CA2808185A1 - Antibodies to il-1.beta. and il-18, for treatment of disease - Google Patents

Info

Publication number

CA2808185A1

CA2808185A1 CA2808185A CA2808185A CA2808185A1 CA 2808185 A1 CA2808185 A1 CA 2808185A1 CA 2808185 A CA2808185 A CA 2808185A CA 2808185 A CA2808185 A CA 2808185A CA 2808185 A1 CA2808185 A1 CA 2808185A1

Authority

CA

Canada

Prior art keywords

antibody

antibodies

disease

cells

human

Prior art date

2010-08-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 125
• 201000010099 disease Diseases 0.000 title claims abstract description 100
• 238000011282 treatment Methods 0.000 title abstract description 49
• 238000000034 method Methods 0.000 claims abstract description 151
• 102000003810 Interleukin-18 Human genes 0.000 claims description 109
• 108090000171 Interleukin-18 Proteins 0.000 claims description 109
• 108010002352 Interleukin-1 Proteins 0.000 claims description 50
• 102000000589 Interleukin-1 Human genes 0.000 claims description 49
• 230000000694 effects Effects 0.000 claims description 31
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 30
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 27
• 208000011231 Crohn disease Diseases 0.000 claims description 20
• 230000001404 mediated effect Effects 0.000 claims description 19
• 206010064930 age-related macular degeneration Diseases 0.000 claims description 17
• 208000002780 macular degeneration Diseases 0.000 claims description 16
• 208000023275 Autoimmune disease Diseases 0.000 claims description 13
• 230000000903 blocking effect Effects 0.000 claims description 12
• 230000003472 neutralizing effect Effects 0.000 claims description 12
• 108010034143 Inflammasomes Proteins 0.000 claims description 11
• 208000026278 immune system disease Diseases 0.000 claims description 10
• 206010009900 Colitis ulcerative Diseases 0.000 claims description 9
• 201000006704 Ulcerative Colitis Diseases 0.000 claims description 9
• 238000002560 therapeutic procedure Methods 0.000 claims description 9
• 230000002757 inflammatory effect Effects 0.000 claims description 8
• 208000011594 Autoinflammatory disease Diseases 0.000 claims description 7
• 230000009977 dual effect Effects 0.000 claims description 4
• 239000000203 mixture Substances 0.000 abstract description 37
• 210000004027 cell Anatomy 0.000 description 159
• 241000282414 Homo sapiens Species 0.000 description 117
• 108090000623 proteins and genes Proteins 0.000 description 86
• 230000027455 binding Effects 0.000 description 82
• 239000000427 antigen Substances 0.000 description 64
• 108091007433 antigens Proteins 0.000 description 63
• 102000036639 antigens Human genes 0.000 description 63
• 102000004169 proteins and genes Human genes 0.000 description 62
• 235000018102 proteins Nutrition 0.000 description 58
• 108060003951 Immunoglobulin Proteins 0.000 description 53
• 102000018358 immunoglobulin Human genes 0.000 description 53
• 239000013598 vector Substances 0.000 description 44
• 108090000765 processed proteins & peptides Proteins 0.000 description 38
• 230000014509 gene expression Effects 0.000 description 36
• 241000699670 Mus sp. Species 0.000 description 35
• 102000005962 receptors Human genes 0.000 description 34
• 108020003175 receptors Proteins 0.000 description 34
• 241000699666 Mus <mouse, genus> Species 0.000 description 33
• 150000007523 nucleic acids Chemical class 0.000 description 32
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 30
• 102000004196 processed proteins & peptides Human genes 0.000 description 30
• 241001465754 Metazoa Species 0.000 description 28
• 238000004519 manufacturing process Methods 0.000 description 27
• 206010028980 Neoplasm Diseases 0.000 description 26
• 210000001072 colon Anatomy 0.000 description 26
• -1 e.g. Proteins 0.000 description 26
• 235000018417 cysteine Nutrition 0.000 description 25
• 208000035475 disorder Diseases 0.000 description 25
• 102000039446 nucleic acids Human genes 0.000 description 25
• 108020004707 nucleic acids Proteins 0.000 description 25
• 229920001184 polypeptide Polymers 0.000 description 25
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 24
• 235000001014 amino acid Nutrition 0.000 description 23
• 210000004408 hybridoma Anatomy 0.000 description 23
• 108010076504 Protein Sorting Signals Proteins 0.000 description 22
• 125000003275 alpha amino acid group Chemical group 0.000 description 22
• 210000001508 eye Anatomy 0.000 description 22
• 108091033319 polynucleotide Proteins 0.000 description 22
• 102000040430 polynucleotide Human genes 0.000 description 22
• 239000002157 polynucleotide Substances 0.000 description 22
• 108020004414 DNA Proteins 0.000 description 21
• 238000003556 assay Methods 0.000 description 21
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 20
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 20
• 238000005516 engineering process Methods 0.000 description 20
• 230000001965 increasing effect Effects 0.000 description 20
• 206010061218 Inflammation Diseases 0.000 description 19
• 229940024606 amino acid Drugs 0.000 description 19
• 239000003814 drug Substances 0.000 description 19
• 239000012634 fragment Substances 0.000 description 19
• 230000006870 function Effects 0.000 description 19
• 230000004054 inflammatory process Effects 0.000 description 19
• 210000001519 tissue Anatomy 0.000 description 19
• 150000001413 amino acids Chemical class 0.000 description 18
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 17
