CA2833675C - Atmospheric pressure ion source by interacting high velocity spray with a target - Google Patents
Atmospheric pressure ion source by interacting high velocity spray with a target Download PDFInfo
- Publication number
- CA2833675C CA2833675C CA2833675A CA2833675A CA2833675C CA 2833675 C CA2833675 C CA 2833675C CA 2833675 A CA2833675 A CA 2833675A CA 2833675 A CA2833675 A CA 2833675A CA 2833675 C CA2833675 C CA 2833675C
- Authority
- CA
- Canada
- Prior art keywords
- ion source
- targets
- droplets
- ion
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007921 spray Substances 0.000 title claims description 34
- 150000002500 ions Chemical class 0.000 claims abstract description 264
- 239000012491 analyte Substances 0.000 claims abstract description 49
- 239000007789 gas Substances 0.000 claims description 46
- 239000007788 liquid Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 22
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 230000003116 impacting effect Effects 0.000 claims description 12
- 239000003480 eluent Substances 0.000 claims description 11
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 10
- 238000004811 liquid chromatography Methods 0.000 claims description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000007769 metal material Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 238000011144 upstream manufacturing Methods 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
- 239000010931 gold Substances 0.000 claims description 3
- 229910052737 gold Inorganic materials 0.000 claims description 3
- 239000012212 insulator Substances 0.000 claims description 3
- 239000004065 semiconductor Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 238000002485 combustion reaction Methods 0.000 claims description 2
- 238000000766 differential mobility spectroscopy Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 102100032157 Adenylate cyclase type 10 Human genes 0.000 description 25
- 101000775498 Homo sapiens Adenylate cyclase type 10 Proteins 0.000 description 24
- 239000000523 sample Substances 0.000 description 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 11
- 238000001819 mass spectrum Methods 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000000451 chemical ionisation Methods 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 229910001873 dinitrogen Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000004807 desolvation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
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- 239000000203 mixture Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 1
- 238000001479 atomic absorption spectroscopy Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- ZZORFUFYDOWNEF-UHFFFAOYSA-N sulfadimethoxine Chemical compound COC1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ZZORFUFYDOWNEF-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/7273—Desolvation chambers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0404—Capillaries used for transferring samples or ions
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/061—Ion deflecting means, e.g. ion gates
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
- H01J49/142—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using a solid target which is not previously vapourised
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/24—Vacuum systems, e.g. maintaining desired pressures
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1106694.1 | 2011-04-20 | ||
| GBGB1106694.1A GB201106694D0 (en) | 2011-04-20 | 2011-04-20 | Atmospheric pressure ion source by interacting high velocity spray with a target |
| US201161478725P | 2011-04-25 | 2011-04-25 | |
| US61/478,725 | 2011-04-25 | ||
| GB1204937.5 | 2012-03-21 | ||
| GBGB1204937.5A GB201204937D0 (en) | 2012-03-21 | 2012-03-21 | Atomspheric pressure ion source by interacting high velocity spray with a target |
| US201261614734P | 2012-03-23 | 2012-03-23 | |
| US61/614,734 | 2012-03-23 | ||
| PCT/GB2012/050888 WO2012143737A1 (en) | 2011-04-20 | 2012-04-20 | Atmospheric pressure ion source by interacting high velocity spray with a target |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2833675A1 CA2833675A1 (en) | 2012-10-26 |
| CA2833675C true CA2833675C (en) | 2019-01-15 |
Family
ID=46261648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2833675A Active CA2833675C (en) | 2011-04-20 | 2012-04-20 | Atmospheric pressure ion source by interacting high velocity spray with a target |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8809777B2 (OSRAM) |
