CN103209700A - 广谱抗生素Arylomycin类似物 - Google Patents

广谱抗生素Arylomycin类似物 Download PDF

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Publication number
CN103209700A
CN103209700A CN2011800550186A CN201180055018A CN103209700A CN 103209700 A CN103209700 A CN 103209700A CN 2011800550186 A CN2011800550186 A CN 2011800550186A CN 201180055018 A CN201180055018 A CN 201180055018A CN 103209700 A CN103209700 A CN 103209700A
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CN
China
Prior art keywords
alkyl
staphylococcus
amino
arylomycin
signal peptidase
Prior art date
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Pending
Application number
CN2011800550186A
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English (en)
Chinese (zh)
Inventor
弗洛伊德·E·罗梅斯伯格
彼得·A·史密斯
塔克·C·罗伯茨
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Scripps Research Institute
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Scripps Research Institute
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Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of CN103209700A publication Critical patent/CN103209700A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN2011800550186A 2010-09-15 2011-08-31 广谱抗生素Arylomycin类似物 Pending CN103209700A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38298810P 2010-09-15 2010-09-15
US61/382,988 2010-09-15
PCT/US2011/049967 WO2012036907A2 (en) 2010-09-15 2011-08-31 Broad spectrum antibiotic arylomycin analogs

Publications (1)

Publication Number Publication Date
CN103209700A true CN103209700A (zh) 2013-07-17

Family

ID=45832167

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800550186A Pending CN103209700A (zh) 2010-09-15 2011-08-31 广谱抗生素Arylomycin类似物

Country Status (10)

Country Link
US (1) US9187524B2 (enExample)
EP (1) EP2616093A4 (enExample)
JP (1) JP2013539751A (enExample)
KR (1) KR20130105659A (enExample)
CN (1) CN103209700A (enExample)
BR (1) BR112013006265A2 (enExample)
CA (1) CA2811295A1 (enExample)
MX (1) MX2013003035A (enExample)
RU (1) RU2013112483A (enExample)
WO (1) WO2012036907A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661084A (zh) * 2014-05-20 2017-05-10 阿奇克斯制药公司 大环广谱抗生素
CN110520413A (zh) * 2017-02-15 2019-11-29 阿奇克斯制药公司 大环广谱抗生素
CN116023430A (zh) * 2022-12-20 2023-04-28 中国药科大学 2-(2-(2-苯甲酰氨基)乙酰胺)苯甲酸类衍生物及其制备方法和用途

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013003035A (es) 2010-09-15 2013-12-16 Scripps Research Inst Analogos de arilomicina como antibióticos de amplio espectro.
TWI642684B (zh) * 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
KR20140140580A (ko) * 2012-03-14 2014-12-09 더 스크립스 리서치 인스티튜트 광범위 항생제 아릴로마이신 유사체
CN104903302B (zh) * 2012-11-21 2019-03-29 阿奇克斯制药公司 大环广谱抗生素
CN103103261A (zh) * 2013-01-05 2013-05-15 张国新 检测幽门螺杆菌对克拉霉素耐药性试剂盒及制备方法
EP3212183B1 (en) * 2014-10-31 2019-10-02 University of Rochester Synergistic compositions for treating microbial infections
KR20180109858A (ko) 2015-11-20 2018-10-08 알큐엑스 파마슈티컬스, 인크. 마크로시클릭 광범위 항생제
WO2017214534A1 (en) 2016-06-10 2017-12-14 The Scripps Research Institute Synthesis of the arylomycin macrocyclic core
EP3388445A1 (en) * 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Peptide macrocycles and use thereof in the treatment of bacterial infections
JP7078807B2 (ja) 2019-05-28 2022-05-31 エフ．ホフマン－ラ ロシュ アーゲー 大環状広域スペクトル抗生物質

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048694A (en) * 1995-11-03 2000-04-11 E. I. Du Pont De Nemours And Company Bacterial positive selection vector

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US6951840B2 (en) * 2001-08-31 2005-10-04 Eli Lilly And Company Lipoglycopeptide antibiotics
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
WO2011112441A1 (en) 2010-03-09 2011-09-15 Merck Sharp & Dohme Corp. Bridged lipoglycopeptides that potentiate the activity of beta-lactam antibacterials
MX2013003035A (es) 2010-09-15 2013-12-16 Scripps Research Inst Analogos de arilomicina como antibióticos de amplio espectro.
TWI642684B (zh) 2011-05-27 2018-12-01 Ｒｑｘ製藥股份有限公司 廣效性抗生素
KR20140140580A (ko) 2012-03-14 2014-12-09 더 스크립스 리서치 인스티튜트 광범위 항생제 아릴로마이신 유사체

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048694A (en) * 1995-11-03 2000-04-11 E. I. Du Pont De Nemours And Company Bacterial positive selection vector

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JUDITH SCHIMANA 等: "Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tü 6075. I. Taxonomy, fermentation, isolation and biological activities.", 《THE JOURNAL OF ANTIBIOTICS》, vol. 55, no. 6, 30 June 2002 (2002-06-30), pages 565 - 570 *
MARK S. BUTLER 等: "Natural products—The future scaffolds for novel antibiotics？", 《BIOCHEMICAL PHARMACOLOGY》, vol. 71, 31 December 2006 (2006-12-31), pages 919 - 929 *
PALANIAPPAN KULANTHAIVEL等: "Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》, vol. 279, no. 35, 1 June 2004 (2004-06-01), pages 36250 - 36258 *
PETER A. SMITH 等: "Broad-Spectrum Antibiotic Activity of the Arylomycin Natural Products Is Masked by Natural Target Mutations", 《CHEM BIOL.》, vol. 17, no. 11, 24 November 2010 (2010-11-24), pages 1223 - 1231, XP027511224, DOI: doi:10.1016/j.chembiol.2010.09.009 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661084A (zh) * 2014-05-20 2017-05-10 阿奇克斯制药公司 大环广谱抗生素
CN106661084B (zh) * 2014-05-20 2021-08-31 阿奇克斯制药公司 大环广谱抗生素
CN110520413A (zh) * 2017-02-15 2019-11-29 阿奇克斯制药公司 大环广谱抗生素
CN110520413B (zh) * 2017-02-15 2023-02-17 阿奇克斯制药公司 大环广谱抗生素
CN116023430A (zh) * 2022-12-20 2023-04-28 中国药科大学 2-(2-(2-苯甲酰氨基)乙酰胺)苯甲酸类衍生物及其制备方法和用途

Also Published As

Publication number Publication date
US20130281360A1 (en) 2013-10-24
RU2013112483A (ru) 2014-10-20
BR112013006265A2 (pt) 2016-06-07
JP2013539751A (ja) 2013-10-28
WO2012036907A3 (en) 2012-08-09
US9187524B2 (en) 2015-11-17
EP2616093A2 (en) 2013-07-24
MX2013003035A (es) 2013-12-16
KR20130105659A (ko) 2013-09-25
EP2616093A4 (en) 2014-02-26
WO2012036907A2 (en) 2012-03-22
CA2811295A1 (en) 2012-03-22

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Application publication date: 20130717