES (1) ES2739612T3 (Direct)
HU (1) HUE044611T2 (Direct)
IN (1) IN2014KN01713A (Direct)
MX (1) MX360208B (Direct)
PL (1) PL2818482T3 (Direct)
PT (1) PT2818482T (Direct)
RU (1) RU2632645C2 (Direct)
WO (1) WO2013125636A1 (Direct)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2471379T3 (es) 2008-08-05 2014-06-26 Toray Industries, Inc. Método para detectar el cáncer
BRPI0911926A2 (pt) 2008-08-05 2020-08-18 Toray Industries, Inc composições farmacêuticas, anticorpos e usos de um anticorpo ou um fragmento do mesmo.
ES2540858T3 (es) * 2010-02-04 2015-07-14 Toray Industries, Inc. Composición farmacéutica para el tratamiento y/o la prevención de cáncer
DK2740489T3 (en) * 2011-08-04 2017-01-16 Toray Industries Pharmaceutical composition for the treatment and / or prevention of pancreatic cancer
PT2741085T (pt) * 2011-08-04 2017-06-30 Toray Industries Método para a deteção de cancro prancreático
RU2631804C2 (ru) 2012-02-21 2017-09-26 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения или профилактики рака
US9416193B2 (en) * 2012-03-30 2016-08-16 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of liver cancer
AU2013241043B2 (en) 2012-03-30 2017-11-09 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of gall bladder cancer
CN104471403B (zh) 2012-07-19 2017-03-01 东丽株式会社 癌的检测方法
MX358772B (es) 2012-07-19 2018-09-04 Toray Industries Metodo para detectar cancer.
SG11201500730XA (en) 2012-08-24 2015-02-27 Univ California Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
KR102255616B1 (ko) 2013-08-09 2021-05-25 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
KR102588359B1 (ko) 2016-03-04 2023-10-13 제이엔 바이오사이언시즈 엘엘씨 Tigit에 대한 항체
SG11201811559WA (en) 2016-06-27 2019-01-30 Univ California Cancer treatment combinations
CN109843327B (zh) 2016-07-07 2022-05-13 小利兰·斯坦福大学托管委员会 抗体佐剂缀合物
CA3041979A1 (en) 2016-10-28 2018-05-03 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
KR20200136935A (ko) 2018-03-30 2020-12-08 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
CA3130794A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
CN114585390A (zh) 2019-06-13 2022-06-03 博尔特生物治疗药物有限公司 氨基苯并氮呯化合物、免疫缀合物及其用途
CN114746404A (zh) 2019-09-30 2022-07-12 博尔特生物治疗药物有限公司 酰胺连接的氨基苯并氮杂䓬免疫缀合物及其用途
MX2022004875A (es) 2019-10-25 2022-06-17 Bolt Biotherapeutics Inc Inmunoconjugados de tienoazepina, inmunoconjugados y usos de estos.
WO2021182571A1 (ja) 2020-03-12 2021-09-16 東レ株式会社 癌の治療及び/又は予防のための医薬品
CA3175137A1 (en) 2020-03-12 2021-09-16 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
US20230159635A1 (en) * 2020-03-12 2023-05-25 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
WO2021182570A1 (ja) 2020-03-12 2021-09-16 東レ株式会社 癌の治療及び/又は予防のための医薬品
JP7793985B2 (ja) 2020-03-12 2026-01-06 東レ株式会社 癌の治療及び/又は予防のための医薬品
WO2021226440A1 (en) 2020-05-08 2021-11-11 Bolt Biotherapeutics, Inc. Elastase-substrate, peptide linker immunoconjugates, and uses thereof
PH12022553257A1 (en) 2020-06-02 2024-02-19 Arcus Biosciences Inc Antibodies to tigit
CA3186059A1 (en) 2020-08-13 2022-02-17 Romas Kudirka Pyrazoloazepine immunoconjugates, and uses thereof
WO2022270523A1 (ja) 2021-06-23 2022-12-29 東レ株式会社 癌の治療及び/又は予防のための医薬品
WO2022270524A1 (ja) 2021-06-23 2022-12-29 東レ株式会社 癌の治療及び/又は予防のための医薬品
KR20240041917A (ko) 2021-07-27 2024-04-01 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
US20250325663A1 (en) * 2021-07-27 2025-10-23 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
US20250066502A1 (en) 2021-07-27 2025-02-27 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
JPWO2023033129A1 (Direct) 2021-09-03 2023-03-09
US20250000995A1 (en) 2021-10-29 2025-01-02 Bolt Biotherapeutics, Inc. Tlr agonist immunoconjugates with cysteine-mutant antibodies, and uses thereof
WO2024005123A1 (ja) 2022-06-30 2024-01-04 東レ株式会社 癌の治療及び/又は予防用医薬組成物