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 17
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 17
• 201000011510 cancer Diseases 0.000 description 17
• 206010012601 diabetes mellitus Diseases 0.000 description 17
• 108090000426 Caspase-1 Proteins 0.000 description 16
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 16
• 239000003795 chemical substances by application Substances 0.000 description 16
• 239000003446 ligand Substances 0.000 description 16
• 125000003729 nucleotide group Chemical group 0.000 description 16
• 230000001225 therapeutic effect Effects 0.000 description 16
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 15
• 102100035904 Caspase-1 Human genes 0.000 description 15
• 102000004877 Insulin Human genes 0.000 description 15
• 108090001061 Insulin Proteins 0.000 description 15
• 229940125396 insulin Drugs 0.000 description 15
• 230000028327 secretion Effects 0.000 description 15
• 102000004127 Cytokines Human genes 0.000 description 14
• 108090000695 Cytokines Proteins 0.000 description 14
• 241000124008 Mammalia Species 0.000 description 14
• 206010035226 Plasma cell myeloma Diseases 0.000 description 14
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 14
• 229940072221 immunoglobulins Drugs 0.000 description 14
• 125000000539 amino acid group Chemical group 0.000 description 13
• 150000001945 cysteines Chemical class 0.000 description 13
• 230000004927 fusion Effects 0.000 description 13
• 201000000050 myeloid neoplasm Diseases 0.000 description 13
• 239000002773 nucleotide Substances 0.000 description 13
• 210000001744 T-lymphocyte Anatomy 0.000 description 12
• 241000700605 Viruses Species 0.000 description 12
• 230000004913 activation Effects 0.000 description 12
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 12
• 229940079593 drug Drugs 0.000 description 12
• 239000013604 expression vector Substances 0.000 description 12
• 239000001963 growth medium Substances 0.000 description 12
• 208000027866 inflammatory disease Diseases 0.000 description 12
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 12
• 210000002966 serum Anatomy 0.000 description 12
• 208000019693 Lung disease Diseases 0.000 description 11
• 108091028043 Nucleic acid sequence Proteins 0.000 description 11
• 238000013459 approach Methods 0.000 description 11
• 230000015572 biosynthetic process Effects 0.000 description 11
• 206010009887 colitis Diseases 0.000 description 11
• 208000022993 cryopyrin-associated periodic syndrome Diseases 0.000 description 11
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 11
• 229920003045 dextran sodium sulfate Polymers 0.000 description 11
• 125000005647 linker group Chemical group 0.000 description 11
• 238000002965 ELISA Methods 0.000 description 10
• 102000004190 Enzymes Human genes 0.000 description 10
• 108090000790 Enzymes Proteins 0.000 description 10
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 10
• 230000004071 biological effect Effects 0.000 description 10
• 238000004113 cell culture Methods 0.000 description 10
• 238000010367 cloning Methods 0.000 description 10
• 239000012636 effector Substances 0.000 description 10
• 239000003623 enhancer Substances 0.000 description 10
• 229940088598 enzyme Drugs 0.000 description 10
• 238000009472 formulation Methods 0.000 description 10
• 239000000463 material Substances 0.000 description 10
• QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 10
• 229960002702 piroxicam Drugs 0.000 description 10
• 230000004044 response Effects 0.000 description 10
• 241000894007 species Species 0.000 description 10
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 9
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 9
• 241001529936 Murinae Species 0.000 description 9
• 230000001363 autoimmune Effects 0.000 description 9
• 239000000872 buffer Substances 0.000 description 9
• 230000028993 immune response Effects 0.000 description 9
• 210000004962 mammalian cell Anatomy 0.000 description 9
• 230000035772 mutation Effects 0.000 description 9
• 239000013612 plasmid Substances 0.000 description 9
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
• 241000894006 Bacteria Species 0.000 description 8
• 108091026890 Coding region Proteins 0.000 description 8
• 108020004705 Codon Proteins 0.000 description 8
• 108091034117 Oligonucleotide Proteins 0.000 description 8
• 230000004075 alteration Effects 0.000 description 8
• 238000004458 analytical method Methods 0.000 description 8
• 230000001684 chronic effect Effects 0.000 description 8
• 239000000562 conjugate Substances 0.000 description 8
• 230000012010 growth Effects 0.000 description 8
• 238000001727 in vivo Methods 0.000 description 8
• 230000003993 interaction Effects 0.000 description 8
• 239000002609 medium Substances 0.000 description 8
• 230000037361 pathway Effects 0.000 description 8
• 230000008569 process Effects 0.000 description 8
• 238000000746 purification Methods 0.000 description 8
• 230000010076 replication Effects 0.000 description 8
• 206010039073 rheumatoid arthritis Diseases 0.000 description 8
• 239000000758 substrate Substances 0.000 description 8
• 235000000346 sugar Nutrition 0.000 description 8
• 102100024746 Dihydrofolate reductase Human genes 0.000 description 7
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 7
• 206010022489 Insulin Resistance Diseases 0.000 description 7
• 208000029523 Interstitial Lung disease Diseases 0.000 description 7
• 102100024952 Protein CBFA2T1 Human genes 0.000 description 7
