AU2011326164B2 - Fusion proteins comprising an engineered knottin peptide and uses thereof - Google Patents

Fusion proteins comprising an engineered knottin peptide and uses thereof Download PDF

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Publication number
AU2011326164B2
AU2011326164B2 AU2011326164A AU2011326164A AU2011326164B2 AU 2011326164 B2 AU2011326164 B2 AU 2011326164B2 AU 2011326164 A AU2011326164 A AU 2011326164A AU 2011326164 A AU2011326164 A AU 2011326164A AU 2011326164 B2 AU2011326164 B2 AU 2011326164B2
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Australia
Prior art keywords
receptor
binding
knottin
integrin
eeti
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Ceased
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AU2011326164A
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English (en)
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AU2011326164A1 (en
Inventor
Jennifer R. Cochran
Douglas S. Jones
Mihalis S. Kariolis
Ping-Chuan Tsai
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Leland Stanford Junior University
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Leland Stanford Junior University
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Publication of AU2011326164A1 publication Critical patent/AU2011326164A1/en
Application granted granted Critical
Publication of AU2011326164B2 publication Critical patent/AU2011326164B2/en
Priority to AU2016210712A priority Critical patent/AU2016210712B2/en
Priority to AU2018200587A priority patent/AU2018200587B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Insects & Arthropods (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2011326164A 2010-11-08 2011-11-07 Fusion proteins comprising an engineered knottin peptide and uses thereof Ceased AU2011326164B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2016210712A AU2016210712B2 (en) 2010-11-08 2016-08-04 Fusion proteins comprising an engineered knottin peptide and uses thereof
AU2018200587A AU2018200587B2 (en) 2010-11-08 2018-01-24 Fusion proteins comprising an engineered knottin peptide and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41135010P 2010-11-08 2010-11-08
US61/411,350 2010-11-08
PCT/US2011/059599 WO2012064658A1 (en) 2010-11-08 2011-11-07 Fusion proteins comprising an engineered knottin peptide and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016210712A Division AU2016210712B2 (en) 2010-11-08 2016-08-04 Fusion proteins comprising an engineered knottin peptide and uses thereof

Publications (2)

Publication Number Publication Date
AU2011326164A1 AU2011326164A1 (en) 2013-05-30
AU2011326164B2 true AU2011326164B2 (en) 2016-05-05

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2011326164A Ceased AU2011326164B2 (en) 2010-11-08 2011-11-07 Fusion proteins comprising an engineered knottin peptide and uses thereof
AU2016210712A Ceased AU2016210712B2 (en) 2010-11-08 2016-08-04 Fusion proteins comprising an engineered knottin peptide and uses thereof
AU2018200587A Ceased AU2018200587B2 (en) 2010-11-08 2018-01-24 Fusion proteins comprising an engineered knottin peptide and uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2016210712A Ceased AU2016210712B2 (en) 2010-11-08 2016-08-04 Fusion proteins comprising an engineered knottin peptide and uses thereof
AU2018200587A Ceased AU2018200587B2 (en) 2010-11-08 2018-01-24 Fusion proteins comprising an engineered knottin peptide and uses thereof

Country Status (7)

Country Link
US (3) US10844106B2 (enExample)
EP (2) EP3604549A1 (enExample)
JP (2) JP6170435B2 (enExample)
AU (3) AU2011326164B2 (enExample)
CA (1) CA2817197C (enExample)
DK (1) DK2638173T3 (enExample)
WO (1) WO2012064658A1 (enExample)

