CA2833942A1 - Novel compound useful for the treatment of degenerative and inflammatory diseases - Google Patents
Novel compound useful for the treatment of degenerative and inflammatory diseases Download PDFInfo
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- CA2833942A1 CA2833942A1 CA2833942A CA2833942A CA2833942A1 CA 2833942 A1 CA2833942 A1 CA 2833942A1 CA 2833942 A CA2833942 A CA 2833942A CA 2833942 A CA2833942 A CA 2833942A CA 2833942 A1 CA2833942 A1 CA 2833942A1
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- A—HUMAN NECESSITIES
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/EP2012/057652 WO2012146657A1 (en) | 2011-04-28 | 2012-04-26 | Novel compound useful for the treatment of degenerative and inflammatory diseases |
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| AR086042A1 (es) * | 2011-04-28 | 2013-11-13 | Galapagos Nv | Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica |
| MX2015015150A (es) * | 2013-04-29 | 2016-02-18 | Sanofi Sa | Composiciones farmaceuticas inhalables y los dispositivos inhaladores que las contienen. |
| GB201321733D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| KR101690760B1 (ko) * | 2014-11-05 | 2016-12-30 | 조길래 | 피부자극완화, 탈모방지 및 발모촉진 효과를 나타내는 카페오일펜타펩타이드 및 이를 함유하는 탈모방지 및 발모촉진용 화장료 조성물 |
| TW201705961A (zh) * | 2015-06-11 | 2017-02-16 | 阿爾米雷爾有限公司 | 作為ｊａｋ抑制劑的２－（吡唑并吡啶－３－基）嘧啶衍生物 |
| KR20180026459A (ko) * | 2015-06-18 | 2018-03-12 | 세파론, 인코포레이티드 | 1,4-치환된 피페리딘 유도체 |
| WO2016205590A1 (en) | 2015-06-18 | 2016-12-22 | Cephalon, Inc. | Substituted 4-benzyl and 4-benzoyl piperidine derivatives |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| DE102015215820A1 (de) * | 2015-08-19 | 2017-02-23 | Siemens Healthcare Gmbh | Steuern eines medizintechnischen Geräts |
| KR102598246B1 (ko) * | 2016-07-26 | 2023-11-02 | 톈진 롱보진 파마시우티컬 씨오., 엘티디. | Jak 저해제로서 헤테로사이클릭 화합물, 및 이의 염 및 치료학적 용도 |
| TWI752098B (zh) * | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
| WO2018163971A1 (ja) * | 2017-03-09 | 2018-09-13 | 富士フイルム株式会社 | 音響レンズ用樹脂材料、音響レンズ、音響波プローブ、音響波測定装置、超音波診断装置、光音響波測定装置および超音波内視鏡 |
| EA035568B1 (ru) * | 2017-09-29 | 2020-07-08 | Эррей Биофарма Инк. | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ |
| EA037208B1 (ru) * | 2017-09-29 | 2021-02-19 | Эррей Биофарма Инк. | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДИНОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI783057B (zh) * | 2017-10-10 | 2022-11-11 | 美商絡速藥業公司 | 製備6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈的方法 |
| US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
| EP3740490A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| JP7060694B2 (ja) | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物 |
| CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
| US20210379056A1 (en) * | 2018-09-30 | 2021-12-09 | Applied Pharmaceutical Science, Inc. | Substituted pyrazole fused ring derivative, preparation method therefor, and application thereof |
| EP3891148A4 (en) * | 2018-12-07 | 2022-09-07 | Sunshine Lake Pharma Co., Ltd. | RET INHIBITOR, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| WO2020114487A1 (en) * | 2018-12-07 | 2020-06-11 | Sunshine Lake Pharma Co., Ltd. | Ret inhibitors, pharmaceutical compositions and uses thereof |
| CN115605477B (zh) * | 2020-04-22 | 2024-07-05 | 深圳众格生物科技有限公司 | 一种吡唑并[1,5-a]吡啶类衍生物及其制备方法，组合物以及用途 |
| CN113713083A (zh) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | 一种用于治疗脱发的药物组合 |
| BR112023003835A2 (pt) | 2020-09-01 | 2023-04-04 | Syngenta Crop Protection Ag | Derivados heterocíclicos com substituintes contendo enxofre ativos em termos pesticidas |
| WO2022064459A1 (en) | 2020-09-28 | 2022-03-31 | 1ST Biotherapeutics, Inc. | Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same |