| EP (2) | EP2700086B1 (OSRAM) |
| JP (1) | JP6080311B2 (OSRAM) |
| CN (1) | CN103597574B (OSRAM) |
| CA (1) | CA2833675C (OSRAM) |
| GB (1) | GB2499681B (OSRAM) |
| WO (1) | WO2012143737A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2507298B (en) * | 2012-10-25 | 2016-07-13 | Micromass Ltd | Improved reproducibility of impact-based ionization source for low and high organic mobile phase compositions using a mesh target |
| GB2517670B (en) * | 2013-03-15 | 2020-04-29 | Smiths Detection Watford Ltd | Ion modification |
| US9305761B2 (en) | 2013-08-14 | 2016-04-05 | Waters Technologies Corporation | Ion source for mass spectrometer and method of producing analyte ion stream |
| US9768004B2 (en) * | 2013-11-26 | 2017-09-19 | Waters Technologies Corporation | Systems, devices, and methods for connecting a chromatography system to a mass spectrometer |
| US9870908B2 (en) * | 2014-02-26 | 2018-01-16 | Micromass Uk Limited | Ambient ionisation with an impactor spray source |
| US9953819B2 (en) | 2014-02-26 | 2018-04-24 | Micromass Uk Limited | Impactor spray atmospheric pressure ion source with target paddle |
| GB201403370D0 (en) * | 2014-02-26 | 2014-04-09 | Micromass Ltd | Impactor spray atmospheric pressure ion source with target paddle |
| WO2015132579A1 (en) * | 2014-03-04 | 2015-09-11 | Micromass Uk Limited | Sample introduction system for spectrometers |
| JP6368254B2 (ja) * | 2015-01-28 | 2018-08-01 | 花王株式会社 | 脂質の網羅的解析方法 |
| US10978284B2 (en) | 2015-03-06 | 2021-04-13 | Micromass Uk Limited | Imaging guided ambient ionisation mass spectrometry |
| GB2553918B (en) | 2015-03-06 | 2022-10-12 | Micromass Ltd | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
| WO2016142690A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device |
| WO2016142686A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Liquid trap or separator for electrosurgical applications |
| US10777398B2 (en) | 2015-03-06 | 2020-09-15 | Micromass Uk Limited | Spectrometric analysis |
| EP3266037B8 (en) * | 2015-03-06 | 2023-02-22 | Micromass UK Limited | Improved ionisation of samples provided as aerosol, smoke or vapour |
| US11282688B2 (en) | 2015-03-06 | 2022-03-22 | Micromass Uk Limited | Spectrometric analysis of microbes |
| GB2551669B (en) | 2015-03-06 | 2021-04-14 | Micromass Ltd | Physically guided rapid evaporative ionisation mass spectrometry ("Reims") |
| EP3265822B1 (en) | 2015-03-06 | 2021-04-28 | Micromass UK Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| JP6783240B2 (ja) | 2015-03-06 | 2020-11-11 | マイクロマス ユーケー リミテッド | 生体内内視鏡的組織同定機器 |
| EP3265819B1 (en) | 2015-03-06 | 2020-10-14 | Micromass UK Limited | Chemically guided ambient ionisation mass spectrometry |
| CN108700590B (zh) | 2015-03-06 | 2021-03-02 | 英国质谱公司 | 细胞群体分析 |
| EP3570315B1 (en) | 2015-03-06 | 2024-01-31 | Micromass UK Limited | Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples |
| CN107548516B (zh) * | 2015-03-06 | 2019-11-15 | 英国质谱公司 | 用于改进电离的碰撞表面 |
| DE102016007402A1 (de) | 2015-06-23 | 2016-12-29 | Dionex Corporation | Verfahren und systeme zur erkennung von nichtflüchtigen gelösten stoffen |
| GB201517195D0 (en) | 2015-09-29 | 2015-11-11 | Micromass Ltd | Capacitively coupled reims technique and optically transparent counter electrode |
| EP3443354B1 (en) | 2016-04-14 | 2025-08-20 | Micromass UK Limited | Spectrometric analysis of plants |
| GB2563194B (en) * | 2016-04-21 | 2020-08-05 | Waters Technologies Corp | Dual mode ionization device |
| GB2567793B (en) * | 2017-04-13 | 2023-03-22 | Micromass Ltd | A method of fragmenting and charge reducing biomolecules |
| GB201721700D0 (en) * | 2017-12-22 | 2018-02-07 | Micromass Ltd | Ion source |
| GB201807914D0 (en) * | 2018-05-16 | 2018-06-27 | Micromass Ltd | Impactor spray or electrospray ionisation ion source |
| US12485437B2 (en) * | 2019-05-24 | 2025-12-02 | National Institute Of Advanced Industrial Science And Technology | Spray ionization device, analysis device, and surface coating device |
| WO2021020179A1 (ja) | 2019-07-31 | 2021-02-04 | 国立研究開発法人産業技術総合研究所 | スプレーイオン化装置、分析装置および表面塗布装置 |
| GB201915843D0 (en) * | 2019-10-31 | 2019-12-18 | Micromass Ltd | Ion source |
| EP4082669B1 (en) | 2020-02-03 | 2024-11-27 | National Institute Of Advanced Industrial Science and Technology | Spray ionization device |
