CA2809830C - Compounds comprising n-acyl-2-amino-1,3-thiazole for modulating intracellular calcium - Google Patents

Compounds comprising n-acyl-2-amino-1,3-thiazole for modulating intracellular calcium Download PDF

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Publication number
CA2809830C
CA2809830C CA2809830A CA2809830A CA2809830C CA 2809830 C CA2809830 C CA 2809830C CA 2809830 A CA2809830 A CA 2809830A CA 2809830 A CA2809830 A CA 2809830A CA 2809830 C CA2809830 C CA 2809830C
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calcium
compound
pharmaceutically acceptable
store
optionally substituted
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French (fr)
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CA2809830A1 (en
Inventor
Jeffrey P. Whitten
Yazhong Pei
Jianguo Cao
Zhijun Wang
Evan Rogers
Brian Dyck
Jonathan Grey
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Calcimedica Inc
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Calcimedica Inc
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
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CA2809830A 2010-08-27 2011-08-26 Compounds comprising n-acyl-2-amino-1,3-thiazole for modulating intracellular calcium Active CA2809830C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37784210P 2010-08-27 2010-08-27
US61/377,842 2010-08-27
PCT/US2011/049424 WO2012027710A2 (en) 2010-08-27 2011-08-26 Compounds that modulate intracellular calcium

Publications (2)

Publication Number Publication Date
CA2809830A1 CA2809830A1 (en) 2012-03-01
CA2809830C true CA2809830C (en) 2019-09-10

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CA2809830A Active CA2809830C (en) 2010-08-27 2011-08-26 Compounds comprising n-acyl-2-amino-1,3-thiazole for modulating intracellular calcium

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US (2) US9079891B2 (enExample)
EP (1) EP2609095A4 (enExample)
JP (1) JP5916149B2 (enExample)
CN (3) CN114591311A (enExample)
AU (1) AU2011293201B2 (enExample)
CA (1) CA2809830C (enExample)
MX (1) MX337711B (enExample)
WO (1) WO2012027710A2 (enExample)

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EP2609095A4 (en) 2010-08-27 2014-06-18 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
JP6050335B2 (ja) 2011-05-23 2016-12-21 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ チアゾール誘導体
SG10201607345YA (en) * 2012-03-02 2016-11-29 Ralexar Therapeutics Inc Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
JP2016503395A (ja) 2012-10-31 2016-02-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 病害生物防除剤としての複素環化合物
EP2738172A1 (en) * 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
EP2848615A1 (en) 2013-07-03 2015-03-18 Almirall, S.A. New pyrazole derivatives as CRAC channel modulators
RS60479B1 (sr) 2013-09-04 2020-08-31 Ellora Therapeutics Inc Modulatori receptora x jetre (lxr)
JP2016532713A (ja) 2013-09-04 2016-10-20 アレクサー セラピューティクス， インク． 肝臓ｘ受容体（ｌｘｒ）調節因子
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JP6894923B2 (ja) 2016-04-11 2021-06-30 ジェンフィＧｅｎｆｉｔ 胆汁うっ滞性及び線維性の疾患の処置方法
JP2019513762A (ja) * 2016-04-11 2019-05-30 ジェンフィＧｅｎｆｉｔ 胆汁うっ滞及び線維症の処置方法
JP7193071B2 (ja) * 2017-02-08 2022-12-20 国立大学法人東海国立大学機構 蛍光発光材料および紫外線吸収剤
CN107501258B8 (zh) * 2017-09-14 2018-10-16 青岛大学附属医院 一种噻唑基烟酰胺类化合物及其在制备抗过敏和哮喘药物中的应用
US10670609B2 (en) 2017-09-22 2020-06-02 Government Of The United States, As Represented By The Secretary Of The Air Force Ytterbium as a surrogate cation to measure calcium flux
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JP2023528537A (ja) 2020-03-20 2023-07-04 カルシメディカ，インク． 急性肺傷害及び急性呼吸窮迫症候群を処置するための方法及び組成物
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