CA2858571C - Composition and method for neuropeptide s receptor (npsr) antagonists - Google Patents
Composition and method for neuropeptide s receptor (npsr) antagonists Download PDFInfo
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- CA2858571C CA2858571C CA2858571A CA2858571A CA2858571C CA 2858571 C CA2858571 C CA 2858571C CA 2858571 A CA2858571 A CA 2858571A CA 2858571 A CA2858571 A CA 2858571A CA 2858571 C CA2858571 C CA 2858571C
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- pharmaceutically acceptable
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
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- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
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- BFFRNSYPZZUZDR-UHFFFAOYSA-N tert-butyl n-[2-(aminomethyl)phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=CC=C1CN BFFRNSYPZZUZDR-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201161568540P | 2011-12-08 | 2011-12-08 | |
| US61/568,540 | 2011-12-08 | ||
| PCT/US2012/068257 WO2013086200A1 (en) | 2011-12-08 | 2012-12-06 | Composition and method for neuropeptide s receptor (npsr) antagonists |
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| CA2858571A1 CA2858571A1 (en) | 2013-06-13 |
| CA2858571C true CA2858571C (en) | 2021-03-16 |
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| CA2858571A Active CA2858571C (en) | 2011-12-08 | 2012-12-06 | Composition and method for neuropeptide s receptor (npsr) antagonists |
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| EP (1) | EP2788359B1 (cg-RX-API-DMAC7.html) |
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| AU (1) | AU2012347758B2 (cg-RX-API-DMAC7.html) |
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| US11142546B2 (en) | 2016-04-04 | 2021-10-12 | Research Triangle Institute | Neuropeptide S receptor (NPSR) agonists |
| JOP20190060A1 (ar) * | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
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| JPS4917489B1 (cg-RX-API-DMAC7.html) * | 1970-01-22 | 1974-05-01 | ||
| DE3469531D1 (en) * | 1983-09-15 | 1988-04-07 | Ciba Geigy Ag | 5- and 6-azaphthalides, their mixture of isomers, process for their production and their use in recording materials which are sensitive to pressure and heat |
| JPH06502628A (ja) * | 1990-11-22 | 1994-03-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 除草作用をもつイソニコチン酸誘導体および関係するスピロ化合物 |
| AU2001294239A1 (en) | 2000-10-13 | 2002-04-22 | Takeda Chemical Industries Ltd. | Novel g protein-coupled receptor protein and dna thereof |
| AU2002246983A1 (en) * | 2001-01-11 | 2002-07-24 | Bristol-Myers Squibb Pharma Company | 1,2-disubstituted cyclic inhibitors of matrix metallorproteases and tnf-alpha |
| US9012407B2 (en) * | 2004-04-23 | 2015-04-21 | The Regents Of The University Of California | Therapies which act on neuropeptide S receptors |
| US8541595B2 (en) * | 2008-11-13 | 2013-09-24 | Merch Sharp & Dohme Corp. | Imidazoisoindole neuropeptide S receptor antagonists |
| US8389720B2 (en) * | 2008-11-13 | 2013-03-05 | Merck Sharp & Dohme Corp. | Quinolone neuropeptide S receptor antagonists |
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- 2012-12-06 WO PCT/US2012/068257 patent/WO2013086200A1/en not_active Ceased
- 2012-12-06 US US14/363,079 patent/US9150582B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US20150057268A1 (en) | 2015-02-26 |
| EP2788359A1 (en) | 2014-10-15 |
| JP6381445B2 (ja) | 2018-08-29 |
| US9150582B2 (en) | 2015-10-06 |
| AU2012347758B2 (en) | 2017-01-19 |
| EP2788359A4 (en) | 2015-06-10 |
| JP2015500293A (ja) | 2015-01-05 |
| ES2624853T3 (es) | 2017-07-17 |
| CA2858571A1 (en) | 2013-06-13 |
| AU2012347758A1 (en) | 2014-06-05 |
| WO2013086200A1 (en) | 2013-06-13 |
| EP2788359B1 (en) | 2017-03-01 |
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Effective date: 20171110 |