CA2852386C - Absorbable in situ gel-forming system, method of making and use thereof - Google Patents

Absorbable in situ gel-forming system, method of making and use thereof Download PDF

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Publication number
CA2852386C
CA2852386C CA2852386A CA2852386A CA2852386C CA 2852386 C CA2852386 C CA 2852386C CA 2852386 A CA2852386 A CA 2852386A CA 2852386 A CA2852386 A CA 2852386A CA 2852386 C CA2852386 C CA 2852386C
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CA
Canada
Prior art keywords
forming composition
situ gel
lactide
gel
glycolide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2852386A
Other languages
English (en)
French (fr)
Other versions
CA2852386A1 (en
Inventor
Shalaby W. Shalaby
Joel Corbett
Jason OLBRICH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poly Med Inc
Original Assignee
Poly Med Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poly Med Inc filed Critical Poly Med Inc
Publication of CA2852386A1 publication Critical patent/CA2852386A1/en
Application granted granted Critical
Publication of CA2852386C publication Critical patent/CA2852386C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
CA2852386A 2011-10-17 2011-10-17 Absorbable in situ gel-forming system, method of making and use thereof Active CA2852386C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/056537 WO2013058726A1 (en) 2011-10-17 2011-10-17 Absorbable in situ gel-forming system, method of making and use thereof

Publications (2)

Publication Number Publication Date
CA2852386A1 CA2852386A1 (en) 2013-04-25
CA2852386C true CA2852386C (en) 2019-05-21

Family

ID=48141188

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2852386A Active CA2852386C (en) 2011-10-17 2011-10-17 Absorbable in situ gel-forming system, method of making and use thereof

Country Status (5)

Country Link
EP (1) EP2768544A4 (ja)
JP (1) JP5989126B2 (ja)
CN (2) CN103998069A (ja)
CA (1) CA2852386C (ja)
WO (1) WO2013058726A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150305892A1 (en) * 2014-04-25 2015-10-29 Abbott Cardiovascular Systems Inc. Methods and Devices for Treating a Bodily Lumen with In Situ Generated Structural Support
CN104189951B (zh) * 2014-09-19 2017-06-30 赣南师范学院 一种注射用快速形成原位小分子水凝胶的液态制剂及其制备方法和应用
CN104383276A (zh) * 2014-10-27 2015-03-04 济南高达信息技术有限公司 一种治疗蜘蛛痣的中药口服液制剂及其制备方法
ES2836805T3 (es) * 2015-08-03 2021-06-28 Tolmar International Ltd Sistema de administración de polímeros líquidos para la administración extendida de fármacos
JP6835841B2 (ja) * 2015-11-16 2021-02-24 エボニック オペレーションズ ゲーエムベーハー 非核酸系逆転写酵素阻害剤とポリ（ラクチド−ｃｏ−グリコリド）とを含む注射液
WO2017192753A1 (en) * 2016-05-03 2017-11-09 Bvw Holding Ag Multiphase gel
US20220202703A1 (en) * 2019-03-15 2022-06-30 Poly-Med, Inc. In situ gel-forming delivery systems, methods and compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413539B1 (en) * 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
CA2228118A1 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
CA2260047A1 (en) * 1996-07-29 1998-02-05 Micro Therapeutics, Inc. Novel methods for embolizing vascular sites with an embolizing composition comprising dimethylsulfoxide
US5854382A (en) * 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
CN1321092A (zh) * 1998-06-30 2001-11-07 安姆根有限公司 用于生物活性剂的延缓给药的热敏生物可降解水凝胶
US6245740B1 (en) * 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
CA2371321C (en) * 1999-05-21 2008-12-23 Micro Therapeutics, Inc. Novel high viscosity embolizing compositions
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20040142039A1 (en) * 2002-10-31 2004-07-22 Pfizer Inc Solid and semi-solid polymeric ionic conjugates
CN1950114A (zh) * 2004-05-12 2007-04-18 苏尔莫迪克斯公司 用于医疗物品的天然生物可降解的多糖涂层
US20050255091A1 (en) * 2004-05-14 2005-11-17 Loomis Gary L Hydrogels for biomedical applications
CN1899264A (zh) * 2006-07-20 2007-01-24 上海交通大学 温度敏感型水凝胶释药体系及其制备方法
CN100562358C (zh) * 2007-05-17 2009-11-25 浙江大学 以水凝胶微球为模板制备中空微球的方法
US20090233887A1 (en) * 2008-03-12 2009-09-17 Shalaby Shalaby W Hydroswellable, Segmented, Aliphatic Polyurethanes and Polyurethane Ureas
CN101721349B (zh) * 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
CN102146200B (zh) * 2011-04-19 2012-08-22 复旦大学 一种基于化学交联凝胶颗粒的温敏性水凝胶及其制备方法

Also Published As

Publication number Publication date
JP5989126B2 (ja) 2016-09-07
JP2014532082A (ja) 2014-12-04
EP2768544A1 (en) 2014-08-27
EP2768544A4 (en) 2015-06-24
CA2852386A1 (en) 2013-04-25
CN103998069A (zh) 2014-08-20
WO2013058726A1 (en) 2013-04-25
CN107252498B (zh) 2021-02-19
CN107252498A (zh) 2017-10-17

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