CA2836478A1 - Proteines therapeutiques conjuguees avec des polymeres solubles dans l'eau par un groupe sulfhydryle de cysteine reduite - Google Patents

Proteines therapeutiques conjuguees avec des polymeres solubles dans l'eau par un groupe sulfhydryle de cysteine reduite Download PDF

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Publication number
CA2836478A1
CA2836478A1 CA2836478A CA2836478A CA2836478A1 CA 2836478 A1 CA2836478 A1 CA 2836478A1 CA 2836478 A CA2836478 A CA 2836478A CA 2836478 A CA2836478 A CA 2836478A CA 2836478 A1 CA2836478 A1 CA 2836478A1
Authority
CA
Canada
Prior art keywords
therapeutic protein
group
peg
protein
soluble polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2836478A
Other languages
English (en)
Inventor
Juergen Siekmann
Alfred Weber
Hanspeter Rottensteiner
Peter Turecek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Priority to CA3012117A priority Critical patent/CA3012117A1/fr
Publication of CA2836478A1 publication Critical patent/CA2836478A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des matériaux et des procédés pour conjuguer un polymère soluble dans l'eau à une protéine thérapeutique.
CA2836478A 2011-05-27 2012-05-25 Proteines therapeutiques conjuguees avec des polymeres solubles dans l'eau par un groupe sulfhydryle de cysteine reduite Abandoned CA2836478A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3012117A CA3012117A1 (fr) 2011-05-27 2012-05-25 Fusion de psa avec des serpines et autres proteines therapeutiques

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161490869P 2011-05-27 2011-05-27
US61/490,869 2011-05-27
PCT/US2012/039637 WO2012166622A1 (fr) 2011-05-27 2012-05-25 Protéines thérapeutiques à plus longue demi-vie et leurs procédés de préparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3012117A Division CA3012117A1 (fr) 2011-05-27 2012-05-25 Fusion de psa avec des serpines et autres proteines therapeutiques

Publications (1)

Publication Number Publication Date
CA2836478A1 true CA2836478A1 (fr) 2012-12-06

Family

ID=46208843

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3012117A Abandoned CA3012117A1 (fr) 2011-05-27 2012-05-25 Fusion de psa avec des serpines et autres proteines therapeutiques
CA2836478A Abandoned CA2836478A1 (fr) 2011-05-27 2012-05-25 Proteines therapeutiques conjuguees avec des polymeres solubles dans l'eau par un groupe sulfhydryle de cysteine reduite

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3012117A Abandoned CA3012117A1 (fr) 2011-05-27 2012-05-25 Fusion de psa avec des serpines et autres proteines therapeutiques

Country Status (7)

Country Link
US (5) US20120329127A1 (fr)
EP (3) EP3412314A1 (fr)
JP (6) JP2014520094A (fr)
AU (5) AU2012262428C1 (fr)
CA (2) CA3012117A1 (fr)
TW (4) TW201835109A (fr)
WO (1) WO2012166622A1 (fr)

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EP2825205A1 (fr) * 2012-03-16 2015-01-21 Belrose Pharma Inc. Conjugués polymères d'inhibiteurs de la c1-estérase
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
CN103333250A (zh) * 2013-06-24 2013-10-02 上海大学 一种生物安全性好的纳米荧光探针的制备方法
WO2015086853A1 (fr) 2013-12-13 2015-06-18 Novo Nordisk Health Care Ag Procédé de conjugaison thioéther de protéines
US10046058B2 (en) 2014-12-02 2018-08-14 Rezolute, Inc. Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
CN107708679A (zh) 2015-06-04 2018-02-16 安特里阿比奥有限公司 用于制备位点特异性蛋白质偶联物的胺聚乙二醇化方法
US10589615B2 (en) * 2015-08-03 2020-03-17 Ford Global Technologies, Llc Decoupler for a hydraulic engine mount
MA45473A (fr) * 2016-04-04 2019-02-13 Shire Human Genetic Therapies Inhibiteur de c1 estérase conjugué et ses utilisations
US11231415B2 (en) 2016-05-12 2022-01-25 Z Biotech Llc Multivalent glycan microarray platform
JP6773987B2 (ja) * 2019-08-22 2020-10-21 サミー株式会社 遊技機
AU2020338947A1 (en) 2019-08-27 2022-03-31 Tonix Pharma Limited Modified TFF2 polypeptides
JP6773989B2 (ja) * 2019-09-09 2020-10-21 サミー株式会社 遊技機
CN114652848A (zh) * 2022-03-18 2022-06-24 山东大学齐鲁医院 一种peg化人血清白蛋白纳米材料及其制备方法和在肿瘤诊疗中的应用

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Also Published As

Publication number Publication date
US20120329127A1 (en) 2012-12-27
JP2021183636A (ja) 2021-12-02
TWI714769B (zh) 2021-01-01
WO2012166622A1 (fr) 2012-12-06
US20190142958A1 (en) 2019-05-16
AU2019202970A1 (en) 2019-05-16
TW201731863A (zh) 2017-09-16
EP3808378A1 (fr) 2021-04-21
AU2017239551A1 (en) 2017-10-26
AU2012262428C1 (en) 2018-10-11
US20180318432A1 (en) 2018-11-08
AU2018204313A1 (en) 2018-07-05
JP2020059717A (ja) 2020-04-16
EP2714093A1 (fr) 2014-04-09
CA3012117A1 (fr) 2012-12-06
TW201247709A (en) 2012-12-01
US20220175939A1 (en) 2022-06-09
TW201835109A (zh) 2018-10-01
JP2014520094A (ja) 2014-08-21
AU2012262428B2 (en) 2017-07-06
EP3412314A1 (fr) 2018-12-12
JP2018162293A (ja) 2018-10-18
TW202039006A (zh) 2020-11-01
US20210106691A1 (en) 2021-04-15
EP3808378A8 (fr) 2021-06-09
AU2021202508A1 (en) 2021-05-20
JP2017206513A (ja) 2017-11-24
JP2019151643A (ja) 2019-09-12

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211220