| JP7282346B2 (ja) | 2020-03-11 | 2023-05-29 | 国立研究開発法人産業技術総合研究所 | スプレーイオン化装置、分析装置および表面塗布装置 |
| CN113217247B (zh) * | 2021-06-01 | 2022-04-29 | 哈尔滨工程大学 | 一种柴油机多次喷射喷雾贯穿距预测方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS59153164A (ja) * | 1983-02-21 | 1984-09-01 | Jeol Ltd | 液体クロマトグラフ質量分析装置 |
| JPH0698243B2 (ja) | 1987-12-07 | 1994-12-07 | 株式会社新興技術研究所 | 管内洗浄機構を有する蒸留器 |
| US5495108A (en) * | 1994-07-11 | 1996-02-27 | Hewlett-Packard Company | Orthogonal ion sampling for electrospray LC/MS |
| US6294779B1 (en) | 1994-07-11 | 2001-09-25 | Agilent Technologies, Inc. | Orthogonal ion sampling for APCI mass spectrometry |
| US5986259A (en) * | 1996-04-23 | 1999-11-16 | Hitachi, Ltd. | Mass spectrometer |
| JPH10267806A (ja) * | 1997-03-27 | 1998-10-09 | Jeol Ltd | 超音波霧化装置 |
| GB2324906B (en) * | 1997-04-29 | 2002-01-09 | Masslab Ltd | Ion source for a mass analyser and method of providing a source of ions for analysis |
| JPH1151902A (ja) * | 1997-08-05 | 1999-02-26 | Jeol Ltd | Ｌｃ／ｍｓインターフェイス |
| JP2002190272A (ja) * | 2000-12-21 | 2002-07-05 | Jeol Ltd | エレクトロスプレー・イオン源 |
| US20030119193A1 (en) * | 2001-04-25 | 2003-06-26 | Robert Hess | System and method for high throughput screening of droplets |
| JP4133631B2 (ja) | 2002-08-19 | 2008-08-13 | 日本電子株式会社 | エレクトロスプレー質量分析装置 |
| US6646257B1 (en) * | 2002-09-18 | 2003-11-11 | Agilent Technologies, Inc. | Multimode ionization source |
| US7368728B2 (en) | 2002-10-10 | 2008-05-06 | Universita' Degli Studi Di Milano | Ionization source for mass spectrometry analysis |
| CN101073137A (zh) * | 2004-03-30 | 2007-11-14 | 普渡研究基金会 | 用于解吸电喷雾离子化的方法和系统 |
| US7424980B2 (en) * | 2004-04-08 | 2008-09-16 | Bristol-Myers Squibb Company | Nano-electrospray nebulizer |
| US7034291B1 (en) | 2004-10-22 | 2006-04-25 | Agilent Technologies, Inc. | Multimode ionization mode separator |
| DE102004053064B4 (de) * | 2004-11-03 | 2007-11-08 | Bruker Daltonik Gmbh | Ionisierung durch Tröpfchenaufprall |
| US7411186B2 (en) | 2005-12-20 | 2008-08-12 | Agilent Technologies, Inc. | Multimode ion source with improved ionization |
| EP1855306B1 (en) * | 2006-05-11 | 2019-11-13 | ISB - Ion Source & Biotechnologies S.R.L. | Ionization source and method for mass spectrometry |
| US8183525B2 (en) * | 2007-01-16 | 2012-05-22 | Astrazeneca Ab | Method and system for analysing a dose formulation of a metered dose device |
| US7960711B1 (en) * | 2007-01-22 | 2011-06-14 | Chem-Space Associates, Inc. | Field-free electrospray nebulizer |
| US7977629B2 (en) * | 2007-09-26 | 2011-07-12 | M&M Mass Spec Consulting, LLC | Atmospheric pressure ion source probe for a mass spectrometer |
| CN202172060U (zh) | 2008-05-30 | 2012-03-21 | 珀金埃尔默健康科学股份有限公司 | 用于电离化学种的设备 |
| WO2010039675A1 (en) * | 2008-09-30 | 2010-04-08 | Prosolia, Inc. | Method and apparatus for embedded heater for desorption and ionization of analytes |
| DE102009037715B4 (de) * | 2009-08-17 | 2012-04-26 | Bruker Daltonik Gmbh | Führung von Sprühtröpfchen zur Einlasskapillare eines Massenspektrometers |
| US8097845B2 (en) * | 2010-03-11 | 2012-01-17 | Battelle Memorial Institute | Focused analyte spray emission apparatus and process for mass spectrometric analysis |
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2012
- 2012-04-20 WO PCT/GB2012/050888 patent/WO2012143737A1/en not_active Ceased
- 2012-04-20 JP JP2014505727A patent/JP6080311B2/ja active Active
- 2012-04-20 EP EP12721575.4A patent/EP2700086B1/en active Active
- 2012-04-20 CN CN201280027496.0A patent/CN103597574B/zh active Active
- 2012-04-20 GB GB1207004.1A patent/GB2499681B/en active Active
- 2012-04-20 EP EP19188721.5A patent/EP3582251B1/en active Active
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2014
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|---|---|
| JP6080311B2 (ja) | 2017-02-15 |
| US20140151547A1 (en) | 2014-06-05 |
| GB2499681B (en) | 2016-02-10 |
| US9082603B2 (en) | 2015-07-14 |
| WO2012143737A1 (en) | 2012-10-26 |
| US8809777B2 (en) | 2014-08-19 |
| US20150155151A1 (en) | 2015-06-04 |
| US8921777B2 (en) | 2014-12-30 |
| CN103597574B (zh) | 2016-09-07 |
| EP2700086A1 (en) | 2014-02-26 |
| JP2014515831A (ja) | 2014-07-03 |
| US20140339420A1 (en) | 2014-11-20 |
| CA2833675A1 (en) | 2012-10-26 |
| EP3582251B1 (en) | 2020-12-16 |
| EP2700086B1 (en) | 2019-09-11 |
| CN103597574A (zh) | 2014-02-19 |
| EP3582251A1 (en) | 2019-12-18 |
| GB201207004D0 (en) | 2012-06-06 |
| GB2499681A (en) | 2013-08-28 |
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