CA2861939A1 - Nouveaux derives d'arylalcene et utilisation de ceux-ci en tant que modulateurs selectifs de recepteur d'oestrogene - Google Patents

Nouveaux derives d'arylalcene et utilisation de ceux-ci en tant que modulateurs selectifs de recepteur d'oestrogene Download PDF

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CA2861939A1
CA2861939A1 CA2861939A CA2861939A CA2861939A1 CA 2861939 A1 CA2861939 A1 CA 2861939A1 CA 2861939 A CA2861939 A CA 2861939A CA 2861939 A CA2861939 A CA 2861939A CA 2861939 A1 CA2861939 A1 CA 2861939A1
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alkyl
group
halogen
ring
phenyl
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CA2861939A
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Inventor
Dengming Xiao
Li Zhu
Yuandong Hu
Rong Yu
Wei Hu
Na Zhao
Yong Peng
Hong Luo
Yongxin Han
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Centaurus Biopharma Co Ltd
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Centaurus Biopharma Co Ltd
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Priority claimed from CN2011104561181A external-priority patent/CN102532073A/zh
Priority claimed from CN2011104578981A external-priority patent/CN102584687A/zh
Application filed by Centaurus Biopharma Co Ltd filed Critical Centaurus Biopharma Co Ltd
Publication of CA2861939A1 publication Critical patent/CA2861939A1/fr
Abandoned legal-status Critical Current

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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
CA2861939A 2011-12-30 2012-12-28 Nouveaux derives d'arylalcene et utilisation de ceux-ci en tant que modulateurs selectifs de recepteur d'oestrogene Abandoned CA2861939A1 (fr)

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CN201110456118.1 2011-12-30
CN2011104578981A CN102584687A (zh) 2011-12-30 2011-12-30 作为选择性雌激素受体调节剂的乙烯衍生物
US201261646668P 2012-05-14 2012-05-14
US201261646628P 2012-05-14 2012-05-14
US61/646,628 2012-05-14
US61/646,668 2012-05-14
PCT/CN2012/087884 WO2013097773A1 (fr) 2011-12-30 2012-12-28 Nouveaux dérivés d'arylalcène et utilisation de ceux-ci en tant que modulateurs sélectifs de récepteur d'œstrogène

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US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
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BR112018016490A2 (pt) 2016-02-15 2018-12-18 Sanofi derivados de 6,7-di-hidro-5h-benzo[7]anuleno como moduladores de receptor de estrogênio
AU2017362460B2 (en) 2016-11-17 2021-07-22 Sanofi Novel substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
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CN107674051B (zh) * 2017-09-20 2021-01-08 南京医科大学 4-羟基他莫昔酚环状衍生物乏氧活化前药及其药物用途
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CN108514539B (zh) * 2018-07-11 2021-07-27 广州市腾宇化妆品有限公司 一种基于温和效果化妆品用防腐组合物及该化妆品制备方法
WO2020025574A1 (fr) * 2018-08-03 2020-02-06 Bayer Aktiengesellschaft Procédé de préparation de 6-(haloalkyl)-2-halo-5-acylpyridines et d'intermédiaires pour ce procédé
JP7413363B2 (ja) 2018-09-07 2024-01-15 サノフイ メチル６－（２，４－ジクロロフェニル）－５－［４－［（３ｓ）－１－（３－フルオロプロピル）ピロリジン－３－イル］オキシフェニル］－８，９－ジヒドロ－７ｈ－ベンゾ［７］アヌレン－２－カルボキシレートの調製方法
CN117050002A (zh) 2018-11-21 2023-11-14 冰洲石生物科技公司 具有雌激素受体α降解活性的新型化合物及其用途
MX2022001915A (es) 2019-12-20 2022-03-17 Landos Biopharma Inc Ligandos de proteina 2 tipo lantionina c, celulas preparadas con los mismos y terapias que usan los mismos.
CN116234803A (zh) 2019-12-23 2023-06-06 冰洲石生物科技公司 用于治疗癌症的雌激素受体降解剂和细胞周期蛋白依赖性激酶抑制剂的组合

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