CN119744176A (zh) 2022-08-24 2025-04-01 东丽株式会社 用于癌的治疗和/或预防的药品
JPWO2024043257A1 (Direct) 2022-08-24 2024-02-29
WO2024043252A1 (ja) 2022-08-24 2024-02-29 東レ株式会社 癌の治療及び/又は予防のための医薬品
CN119768184A (zh) 2022-08-30 2025-04-04 东丽株式会社 用于癌的治疗和/或预防的药品
WO2024048541A1 (ja) 2022-08-30 2024-03-07 東レ株式会社 癌の治療及び/又は予防のための医薬品
EP4640235A1 (en) 2022-12-23 2025-10-29 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
EP4665404A1 (en) 2023-02-14 2025-12-24 Bolt Biotherapeutics, Inc. Aza-benzazepine immunoconjugates, and uses thereof
WO2024186626A1 (en) 2023-03-03 2024-09-12 Bolt Biotherapeutics, Inc. Aza-bicyclic sting agonist immunoconjugates, and uses thereof
WO2025058000A1 (ja) * 2023-09-13 2025-03-20 東レ株式会社 癌の治療、予防及び/又は診断用医薬組成物

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
ATE340590T1 (de) 1994-07-13 2006-10-15 Chugai Pharmaceutical Co Ltd Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper
US5698396A (en) 1995-06-07 1997-12-16 Ludwig Institute For Cancer Research Method for identifying auto-immunoreactive substances from a subject
FR2761994B1 (fr) 1997-04-11 1999-06-18 Centre Nat Rech Scient Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
EP2363484A3 (en) 1998-04-03 2012-04-25 Chugai Seiyaku Kabushiki Kaisha Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody
US20030118599A1 (en) 1999-04-02 2003-06-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
PL200772B1 (pl) 1998-07-14 2009-02-27 Corixa Corp Izolowany polipeptyd, fuzja białkowa oraz ich zastosowanie, izolowany epitop komórki T, wektor ekspresyjny, komórka gospodarza, sposób stymulowania i/lub namnażania komórek T, izolowana populacja komórek T, kompozycja i jej zastosowanie oraz izolowane komórki T
RU2234942C2 (ru) 1998-07-14 2004-08-27 Корикса Корпорейшн Выделенный опухолевый полипептид предстательной железы и кодирующий его полинуклеотид
US6969518B2 (en) 1998-12-28 2005-11-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US6335170B1 (en) 1999-02-22 2002-01-01 Torben F. Orntoft Gene expression in bladder tumors
US6444425B1 (en) 1999-04-02 2002-09-03 Corixa Corporation Compounds for therapy and diagnosis of lung cancer and methods for their use
HK1045332A1 (zh) 1999-04-02 2002-11-22 Corixa Corporation 用於治療和診斷肺癌的化合物及其使用方法
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
JP2003528587A (ja) 1999-10-29 2003-09-30 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド 27個のヒト分泌タンパク質
US20020006404A1 (en) 1999-11-08 2002-01-17 Idec Pharmaceuticals Corporation Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
HUP0500345A2 (hu) 2000-03-29 2005-07-28 Corixa Corporation Készítmények és alkalmazások tüdőrák kezelésére és diagnosztizálására
AU2002239422B2 (en) 2000-11-30 2006-12-07 E. R. Squibb & Sons, L.L.C. Transgenic transchromosomal rodents for making human antibodies
US7919467B2 (en) 2000-12-04 2011-04-05 Immunotope, Inc. Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
US20040029114A1 (en) 2001-01-24 2004-02-12 Eos Technology, Inc. Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
RU2306952C2 (ru) 2001-01-31 2007-09-27 Байоджен Айдек Инк. Лечение в-клеточных злокачественных опухолей с использованием комбинации применений, связанных с антителами, уменьшающими количество b-клеток, и с иммуномодулирующими антителами
AU2002311787A1 (en) 2001-03-28 2002-10-15 Zycos Inc. Translational profiling
WO2002083070A2 (en) 2001-04-10 2002-10-24 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
EP1970448A1 (en) 2001-05-11 2008-09-17 Kirin Pharma Kabushiki Kaisha Human artificial chromosome containting human antibody lambda light chain and non-human animal containting the human artificial chromosome capable of genetic transmission
AU2002311909A1 (en) 2001-05-11 2002-11-25 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US20030190640A1 (en) 2001-05-31 2003-10-09 Mary Faris Genes expressed in prostate cancer