• 201000004681 Psoriasis Diseases 0.000 description 7
• 239000000556 agonist Substances 0.000 description 7
• 208000006673 asthma Diseases 0.000 description 7
• 235000005911 diet Nutrition 0.000 description 7
• 108020001096 dihydrofolate reductase Proteins 0.000 description 7
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 7
• 230000001900 immune effect Effects 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 208000014674 injury Diseases 0.000 description 7
• 230000004048 modification Effects 0.000 description 7
• 238000012986 modification Methods 0.000 description 7
• 239000002953 phosphate buffered saline Substances 0.000 description 7
• 238000003127 radioimmunoassay Methods 0.000 description 7
• 230000002829 reductive effect Effects 0.000 description 7
• 239000000243 solution Substances 0.000 description 7
• 208000011580 syndromic disease Diseases 0.000 description 7
• 238000013518 transcription Methods 0.000 description 7
• 230000035897 transcription Effects 0.000 description 7
• 201000004624 Dermatitis Diseases 0.000 description 6
• 241000588724 Escherichia coli Species 0.000 description 6
• 208000030836 Hashimoto thyroiditis Diseases 0.000 description 6
• 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 description 6
• 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 6
• 230000001154 acute effect Effects 0.000 description 6
• 208000026935 allergic disease Diseases 0.000 description 6
• 230000001588 bifunctional effect Effects 0.000 description 6
• 230000007812 deficiency Effects 0.000 description 6
• 230000002950 deficient Effects 0.000 description 6
• 230000037213 diet Effects 0.000 description 6
• 239000008103 glucose Substances 0.000 description 6
• 230000036541 health Effects 0.000 description 6
• 108010037896 heparin-binding hemagglutinin Proteins 0.000 description 6
• 102000043959 human IL18 Human genes 0.000 description 6
• 229940127121 immunoconjugate Drugs 0.000 description 6
• 238000000338 in vitro Methods 0.000 description 6
• 208000015181 infectious disease Diseases 0.000 description 6
• XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
• 210000000056 organ Anatomy 0.000 description 6
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 6
• 238000002823 phage display Methods 0.000 description 6
• YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 6
• 230000002285 radioactive effect Effects 0.000 description 6
• 230000003248 secreting effect Effects 0.000 description 6
• 238000006467 substitution reaction Methods 0.000 description 6
• 208000024891 symptom Diseases 0.000 description 6
• 229940124597 therapeutic agent Drugs 0.000 description 6
• 108700012359 toxins Proteins 0.000 description 6
• 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 5
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 5
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 5
• 208000002267 Anti-neutrophil cytoplasmic antibody-associated vasculitis Diseases 0.000 description 5
• 206010003827 Autoimmune hepatitis Diseases 0.000 description 5
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
• 208000005590 Choroidal Neovascularization Diseases 0.000 description 5
• 206010060823 Choroidal neovascularisation Diseases 0.000 description 5
• 241000699800 Cricetinae Species 0.000 description 5
• SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 5
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
• 102000003886 Glycoproteins Human genes 0.000 description 5
• 108090000288 Glycoproteins Proteins 0.000 description 5
• 241000282412 Homo Species 0.000 description 5
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 5
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 5
• 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 5
• 208000001145 Metabolic Syndrome Diseases 0.000 description 5
• 241000283984 Rodentia Species 0.000 description 5
• 201000009594 Systemic Scleroderma Diseases 0.000 description 5
• 206010042953 Systemic sclerosis Diseases 0.000 description 5
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 5
• 208000027418 Wounds and injury Diseases 0.000 description 5
• 230000003213 activating effect Effects 0.000 description 5
• 230000004900 autophagic degradation Effects 0.000 description 5
• 230000001580 bacterial effect Effects 0.000 description 5
• 229960002685 biotin Drugs 0.000 description 5
• 239000011616 biotin Substances 0.000 description 5
• 229940098773 bovine serum albumin Drugs 0.000 description 5
• 150000001720 carbohydrates Chemical class 0.000 description 5
• 235000014633 carbohydrates Nutrition 0.000 description 5
• 230000000295 complement effect Effects 0.000 description 5
• 230000021615 conjugation Effects 0.000 description 5
• 229940127089 cytotoxic agent Drugs 0.000 description 5
• 230000006378 damage Effects 0.000 description 5
• QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 5
• SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 5
• 230000002163 immunogen Effects 0.000 description 5
• 230000016784 immunoglobulin production Effects 0.000 description 5
• 238000011534 incubation Methods 0.000 description 5
• 210000004969 inflammatory cell Anatomy 0.000 description 5
• 238000007912 intraperitoneal administration Methods 0.000 description 5
• 208000017169 kidney disease Diseases 0.000 description 5
• 210000000265 leukocyte Anatomy 0.000 description 5
• 210000002540 macrophage Anatomy 0.000 description 5
• 239000003550 marker Substances 0.000 description 5
• 230000007246 mechanism Effects 0.000 description 5
