CA2815492C - Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members - Google Patents
Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members Download PDFInfo
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- CA2815492C CA2815492C CA2815492A CA2815492A CA2815492C CA 2815492 C CA2815492 C CA 2815492C CA 2815492 A CA2815492 A CA 2815492A CA 2815492 A CA2815492 A CA 2815492A CA 2815492 C CA2815492 C CA 2815492C
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Landscapes
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| US41111710P | 2010-11-08 | 2010-11-08 | |
| US61/411,117 | 2010-11-08 | ||
| PCT/EP2011/069522 WO2012062694A1 (en) | 2010-11-08 | 2011-11-07 | Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members |
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| CA2815492A1 CA2815492A1 (en) | 2012-05-18 |
| CA2815492C true CA2815492C (en) | 2019-04-09 |
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| EP (1) | EP2637661B1 (enExample) |
| JP (4) | JP2013542228A (enExample) |
| KR (1) | KR101854484B1 (enExample) |
| CN (2) | CN103200943A (enExample) |
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| BR (1) | BR112013009624A2 (enExample) |
| CA (1) | CA2815492C (enExample) |
| MX (1) | MX360157B (enExample) |
| RU (1) | RU2589695C2 (enExample) |
| TR (1) | TR201802943T4 (enExample) |
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| EP2766015A1 (en) * | 2011-10-14 | 2014-08-20 | Novartis AG | 2-carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases |
| CA2853582A1 (en) * | 2011-11-02 | 2013-05-10 | Novartis Ag | 2-carboxamide cycloamino urea derivatives for use in treating vegf - dependent diseases |
| MY176031A (en) * | 2012-08-07 | 2020-07-22 | Array Biopharma Inc | Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor |
| AU2013302702A1 (en) * | 2012-08-16 | 2015-02-19 | Novartis Ag | Combination of Pl3K inhibitor and c-Met inhibitor |
| WO2014161938A1 (en) * | 2013-04-05 | 2014-10-09 | Sanofi | Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor |
| CA2930359C (en) * | 2013-12-06 | 2022-03-01 | Novartis Ag | Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor |
| BR112020024296A2 (pt) | 2018-08-27 | 2021-03-09 | Regeneron Pharmaceuticals, Inc. | Métodos para produção de um intermediário de purificação de proteína concentrado, para monitoramento e controle dos atributos de qualidade críticos em um intermediário de purificação de proteína e para monitorar e controlar os níveis de excipientes no fluido de cultura de células colhido e/ou intermediário de purificação de proteína, e, intermediário de purificação de proteína |
| EP3849538A4 (en) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
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| KR102449659B1 (ko) * | 2008-03-18 | 2022-09-29 | 제넨테크, 인크. | 항-ｈｅｒ２ 항체-약물 접합체와 화학요법제의 병용물, 및 사용 방법 |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
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- 2011-11-07 CN CN201510770643.9A patent/CN105412105A/zh active Pending
- 2011-11-07 BR BR112013009624A patent/BR112013009624A2/pt not_active IP Right Cessation
- 2011-11-07 RU RU2013126485/15A patent/RU2589695C2/ru active
- 2011-11-07 TR TR2018/02943T patent/TR201802943T4/tr unknown
- 2011-11-07 JP JP2013537156A patent/JP2013542228A/ja active Pending
- 2011-11-07 AU AU2011328227A patent/AU2011328227B2/en active Active
- 2011-11-07 WO PCT/EP2011/069522 patent/WO2012062694A1/en not_active Ceased
- 2011-11-07 US US13/879,644 patent/US20130209461A1/en not_active Abandoned
- 2011-11-07 KR KR1020137011803A patent/KR101854484B1/ko active Active
- 2011-11-07 MX MX2013005182A patent/MX360157B/es active IP Right Grant
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2015
- 2015-05-26 US US14/721,064 patent/US20150250778A1/en not_active Abandoned
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2016
- 2016-07-07 JP JP2016134705A patent/JP2016222686A/ja not_active Withdrawn
-
2018
- 2018-07-12 US US16/033,764 patent/US20180325883A1/en not_active Abandoned
- 2018-10-24 JP JP2018199647A patent/JP2019048822A/ja not_active Withdrawn
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2019
- 2019-09-17 US US16/573,909 patent/US20200022967A1/en not_active Abandoned
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2020
- 2020-03-26 JP JP2020056250A patent/JP2020114849A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2637661B1 (en) | 2017-12-20 |
| US20150250778A1 (en) | 2015-09-10 |
| US20180325883A1 (en) | 2018-11-15 |
| RU2589695C2 (ru) | 2016-07-10 |
| WO2012062694A1 (en) | 2012-05-18 |
| JP2020114849A (ja) | 2020-07-30 |
| BR112013009624A2 (pt) | 2016-07-12 |
| TR201802943T4 (tr) | 2018-03-21 |
| JP2013542228A (ja) | 2013-11-21 |
| RU2013126485A (ru) | 2014-12-20 |
| MX2013005182A (es) | 2013-07-03 |
| JP2019048822A (ja) | 2019-03-28 |
| AU2011328227B2 (en) | 2015-04-09 |
| KR101854484B1 (ko) | 2018-05-03 |
| KR20130143582A (ko) | 2013-12-31 |
| US20130209461A1 (en) | 2013-08-15 |
| CN105412105A (zh) | 2016-03-23 |
| US20200022967A1 (en) | 2020-01-23 |
| JP2016222686A (ja) | 2016-12-28 |
| EP2637661A1 (en) | 2013-09-18 |
| CN103200943A (zh) | 2013-07-10 |
| AU2011328227A1 (en) | 2013-04-18 |
| CA2815492A1 (en) | 2012-05-18 |
| MX360157B (es) | 2018-10-24 |
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