CA2836643C - Compositions de poudre seche de vancomycine et methodes associees - Google Patents
Compositions de poudre seche de vancomycine et methodes associees Download PDFInfo
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- CA2836643C CA2836643C CA2836643A CA2836643A CA2836643C CA 2836643 C CA2836643 C CA 2836643C CA 2836643 A CA2836643 A CA 2836643A CA 2836643 A CA2836643 A CA 2836643A CA 2836643 C CA2836643 C CA 2836643C
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- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 108010049589 leucyl-leucyl-leucine Proteins 0.000 description 1
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- 230000001404 mediated effect Effects 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
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- 239000003094 microcapsule Substances 0.000 description 1
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- 239000002105 nanoparticle Substances 0.000 description 1
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
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- 239000004033 plastic Substances 0.000 description 1
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- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000012383 pulmonary drug delivery Methods 0.000 description 1
- 229950003551 ramoplanin Drugs 0.000 description 1
- 108010076689 ramoplanin Proteins 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000009121 systemic therapy Methods 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 229960001608 teicoplanin Drugs 0.000 description 1
- 108010089019 telavancin Proteins 0.000 description 1
- 229960005240 telavancin Drugs 0.000 description 1
- ONUMZHGUFYIKPM-MXNFEBESSA-N telavancin Chemical compound O1[C@@H](C)[C@@H](O)[C@](NCCNCCCCCCCCCC)(C)C[C@@H]1O[C@H]1[C@H](OC=2C3=CC=4[C@H](C(N[C@H]5C(=O)N[C@H](C(N[C@@H](C6=CC(O)=C(CNCP(O)(O)=O)C(O)=C6C=6C(O)=CC=C5C=6)C(O)=O)=O)[C@H](O)C5=CC=C(C(=C5)Cl)O3)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](CC(C)C)NC)[C@H](O)C3=CC=C(C(=C3)Cl)OC=2C=4)O[C@H](CO)[C@@H](O)[C@@H]1O ONUMZHGUFYIKPM-MXNFEBESSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- HABDXNKVAIZXKJ-XTTLPDOESA-N vancocin sulfate Chemical compound OS(O)(=O)=O.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 HABDXNKVAIZXKJ-XTTLPDOESA-N 0.000 description 1
- 229940070668 vancomycin 250 mg Drugs 0.000 description 1
- 229940070384 ventolin Drugs 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Cette invention concerne des compositions de poudre sèche de vancomycine et des méthodes permettant de les administrer et de les préparer. Une composition de la présente invention peut être administrée à un sujet par administration pulmonaire en quantité efficace pour traiter et/ou prévenir une infection bactérienne chez le sujet. L'administration d'une quantité efficace d'une composition de la présente invention peut être particulièrement utile dans le traitement d'une infection bactérienne à Gram positif chez un sujet souffrant de pneumonie, de fibrose kystique, de bronchectasie ou d'une autre maladie pulmonaire chronique avec infection bactérienne des voies respiratoires et/ou du poumon du sujet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2981038A CA2981038C (fr) | 2011-05-19 | 2012-05-21 | Compositions de poudre seche de vancomycine et methodes associees |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161487971P | 2011-05-19 | 2011-05-19 | |