• 239000012528 membrane Substances 0.000 description 5
• 108020004999 messenger RNA Proteins 0.000 description 5
• 208000010125 myocardial infarction Diseases 0.000 description 5
• 229920000642 polymer Polymers 0.000 description 5
• 238000010188 recombinant method Methods 0.000 description 5
• 230000009467 reduction Effects 0.000 description 5
• 239000003053 toxin Substances 0.000 description 5
• 231100000765 toxin Toxicity 0.000 description 5
• 238000012546 transfer Methods 0.000 description 5
• 238000002054 transplantation Methods 0.000 description 5
• 230000003612 virological effect Effects 0.000 description 5
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 4
• 241000702423 Adeno-associated virus - 2 Species 0.000 description 4
• 201000004569 Blindness Diseases 0.000 description 4
• 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 4
• 206010009944 Colon cancer Diseases 0.000 description 4
• 241000196324 Embryophyta Species 0.000 description 4
• 206010016207 Familial Mediterranean fever Diseases 0.000 description 4
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 4
• 206010018364 Glomerulonephritis Diseases 0.000 description 4
• 206010020751 Hypersensitivity Diseases 0.000 description 4
• 108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 4
• 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 4
• 102000003814 Interleukin-10 Human genes 0.000 description 4
• 108090000174 Interleukin-10 Proteins 0.000 description 4
• 108050003558 Interleukin-17 Proteins 0.000 description 4
• 102000013691 Interleukin-17 Human genes 0.000 description 4
• 102000004557 Interleukin-18 Receptors Human genes 0.000 description 4
• 108010017537 Interleukin-18 Receptors Proteins 0.000 description 4
• 208000012659 Joint disease Diseases 0.000 description 4
• YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 4
• 241000235649 Kluyveromyces Species 0.000 description 4
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 4
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
• 108090000157 Metallothionein Proteins 0.000 description 4
• 102100022691 NACHT, LRR and PYD domains-containing protein 3 Human genes 0.000 description 4
• 241000238413 Octopus Species 0.000 description 4
• 208000031845 Pernicious anaemia Diseases 0.000 description 4
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
• 206010052779 Transplant rejections Diseases 0.000 description 4
• 206010046851 Uveitis Diseases 0.000 description 4
• 206010047115 Vasculitis Diseases 0.000 description 4
• 201000000028 adult respiratory distress syndrome Diseases 0.000 description 4
• 238000001042 affinity chromatography Methods 0.000 description 4
• 230000007815 allergy Effects 0.000 description 4
• 239000005557 antagonist Substances 0.000 description 4
• 239000003472 antidiabetic agent Substances 0.000 description 4
• 230000008827 biological function Effects 0.000 description 4
• 235000020958 biotin Nutrition 0.000 description 4
• 238000006243 chemical reaction Methods 0.000 description 4
• 150000001875 compounds Chemical class 0.000 description 4
• 239000000356 contaminant Substances 0.000 description 4
• 210000000805 cytoplasm Anatomy 0.000 description 4
• 230000003247 decreasing effect Effects 0.000 description 4
• 238000011161 development Methods 0.000 description 4
• 210000004602 germ cell Anatomy 0.000 description 4
• 208000006454 hepatitis Diseases 0.000 description 4
• 201000001421 hyperglycemia Diseases 0.000 description 4
• 229940126904 hypoglycaemic agent Drugs 0.000 description 4
• 238000003018 immunoassay Methods 0.000 description 4
• 239000003112 inhibitor Substances 0.000 description 4
• 230000005764 inhibitory process Effects 0.000 description 4
• 239000007928 intraperitoneal injection Substances 0.000 description 4
• 229960003299 ketamine Drugs 0.000 description 4
• 210000003734 kidney Anatomy 0.000 description 4
• 210000003292 kidney cell Anatomy 0.000 description 4
• 210000004379 membrane Anatomy 0.000 description 4
• 229910052751 metal Inorganic materials 0.000 description 4
• 239000002184 metal Substances 0.000 description 4
• 229960000485 methotrexate Drugs 0.000 description 4
• 239000003094 microcapsule Substances 0.000 description 4
• 201000006417 multiple sclerosis Diseases 0.000 description 4
• 108010087904 neutravidin Proteins 0.000 description 4
• 238000012014 optical coherence tomography Methods 0.000 description 4
• 201000008482 osteoarthritis Diseases 0.000 description 4
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 4
• 102000054765 polymorphisms of proteins Human genes 0.000 description 4
• 238000012545 processing Methods 0.000 description 4
• 239000000047 product Substances 0.000 description 4
• 230000005180 public health Effects 0.000 description 4
• 230000001105 regulatory effect Effects 0.000 description 4
• 239000000126 substance Substances 0.000 description 4
• 150000008163 sugars Chemical class 0.000 description 4
• 201000000596 systemic lupus erythematosus Diseases 0.000 description 4
• 239000011573 trace mineral Substances 0.000 description 4
• 235000013619 trace mineral Nutrition 0.000 description 4
• GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 4
• 229960001641 troglitazone Drugs 0.000 description 4
• 235000002374 tyrosine Nutrition 0.000 description 4
• 230000000007 visual effect Effects 0.000 description 4
• 238000001262 western blot Methods 0.000 description 4
• BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 4
• 229960001600 xylazine Drugs 0.000 description 4
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 3
