CA2818514A1 - Bioreactors, systems, and methods for producing and/or analyzing organs - Google Patents

Bioreactors, systems, and methods for producing and/or analyzing organs Download PDF

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Publication number
CA2818514A1
CA2818514A1 CA2818514A CA2818514A CA2818514A1 CA 2818514 A1 CA2818514 A1 CA 2818514A1 CA 2818514 A CA2818514 A CA 2818514A CA 2818514 A CA2818514 A CA 2818514A CA 2818514 A1 CA2818514 A1 CA 2818514A1
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CA
Canada
Prior art keywords
organ
prior
tissue
bioreactor
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2818514A
Other languages
English (en)
French (fr)
Inventor
Ron Sostek
Joseph Consiglio
David Green
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard Apparatus Regenerative Technology Inc
Original Assignee
Harvard Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard Bioscience Inc filed Critical Harvard Bioscience Inc
Publication of CA2818514A1 publication Critical patent/CA2818514A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/50—Means for positioning or orientating the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
    • G06K19/06009—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code with optically detectable marking
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
    • G06K19/06187—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code with magnetically detectable marking
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
    • G06K19/067—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Mechanical Engineering (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2818514A 2009-11-17 2010-11-17 Bioreactors, systems, and methods for producing and/or analyzing organs Abandoned CA2818514A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26213009P 2009-11-17 2009-11-17
US61/262,130 2009-11-17
US29839310P 2010-01-26 2010-01-26
US61/298,393 2010-01-26
PCT/US2010/002995 WO2011062621A2 (en) 2009-11-17 2010-11-17 Bioreactors, systems, and methods for producing and/or analyzing organs

Publications (1)

Publication Number Publication Date
CA2818514A1 true CA2818514A1 (en) 2011-05-26

Family

ID=44060235

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2818514A Abandoned CA2818514A1 (en) 2009-11-17 2010-11-17 Bioreactors, systems, and methods for producing and/or analyzing organs

Country Status (7)

Country Link
US (1) US20130177972A1 (https=)
EP (1) EP2501794A4 (https=)
JP (1) JP2013510590A (https=)
AU (1) AU2010322460B2 (https=)
CA (1) CA2818514A1 (https=)
RU (1) RU2012125263A (https=)
WO (1) WO2011062621A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116012838A (zh) * 2022-12-30 2023-04-25 创芯国际生物科技(广州)有限公司 基于人工智能的类器官活性识别方法及系统

