CA2811295A1 - Broad spectrum antibiotic arylomycin analogs - Google Patents

Broad spectrum antibiotic arylomycin analogs Download PDF

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Publication number
CA2811295A1
CA2811295A1 CA2811295A CA2811295A CA2811295A1 CA 2811295 A1 CA2811295 A1 CA 2811295A1 CA 2811295 A CA2811295 A CA 2811295A CA 2811295 A CA2811295 A CA 2811295A CA 2811295 A1 CA2811295 A1 CA 2811295A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
arylomycin
staphylococcus
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2811295A
Other languages
English (en)
French (fr)
Inventor
Peter A. Smith
Tucker C. Roberts
Floyd E. Romesberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of CA2811295A1 publication Critical patent/CA2811295A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA2811295A 2010-09-15 2011-08-31 Broad spectrum antibiotic arylomycin analogs Abandoned CA2811295A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38298810P 2010-09-15 2010-09-15
US61/382,988 2010-09-15
PCT/US2011/049967 WO2012036907A2 (en) 2010-09-15 2011-08-31 Broad spectrum antibiotic arylomycin analogs

Publications (1)

Publication Number Publication Date
CA2811295A1 true CA2811295A1 (en) 2012-03-22

Family

ID=45832167

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2811295A Abandoned CA2811295A1 (en) 2010-09-15 2011-08-31 Broad spectrum antibiotic arylomycin analogs

Country Status (10)

Country Link
US (1) US9187524B2 (enExample)
EP (1) EP2616093A4 (enExample)
JP (1) JP2013539751A (enExample)
KR (1) KR20130105659A (enExample)
CN (1) CN103209700A (enExample)
BR (1) BR112013006265A2 (enExample)
CA (1) CA2811295A1 (enExample)
MX (1) MX2013003035A (enExample)
RU (1) RU2013112483A (enExample)
WO (1) WO2012036907A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013003035A (es) 2010-09-15 2013-12-16 Scripps Research Inst Analogos de arilomicina como antibióticos de amplio espectro.
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
KR20140140580A (ko) * 2012-03-14 2014-12-09 더 스크립스 리서치 인스티튜트 광범위 항생제 아릴로마이신 유사체
CN104903302B (zh) * 2012-11-21 2019-03-29 阿奇克斯制药公司 大环广谱抗生素
CN103103261A (zh) * 2013-01-05 2013-05-15 张国新 检测幽门螺杆菌对克拉霉素耐药性试剂盒及制备方法
JP6823588B2 (ja) * 2014-05-20 2021-02-03 アールキューエックス ファーマシューティカルズ，インク． 大環状広域スペクトル抗生物質
EP3212183B1 (en) * 2014-10-31 2019-10-02 University of Rochester Synergistic compositions for treating microbial infections
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
WO2017214534A1 (en) 2016-06-10 2017-12-14 The Scripps Research Institute Synthesis of the arylomycin macrocyclic core
MX2019009752A (es) * 2017-02-15 2019-11-11 Rqx Pharmaceuticals Inc Antibioticos macrociclicos de amplio espectro.
EP3388445A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Peptide macrocycles and use thereof in the treatment of bacterial infections
JP7078807B2 (ja) 2019-05-28 2022-05-31 エフ．ホフマン－ラ ロシュ アーゲー 大環状広域スペクトル抗生物質
CN116023430B (zh) * 2022-12-20 2025-11-25 中国药科大学 2-(2-(2-苯甲酰氨基)乙酰胺)苯甲酸类衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016558A1 (en) 1995-11-03 1997-05-09 E.I. Du Pont De Nemours And Company Positive selection vector for bacillus sp.
US6951840B2 (en) * 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
WO2011112441A1 (en) 2010-03-09 2011-09-15 Merck Sharp & Dohme Corp. Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
MX2013003035A (es) 2010-09-15 2013-12-16 Scripps Research Inst Analogos de arilomicina como antibióticos de amplio espectro.
TWI642684B (zh) 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
KR20140140580A (ko) 2012-03-14 2014-12-09 더 스크립스 리서치 인스티튜트 광범위 항생제 아릴로마이신 유사체

Also Published As

Publication number Publication date
US20130281360A1 (en) 2013-10-24
RU2013112483A (ru) 2014-10-20
BR112013006265A2 (pt) 2016-06-07
JP2013539751A (ja) 2013-10-28
WO2012036907A3 (en) 2012-08-09
US9187524B2 (en) 2015-11-17
EP2616093A2 (en) 2013-07-24
MX2013003035A (es) 2013-12-16
KR20130105659A (ko) 2013-09-25
EP2616093A4 (en) 2014-02-26
WO2012036907A2 (en) 2012-03-22
CN103209700A (zh) 2013-07-17

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20170831