| US61/487,971 | 2011-05-19 | ||
| PCT/US2012/038775 WO2012159103A1 (fr) | 2011-05-19 | 2012-05-21 | Compositions de poudre sèche de vancomycine et méthodes associées |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2981038A Division CA2981038C (fr) | 2011-05-19 | 2012-05-21 | Compositions de poudre seche de vancomycine et methodes associees |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2836643A1 CA2836643A1 (fr) | 2012-11-22 |
| CA2836643C true CA2836643C (fr) | 2017-11-14 |
Family
ID=47177374
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2836643A Expired - Fee Related CA2836643C (fr) | 2011-05-19 | 2012-05-21 | Compositions de poudre seche de vancomycine et methodes associees |
| CA2981038A Expired - Fee Related CA2981038C (fr) | 2011-05-19 | 2012-05-21 | Compositions de poudre seche de vancomycine et methodes associees |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2981038A Expired - Fee Related CA2981038C (fr) | 2011-05-19 | 2012-05-21 | Compositions de poudre seche de vancomycine et methodes associees |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2709646A4 (fr) |
| JP (1) | JP6012716B2 (fr) |
| KR (1) | KR101763195B1 (fr) |
| CN (1) | CN103717231B (fr) |
| AU (1) | AU2012254999B2 (fr) |
| BR (1) | BR112013029803B1 (fr) |
| CA (2) | CA2836643C (fr) |
| IL (1) | IL229506B (fr) |
| MX (1) | MX346244B (fr) |
| SG (1) | SG195038A1 (fr) |
| WO (1) | WO2012159103A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2838111C (fr) | 2005-12-08 | 2016-01-19 | Insmed Incorporated | Compositions a base de lipide d'anti-infectieux pour traiter des infections pulmonaires et procedes d'utilisation de celles-ci |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| EP3581186A1 (fr) | 2012-11-29 | 2019-12-18 | Insmed Incorporated | Formulations de vancomycine stabilisées |
| CA2897651C (fr) | 2013-01-10 | 2021-09-21 | Pulmokine, Inc. | Inhibiteurs de kinase non selectifs |
| CN104043104B (zh) * | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| CA2926793C (fr) | 2013-10-11 | 2022-11-22 | Lawrence S. ZISMAN | Formulations a sechage par pulverisation pour le traitement de l'hypertension arterielle pulmonaire |
| KR20160119259A (ko) * | 2014-02-28 | 2016-10-12 | 알지파마 에이에스 | 낭포성 섬유증 및 cftr 이온 채널의 기능 결함과 관련된 기타 병태의 치료제로서 알기네이트 올리고머의 용도 |
| AU2015229069A1 (en) | 2014-03-14 | 2016-11-03 | CutisPharma,Inc. | Composition and method for vancomycin oral liquid |
| PL3142643T3 (pl) | 2014-05-15 | 2019-12-31 | Insmed Incorporated | Sposoby leczenia zakażeń płuc prątkami niegruźliczymi |
| NZ731955A (en) * | 2014-11-06 | 2023-07-28 | Xellia Pharmaceuticals Aps | Glycopeptide compositions |
| JP6832281B2 (ja) * | 2015-02-06 | 2021-02-24 | ラティチュード ファーマシューティカルズ インコーポレイテッド | バンコマイシンの水溶液製剤 |
| GB201609940D0 (en) * | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
| RU2763525C2 (ru) | 2016-10-27 | 2021-12-30 | Пульмокин, Инк. | Комбинированная терапия для лечения легочной гипертензии |
| CN106963939A (zh) * | 2017-03-22 | 2017-07-21 | 永信药品工业（昆山）股份有限公司 | 盐酸万古霉素药物组合物及其制备方法 |
| JP7210476B2 (ja) * | 2017-05-22 | 2023-01-23 | インスメッド インコーポレイテッド | リポ‐グリコペプチド可切断性誘導体及びその使用 |
| EP3773505A4 (fr) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | Procédés pour la fabrication continue de produits médicamenteux liposomaux |
