CA2841604C - Process for producing viral antigen and vaccines - Google Patents

Process for producing viral antigen and vaccines Download PDF

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Publication number
CA2841604C
CA2841604C CA2841604A CA2841604A CA2841604C CA 2841604 C CA2841604 C CA 2841604C CA 2841604 A CA2841604 A CA 2841604A CA 2841604 A CA2841604 A CA 2841604A CA 2841604 C CA2841604 C CA 2841604C
Authority
CA
Canada
Prior art keywords
equal
virus
carried out
chromatography
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2841604A
Other languages
English (en)
French (fr)
Other versions
CA2841604A1 (en
Inventor
Yi-Qing CUI
Yiding Wang
Jo THUS
Ron VAN 'T HOF
Sabah SHAKER
Geertje Jacoba VAN ROOIJ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BGP Products BV
Original Assignee
BGP Products BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BGP Products BV filed Critical BGP Products BV
Publication of CA2841604A1 publication Critical patent/CA2841604A1/en
Application granted granted Critical
Publication of CA2841604C publication Critical patent/CA2841604C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2841604A 2011-07-20 2012-07-04 Process for producing viral antigen and vaccines Expired - Fee Related CA2841604C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161509630P 2011-07-20 2011-07-20
US61/509,630 2011-07-20
EP11174660.8 2011-07-20
EP11174660 2011-07-20
PCT/EP2012/063045 WO2013010797A1 (en) 2011-07-20 2012-07-04 Process for producing viral antigen and vaccines

Publications (2)

Publication Number Publication Date
CA2841604A1 CA2841604A1 (en) 2013-01-24
CA2841604C true CA2841604C (en) 2020-01-21

Family

ID=45094875

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2841604A Expired - Fee Related CA2841604C (en) 2011-07-20 2012-07-04 Process for producing viral antigen and vaccines

Country Status (12)

Country Link
EP (1) EP2734619B1 (enExample)
JP (1) JP6275641B2 (enExample)
KR (2) KR20140038530A (enExample)
CN (1) CN103827296B (enExample)
AU (1) AU2012286098C1 (enExample)
BR (1) BR112014001049A2 (enExample)
CA (1) CA2841604C (enExample)
ES (1) ES2653197T3 (enExample)
MX (1) MX2014000753A (enExample)
RU (1) RU2565827C2 (enExample)
TW (1) TW201311896A (enExample)
WO (1) WO2013010797A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109568573A (zh) * 2014-12-12 2019-04-05 普莱柯生物工程股份有限公司 疫苗组合物及其制备方法和应用
SG11202004725PA (en) 2017-12-19 2020-07-29 CSL Behring Lengnau AG Protein purification and virus inactivation with alkyl glycosides
JP7360594B2 (ja) * 2017-12-28 2023-10-13 共立製薬株式会社 ワクチン製剤、並びに魚類のイリドウイルス感染症予防方法
US11696948B2 (en) 2018-06-12 2023-07-11 Kbio Holdings Limited Vaccines formed by virus and antigen conjugation
US11529413B2 (en) 2018-06-12 2022-12-20 Kbio Holdings Limited Virus and antigen purification and conjugation
KR102714626B1 (ko) 2018-06-12 2024-10-08 케이바이오 홀딩스 리미티드 바이러스 및 항원 정제 및 접합
US11690907B2 (en) 2018-06-12 2023-07-04 Kbio Holdings Limited Vaccines formed by virus and antigen conjugation
JP2021528999A (ja) * 2018-07-04 2021-10-28 プロバイオジェン アーゲー エンベロープウイルスの精製方法
JP7518825B2 (ja) 2018-11-15 2024-07-18 バイエル・ヘルスケア・エルエルシー 抗体の連続的製造のためのウイルス不活化方法
RU2710239C1 (ru) * 2019-06-14 2019-12-25 Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства Способ получения антигена или антигенов для производства противогриппозной вакцины и вакцина на его основе
EP4054630A2 (en) * 2019-11-07 2022-09-14 Seqirus UK Limited Compositions and methods for producing a viral vaccine with reduced particle size
KR102546626B1 (ko) * 2020-04-29 2023-06-21 에스케이바이오사이언스(주) 인플루엔자 바이러스 항원 정제 조건 신속 확인 시험
EP4144753A4 (en) * 2020-04-29 2024-12-25 SK Bioscience Co., Ltd. Influenza virus production method using disposable culture process system, and test for quickly checking conditions for influenza virus antigen purification
CN112309502B (zh) * 2020-10-14 2024-09-20 深圳市新合生物医疗科技有限公司 一种计算肿瘤新抗原负荷的方法及系统
JP2023141423A (ja) * 2022-03-24 2023-10-05 国立大学法人 東京大学 ウイルスの精製方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140762A (en) * 1974-01-14 1979-02-20 Sandoz Ltd. Influenza sub-unit vaccine
US4240762A (en) * 1979-03-12 1980-12-23 Johnston Pump Company Seal-aligning rigid coupling assembly
SE8405493D0 (sv) * 1984-11-01 1984-11-01 Bror Morein Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel
EP1597400B8 (en) * 2003-02-25 2013-10-09 MedImmune, LLC Methods of producing influenza vaccine compositions
RU2283139C1 (ru) * 2005-03-21 2006-09-10 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Способ получения антигенов для вакцины против вирусов гриппа
EP1982727A1 (en) * 2007-04-17 2008-10-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for purification of viral proteins
WO2009029695A1 (en) * 2007-08-28 2009-03-05 Baxter International Inc. Method for producing viral vaccines
US20110014230A1 (en) * 2008-03-18 2011-01-20 Novartis Ag preparation of influenza virus vaccine antigens
AU2009296628B2 (en) * 2008-09-24 2015-01-15 Medimmune, Llc Methods for purification of viruses
US8202726B2 (en) * 2008-09-24 2012-06-19 Medimmune, Llc Methods for cultivating cells, propagating and purifying viruses
GB0918830D0 (en) * 2009-10-27 2009-12-09 Glaxosmithkline Biolog Niederl Process

Also Published As

Publication number Publication date
AU2012286098C1 (en) 2016-09-15
RU2014101484A (ru) 2015-07-27
EP2734619A1 (en) 2014-05-28
BR112014001049A2 (pt) 2017-02-21
KR20160096215A (ko) 2016-08-12
KR20140038530A (ko) 2014-03-28
CA2841604A1 (en) 2013-01-24
EP2734619B1 (en) 2017-09-06
CN103827296B (zh) 2016-11-16
TW201311896A (zh) 2013-03-16
RU2565827C2 (ru) 2015-10-20
AU2012286098A1 (en) 2014-01-23
JP2014524747A (ja) 2014-09-25
WO2013010797A1 (en) 2013-01-24
MX2014000753A (es) 2014-05-07
JP6275641B2 (ja) 2018-02-07
CN103827296A (zh) 2014-05-28
ES2653197T3 (es) 2018-02-06

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Legal Events

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EEER Examination request

Effective date: 20170623

MKLA Lapsed

Effective date: 20220301

MKLA Lapsed

Effective date: 20200831

MKLA Lapsed

Effective date: 20200831