CA2864779C - One-way separator for retaining and recirculating cells - Google Patents
One-way separator for retaining and recirculating cells Download PDFInfo
- Publication number
- CA2864779C CA2864779C CA2864779A CA2864779A CA2864779C CA 2864779 C CA2864779 C CA 2864779C CA 2864779 A CA2864779 A CA 2864779A CA 2864779 A CA2864779 A CA 2864779A CA 2864779 C CA2864779 C CA 2864779C
- Authority
- CA
- Canada
- Prior art keywords
- solids
- separator
- plastic bag
- cells
- passages
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/06—Tubular
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/22—Settling tanks; Sedimentation by gravity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12001121 | 2012-02-20 | ||
| EP12001121.8 | 2012-02-20 | ||
| PCT/EP2013/053390 WO2013124326A1 (de) | 2012-02-20 | 2013-02-20 | Einweg abscheider zur rückhaltung und rückführung von zellen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2864779A1 CA2864779A1 (en) | 2013-08-29 |
| CA2864779C true CA2864779C (en) | 2021-10-19 |
Family
ID=47754472
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2864781A Expired - Fee Related CA2864781C (en) | 2012-02-20 | 2013-02-20 | One-way separator for retaining and recirculating cells |
| CA2864779A Active CA2864779C (en) | 2012-02-20 | 2013-02-20 | One-way separator for retaining and recirculating cells |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2864781A Expired - Fee Related CA2864781C (en) | 2012-02-20 | 2013-02-20 | One-way separator for retaining and recirculating cells |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9809792B2 (de) |
| EP (2) | EP2817406B1 (de) |
| JP (2) | JP6474616B2 (de) |
| KR (2) | KR102059895B1 (de) |
| CN (3) | CN111893022A (de) |
| AU (2) | AU2013224135B2 (de) |
| BR (2) | BR112014020462B1 (de) |
| CA (2) | CA2864781C (de) |
| DK (2) | DK2817406T3 (de) |
| ES (2) | ES2758739T3 (de) |
| IL (2) | IL234070B (de) |
| PL (1) | PL2817406T3 (de) |
| SG (2) | SG11201404611RA (de) |
| WO (2) | WO2013124329A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5995871B2 (ja) * | 2011-01-17 | 2016-09-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 分離装置およびその使用 |
| CN111893022A (zh) * | 2012-02-20 | 2020-11-06 | 拜耳股份公司 | 用于截留和返回细胞的一次性分离器 |
| CN113444620B (zh) * | 2013-09-16 | 2024-03-29 | 建新公司 | 用于处理细胞培养物的方法和系统 |
| EP3371295A1 (de) | 2015-11-04 | 2018-09-12 | Northeastern University | Systeme zur herstellung von zellulären immuntherapeutika und verfahren zur verwendung davon |
| KR101791671B1 (ko) | 2015-12-31 | 2017-11-20 | 주식회사 큐리오시스 | 미세입자 분리 및 정렬 장치, 및 그 방법 |
| EP3275992A1 (de) | 2016-07-29 | 2018-01-31 | Bayer Aktiengesellschaft | Adapter für zellkulturgefäss |
| CN106834088A (zh) * | 2017-03-29 | 2017-06-13 | 江苏丰泽生物工程设备制造有限公司 | 一种用于生物反应器中的细胞收集器 |
| CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
| EP3561038A1 (de) * | 2018-04-24 | 2019-10-30 | Bayer AG | Zellseparator |
| US11028359B2 (en) * | 2018-09-11 | 2021-06-08 | Global Life Sciences Solutions Usa Llc | Separation devices, associated methods, and systems |
| DE102018128010B4 (de) | 2018-11-08 | 2021-02-11 | Bastian Steudel | Bioreaktor zum Kultivieren von photoautotrophen Mikroorganismen und dessen Verwendung |