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WO2008045252A2 (en) * 2006-10-04 2008-04-17 The Board Of Trustees Of The Leland Stanford Junior University Engineered integrin binding peptides
WO2012064658A1 (en) 2010-11-08 2012-05-18 The Board Of Trustees Of The Leland Stanford Junior University Fusion proteins comprising an engineered knottin peptide and uses thereof
WO2013078250A2 (en) 2011-11-22 2013-05-30 The Board Of Trustees Of The Leland Stanford Junior University Cystine knot peptides that bind alpha-v-beta-6 integrin
WO2013177187A2 (en) 2012-05-22 2013-11-28 Massachusetts Institute Of Technology Synergistic tumor treatment with extended-pk il-2 and therapeutic agents
WO2014063012A1 (en) * 2012-10-19 2014-04-24 The Board Of Trustees Of The Leland Stanford Junior University Conjugated knottin mini-proteins containing non-natural amino acids
JP2016505826A (ja) * 2012-12-10 2016-02-25 フレッド ハッチンソン キャンサー リサーチ センター スクリーニングの方法
PT2931265T (pt) 2012-12-14 2018-04-16 Univ Leland Stanford Junior Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática
US11013814B2 (en) 2017-03-16 2021-05-25 Blaze Bioscience, Inc. Cartilage-homing peptide conjugates and methods of use thereof
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US20170216403A1 (en) 2014-08-12 2017-08-03 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
CA2957717C (en) * 2014-08-12 2021-10-19 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein
EP3313427A4 (en) * 2015-06-26 2018-12-26 Fred Hutchinson Cancer Research Center Therapeutic peptides and methods of use thereof
JP6966424B2 (ja) 2015-09-09 2021-11-17 フレッド ハッチンソン キャンサー リサーチ センター 軟骨ホーミングペプチド
TWI799366B (zh) * 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
JP7308505B2 (ja) * 2016-01-08 2023-07-14 マキシオン セラピューティクス リミテッド 多様性を変化させた足場ドメインを有する結合メンバー
WO2017139570A1 (en) * 2016-02-12 2017-08-17 Massachusetts Intitute Of Technology Synergistic tumor treatment with il-2, an integrin-binding-fc fusion protein, and a cancer vaccinne
US10765625B2 (en) 2016-03-15 2020-09-08 The Board Of Trustees Of The Leland Stanford Junior University Knottin-drug conjugates and methods of using the same
WO2018044234A1 (en) * 2016-08-31 2018-03-08 Nanyang Technological University Cysteine-rich polypeptides and conjugates and methods of using the same
US10350266B2 (en) 2017-01-10 2019-07-16 Nodus Therapeutics, Inc. Method of treating cancer with a multiple integrin binding Fc fusion protein
WO2018132516A1 (en) 2017-01-10 2018-07-19 Nodus Therapeutics Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator
JP7191025B2 (ja) 2017-01-18 2022-12-16 フレッド ハッチンソン キャンサー センター Ｔｅａｄ相互作用を妨害するためのペプチド組成物およびその使用方法
AU2018283161A1 (en) 2017-06-15 2020-01-02 Blaze Bioscience, Inc. Renal-homing peptide conjugates and methods of use thereof
GB201711208D0 (en) 2017-07-12 2017-08-23 Iontas Ltd Ion channel inhibitors
CA3070230A1 (en) * 2017-07-24 2019-01-31 Rutgers, The State University Of New Jersey Phosphatidylserine targeting fusion molecules and methods for their use
CA3086040A1 (en) 2017-12-19 2019-06-27 Blaze Bioscience, Inc. Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof
WO2020154032A1 (en) 2019-01-23 2020-07-30 Massachusetts Institute Of Technology Combination immunotherapy dosing regimen for immune checkpoint blockade
CN113661240B (zh) * 2019-04-02 2024-11-05 伊莱利利公司 选择和检测结合肽的方法
EP3962511A4 (en) * 2019-04-29 2023-01-18 The Board of Trustees of the Leland Stanford Junior University METHODS OF OCULAR TREATMENT USING A GENETICALLY MODIFIED HEPATOCYTE GROWTH FACTOR DIMERIC FRAGMENT
US20220211861A1 (en) * 2019-05-22 2022-07-07 The Board of Trustees of the Leland Staford Junior University Drug conjugates and methods of using same
AU2020357806A1 (en) * 2019-09-30 2022-05-26 The Board Of Trustees Of The Leland Stanford Junior University Knottin-immunostimulant conjugates and related compositions and methods
WO2022026906A2 (en) * 2020-07-30 2022-02-03 The Board Of Trustees Of The Leland Stanford Junior University Lysosomal targeting molecules comprising knottin peptides and related compositions and methods
MX2020012914A (es) * 2020-11-27 2022-05-30 Centro De Investig Cientifica Y De Educacion Superior De Ensenada Baja California Cicese Proteina andamio para la generacion de proteinas quimericas de union a antigeno.

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WO2002034906A2 (de) * 2000-10-26 2002-05-02 Georg-August-Universität Göttingen Verfahren zur exposition von peptiden und polypeptiden auf der zelloberfläche von bakterien
WO2008045252A2 (en) * 2006-10-04 2008-04-17 The Board Of Trustees Of The Leland Stanford Junior University Engineered integrin binding peptides

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WO2002034906A2 (de) * 2000-10-26 2002-05-02 Georg-August-Universität Göttingen Verfahren zur exposition von peptiden und polypeptiden auf der zelloberfläche von bakterien
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Also Published As

Publication number Publication date
JP6170435B2 (ja) 2017-07-26
CA2817197C (en) 2020-08-04
US20230227523A1 (en) 2023-07-20
DK2638173T3 (da) 2019-09-30
AU2018200587A1 (en) 2018-02-15
EP3604549A1 (en) 2020-02-05
CA2817197A1 (en) 2012-05-18
AU2011326164A1 (en) 2013-05-30
EP2638173A1 (en) 2013-09-18
US11498952B2 (en) 2022-11-15
EP2638173B1 (en) 2019-06-19
JP2014504270A (ja) 2014-02-20
WO2012064658A1 (en) 2012-05-18
US10844106B2 (en) 2020-11-24
AU2016210712A1 (en) 2016-09-08
JP2017160222A (ja) 2017-09-14
JP6535361B2 (ja) 2019-06-26
US20140073518A1 (en) 2014-03-13
US20210206824A1 (en) 2021-07-08
US12240882B2 (en) 2025-03-04
EP2638173A4 (en) 2014-03-26
AU2018200587B2 (en) 2019-12-12
AU2016210712B2 (en) 2017-10-26

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