CA2809086A1 - Pure intermediate - Google Patents

Pure intermediate Download PDF

Info

Publication number
CA2809086A1
CA2809086A1 CA2809086A CA2809086A CA2809086A1 CA 2809086 A1 CA2809086 A1 CA 2809086A1 CA 2809086 A CA2809086 A CA 2809086A CA 2809086 A CA2809086 A CA 2809086A CA 2809086 A1 CA2809086 A1 CA 2809086A1
Authority
CA
Canada
Prior art keywords
salt
acid
iii
methyl
triazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2809086A
Other languages
English (en)
French (fr)
Inventor
Vinayak Govind Gore
Vinay Kumar Shukla
Sandeep Mekde
Suresh Hasbe
Shreyas Bhandari
Dhananjay Shinde
Madhukar Shaligram Patil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Original Assignee
Generics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics UK Ltd filed Critical Generics UK Ltd
Publication of CA2809086A1 publication Critical patent/CA2809086A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2809086A 2010-08-27 2011-08-26 Pure intermediate Abandoned CA2809086A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2395/MUM/2010 2010-08-27
IN2395MU2010 2010-08-27
PCT/GB2011/051611 WO2012025762A2 (en) 2010-08-27 2011-08-26 Pure intermediate

Publications (1)

Publication Number Publication Date
CA2809086A1 true CA2809086A1 (en) 2012-03-01

Family

ID=44653355

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2809086A Abandoned CA2809086A1 (en) 2010-08-27 2011-08-26 Pure intermediate

Country Status (7)

Country Link
US (1) US9150524B2 (enExample)
EP (1) EP2609087A2 (enExample)
JP (1) JP5958863B2 (enExample)
CN (1) CN103298795A (enExample)
CA (1) CA2809086A1 (enExample)
NZ (1) NZ607428A (enExample)
WO (1) WO2012025762A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103664810B (zh) * 2013-12-11 2016-09-14 深圳劲创生物技术有限公司 一种合成来曲唑的工艺
CN117924195A (zh) * 2023-08-23 2024-04-26 中科帆凯(大连)新材料有限公司 一种制备纯的来曲唑中间体的方法
CN117285477A (zh) * 2023-09-04 2023-12-26 河南康达制药有限公司 一种来曲唑的合成工艺及其装置

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978672A (en) 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4749713A (en) 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
CN1325482C (zh) 2001-12-11 2007-07-11 埃默里大学 双(氰基苯基)甲基－三唑在预防乳腺癌中的用途
WO2004076409A2 (en) * 2003-02-06 2004-09-10 Sun Pharmaceutical Industries Limited Regiospecific process for the preparation of 4-[1- (4-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile
AU2003282380A1 (en) * 2003-11-14 2004-06-06 ADIBHATLA, KALI,SATYA, Bhujanga,rao A method for the separation of the letrozole precursor 4-1-(1,2,4-triazolyl) methyl benzonitrile from its 1,3,4-triazolyl isomer
US20050209294A1 (en) 2004-03-17 2005-09-22 Wadhwa Lalit K Process for producing 4-(1H-1,2,4-triazol-1-ylmethyl)benzonitrile
CN100560573C (zh) * 2004-09-28 2009-11-18 北京德众万全医药科技有限公司 一种高纯度来曲唑的制备方法
CA2608904A1 (en) * 2005-07-06 2007-09-07 Sicor Inc. Improved process for the preparation of letrozole
WO2007039912A1 (en) 2005-10-05 2007-04-12 Usv Limited A one pot process for the preparation of 4-[1-cyanophenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile
WO2007054964A2 (en) 2005-10-20 2007-05-18 Cadila Healthcare Limited Process for the preparation of letrozole
WO2007090464A1 (en) 2006-02-08 2007-08-16 Solmag S.P.A. Process for preparing letrozole
US8003804B2 (en) 2006-03-17 2011-08-23 Cipla Limited Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
WO2007144896A1 (en) 2006-06-13 2007-12-21 Natco Pharma Limited A method of manufacture of letrozole
CN101033214B (zh) * 2006-07-06 2011-05-18 上海复旦复华药业有限公司 来曲唑的制备方法
US8198460B2 (en) 2007-11-28 2012-06-12 Fresenius Kabi Oncology Ltd. Process for preparation of letrozole and its intermediates
WO2010146391A1 (en) 2009-06-15 2010-12-23 Generics [Uk] Limited Regioselective synthesis of letrozole
WO2011000396A1 (en) 2009-07-02 2011-01-06 Synthon B.V. Purification of letrozole intermediate

Also Published As

Publication number Publication date
NZ607428A (en) 2015-10-30
JP5958863B2 (ja) 2016-08-02
CN103298795A (zh) 2013-09-11
AU2011294906B2 (en) 2016-05-19
EP2609087A2 (en) 2013-07-03
WO2012025762A2 (en) 2012-03-01
US20130203826A1 (en) 2013-08-08
JP2013536217A (ja) 2013-09-19
AU2011294906A1 (en) 2013-03-14
AU2011294906A8 (en) 2016-05-26
WO2012025762A3 (en) 2012-05-03
US9150524B2 (en) 2015-10-06

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130221

FZDE Discontinued

Effective date: 20181119