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9757098B2 (en) 2007-07-16 2017-09-12 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
WO2009010960A2 (en) 2007-07-16 2009-01-22 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
US9901362B2 (en) * 2007-07-16 2018-02-27 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
US9999353B2 (en) * 2007-07-16 2018-06-19 Dune Medical Devices Ltd. Medical device and method for use in tissue characterization and treatment
US8781201B2 (en) * 2009-03-04 2014-07-15 Robert E. Sandstrom Method of operating a pathology laboratory
US8507263B2 (en) 2009-08-07 2013-08-13 Maria Adelaide Asnaghi Rotating bioreactor
US9469671B2 (en) * 2011-09-03 2016-10-18 Therapeutic Proteins International, LLC Closed bioreactor
JP6095671B2 (ja) * 2011-10-07 2017-03-15 ポール テクノロジー ユーケイ リミテッドＰａｌｌ Ｔｅｃｈｎｏｌｏｇｙ Ｕｋ Ｌｉｍｉｔｅｄ 流体処理制御システムおよび対応する方法
EP2841010B1 (en) 2012-04-24 2023-08-23 Harvard Apparatus Regenerative Technology, Inc. Supports for engineered tissue scaffolds
WO2014004746A2 (en) 2012-06-26 2014-01-03 Harvard Bioscience, Inc. Methods and compositions for promoting the structural integrity of scaffolds for tissue engineering
US10357223B2 (en) 2012-07-03 2019-07-23 University of Pittsburgh—of the Commonwealth System of Higher Education Method and apparatus to detect lipid contents in tissues using ultrasound
US9040921B2 (en) 2012-07-28 2015-05-26 Harvard Apparatus Regenerative Technology, Inc. Analytical methods
JP6017219B2 (ja) * 2012-08-01 2016-10-26 オリンパス株式会社 蛍光観察装置および蛍光観察システム
KR20150059754A (ko) * 2012-09-04 2015-06-02 안트로제네시스 코포레이션 조직 생성 방법
EP2943231A4 (en) 2013-01-09 2016-12-07 Harvard Apparatus Regenerative Tech Inc SYNTHETIC SCAFFOLD
EP2787069B1 (de) * 2013-04-04 2015-08-05 Universität Leipzig Verfahren und Vorrichtung zur Dezellularisierung von Organen und Geweben
JP2015000140A (ja) * 2013-06-13 2015-01-05 キヤノン株式会社 被検体情報取得装置
GB201310773D0 (en) * 2013-06-17 2013-07-31 Northwick Park Inst For Medcal Res Ltd Implant and method of producing an implant
JP2015030211A (ja) * 2013-08-04 2015-02-16 泰 金田 自然な方向にそって印刷する３次元印刷方法および３ｄプリンタ
WO2015061793A1 (en) * 2013-10-25 2015-04-30 The University Of Akron Multipurpose imaging and display system
JP2015110326A (ja) * 2013-11-11 2015-06-18 利仁 曽根 ３ｄプリンタを利用した胚性幹細胞、人工多能性幹細胞などによる臓器製作システム、装置、交換部品及びｉｃチップ
DE102014205888B3 (de) * 2014-03-28 2015-05-28 Siemens Aktiengesellschaft Frequenzüberwachung von Gradientenpulsen bei der Magnetresonanz-Bildgebung
TWI518583B (zh) * 2014-04-18 2016-01-21 三緯國際立體列印科技股份有限公司 立體列印裝置及其列印異常偵測方法
EP3247281B1 (en) 2015-01-23 2020-12-02 The University of North Carolina at Chapel Hill Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects
DE102015203537B3 (de) * 2015-02-27 2016-06-23 Celltool Gmbh Vorrichtung und Verfahren zur Überprüfung eines Materials für eine Transplantation
CN104970768B (zh) * 2015-05-11 2018-02-06 西南交通大学 一种半体内血液循环环境生物介入材料实验装置
CN106696292B (zh) * 2015-07-31 2019-03-05 三纬国际立体列印科技股份有限公司 立体打印装置
US9879216B2 (en) * 2015-12-10 2018-01-30 International Business Machines Corporation Infrared signal monitoring for cell cultures
TWI582885B (zh) * 2015-12-30 2017-05-11 國立中央大學 低溫製造組織工程用支架的平台結構及低溫製造組織工程用支架的製造方法
SG10201602102PA (en) * 2016-03-17 2017-10-30 Changi General Hospital Pte Ltd Lung simulation model
JP6111510B1 (ja) 2016-05-02 2017-04-12 インテグリカルチャー株式会社 成長誘導システム、成長誘導制御装置、成長誘導制御方法、および、成長誘導制御プログラム
CN109153959B (zh) * 2016-05-02 2021-06-18 整合培育株式会社 生长诱导系统、生长诱导控制装置、生长诱导控制方法和生长诱导控制程序
JP7084320B2 (ja) 2016-06-15 2022-06-14 ザ ジェネラル ホスピタル コーポレイション 生体直交型反応を用いた生体材料の代謝標識及び分子増強
US10738272B2 (en) 2016-06-27 2020-08-11 General Electric Company Heating assembly for a bioreactor and an associated method thereof
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
US10345208B2 (en) 2016-07-12 2019-07-09 Deka Products Limited Partnership System and method for applying force to a device
JP2019525776A (ja) 2016-07-22 2019-09-12 エー・テー・ハー・チューリッヒＥｔｈ Ｚｕｅｒｉｃｈ 体外で肝臓に潅流する潅流ループアセンブリ及び肝臓チェンバーアセンブリ
CN115044471B (zh) 2016-08-27 2025-05-27 三维生物科技有限公司 生物反应器
US20190242896A1 (en) * 2016-09-02 2019-08-08 The University Of North Carolina At Chapel Hill System and method for noninvasively assessing bioengineered organs
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
WO2018136739A1 (en) * 2017-01-21 2018-07-26 The Johns Hopkins University Tissue scaffold mold apparatus and use in making tissue engineered organs with hollow structures
WO2018157456A1 (zh) * 2017-03-03 2018-09-07 北京博辉瑞进生物科技有限公司 一种生物组织基质材料、制备方法及在耳科修复材料中的应用
US10967578B2 (en) * 2017-07-11 2021-04-06 Daniel S. Clark 5D part growing machine with volumetric display technology
US11919246B2 (en) 2017-07-11 2024-03-05 Daniel S. Clark 5D part growing machine with volumetric display technology
US12297416B2 (en) 2017-07-12 2025-05-13 Deka Products Limited Partneship System and method for transferring tissue
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
CN111132595A (zh) * 2017-09-11 2020-05-08 三维生物科技有限公司 大型生物反应器
US11881119B2 (en) * 2017-12-06 2024-01-23 Cilag Gmbh International Modeling air leaks in lungs
EP3740067B1 (en) 2018-01-19 2024-11-06 ETH Zürich Perfusion loop assembly for an ex-vivo liver perfusion and a method for ex-vivo liver perfusion
CN111867528A (zh) * 2018-01-19 2020-10-30 马里兰大学巴尔的摩分校 用于在运输期间处理人体器官的技术
EP3746543A4 (en) * 2018-01-29 2021-11-10 Culture Biosciences, Inc. AUTOMATED CONTROL PROCESSES FOR A FERMENTATION SYSTEM
US20230212490A1 (en) * 2018-03-19 2023-07-06 Tissuebynet Corporation Production Device, Production System and Production Method for Cell Structure
US11926091B2 (en) 2018-03-27 2024-03-12 UNITED STATES OF AMERICA has certain rights in the invention from DOE Grant No. DE-SC0008581 In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
US12378511B2 (en) * 2018-10-09 2025-08-05 The Trustees Of The University Of Pennsylvania Portable bioreactors and portable bioreactor systems for analyzing biofilm formation and degradation
ES1226226Y (es) * 2019-01-10 2019-05-31 Meta Cell Tech Sl Recipiente para tratamiento ex vivo de liquidos biologicos
US12024696B2 (en) * 2019-05-08 2024-07-02 Molecular Devices (Austria) GmbH System and method for organoid culture
WO2020231954A1 (en) 2019-05-10 2020-11-19 The University Of North Carolina At Chapel Hill Office Of Technology Commercialization Methods, systems, and computer readable media for generating images of microvasculature using ultrasound
US11834640B2 (en) * 2019-09-15 2023-12-05 Board Of Regents, The University Of Texas System Device and uses thereof for treating diabetes
WO2021231956A1 (en) * 2020-05-14 2021-11-18 North Carolina State University Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
DE102020118976A1 (de) * 2020-05-26 2021-12-16 Medical & Science Aktiengesellschaft Verfahren und Anordnung zur Bestimmung der flächig-räumlichen Temperaturverteilung im Mund- und Rachenraum eines Probanden
US12280540B2 (en) 2020-09-27 2025-04-22 San Diego State University Research Foundation In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
WO2023164217A1 (en) * 2022-02-25 2023-08-31 Advanced Solutions Life Sciences, Llc Bioreactor assemblies, perfusion bioreactor systems, and methods
US20230313111A1 (en) * 2022-04-04 2023-10-05 Arcology Inc. Dba Biosphere Bioreactors configured for uv sterilization, and methods of using uv sterilization in bioprocesses
CN115322953A (zh) * 2022-08-15 2022-11-11 中国医学科学院生物医学工程研究所 一种用于细胞三维培养的高效接种方法及其应用
US20240377260A1 (en) * 2023-05-08 2024-11-14 Lsi Industries, Inc. Infrared sensor assembly for receiving interchangeable lenses
WO2024259392A2 (en) * 2023-06-14 2024-12-19 Organai Health, Inc. Apparatuses, systems, and methods for rapid on-site multiscale multimodal donor organ viability factor characterization