| EP3730599A1 (de) * | 2019-04-24 | 2020-10-28 | Sartorius Stedim Biotech GmbH | Bioreaktor zur verwendung auf einer beweglichen plattform, bioreaktorbewegungssystem und verfahren zur durchführung eines bioverfahrens unter verwendung eines bioreaktorbewegungssystems |
| JP7352146B2 (ja) * | 2019-07-23 | 2023-09-28 | 住友ベークライト株式会社 | 分離器及び培養システム |
| GB2623112A (en) * | 2022-10-07 | 2024-04-10 | Oribiotech Ltd | A device |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE356288B (de) * | 1971-04-29 | 1973-05-21 | Gustavsbergs Fabriker Ab | |
| DE2548950A1 (de) * | 1975-10-31 | 1977-05-12 | Sigma Corp | Vorrichtung und verfahren zur schnellabscheidung der festen bestandteile aus einem aus festen und fluessigen bestandteilen zusammengesetzten gemisch |
| US4268392A (en) * | 1979-06-01 | 1981-05-19 | Tiger Manufacturing Company | Disposable plastic trap bag |
| US4814278A (en) * | 1985-02-05 | 1989-03-21 | Teijin Limited | Culture apparatus and method |
| US4783255A (en) * | 1985-11-29 | 1988-11-08 | Bogusch Eugene D | Split countercurrent flow tube settler |
| EP0471947A1 (de) * | 1990-06-29 | 1992-02-26 | Sekisui Chemical Co., Ltd. | Züchtungsbeutel |
| US5320963A (en) * | 1992-11-25 | 1994-06-14 | National Research Council Of Canada | Bioreactor for the perfusion culture of cells |
| GB9309429D0 (en) | 1993-05-07 | 1993-06-23 | Bioscot Ltd | Fermenter accessory |
| US5350527A (en) * | 1993-09-14 | 1994-09-27 | Kitko John C | Oily water separation and water reclamation system |
| DE4401576A1 (de) * | 1994-01-20 | 1995-07-27 | Bielomatik Leuze & Co | Fremdstoff-Abscheider |
| US5698102A (en) * | 1996-06-19 | 1997-12-16 | Khudenko Engineering Inc. | Lamellar separator |
| DE19707497A1 (de) * | 1996-08-16 | 1998-02-19 | Boehringer Mannheim Gmbh | Reaktionsbeutelvorrichtung zur Durchführung von mehrstufigen Kultivierungs/Separations-Vorgängen und/oder Reaktionen |
| AUPP336098A0 (en) * | 1998-05-07 | 1998-05-28 | Lewis, Gregory Leslie | In vessel solids separator |
| FR2781202B1 (fr) | 1998-07-16 | 2001-01-12 | Stedim Sa | Poches pour produits fluides bio-pharmaceutiques |
| GB2339763A (en) | 1998-07-24 | 2000-02-09 | Applied Photosynthetics Limite | Partitioned bag for use as photobioreactor |
| AU778225C (en) * | 1999-08-06 | 2005-07-14 | Koninklijke Philips Electronics N.V. | Particle characterisation apparatus |
| JP2001078757A (ja) * | 1999-09-16 | 2001-03-27 | Asahi Medical Co Ltd | 細胞分離方法及び細胞分離用流体 |
| JP2002143875A (ja) * | 2000-08-23 | 2002-05-21 | Togami Electric Mfg Co Ltd | 水、廃水または下水処理装置およびその製造方法 |
| DK1451290T3 (da) * | 2001-08-31 | 2011-04-26 | Bayer Schering Pharma Ag | Indretning og fremgangsmåde til udførelse af fermentering af høj celledensitet |
| DE10223536A1 (de) * | 2002-05-27 | 2003-12-18 | J Hinrich Peters | Verfahren zur Trennung nicht-adhärenter Zellen von adhärenten Zellen |
| DE10256848A1 (de) * | 2002-12-04 | 2004-07-08 | Sibylle Latza | Verfahren und Vorrichtung zum Separieren von Vollblut unter Schwerkraft in ein Erythrozytenkonzentrat und Plasma |
| CN1286966C (zh) * | 2003-12-10 | 2006-11-29 | 上海伯瑞生物技术发展有限公司 | 造血细胞连续灌注悬浮培养过程细胞沉降截留装置 |
| ATE491509T1 (de) * | 2005-10-03 | 2011-01-15 | Zeta Biopharma Gmbh | Einweggebinde mit rührer |
| DE102006018824A1 (de) | 2006-04-22 | 2007-10-25 | Bayer Technology Services Gmbh | Einweg-Bioreaktor |