| US20240174662A1 (en) * | 2021-02-01 | 2024-05-30 | Janssen Biotech, Inc. | Small molecule inhibitors of salt inducible kinases |
| WO2022165529A1 (en) * | 2021-02-01 | 2022-08-04 | Janssen Biotech, Inc. | Small molecule inhibitors of salt inducible kinases |
| US20250145640A1 (en) | 2021-08-10 | 2025-05-08 | Syngenta Crop Protection Ag | 2,2-difluoro-5h-[1,3]dioxolo[4,5-f]isoindol-7-one derivatives as pesticides |
| CN114409675B (zh) * | 2022-01-07 | 2023-08-04 | 重庆医科大学 | 螺环异恶唑酮色满衍生物在制备用于治疗jak1介导的疾病药物中的用途 |
| UY40202A (es) | 2022-04-01 | 2023-10-31 | Syngenta Crop Protection Ag | Derivados de pirazolopiridina activos como pesticidas con sustituyentes que contienen azufre |
| PY2404178A (es) | 2023-01-23 | 2024-11-12 | Syngenta Crop Protection Ag | Derivados heterocíclicos activos como pesticidas con sustituyentes que contienen azufre |
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| JP2008503712A (ja) | 2004-06-21 | 2008-02-07 | ガラパゴス・ナムローゼ・フェンノートシャップ | 骨関節炎治療の方法及び手段 |
| BRPI0716239A2 (pt) * | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
| WO2009017954A1 (en) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
| CN102131389A (zh) * | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | 三唑并吡啶jak抑制剂化合物和方法 |
| WO2010010186A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
| JO3041B1 (ar) * | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
| TWI462920B (zh) * | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
| AR086042A1 (es) * | 2011-04-28 | 2013-11-13 | Galapagos Nv | Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica |
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2012
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- 2012-04-26 CA CA2833942A patent/CA2833942A1/en not_active Abandoned
- 2012-04-26 EP EP12717289.8A patent/EP2702059B1/en active Active
- 2012-04-26 CN CN201280020782.4A patent/CN103492386B/zh active Active
- 2012-04-26 MX MX2013012281A patent/MX355653B/es active IP Right Grant
- 2012-04-26 JP JP2014506863A patent/JP5947371B2/ja active Active
- 2012-04-26 UY UY0001034037A patent/UY34037A/es not_active Application Discontinuation
- 2012-04-26 SG SG2013077060A patent/SG194508A1/en unknown
- 2012-04-26 KR KR1020137029055A patent/KR101934707B1/ko not_active Expired - Fee Related
- 2012-04-26 US US14/114,218 patent/US8975406B2/en active Active
- 2012-04-26 JP JP2014506865A patent/JP5947372B2/ja active Active
- 2012-04-26 MX MX2013012282A patent/MX360697B/es active IP Right Grant
- 2012-04-26 WO PCT/EP2012/057652 patent/WO2012146657A1/en not_active Ceased
- 2012-04-26 EP EP12717288.0A patent/EP2702058B1/en active Active
- 2012-04-26 WO PCT/EP2012/057654 patent/WO2012146659A1/en not_active Ceased
- 2012-04-26 BR BR112013027338A patent/BR112013027338A2/pt not_active Application Discontinuation
- 2012-04-26 EA EA201391584A patent/EA024743B1/ru not_active IP Right Cessation
- 2012-04-26 AU AU2012247482A patent/AU2012247482B2/en not_active Ceased
- 2012-04-26 TW TW101115010A patent/TWI536990B/zh not_active IP Right Cessation
- 2012-04-26 AU AU2012247484A patent/AU2012247484B2/en not_active Ceased
- 2012-04-26 CA CA2833963A patent/CA2833963C/en active Active
- 2012-04-26 CN CN201280020639.5A patent/CN103492385B/zh active Active
- 2012-04-27 US US13/459,055 patent/US8802682B2/en active Active
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2013
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- 2013-10-18 ZA ZA2013/07793A patent/ZA201307793B/en unknown
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2014
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2016
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2017
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| Date | Code | Title | Description |
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Effective date: 20180426 |