• 208000036487 Arthropathies Diseases 0.000 description 3
• 201000001320 Atherosclerosis Diseases 0.000 description 3
• 206010050245 Autoimmune thrombocytopenia Diseases 0.000 description 3
• 108090001008 Avidin Proteins 0.000 description 3
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
• 201000003274 CINCA syndrome Diseases 0.000 description 3
• 206010006895 Cachexia Diseases 0.000 description 3
• 241000282693 Cercopithecidae Species 0.000 description 3
• 108091035707 Consensus sequence Proteins 0.000 description 3
• 206010012689 Diabetic retinopathy Diseases 0.000 description 3
• 241000206602 Eukaryota Species 0.000 description 3
• 208000035690 Familial cold urticaria Diseases 0.000 description 3
• 241000233866 Fungi Species 0.000 description 3
• 208000009329 Graft vs Host Disease Diseases 0.000 description 3
• 208000015023 Graves' disease Diseases 0.000 description 3
• 241000238631 Hexapoda Species 0.000 description 3
• 101001109465 Homo sapiens NACHT, LRR and PYD domains-containing protein 3 Proteins 0.000 description 3
• 208000031226 Hyperlipidaemia Diseases 0.000 description 3
• 206010020772 Hypertension Diseases 0.000 description 3
• 102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 3
• 241001138401 Kluyveromyces lactis Species 0.000 description 3
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
• 208000005777 Lupus Nephritis Diseases 0.000 description 3
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 3
• 102000003792 Metallothionein Human genes 0.000 description 3
• 229930193140 Neomycin Natural products 0.000 description 3
• 241000283973 Oryctolagus cuniculus Species 0.000 description 3
• 229910019142 PO4 Inorganic materials 0.000 description 3
• 239000002202 Polyethylene glycol Substances 0.000 description 3
• 229920001213 Polysorbate 20 Polymers 0.000 description 3
• 208000036824 Psoriatic arthropathy Diseases 0.000 description 3
• 241000700159 Rattus Species 0.000 description 3
• 108020004511 Recombinant DNA Proteins 0.000 description 3
• 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 3
• 108010003723 Single-Domain Antibodies Proteins 0.000 description 3
• 101150006914 TRP1 gene Proteins 0.000 description 3
• 229940123464 Thiazolidinedione Drugs 0.000 description 3
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
• 102000018594 Tumour necrosis factor Human genes 0.000 description 3
• 108050007852 Tumour necrosis factor Proteins 0.000 description 3
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 3
• 208000000208 Wet Macular Degeneration Diseases 0.000 description 3
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 3
• 239000013543 active substance Substances 0.000 description 3
• 239000002671 adjuvant Substances 0.000 description 3
• 125000000217 alkyl group Chemical group 0.000 description 3
• 208000007502 anemia Diseases 0.000 description 3
• 210000004102 animal cell Anatomy 0.000 description 3
• 239000003242 anti bacterial agent Substances 0.000 description 3
• 229940088710 antibiotic agent Drugs 0.000 description 3
• 229940049595 antibody-drug conjugate Drugs 0.000 description 3
• 239000002246 antineoplastic agent Substances 0.000 description 3
• 208000010668 atopic eczema Diseases 0.000 description 3
• 230000009286 beneficial effect Effects 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 210000001124 body fluid Anatomy 0.000 description 3
• 230000001413 cellular effect Effects 0.000 description 3
• 210000003169 central nervous system Anatomy 0.000 description 3
• 230000008859 change Effects 0.000 description 3
• 239000002738 chelating agent Substances 0.000 description 3
• 239000003153 chemical reaction reagent Substances 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 239000003593 chromogenic compound Substances 0.000 description 3
• 208000037976 chronic inflammation Diseases 0.000 description 3
• 230000006020 chronic inflammation Effects 0.000 description 3
• 230000006957 competitive inhibition Effects 0.000 description 3
• 238000004590 computer program Methods 0.000 description 3
• 229920001577 copolymer Polymers 0.000 description 3
• 210000004087 cornea Anatomy 0.000 description 3
• 238000012258 culturing Methods 0.000 description 3
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 3
• 239000002254 cytotoxic agent Substances 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 238000012217 deletion Methods 0.000 description 3
• 230000037430 deletion Effects 0.000 description 3
• 239000003085 diluting agent Substances 0.000 description 3
• 238000010790 dilution Methods 0.000 description 3
• 239000012895 dilution Substances 0.000 description 3
• 206010064570 familial cold autoinflammatory syndrome Diseases 0.000 description 3
• 239000012530 fluid Substances 0.000 description 3
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 3
• 239000000499 gel Substances 0.000 description 3
• 229960004580 glibenclamide Drugs 0.000 description 3
• ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 3
• 208000024908 graft versus host disease Diseases 0.000 description 3
• 210000002443 helper t lymphocyte Anatomy 0.000 description 3
• 231100000283 hepatitis Toxicity 0.000 description 3
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 3
• 210000004754 hybrid cell Anatomy 0.000 description 3
• 210000000987 immune system Anatomy 0.000 description 3
• 238000001114 immunoprecipitation Methods 0.000 description 3
• 230000008676 import Effects 0.000 description 3
• 230000028709 inflammatory response Effects 0.000 description 3