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2001A (en) * 1841-03-12 Sawmill
US7027A (en) * 1850-01-15 Circulak
US3995444A (en) * 1974-11-08 1976-12-07 American Hospital Supply Corporation Organ perfusion system
JPH0291001A (ja) * 1988-09-28 1990-03-30 Olympus Optical Co Ltd 臓器保存装置
JPH02295901A (ja) * 1989-05-09 1990-12-06 Olympus Optical Co Ltd 臓器保存装置
DK85093D0 (da) * 1993-07-16 1993-07-16 Landsforeningen Til Kraeftens Method and apparatus for performing operations
US5586438A (en) * 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
CA2304598C (en) * 1997-09-23 2009-03-10 Waleed H. Hassanein Compositions, methods and devices for maintaining an organ
US6582953B2 (en) * 1999-04-14 2003-06-24 Breonics, Inc. Organ chamber for exsanguinous metabolic support system
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
DK1773976T4 (da) * 2004-06-04 2020-02-10 Global Life Sciences Solutions Usa Llc Engangsbioreaktorsystemer og -fremgangsmåder
MX369594B (es) * 2005-08-26 2019-11-13 Univ Minnesota Descelularizacion y recelularizacion de organos y tejidos.
WO2007095192A2 (en) * 2006-02-10 2007-08-23 Tengion Inc. Bioreactor for organ reconstruction and augmentation
JP2010520127A (ja) * 2007-02-28 2010-06-10 エクセレレックス インク． フレキシブルコンテナ内の液体の重量測定
US8114664B2 (en) * 2007-07-12 2012-02-14 Worcester Polytechnic Institute Scalable wall bioreactor for culture of plant and animal tissues

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116012838A (zh) * 2022-12-30 2023-04-25 创芯国际生物科技(广州)有限公司 基于人工智能的类器官活性识别方法及系统
CN116012838B (zh) * 2022-12-30 2023-11-07 创芯国际生物科技(广州)有限公司 基于人工智能的类器官活性识别方法及系统

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EP2501794A2 (en) 2012-09-26
AU2010322460B2 (en) 2015-05-28
WO2011062621A2 (en) 2011-05-26
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