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
JP2005535290A (ja) 2002-02-22 2005-11-24 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための組成物と方法
US20050003390A1 (en) 2002-05-17 2005-01-06 Axenovich Sergey A. Targets for controlling cellular growth and for diagnostic methods
US20040126379A1 (en) 2002-08-21 2004-07-01 Boehringer Ingelheim International Gmbh Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents
US20060121029A1 (en) 2002-08-30 2006-06-08 Hiroshi Shiku Method and composition for regulating the activity of regulatory t cells
US20070048301A1 (en) 2002-11-26 2007-03-01 Bodary-Winter Sarah C Compositions and methods for the treatment of immune related diseases
WO2004076682A2 (en) 2003-02-26 2004-09-10 Surromed, Inc. Targets for controlling cellular growth and for diagnostic methods
WO2004097051A2 (en) 2003-04-29 2004-11-11 Wyeth Methods for diagnosing aml and mds differential gene expression
JP2007516693A (ja) 2003-06-09 2007-06-28 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン 癌の治療および診断のための組成物および方法
WO2005007830A2 (en) 2003-07-14 2005-01-27 Mayo Foundation For Medical Education And Research Methods and compositions for diagnosis, staging and prognosis of prostate cancer
US20050032113A1 (en) 2003-07-17 2005-02-10 Mitsubishi Pharma Corporation Membrane protein library for proteome analysis and method for preparing same
EP2361929A1 (en) 2004-01-26 2011-08-31 Debiovision Inc. Neoplasm-specific polypeptides and their use
PT1735348E (pt) 2004-03-19 2012-07-24 Imclone Llc Anticorpo anti-receptor do factor de crescimento humano
PE20060287A1 (es) 2004-03-30 2006-05-16 Glaxo Group Ltd INMUNOGLOBULINAS DE UNION SELECTIVA A hOSM
WO2005100998A2 (en) 2004-04-16 2005-10-27 Europroteome Ag Membrane markers for use in cancer diagnosis and therapy
DE102004026135A1 (de) 2004-05-25 2006-01-05 Immatics Biotechnologies Gmbh An MHC-Moleküle bindende Tumor-assoziierte Peptide
WO2006002378A2 (en) 2004-06-23 2006-01-05 Avalon Pharmaceuticals Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods
NZ556095A (en) 2005-01-21 2010-01-29 Genentech Inc Fixed dosing of her antibodies
EP1849002A4 (en) 2005-02-18 2008-08-20 Childrens Medical Center Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin
JP5069214B2 (ja) 2005-03-11 2012-11-07 ヴァーミリオン インコーポレイテッド 卵巣癌及び子宮内膜癌のバイオマーカー:ヘプシジン
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Herceptin(登録商標)補助療法
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
EP1991701A4 (en) 2006-02-14 2010-03-17 Dana Farber Cancer Inst Inc COMPOSITIONS, KITS AND METHODS OF IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF CANCER
WO2008073162A2 (en) 2006-08-17 2008-06-19 Cell Signaling Technology, Inc. Lysine acetylation sites
US20080107668A1 (en) 2006-08-30 2008-05-08 Immunotope, Inc. Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
WO2008031041A2 (en) 2006-09-07 2008-03-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Melanoma gene signature
WO2008059252A2 (en) 2006-11-15 2008-05-22 Oxford Biomedica (Uk) Limited Methods and composition fro t cell receptors which recognize 5t4 antigen
DK3106873T3 (da) 2007-10-25 2019-09-23 Toray Industries Fremgangsmåde til detektering af cancer
JP5663834B2 (ja) 2008-03-14 2015-02-04 東ソー株式会社 遺伝子組換え抗体の製造方法
KR101751065B1 (ko) 2008-03-18 2017-06-26 제넨테크, 인크. 항-her2 항체-약물 접합체와 화학요법제의 병용물, 및 사용 방법
CA2732098C (en) * 2008-07-31 2016-11-22 Senomyx, Inc. Compositions comprising sweetness enhancers and methods of making them
ES2471379T3 (es) 2008-08-05 2014-06-26 Toray Industries, Inc. Método para detectar el cáncer
BRPI0911926A2 (pt) 2008-08-05 2020-08-18 Toray Industries, Inc composições farmacêuticas, anticorpos e usos de um anticorpo ou um fragmento do mesmo.
