CA2817197C - Fusion proteins comprising an engineered knottin peptide and uses thereof - Google Patents
Fusion proteins comprising an engineered knottin peptide and uses thereof Download PDFInfo
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- CA2817197C CA2817197C CA2817197A CA2817197A CA2817197C CA 2817197 C CA2817197 C CA 2817197C CA 2817197 A CA2817197 A CA 2817197A CA 2817197 A CA2817197 A CA 2817197A CA 2817197 C CA2817197 C CA 2817197C
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- knottin
- axl
- integrin
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Insects & Arthropods (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US41135010P | 2010-11-08 | 2010-11-08 | |
| US61/411,350 | 2010-11-08 | ||
| PCT/US2011/059599 WO2012064658A1 (en) | 2010-11-08 | 2011-11-07 | Fusion proteins comprising an engineered knottin peptide and uses thereof |
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| CA2817197A1 CA2817197A1 (en) | 2012-05-18 |
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| WO2008045252A2 (en) * | 2006-10-04 | 2008-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered integrin binding peptides |
| EP3604549A1 (en) * | 2010-11-08 | 2020-02-05 | The Board of Trustees of the Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| WO2013078250A2 (en) | 2011-11-22 | 2013-05-30 | The Board Of Trustees Of The Leland Stanford Junior University | Cystine knot peptides that bind alpha-v-beta-6 integrin |
| US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| US9587001B2 (en) | 2012-10-19 | 2017-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Conjugated knottin mini-proteins containing non-natural amino acids |
| CN105189540A (zh) | 2012-12-10 | 2015-12-23 | 弗莱德哈钦森癌症研究中心 | 含脂质运载蛋白融合伴侣 |
| WO2014093690A1 (en) | 2012-12-14 | 2014-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| CA2957717C (en) * | 2014-08-12 | 2021-10-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein |
| US20170216403A1 (en) | 2014-08-12 | 2017-08-03 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker |
| EP3313427A4 (en) * | 2015-06-26 | 2018-12-26 | Fred Hutchinson Cancer Research Center | Therapeutic peptides and methods of use thereof |
| WO2017044894A2 (en) | 2015-09-09 | 2017-03-16 | Fred Hutchinson Cancer Research Center | Cartilage-homing peptides |
| TWI799366B (zh) | 2015-09-15 | 2023-04-21 | 美商建南德克公司 | 胱胺酸結骨架平臺 |
| EP3786292A1 (en) * | 2016-01-08 | 2021-03-03 | Maxion Therapeutics Limited | Binding members with altered diversity scaffold domains |
| US10888603B2 (en) * | 2016-02-12 | 2021-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating cancer cells expressing tumor-associated integrins |
| WO2017160879A1 (en) | 2016-03-15 | 2017-09-21 | The Board Of Trustees Of The Leland Stanford Junior University | Knottin-drug conjugates and methods of using the same |
| WO2018044234A1 (en) * | 2016-08-31 | 2018-03-08 | Nanyang Technological University | Cysteine-rich polypeptides and conjugates and methods of using the same |
| US10350266B2 (en) | 2017-01-10 | 2019-07-16 | Nodus Therapeutics, Inc. | Method of treating cancer with a multiple integrin binding Fc fusion protein |
| AU2018207303A1 (en) | 2017-01-10 | 2019-07-25 | xCella Biosciences, Inc. | Combination tumor treatment with an integrin-binding-Fc fusion protein and immune modulator |
| WO2018136614A1 (en) | 2017-01-18 | 2018-07-26 | Fred Hutchinson Cancer Research Center | Peptide compositions and methods of use thereof for disrupting tead interactions |
| CA3056421A1 (en) | 2017-03-16 | 2018-09-20 | Blaze Bioscience, Inc. | Cartilage-homing peptide conjugates and methods of use thereof |
| WO2018232122A1 (en) | 2017-06-15 | 2018-12-20 | Blaze Bioscience, Inc. | Renal-homing peptide conjugates and methods of use thereof |
| GB201711208D0 (en) | 2017-07-12 | 2017-08-23 | Iontas Ltd | Ion channel inhibitors |
| US11352404B2 (en) | 2017-07-24 | 2022-06-07 | Rutgers, The State University Of New Jersey | Phosphatidylserine targeting fusion molecules and methods for their use |
| WO2019126240A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
| EP3914289A1 (en) | 2019-01-23 | 2021-12-01 | Massachusetts Institute of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
| JP2022527351A (ja) * | 2019-04-02 | 2022-06-01 | イーライ リリー アンド カンパニー | 結合ペプチドを選択し検出するための方法 |
| EP3962511A4 (en) * | 2019-04-29 | 2023-01-18 | The Board of Trustees of the Leland Stanford Junior University | METHODS OF OCULAR TREATMENT USING A GENETICALLY MODIFIED HEPATOCYTE GROWTH FACTOR DIMERIC FRAGMENT |
