CA2825311A1 - Methods of treating tachycardia and/or controlling heart rate while minimizing and/or controlling hypotension - Google Patents
Methods of treating tachycardia and/or controlling heart rate while minimizing and/or controlling hypotension Download PDFInfo
- Publication number
- CA2825311A1 CA2825311A1 CA2825311A CA2825311A CA2825311A1 CA 2825311 A1 CA2825311 A1 CA 2825311A1 CA 2825311 A CA2825311 A CA 2825311A CA 2825311 A CA2825311 A CA 2825311A CA 2825311 A1 CA2825311 A1 CA 2825311A1
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- Prior art keywords
- equal
- μmol
- subject
- phenylpropionate
- hydroxy
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- 229960005156 digoxin Drugs 0.000 description 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
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- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
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- 208000019622 heart disease Diseases 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
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- 208000013433 lightheadedness Diseases 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
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- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
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- 150000007524 organic acids Chemical class 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
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- 229960003712 propranolol Drugs 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
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- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161436992P | 2011-01-27 | 2011-01-27 | |
| US61/436,992 | 2011-01-27 | ||
| PCT/US2012/022696 WO2012103314A1 (en) | 2011-01-27 | 2012-01-26 | Methods of treating tachycardia and/or controlling heart rate while minimizing and/or controlling hypotension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2825311A1 true CA2825311A1 (en) | 2012-08-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2825311A Abandoned CA2825311A1 (en) | 2011-01-27 | 2012-01-26 | Methods of treating tachycardia and/or controlling heart rate while minimizing and/or controlling hypotension |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8686036B2 (https=) |
| EP (1) | EP2667867B1 (https=) |
| JP (1) | JP2014505074A (https=) |
| KR (1) | KR20140034729A (https=) |
| CN (1) | CN103338763A (https=) |
| AU (1) | AU2012211318C1 (https=) |
| BR (1) | BR112013016701A2 (https=) |
| CA (1) | CA2825311A1 (https=) |
| MX (1) | MX2013008713A (https=) |
| WO (1) | WO2012103314A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103347513A (zh) | 2011-01-27 | 2013-10-09 | 巴克斯特国际公司 | (s)-艾司洛尔用于控制与心脏病治疗相关的静脉刺激的应用 |
| RU2613564C1 (ru) * | 2015-12-02 | 2017-03-17 | федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет имени И.И. Мечникова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СЗГМУ им. И.И. Мечникова Минздрава России) | Способ прогнозирования интраоперационной артериальной гипотензии при проведении анестезии |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0179808B1 (en) | 1984-04-09 | 1991-10-30 | The Du Pont Merck Pharmaceutical Company | Pharmaceutical composition suitable for treatment or prophylaxis of cardiac disorders |
| EP0248879A4 (en) * | 1985-12-04 | 1990-02-26 | Du Pont | PRODUCTION OF ARYLOXYPROPANOLAMINES AND ARYLÄTHANOLAMINES. |
| JP2521317B2 (ja) * | 1986-09-02 | 1996-08-07 | ザ・デュポン・メルク・ファーマシュウティカル・カンパニー | ｄｌ―メチル３―［４―（２―ヒドロキシ―３―イソプロピルアミノ）プロポキシ］フエニルプロピオネ―ト［（ｄｌ―エスモロ―ル）］の分割 |
| US4857552A (en) | 1988-06-08 | 1989-08-15 | E. I. Du Pont De Nemours And Co. | Stable pharmaceutical composition |
| US5849843A (en) | 1993-11-16 | 1998-12-15 | Baxter International Inc. | Polymeric compositions for medical packaging and devices |
| US5998019A (en) | 1993-11-16 | 1999-12-07 | Baxter International Inc. | Multi-layered polymer structure for medical products |
| US5977409A (en) * | 1997-04-15 | 1999-11-02 | University Of Toledo | Method of using α-substituted benzylamine chiral auxiliary synthetic reagents |
| TWI277414B (en) * | 2001-01-12 | 2007-04-01 | Baxter Int | Esmolol formulation |
| US6310094B1 (en) | 2001-01-12 | 2001-10-30 | Baxter International Inc. | Ready-to-use esmolol solution |
| EP1652533B2 (en) * | 2003-08-08 | 2014-11-19 | Ono Pharmaceutical Co., Ltd. | Heart-slowing drug containing short-acting beta-blocker as the active ingredient |
| US20080293814A1 (en) | 2007-05-22 | 2008-11-27 | Deepak Tiwari | Concentrate esmolol |
| CN101323580A (zh) | 2008-07-25 | 2008-12-17 | 河北科技大学 | 手性芳氧丙醇胺类化合物及其盐的合成方法 |
| CN101881755B (zh) | 2009-05-04 | 2013-05-29 | 南京海辰药业有限公司 | 通过高效液相色谱法检测盐酸艾司洛尔光学异构体的方法 |
| CN101891636A (zh) | 2009-05-21 | 2010-11-24 | 南京海辰药业有限公司 | 制备盐酸艾司洛尔光学异构体的新方法 |
| CN102106846A (zh) | 2009-12-23 | 2011-06-29 | 南京海辰药业有限公司 | 左旋盐酸艾司洛尔药物组合物及其制备方法 |
| CN103347513A (zh) | 2011-01-27 | 2013-10-09 | 巴克斯特国际公司 | (s)-艾司洛尔用于控制与心脏病治疗相关的静脉刺激的应用 |
-
2012
- 2012-01-26 AU AU2012211318A patent/AU2012211318C1/en not_active Ceased
- 2012-01-26 CA CA2825311A patent/CA2825311A1/en not_active Abandoned
- 2012-01-26 CN CN2012800065096A patent/CN103338763A/zh active Pending
- 2012-01-26 EP EP12702941.1A patent/EP2667867B1/en not_active Not-in-force
- 2012-01-26 KR KR1020137018030A patent/KR20140034729A/ko not_active Withdrawn
- 2012-01-26 US US13/359,065 patent/US8686036B2/en active Active
- 2012-01-26 MX MX2013008713A patent/MX2013008713A/es active IP Right Grant
- 2012-01-26 JP JP2013551327A patent/JP2014505074A/ja not_active Withdrawn
- 2012-01-26 WO PCT/US2012/022696 patent/WO2012103314A1/en not_active Ceased
- 2012-01-26 BR BR112013016701A patent/BR112013016701A2/pt not_active IP Right Cessation
-
2013
- 2013-11-08 US US14/075,857 patent/US9084763B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9084763B2 (en) | 2015-07-21 |
| MX2013008713A (es) | 2013-08-29 |
| KR20140034729A (ko) | 2014-03-20 |
| EP2667867A1 (en) | 2013-12-04 |
| EP2667867B1 (en) | 2015-05-27 |
| WO2012103314A1 (en) | 2012-08-02 |
| BR112013016701A2 (pt) | 2017-07-04 |
| US20140066503A1 (en) | 2014-03-06 |
| US20120302637A1 (en) | 2012-11-29 |
| AU2012211318C1 (en) | 2016-08-04 |
| CN103338763A (zh) | 2013-10-02 |
| AU2012211318B2 (en) | 2016-01-28 |
| US8686036B2 (en) | 2014-04-01 |
| JP2014505074A (ja) | 2014-02-27 |
| AU2012211318A1 (en) | 2013-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20180126 |