AU2012347758B2 - Composition and method for neuropeptide S receptor (NPSR) antagonists - Google Patents

Composition and method for neuropeptide S receptor (NPSR) antagonists Download PDF

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Publication number
AU2012347758B2
AU2012347758B2 AU2012347758A AU2012347758A AU2012347758B2 AU 2012347758 B2 AU2012347758 B2 AU 2012347758B2 AU 2012347758 A AU2012347758 A AU 2012347758A AU 2012347758 A AU2012347758 A AU 2012347758A AU 2012347758 B2 AU2012347758 B2 AU 2012347758B2
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compound
phenyl
tetrahydrofuro
pyridin
isobutyl
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AU2012347758A
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AU2012347758A1 (en
Inventor
Brian GILMOUR
Carla HASSLER
Scott RUNYON
Yanan Zhang
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RTI International Inc
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RTI International Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AU2012347758A 2011-12-08 2012-12-06 Composition and method for neuropeptide S receptor (NPSR) antagonists Active AU2012347758B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568540P 2011-12-08 2011-12-08
US61/568,540 2011-12-08
PCT/US2012/068257 WO2013086200A1 (en) 2011-12-08 2012-12-06 Composition and method for neuropeptide s receptor (npsr) antagonists

Publications (2)

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AU2012347758A1 AU2012347758A1 (en) 2014-06-05
AU2012347758B2 true AU2012347758B2 (en) 2017-01-19

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Country Status (7)

Country Link
US (1) US9150582B2 (cg-RX-API-DMAC7.html)
EP (1) EP2788359B1 (cg-RX-API-DMAC7.html)
JP (1) JP6381445B2 (cg-RX-API-DMAC7.html)
AU (1) AU2012347758B2 (cg-RX-API-DMAC7.html)
CA (1) CA2858571C (cg-RX-API-DMAC7.html)
ES (1) ES2624853T3 (cg-RX-API-DMAC7.html)
WO (1) WO2013086200A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
US11142546B2 (en) 2016-04-04 2021-10-12 Research Triangle Institute Neuropeptide S receptor (NPSR) agonists
JOP20190060A1 (ar) * 2016-09-26 2019-03-26 Chugai Pharmaceutical Co Ltd مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055491A2 (en) * 2001-01-11 2002-07-18 Bristol Myers Squibb Company P 1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4917489B1 (cg-RX-API-DMAC7.html) * 1970-01-22 1974-05-01
DE3469531D1 (en) * 1983-09-15 1988-04-07 Ciba Geigy Ag 5- and 6-azaphthalides, their mixture of isomers, process for their production and their use in recording materials which are sensitive to pressure and heat
JPH06502628A (ja) * 1990-11-22 1994-03-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 除草作用をもつイソニコチン酸誘導体および関係するスピロ化合物
AU2001294239A1 (en) 2000-10-13 2002-04-22 Takeda Chemical Industries Ltd. Novel g protein-coupled receptor protein and dna thereof
US9012407B2 (en) * 2004-04-23 2015-04-21 The Regents Of The University Of California Therapies which act on neuropeptide S receptors
US8541595B2 (en) * 2008-11-13 2013-09-24 Merch Sharp & Dohme Corp. Imidazoisoindole neuropeptide S receptor antagonists
US8389720B2 (en) * 2008-11-13 2013-03-05 Merck Sharp & Dohme Corp. Quinolone neuropeptide S receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055491A2 (en) * 2001-01-11 2002-07-18 Bristol Myers Squibb Company P 1,2-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLORPROTEASES AND TNF-$g(a)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EPSZTAJN J. ET. AL. TETRAHEDRON LETTERS, vol . 21, no. 49, 1 December 1980, pages 4739-4742, *
TEWARI J. D. : "Dyes derived from Cinchomeronic Acid" JOURNAL OF THE CHEMICAL SOCIETY, vol. 1929, 1 October 1929 pages 1642-1644 *
XUE, C.-B. et al. Synthesis and Structure-Activity Relationship of a Novel Sulfone Series of TNF-a Converting Enzyme Inhibitors. Bioorganic & Medicinal Chemistry Letters. 2004, Vol.14, pages 4453-4459. *

Also Published As

Publication number Publication date
US20150057268A1 (en) 2015-02-26
EP2788359A1 (en) 2014-10-15
JP6381445B2 (ja) 2018-08-29
CA2858571C (en) 2021-03-16
US9150582B2 (en) 2015-10-06
EP2788359A4 (en) 2015-06-10
JP2015500293A (ja) 2015-01-05
ES2624853T3 (es) 2017-07-17
CA2858571A1 (en) 2013-06-13
AU2012347758A1 (en) 2014-06-05
WO2013086200A1 (en) 2013-06-13
EP2788359B1 (en) 2017-03-01

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