| WO2020081599A1 (fr) * | 2018-10-15 | 2020-04-23 | Savara Inc. | Séparation de la vancomycine et de ses produits de dégradation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2129691B (en) | 1982-10-08 | 1987-08-05 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| NO166268C (no) | 1985-07-30 | 1991-07-03 | Glaxo Group Ltd | Innretning for administrering av medikamenter til pasienter. |
| JPH03193735A (ja) * | 1989-12-22 | 1991-08-23 | Shionogi & Co Ltd | グリコペプチド系抗生物質の安定化組成物 |
| JPH05963A (ja) | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| JP4142149B2 (ja) * | 1997-07-10 | 2008-08-27 | 明治製菓株式会社 | バンコマイシンの凍結乾燥製剤 |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| HU229310B1 (en) * | 1999-10-29 | 2013-10-28 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
| EP1992335A1 (fr) * | 2001-11-01 | 2008-11-19 | Nektar Therapeutics | Procédés de séchage par pulvérisation et compositions correspondantes |
| DE10358387A1 (de) * | 2003-12-13 | 2005-07-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung |
| FR2872044B1 (fr) * | 2004-06-28 | 2007-06-29 | Flamel Technologies Sa | Formulation pharmaceutique a base d'antibiotique sous forme microcapsulaire |
| EP2050437A1 (fr) * | 2007-10-15 | 2009-04-22 | Laboratoires SMB | Compositions de poudre sèche pharmaceutiquement améliorées pour l'inhalation |
| PL2344129T3 (pl) * | 2008-10-07 | 2018-07-31 | Horizon Orphan Llc | Formulacje fluorochinolonu w aerozolu dla poprawy właściwości farmakokinetycznych |
| AU2010229721A1 (en) * | 2009-03-26 | 2011-10-06 | Pulmatrix, Inc. | Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis |
| PT2410981T (pt) * | 2009-03-26 | 2017-05-25 | Pulmatrix Inc | Formulações em pó seco e métodos para tratar doenças pulmonares |
-
2012
- 2012-05-21 MX MX2013013503A patent/MX346244B/es active IP Right Grant
- 2012-05-21 CN CN201280035537.0A patent/CN103717231B/zh not_active Expired - Fee Related
- 2012-05-21 WO PCT/US2012/038775 patent/WO2012159103A1/fr active Application Filing
- 2012-05-21 SG SG2013085394A patent/SG195038A1/en unknown
- 2012-05-21 CA CA2836643A patent/CA2836643C/fr not_active Expired - Fee Related
- 2012-05-21 KR KR1020137033895A patent/KR101763195B1/ko active IP Right Grant
- 2012-05-21 CA CA2981038A patent/CA2981038C/fr not_active Expired - Fee Related
- 2012-05-21 EP EP12785744.9A patent/EP2709646A4/fr not_active Withdrawn
- 2012-05-21 AU AU2012254999A patent/AU2012254999B2/en not_active Ceased
- 2012-05-21 JP JP2014511611A patent/JP6012716B2/ja not_active Expired - Fee Related
- 2012-05-21 BR BR112013029803-0A patent/BR112013029803B1/pt not_active IP Right Cessation
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2013
- 2013-11-19 IL IL229506A patent/IL229506B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2709646A4 (fr) | 2015-05-13 |
| AU2012254999B2 (en) | 2016-02-11 |
| MX346244B (es) | 2017-03-13 |
| BR112013029803A2 (pt) | 2017-01-17 |
| BR112013029803B1 (pt) | 2021-07-13 |
| IL229506A0 (en) | 2014-01-30 |
| KR20140032450A (ko) | 2014-03-14 |
| CA2981038A1 (fr) | 2012-11-22 |
| KR101763195B1 (ko) | 2017-07-31 |
| CN103717231A (zh) | 2014-04-09 |
| NZ618002A (en) | 2015-03-27 |
| IL229506B (en) | 2019-07-31 |
| CN103717231B (zh) | 2016-08-17 |
| JP2014515356A (ja) | 2014-06-30 |
| EP2709646A1 (fr) | 2014-03-26 |
| WO2012159103A1 (fr) | 2012-11-22 |
| CA2981038C (fr) | 2018-09-25 |
| MX2013013503A (es) | 2014-05-12 |
| NZ704819A (en) | 2016-05-27 |
| SG195038A1 (en) | 2013-12-30 |
| JP6012716B2 (ja) | 2016-10-25 |
| CA2836643A1 (fr) | 2012-11-22 |
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| MKLA | Lapsed |
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