CA2863388C - Materials and methods for treating diarrhea - Google Patents

Materials and methods for treating diarrhea Download PDF

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Publication number
CA2863388C
CA2863388C CA2863388A CA2863388A CA2863388C CA 2863388 C CA2863388 C CA 2863388C CA 2863388 A CA2863388 A CA 2863388A CA 2863388 A CA2863388 A CA 2863388A CA 2863388 C CA2863388 C CA 2863388C
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CA
Canada
Prior art keywords
glucose
composition
diarrhea
secretion
free
Prior art date
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Active
Application number
CA2863388A
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English (en)
French (fr)
Other versions
CA2863388A1 (en
Inventor
Sadasivan Vidyasagar
Paul Okunieff
Lurong Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida Research Foundation Inc
Original Assignee
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida Research Foundation Inc filed Critical University of Florida Research Foundation Inc
Publication of CA2863388A1 publication Critical patent/CA2863388A1/en
Application granted granted Critical
Publication of CA2863388C publication Critical patent/CA2863388C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/20Elemental chlorine; Inorganic compounds releasing chlorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2863388A 2012-02-08 2013-02-08 Materials and methods for treating diarrhea Active CA2863388C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261596480P 2012-02-08 2012-02-08
US61/596,480 2012-02-08
PCT/US2013/025294 WO2013119917A1 (en) 2012-02-08 2013-02-08 Materials and methods for treating diarrhea

Publications (2)

Publication Number Publication Date
CA2863388A1 CA2863388A1 (en) 2013-08-15
CA2863388C true CA2863388C (en) 2020-11-17

Family

ID=48948047

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2863388A Active CA2863388C (en) 2012-02-08 2013-02-08 Materials and methods for treating diarrhea

Country Status (15)

Country Link
US (4) US20140377374A1 (en:Method)
EP (1) EP2812007B1 (en:Method)
JP (1) JP6084238B2 (en:Method)
KR (2) KR102262179B1 (en:Method)
CN (1) CN104093410B (en:Method)
AP (1) AP3941A (en:Method)
AU (1) AU2013216871B2 (en:Method)
BR (1) BR112014019350B1 (en:Method)
CA (1) CA2863388C (en:Method)
EA (1) EA034014B1 (en:Method)
ES (1) ES2862392T3 (en:Method)
HK (1) HK1204290A1 (en:Method)
IN (1) IN2014DN06737A (en:Method)
MX (1) MX368543B (en:Method)
WO (1) WO2013119917A1 (en:Method)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153298B (zh) 2010-09-24 2015-11-25 佛罗里达大学研究基金会有限公司 用于改善胃肠功能的材料和方法
BR112015021931A8 (pt) 2013-03-11 2018-01-23 Univ Florida usos de composições farmacêuticas para prevenção e/ou tratamento de complicações do pulmão induzidas por radiação e da função pulmonar
CN107106527B (zh) * 2014-11-24 2020-11-24 恩特林斯科健康解决方案股份公司 用于治疗疾病症状的氨基酸组合物
CA3135553C (en) 2016-10-04 2024-05-21 University Of Florida Research Foundation, Incorporated Amino acid compositions and uses thereof
WO2019070753A1 (en) * 2017-10-02 2019-04-11 University Of Florida Research Foundation, Incorporated AMINO ACID COMPOSITIONS AND METHODS FOR TREATING DIARRHEA
JP2023531874A (ja) * 2020-06-02 2023-07-26 ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド 下痢を治療するための製剤および方法
CN116194136A (zh) 2020-07-02 2023-05-30 佛罗里达大学研究基金会公司 用于促进水化的制剂及其使用方法
CN118369093A (zh) * 2021-05-28 2024-07-19 可口可乐公司 氨基酸水合配制品及使用方法
CN115531363B (zh) * 2021-06-30 2024-03-29 中国科学技术大学 预防、抑制或治疗轮状病毒感染的药物组合物及其用途
US11878073B1 (en) 2022-09-20 2024-01-23 Entrinsic, LLC Generation of hydration-targeted formulations and methods of use therein

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290538A (en) * 1988-12-22 1994-03-01 Skrezek Christian Nephro protective infusion solutions
JP3301646B2 (ja) * 1993-03-19 2002-07-15 シスメックス株式会社 幼若細胞測定用試薬
ATE287703T1 (de) * 1995-04-14 2005-02-15 Nektar Therapeutics Pulverförmige pharmazeutische formulierungen mit verbesserter dispergierbarkeit
JP4255656B2 (ja) * 2001-09-17 2009-04-15 株式会社メニコン 眼科用液剤及びコンタクトレンズ用液剤
US20030143293A1 (en) * 2002-01-31 2003-07-31 Sergei Shushunov Compositions and methods for treating diarrhea
JP2004123642A (ja) * 2002-10-04 2004-04-22 Shimizu Pharmaceutical Co Ltd 電解質組成物
DK175877B1 (da) * 2002-11-11 2005-05-09 Pharmalett As Præparater til anvendelse som terapeutisk middel
US20050100637A1 (en) * 2003-11-12 2005-05-12 Robert Murray Carbohydrate and electrolyte replacement composition
GB0503337D0 (en) * 2005-02-17 2005-03-23 Glaxosmithkline Biolog Sa Compositions
JP4811576B2 (ja) * 2005-03-31 2011-11-09 味の素株式会社 水分電解質補給飲料
JP4512013B2 (ja) * 2005-09-07 2010-07-28 和光堂株式会社 液体飲料組成物及びその製造方法
DE102006018293A1 (de) * 2006-04-20 2007-10-25 Fresenius Kabi Deutschland Gmbh Pädiatrische Aminosäurelösung zur parenteralen Ernäherung
CN103153298B (zh) * 2010-09-24 2015-11-25 佛罗里达大学研究基金会有限公司 用于改善胃肠功能的材料和方法
BR112015021931A8 (pt) * 2013-03-11 2018-01-23 Univ Florida usos de composições farmacêuticas para prevenção e/ou tratamento de complicações do pulmão induzidas por radiação e da função pulmonar

Also Published As

Publication number Publication date
EP2812007B1 (en) 2020-12-30
US20210299076A1 (en) 2021-09-30
BR112014019350A8 (pt) 2017-07-11
CN104093410A (zh) 2014-10-08
BR112014019350B1 (pt) 2020-09-24
BR112014019350A2 (en:Method) 2017-06-20
EP2812007A4 (en) 2015-09-09
US20140377374A1 (en) 2014-12-25
EP2812007A1 (en) 2014-12-17
JP6084238B2 (ja) 2017-02-22
EA201400827A1 (ru) 2014-12-30
CA2863388A1 (en) 2013-08-15
MX368543B (es) 2019-10-07
KR102262179B1 (ko) 2021-06-07
AP2014007916A0 (en) 2014-09-30
US20150297636A1 (en) 2015-10-22
AU2013216871A1 (en) 2014-09-11
AU2013216871B2 (en) 2017-08-17
KR20200105525A (ko) 2020-09-07
HK1204290A1 (en) 2015-11-13
ES2862392T3 (es) 2021-10-07
AP3941A (en) 2016-12-16
KR20140120941A (ko) 2014-10-14
IN2014DN06737A (en:Method) 2015-05-22
US20250073260A1 (en) 2025-03-06
WO2013119917A1 (en) 2013-08-15
CN104093410B (zh) 2018-04-27
EA034014B1 (ru) 2019-12-19
MX2014009557A (es) 2014-11-10
JP2015506981A (ja) 2015-03-05

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