• 230000000968 intestinal effect Effects 0.000 description 3
• 238000002955 isolation Methods 0.000 description 3
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 3
• 238000011542 limb amputation Methods 0.000 description 3
• 208000014018 liver neoplasm Diseases 0.000 description 3
• 210000004698 lymphocyte Anatomy 0.000 description 3
• 150000002739 metals Chemical class 0.000 description 3
• 238000002156 mixing Methods 0.000 description 3
• 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 3
• 229960004927 neomycin Drugs 0.000 description 3
• 230000002018 overexpression Effects 0.000 description 3
• 239000012188 paraffin wax Substances 0.000 description 3
• 230000001575 pathological effect Effects 0.000 description 3
• 230000007170 pathology Effects 0.000 description 3
• 210000001322 periplasm Anatomy 0.000 description 3
• 239000008194 pharmaceutical composition Substances 0.000 description 3
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
• 239000010452 phosphate Substances 0.000 description 3
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
• 239000002243 precursor Substances 0.000 description 3
• 238000002360 preparation method Methods 0.000 description 3
• 230000002265 prevention Effects 0.000 description 3
• 238000000159 protein binding assay Methods 0.000 description 3
• 208000002574 reactive arthritis Diseases 0.000 description 3
• 230000002207 retinal effect Effects 0.000 description 3
• 238000012552 review Methods 0.000 description 3
• 201000000306 sarcoidosis Diseases 0.000 description 3
• 238000012216 screening Methods 0.000 description 3
• 235000004400 serine Nutrition 0.000 description 3
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 239000002904 solvent Substances 0.000 description 3
• 206010041823 squamous cell carcinoma Diseases 0.000 description 3
• 230000000638 stimulation Effects 0.000 description 3
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 3
• 230000008685 targeting Effects 0.000 description 3
• 238000012360 testing method Methods 0.000 description 3
• 230000005030 transcription termination Effects 0.000 description 3
• 230000009261 transgenic effect Effects 0.000 description 3
• GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 3
• 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 3
• 241000701161 unidentified adenovirus Species 0.000 description 3
• LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 description 2
• HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 description 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
• GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 2
• GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 2
• VPFUWHKTPYPNGT-UHFFFAOYSA-N 3-(3,4-dihydroxyphenyl)-1-(5-hydroxy-2,2-dimethylchromen-6-yl)propan-1-one Chemical compound OC1=C2C=CC(C)(C)OC2=CC=C1C(=O)CCC1=CC=C(O)C(O)=C1 VPFUWHKTPYPNGT-UHFFFAOYSA-N 0.000 description 2
• OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 description 2
• 208000030507 AIDS Diseases 0.000 description 2
• 208000004611 Abdominal Obesity Diseases 0.000 description 2
• 102000013563 Acid Phosphatase Human genes 0.000 description 2
• 108010051457 Acid Phosphatase Proteins 0.000 description 2
• 208000026872 Addison Disease Diseases 0.000 description 2
• 229920000936 Agarose Polymers 0.000 description 2
• 102000009027 Albumins Human genes 0.000 description 2
• 108010088751 Albumins Proteins 0.000 description 2
• 201000004384 Alopecia Diseases 0.000 description 2
• 101710154825 Aminoglycoside 3'-phosphotransferase Proteins 0.000 description 2
• 206010002556 Ankylosing Spondylitis Diseases 0.000 description 2
• 239000004475 Arginine Substances 0.000 description 2
• 206010003445 Ascites Diseases 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 2
• 208000031212 Autoimmune polyendocrinopathy Diseases 0.000 description 2
• 102100040355 Autophagy-related protein 16-1 Human genes 0.000 description 2
• 108091008875 B cell receptors Proteins 0.000 description 2
• 208000003950 B-cell lymphoma Diseases 0.000 description 2
• 241000194108 Bacillus licheniformis Species 0.000 description 2
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
• 229940123208 Biguanide Drugs 0.000 description 2
• 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 2
• 208000033222 Biliary cirrhosis primary Diseases 0.000 description 2
• 241000701822 Bovine papillomavirus Species 0.000 description 2
• 206010006187 Breast cancer Diseases 0.000 description 2
• 201000009030 Carcinoma Diseases 0.000 description 2
• 208000024172 Cardiovascular disease Diseases 0.000 description 2
• 206010065941 Central obesity Diseases 0.000 description 2
• 206010008609 Cholangitis sclerosing Diseases 0.000 description 2
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
• 241000193403 Clostridium Species 0.000 description 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
• 208000035473 Communicable disease Diseases 0.000 description 2
• 241000699802 Cricetulus griseus Species 0.000 description 2
• 241000701022 Cytomegalovirus Species 0.000 description 2
• 206010072224 Deficiency of the interleukin-1 receptor antagonist Diseases 0.000 description 2
• 206010012438 Dermatitis atopic Diseases 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• 241000255925 Diptera Species 0.000 description 2
• 206010061818 Disease progression Diseases 0.000 description 2
• 201000005948 Donohue syndrome Diseases 0.000 description 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