| CN100469863C (zh) * | 2006-11-16 | 2009-03-18 | 华东理工大学 | 倾斜式重力沉降活细胞截留装置 |
| CN101469319B (zh) * | 2007-02-01 | 2011-12-28 | 杭州安普生物工程有限公司 | 一种生产有效生物反应器的方法 |
| TWI337621B (en) * | 2007-11-26 | 2011-02-21 | Ind Tech Res Inst | Bio-reaction system and cell separation device |
| US20110070648A1 (en) | 2008-05-15 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Method for cell expansion |
| US8381780B2 (en) * | 2008-05-22 | 2013-02-26 | Xcellerex, Inc. | Lift and support assemblies and methods for collapsible bag containers of vessels and bioreactors |
| DE102008029307A1 (de) * | 2008-06-20 | 2009-12-24 | Bayer Technology Services Gmbh | Verfahren und Vorrichtung zur Rückhaltung und Rückführung von Zellen |
| BRPI0922307B8 (pt) * | 2008-11-28 | 2021-06-22 | Terumo Corp | sistema de bolsa de sangue e cassete |
| DE102010015236A1 (de) * | 2010-03-31 | 2011-10-06 | Kessler + Luch Entwicklungs- Und Ingenieurgesellschaft Mbh & Co. Kg | Abscheider |
| WO2011142670A1 (en) * | 2010-05-12 | 2011-11-17 | Xpand Biotechnology B.V. | Cell-culture-bag |
| CN111893022A (zh) * | 2012-02-20 | 2020-11-06 | 拜耳股份公司 | 用于截留和返回细胞的一次性分离器 |
-
2013
- 2013-02-20 CN CN202010612078.4A patent/CN111893022A/zh active Pending
- 2013-02-20 US US14/379,577 patent/US9809792B2/en active Active
- 2013-02-20 CA CA2864781A patent/CA2864781C/en not_active Expired - Fee Related
- 2013-02-20 SG SG11201404611RA patent/SG11201404611RA/en unknown
- 2013-02-20 AU AU2013224135A patent/AU2013224135B2/en not_active Ceased
- 2013-02-20 DK DK13707318T patent/DK2817406T3/da active
- 2013-02-20 ES ES13707318T patent/ES2758739T3/es active Active
- 2013-02-20 PL PL13707318T patent/PL2817406T3/pl unknown
- 2013-02-20 KR KR1020147022780A patent/KR102059895B1/ko active IP Right Grant
- 2013-02-20 ES ES13706481.2T patent/ES2616147T3/es active Active
- 2013-02-20 DK DK13706481.2T patent/DK2817405T3/en active
- 2013-02-20 WO PCT/EP2013/053393 patent/WO2013124329A1/de active Application Filing
- 2013-02-20 JP JP2014557085A patent/JP6474616B2/ja not_active Expired - Fee Related
- 2013-02-20 EP EP13707318.5A patent/EP2817406B1/de active Active
- 2013-02-20 CN CN201380010084.0A patent/CN104126001A/zh active Pending
- 2013-02-20 CN CN201380020998.5A patent/CN104471051A/zh active Pending
- 2013-02-20 BR BR112014020462-4A patent/BR112014020462B1/pt not_active IP Right Cessation
- 2013-02-20 WO PCT/EP2013/053390 patent/WO2013124326A1/de active Application Filing
- 2013-02-20 BR BR112014020120-0A patent/BR112014020120B1/pt not_active IP Right Cessation
- 2013-02-20 AU AU2013224132A patent/AU2013224132B2/en not_active Ceased
- 2013-02-20 EP EP13706481.2A patent/EP2817405B8/de active Active
- 2013-02-20 JP JP2014557086A patent/JP6239532B2/ja not_active Expired - Fee Related
- 2013-02-20 US US14/379,324 patent/US9840691B2/en active Active
- 2013-02-20 SG SG11201404262WA patent/SG11201404262WA/en unknown
- 2013-02-20 CA CA2864779A patent/CA2864779C/en active Active
- 2013-02-20 KR KR1020147025818A patent/KR102032138B1/ko active IP Right Grant
-
2014
- 2014-08-11 IL IL234070A patent/IL234070B/en active IP Right Grant
- 2014-08-17 IL IL234150A patent/IL234150B/en active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170928 |