CA2826232C - Compositions and uses of synergistic effective amounts of bimatoprost and minoxidil for enhancing hair growth - Google Patents

Compositions and uses of synergistic effective amounts of bimatoprost and minoxidil for enhancing hair growth Download PDF

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Publication number
CA2826232C
CA2826232C CA2826232A CA2826232A CA2826232C CA 2826232 C CA2826232 C CA 2826232C CA 2826232 A CA2826232 A CA 2826232A CA 2826232 A CA2826232 A CA 2826232A CA 2826232 C CA2826232 C CA 2826232C
Authority
CA
Canada
Prior art keywords
composition
bimatoprost
minoxidil
hair
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2826232A
Other languages
English (en)
French (fr)
Other versions
CA2826232A1 (en
Inventor
David F. Woodward
Jenny W. Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CA2826232A1 publication Critical patent/CA2826232A1/en
Application granted granted Critical
Publication of CA2826232C publication Critical patent/CA2826232C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2826232A 2011-01-31 2012-01-30 Compositions and uses of synergistic effective amounts of bimatoprost and minoxidil for enhancing hair growth Active CA2826232C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437785P 2011-01-31 2011-01-31
US61/437,785 2011-01-31
PCT/US2012/023148 WO2012106249A2 (en) 2011-01-31 2012-01-30 Method of enhancing hair growth

Publications (2)

Publication Number Publication Date
CA2826232A1 CA2826232A1 (en) 2012-08-09
CA2826232C true CA2826232C (en) 2019-09-17

Family

ID=45688992

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2826232A Active CA2826232C (en) 2011-01-31 2012-01-30 Compositions and uses of synergistic effective amounts of bimatoprost and minoxidil for enhancing hair growth

Country Status (10)

Country Link
US (3) US8932567B2 (https=)
EP (1) EP2670488A2 (https=)
JP (1) JP6017455B2 (https=)
KR (1) KR20140020895A (https=)
CN (1) CN103747775A (https=)
AU (2) AU2012212481A1 (https=)
BR (1) BR112013019519A2 (https=)
CA (1) CA2826232C (https=)
RU (1) RU2013139682A (https=)
WO (1) WO2012106249A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102318450B (zh) 2008-02-05 2016-10-19 普林斯顿大学理事会 印刷电子设备
US8859616B2 (en) * 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
EP2670488A2 (en) 2011-01-31 2013-12-11 Allergan, Inc. Method of enhancing hair growth
CN105658221B (zh) * 2013-09-26 2022-05-10 高德美国际公司 用于治疗萎缩性皮肤瘢痕形成的前列腺素F2α及其类似物
WO2016159916A1 (en) * 2015-03-31 2016-10-06 Ogi̇g Sağlik Ürünleri̇ Ve Hi̇zmetleri̇ Sanayi̇ Ti̇caret Li̇mi̇ted Şi̇rketi̇ A foamy pharmaceutical formulation used in dermatological diseases
MX2018001843A (es) * 2015-08-13 2018-05-16 River Town Therapeutics Inc Composiciones y metodos para tratar alopecia.
JP7064820B2 (ja) * 2016-03-31 2022-05-11 ピアス株式会社 育毛剤、並びにε‐ポリリジンおよび／またはシャクヤク抽出物の使用
KR102017796B1 (ko) * 2016-07-28 2019-09-03 주식회사 큐어바이오 신규한 aimp1 단백질의 단편과 이를 유효성분으로 포함하는 발모 촉진용 조성물
US10512670B2 (en) 2016-08-08 2019-12-24 Scm Lifescience Co., Ltd. Pharmaceutical composition for preventing or treating hair loss comprising chemokine (C-X-C motif) ligand 1 (CXCL1) protein or CXCL1 protein and minoxidil as active ingredient
KR101849200B1 (ko) * 2017-01-19 2018-04-16 주식회사 효성 충격강도가 개선된 폴리케톤 조성물
KR101878795B1 (ko) * 2017-03-22 2018-08-16 주식회사 효성 내열성이 개선된 폴리케톤 조성물
KR102000217B1 (ko) * 2017-08-08 2019-07-15 에스씨엠생명과학 주식회사 Cxcl1 단백질 및 미녹시딜을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물
AU2019282155A1 (en) 2018-06-04 2021-01-07 Lars BRICHTA Topical compositions for stimulating hair growth
CA3107592A1 (en) * 2018-08-02 2020-02-06 Histogen, Inc. Conditioned medium and extracellular matrix compositions and uses thereof
US12539302B2 (en) 2019-08-07 2026-02-03 Aneira Pharma, Inc. Methods and compositions for the treatment of hair loss
LT3886799T (lt) 2019-08-07 2023-12-27 Aneira Pharma, Inc. Kompozicija, skirta plaukų slinkimo gydymui
CN110755286A (zh) * 2019-11-18 2020-02-07 童婧 一种有助于生发的发际线填充组合物
CN111110721A (zh) * 2020-01-19 2020-05-08 朱炜 一种毛发防脱再生的复合制剂及其使用方法
CA3182478A1 (en) * 2020-05-12 2021-11-18 Chemistry Rx Compositions for treating hair loss
BR102021003531A2 (pt) 2021-02-24 2022-08-30 Eurofarma Laboratorios S.A. Composição farmacêutica tópica espumável
KR102482658B1 (ko) * 2021-12-07 2022-12-29 주식회사 바이오빌리프 비마토프로스트를 포함하는 국소 투여용 약학 조성물
WO2025069091A1 (en) * 2023-09-29 2025-04-03 Pdfe Pharma Innovations - Fzco Novel topical pharmaceutical composition for prevention and treatment of hair loss

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139619A (en) 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
US4968812A (en) 1989-06-23 1990-11-06 Shell Oil Company Spirolactonelactams
US5352708A (en) 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
CN1263442C (zh) * 2000-04-07 2006-07-12 大正制药株式会社 持续性毛发生长组合物
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US7632867B2 (en) * 2007-10-31 2009-12-15 Meta Cosmetics, Llc Prostaglandin analog compositions to treat epithelial-related conditions
US20080275118A1 (en) * 2008-06-12 2008-11-06 Shaw Mari M Health and cosmetic composition and regime for stimulating hair growth and thickening on the head, including the scalp, eyelashes, and eyebrows, and which discourages hair loss
US8470833B2 (en) * 2009-12-15 2013-06-25 Mcneil-Ppc, Inc. Hair growth and/or regrowth compositions
EP2670488A2 (en) 2011-01-31 2013-12-11 Allergan, Inc. Method of enhancing hair growth

Also Published As

Publication number Publication date
US20150290104A1 (en) 2015-10-15
US8932567B2 (en) 2015-01-13
US20180110711A1 (en) 2018-04-26
WO2012106249A3 (en) 2014-02-27
JP6017455B2 (ja) 2016-11-02
AU2017202667A1 (en) 2017-05-11
RU2013139682A (ru) 2015-03-10
US20120302588A1 (en) 2012-11-29
AU2012212481A1 (en) 2013-08-22
EP2670488A2 (en) 2013-12-11
AU2017202667B2 (en) 2019-02-21
CN103747775A (zh) 2014-04-23
WO2012106249A2 (en) 2012-08-09
KR20140020895A (ko) 2014-02-19
JP2014510042A (ja) 2014-04-24
BR112013019519A2 (pt) 2016-08-09
CA2826232A1 (en) 2012-08-09
US9700503B2 (en) 2017-07-11

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Effective date: 20170123

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