• 238000012286 ELISA Assay Methods 0.000 description 2
• 208000008069 Geographic Atrophy Diseases 0.000 description 2
• 208000007465 Giant cell arteritis Diseases 0.000 description 2
• 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 2
• 102100022624 Glucoamylase Human genes 0.000 description 2
• 208000002705 Glucose Intolerance Diseases 0.000 description 2
• 102000005731 Glucose-6-phosphate isomerase Human genes 0.000 description 2
• 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 2
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 244000068988 Glycine max Species 0.000 description 2
• 235000010469 Glycine max Nutrition 0.000 description 2
• 208000024869 Goodpasture syndrome Diseases 0.000 description 2
• 208000003807 Graves Disease Diseases 0.000 description 2
• 108010051696 Growth Hormone Proteins 0.000 description 2
• 206010019280 Heart failures Diseases 0.000 description 2
• 208000005176 Hepatitis C Diseases 0.000 description 2
• 101000964092 Homo sapiens Autophagy-related protein 16-1 Proteins 0.000 description 2
• 101001032334 Homo sapiens Immunity-related GTPase family M protein Proteins 0.000 description 2
• 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 description 2
• 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 2
• 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 description 2
• 101001125026 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 Proteins 0.000 description 2
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
• 206010060378 Hyperinsulinaemia Diseases 0.000 description 2
• 206010020710 Hyperphagia Diseases 0.000 description 2
• 206010020850 Hyperthyroidism Diseases 0.000 description 2
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 2
• 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 2
• 208000028622 Immune thrombocytopenia Diseases 0.000 description 2
• 102100038249 Immunity-related GTPase family M protein Human genes 0.000 description 2
• 208000029462 Immunodeficiency disease Diseases 0.000 description 2
• 102100029571 Immunoglobulin J chain Human genes 0.000 description 2
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 2
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 2
• 206010056997 Impaired fasting glucose Diseases 0.000 description 2
• 208000031773 Insulin resistance syndrome Diseases 0.000 description 2
• 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 2
• 102000003777 Interleukin-1 beta Human genes 0.000 description 2
• 108090000193 Interleukin-1 beta Proteins 0.000 description 2
• 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 description 2
• 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 2
• 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 2
• 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 description 2
• 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 description 2
• 102100035017 Interleukin-18-binding protein Human genes 0.000 description 2
• 101710205006 Interleukin-18-binding protein Proteins 0.000 description 2
• 208000003456 Juvenile Arthritis Diseases 0.000 description 2
• 208000011200 Kawasaki disease Diseases 0.000 description 2
• 244000285963 Kluyveromyces fragilis Species 0.000 description 2
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
• 108090001090 Lectins Proteins 0.000 description 2
• 102000004856 Lectins Human genes 0.000 description 2
• 108010000817 Leuprolide Proteins 0.000 description 2
• 208000016604 Lyme disease Diseases 0.000 description 2
• 239000004472 Lysine Substances 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 2
• 201000002795 Muckle-Wells syndrome Diseases 0.000 description 2
• 102000003945 NF-kappa B Human genes 0.000 description 2
• 108010057466 NF-kappa B Proteins 0.000 description 2
• 238000005481 NMR spectroscopy Methods 0.000 description 2
• 108020005187 Oligonucleotide Probes Proteins 0.000 description 2
• 102000004316 Oxidoreductases Human genes 0.000 description 2
• 108090000854 Oxidoreductases Proteins 0.000 description 2
• 208000018737 Parkinson disease Diseases 0.000 description 2
• 206010034277 Pemphigoid Diseases 0.000 description 2
• 201000011152 Pemphigus Diseases 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 102000035195 Peptidases Human genes 0.000 description 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
• 208000004880 Polyuria Diseases 0.000 description 2
• 208000012654 Primary biliary cholangitis Diseases 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 2
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
• 201000001263 Psoriatic Arthritis Diseases 0.000 description 2
• 206010037660 Pyrexia Diseases 0.000 description 2
• 239000012980 RPMI-1640 medium Substances 0.000 description 2
• 208000033464 Reiter syndrome Diseases 0.000 description 2
• 108020005091 Replication Origin Proteins 0.000 description 2
• 208000017442 Retinal disease Diseases 0.000 description 2
• 206010038923 Retinopathy Diseases 0.000 description 2
• 108010039491 Ricin Proteins 0.000 description 2
• 241000607142 Salmonella Species 0.000 description 2
• 206010039710 Scleroderma Diseases 0.000 description 2
• 206010040047 Sepsis Diseases 0.000 description 2
• 206010040070 Septic Shock Diseases 0.000 description 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
• 241000607720 Serratia Species 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 208000021386 Sjogren Syndrome Diseases 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 102100038803 Somatotropin Human genes 0.000 description 2