PT2837383T (pt) 2008-08-05 2017-03-17 Toray Industries Agente de indução de imunidade
EP2467401B1 (en) 2009-08-19 2017-01-18 Merck Patent GmbH Antibodies for the detection of integrin complexes in ffpe material
JP5746183B2 (ja) 2009-09-22 2015-07-08 プロビオゲン アーゲー 特定のグリカン構造を含有する分子を生成する方法
RU2418587C1 (ru) * 2010-01-21 2011-05-20 Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО "НижГМА Росздрава") Способ лечения злокачественных опухолей головного мозга
ES2583777T3 (es) * 2010-02-04 2016-09-22 Toray Industries, Inc. Composición farmacéutica que comprende anticuerpos anti CAPRIN-1 para el tratamiento y/o la prevención del cáncer
RU2624029C2 (ru) * 2010-02-04 2017-06-30 Торэй Индастриз, Инк. Лекарственный препарат для лечения и/или профилактики рака
DK2532365T3 (en) 2010-02-04 2016-08-15 Toray Industries PHARMACEUTICAL COMPOSITION FOR TREATMENT AND / OR PREVENTION OF CANCER
ES2540858T3 (es) 2010-02-04 2015-07-14 Toray Industries, Inc. Composición farmacéutica para el tratamiento y/o la prevención de cáncer
EP2532366B1 (en) 2010-02-04 2016-09-07 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer
US8709418B2 (en) 2010-02-04 2014-04-29 Toray Industries, Inc. Pharmaceutical composition for treating CAPRIN-1 expressing cancer
KR101271964B1 (ko) 2010-07-08 2013-06-07 강원대학교산학협력단 담낭암 치료용 약제학적 조성물 및 이를 이용한 담낭암의 성장, 전이 억제 및 치료 방법
PL2598531T3 (pl) 2010-07-26 2021-08-30 Progastrine Et Cancers S.À R.L. Sposoby i kompozycje do terapii nowotworu wątroby
JP2012035484A (ja) 2010-08-06 2012-02-23 Tombow Pencil Co Ltd 塗膜転写具
PT2741085T (pt) 2011-08-04 2017-06-30 Toray Industries Método para a deteção de cancro prancreático
DK2740489T3 (en) 2011-08-04 2017-01-16 Toray Industries Pharmaceutical composition for the treatment and / or prevention of pancreatic cancer
PT2740796T (pt) 2011-08-04 2017-07-26 Toray Industries Composição farmacêutica para o tratamento e/ou profilaxia de cancro
AU2013241043B2 (en) 2012-03-30 2017-11-09 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of gall bladder cancer
US9416193B2 (en) 2012-03-30 2016-08-16 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of liver cancer

Also Published As

Publication number Publication date
ES2739612T3 (es) 2020-02-03
DK2818482T3 (da) 2019-07-15
MX2014009748A (es) 2014-11-14
EP2818482A4 (en) 2015-10-07
KR20140130668A (ko) 2014-11-11
US9273130B2 (en) 2016-03-01
RU2632645C2 (ru) 2017-10-06
AU2013223143A1 (en) 2014-09-11
IN2014KN01713A (Direct) 2015-10-23
EP2818482B1 (en) 2019-05-22
BR112014021101A2 (pt) 2022-03-22
WO2013125636A1 (ja) 2013-08-29
MX360208B (es) 2018-10-24
EP2818482A1 (en) 2014-12-31
HUE044611T2 (hu) 2019-11-28
AU2013223143B2 (en) 2017-12-21
KR102009238B1 (ko) 2019-08-09
PT2818482T (pt) 2019-08-06
RU2014138040A (ru) 2016-04-10
CN104169303B (zh) 2018-05-29
JP6187255B2 (ja) 2017-08-30
CA2864864A1 (en) 2013-08-29
PL2818482T3 (pl) 2019-11-29
US20150004171A1 (en) 2015-01-01
JPWO2013125636A1 (ja) 2015-07-30
CN104169303A (zh) 2014-11-26

Similar Documents

Publication Publication Date Title
CA2864864C (en) Pharmaceutical composition for treatment and/or prevention of cancer
AU2013223137B2 (en) Pharmaceutical composition for treatment and/or prevention of cancer
AU2013223147B2 (en) Pharmaceutical composition for treatment and/or prevention of cancer
US9573993B2 (en) Pharmaceutical composition for treatment of cancer comprising an anti-CAPRIN-1 peptide antibody
AU2012290955B2 (en) Drug composition for cancer treatment and/or prevention
AU2012290954B2 (en) Pharmaceutical composition for treatment and/or prophylaxis of cancer
AU2012290957B2 (en) Pharmaceutical composition for treatment and/or prophylaxis of cancer
AU2012290952B2 (en) Cancer treatment and/or prevention drug composition
CA2844030A1 (en) Pharmaceutical composition for treatment and/or prophylaxis of cancer

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20171012