| JP2022533671A (ja) * | 2019-05-22 | 2022-07-25 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 薬物複合体およびその使用方法 |
| US20220257785A1 (en) * | 2019-09-30 | 2022-08-18 | The Board Of Trustees Of The Leland Stanford Junior University | Knottin-immunostimulant conjugates and related compositions and methods |
| US20230211001A1 (en) * | 2020-07-30 | 2023-07-06 | The Board Of Trustees Of The Leland Stanford Junior University | Lysosomal Targeting Molecules Comprising Knottin Peptides And Related Compositions And Methods |
| MX2020012914A (es) * | 2020-11-27 | 2022-05-30 | Centro De Investig Cientifica Y De Educacion Superior De Ensenada Baja California Cicese | Proteina andamio para la generacion de proteinas quimericas de union a antigeno. |
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| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6303749B1 (en) * | 1999-01-29 | 2001-10-16 | Amgen Inc. | Agouti and agouti-related peptide analogs |
| DE10053224A1 (de) * | 2000-10-26 | 2002-05-08 | Univ Goettingen Georg August | Verfahren zur Exposition von Peptiden und Polypeptiden auf der Zelloberfläche von Bakterien |
| WO2002061055A2 (en) | 2001-01-31 | 2002-08-08 | Mount Sinai Hospital | Methods for regulating the kinase domain of ephb2 |
| GB0110430D0 (en) | 2001-04-27 | 2001-06-20 | Medical Res Council | Protein variants and uses thereof |
| AU2005205412B2 (en) | 2004-01-20 | 2011-08-11 | Merus N.V. | Mixtures of binding proteins |
| CA2577329A1 (en) * | 2004-08-16 | 2006-03-02 | Medimmune, Inc. | Eph receptor fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity |
| WO2007100358A2 (en) | 2005-10-07 | 2007-09-07 | University Of Chicago | Convergent synthesis of proteins by kinetically controlled ligation |
| US7666622B2 (en) * | 2005-10-19 | 2010-02-23 | Regeneron Pharmaceuticals, Inc. | Monomeric self-associating fusion polypeptides and therapeutic uses thereof |
| WO2008045252A2 (en) * | 2006-10-04 | 2008-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered integrin binding peptides |
| EP1958957A1 (en) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprising a knottin protein moiety |
| JP2010532360A (ja) * | 2007-07-02 | 2010-10-07 | ワイス・エルエルシー | 骨障害の処置における使用のためのａｘｌのモジュレーター |
| EP2626371A1 (en) * | 2007-07-31 | 2013-08-14 | MedImmune, LLC | Multispecific epitope binding proteins and uses thereof |
| EP2195028A2 (en) * | 2007-09-18 | 2010-06-16 | The Jackson Laboratory | Antibodies and fc fusion protein modifications with enhanced persistence or pharmacokinetic stability in vivo and methods of use thereof |
| US8906356B2 (en) * | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| WO2010048588A2 (en) * | 2008-10-23 | 2010-04-29 | Massachusetts Institute Of Technology | Directed engagement of activating fc receptors |
| US8329826B2 (en) | 2008-11-06 | 2012-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Surface modification of interpenetrating polymer networks |
| US8778888B2 (en) * | 2009-11-06 | 2014-07-15 | The Board Of Trustees Of The Leland Stanford Junior University | Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use |
| KR101951410B1 (ko) | 2010-01-22 | 2019-02-26 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항-전이성 요법에서 ａｘｌ 신호전달의 저해 |
| EP3604549A1 (en) * | 2010-11-08 | 2020-02-05 | The Board of Trustees of the Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| US10350266B2 (en) * | 2017-01-10 | 2019-07-16 | Nodus Therapeutics, Inc. | Method of treating cancer with a multiple integrin binding Fc fusion protein |
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| AU2016210712B2 (en) | 2017-10-26 |
| JP6170435B2 (ja) | 2017-07-26 |
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| AU2016210712A1 (en) | 2016-09-08 |
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| AU2018200587B2 (en) | 2019-12-12 |
| US11498952B2 (en) | 2022-11-15 |
| AU2011326164B2 (en) | 2016-05-05 |
| EP2638173A4 (en) | 2014-03-26 |
| AU2011326164A1 (en) | 2013-05-30 |
| DK2638173T3 (da) | 2019-09-30 |
| JP2014504270A (ja) | 2014-02-20 |
| US10844106B2 (en) | 2020-11-24 |
| EP2638173A1 (en) | 2013-09-18 |
| CA2817197A1 (en) | 2012-05-18 |
| WO2012064658A1 (en) | 2012-05-18 |
| JP2017160222A (ja) | 2017-09-14 |
| US20140073518A1 (en) | 2014-03-13 |
| US20210206824A1 (en) | 2021-07-08 |
| US20230227523A1 (en) | 2023-07-20 |
| AU2018200587A1 (en) | 2018-02-15 |
| US12240882B2 (en) | 2025-03-04 |
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