• 241000256251 Spodoptera frugiperda Species 0.000 description 2
• 208000006045 Spondylarthropathies Diseases 0.000 description 2
• 208000006011 Stroke Diseases 0.000 description 2
• 229940100389 Sulfonylurea Drugs 0.000 description 2
• 108700012920 TNF Proteins 0.000 description 2
• 208000001106 Takayasu Arteritis Diseases 0.000 description 2
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
• 239000004473 Threonine Substances 0.000 description 2
• 102000006601 Thymidine Kinase Human genes 0.000 description 2
• 108020004440 Thymidine kinase Proteins 0.000 description 2
• BGDKAVGWHJFAGW-UHFFFAOYSA-N Tropicamide Chemical compound C=1C=CC=CC=1C(CO)C(=O)N(CC)CC1=CC=NC=C1 BGDKAVGWHJFAGW-UHFFFAOYSA-N 0.000 description 2
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
• DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 2
• 239000004480 active ingredient Substances 0.000 description 2
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
• 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 2
• 235000004279 alanine Nutrition 0.000 description 2
• 231100000360 alopecia Toxicity 0.000 description 2
• 229960004238 anakinra Drugs 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• 230000000259 anti-tumor effect Effects 0.000 description 2
• 239000000611 antibody drug conjugate Substances 0.000 description 2
• 210000000628 antibody-producing cell Anatomy 0.000 description 2
• 210000000612 antigen-presenting cell Anatomy 0.000 description 2
• 230000000890 antigenic effect Effects 0.000 description 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
• 239000000607 artificial tear Substances 0.000 description 2
• 125000004429 atom Chemical group 0.000 description 2
• 201000008937 atopic dermatitis Diseases 0.000 description 2
• 208000037979 autoimmune inflammatory disease Diseases 0.000 description 2
• 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 2
• 208000010928 autoimmune thyroid disease Diseases 0.000 description 2
• 201000003308 autosomal dominant familial periodic fever Diseases 0.000 description 2
• 229940120638 avastin Drugs 0.000 description 2
• 210000003719 b-lymphocyte Anatomy 0.000 description 2
• 244000052616 bacterial pathogen Species 0.000 description 2
• 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 2
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
• 150000004283 biguanides Chemical class 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 210000004369 blood Anatomy 0.000 description 2
• 238000006664 bond formation reaction Methods 0.000 description 2
• DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 2
• 210000004899 c-terminal region Anatomy 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 238000005119 centrifugation Methods 0.000 description 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
• 208000020832 chronic kidney disease Diseases 0.000 description 2
• 208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 2
• 238000011284 combination treatment Methods 0.000 description 2
• 230000001447 compensatory effect Effects 0.000 description 2
• 238000012875 competitive assay Methods 0.000 description 2
• 208000018631 connective tissue disease Diseases 0.000 description 2
• 238000010276 construction Methods 0.000 description 2
• 230000001276 controlling effect Effects 0.000 description 2
• 238000004132 cross linking Methods 0.000 description 2
• 239000003431 cross linking reagent Substances 0.000 description 2
• 231100000433 cytotoxic Toxicity 0.000 description 2
• 231100000599 cytotoxic agent Toxicity 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 231100000135 cytotoxicity Toxicity 0.000 description 2
• 238000007405 data analysis Methods 0.000 description 2
• 239000003405 delayed action preparation Substances 0.000 description 2
• 210000004443 dendritic cell Anatomy 0.000 description 2
• 201000001981 dermatomyositis Diseases 0.000 description 2
• 238000013461 design Methods 0.000 description 2
• 229940039227 diagnostic agent Drugs 0.000 description 2
• 239000000032 diagnostic agent Substances 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• 208000010643 digestive system disease Diseases 0.000 description 2
• 229960005156 digoxin Drugs 0.000 description 2
• 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
• 230000005750 disease progression Effects 0.000 description 2
• 239000003651 drinking water Substances 0.000 description 2
• 235000020188 drinking water Nutrition 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 208000028208 end stage renal disease Diseases 0.000 description 2
• 201000000523 end stage renal failure Diseases 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 239000005038 ethylene vinyl acetate Substances 0.000 description 2
• 210000003527 eukaryotic cell Anatomy 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
• 230000005714 functional activity Effects 0.000 description 2
• UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 2
• 238000001502 gel electrophoresis Methods 0.000 description 2
• 239000011521 glass Substances 0.000 description 2
• ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 description 2
• 229960001381 glipizide Drugs 0.000 description 2
• 230000004153 glucose metabolism Effects 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
• 239000003102 growth factor Substances 0.000 description 2
• 239000000122 growth hormone Substances 0.000 description 2
• 208000007475 hemolytic anemia Diseases 0.000 description 2
• 230000002949 hemolytic effect Effects 0.000 description 2
• 208000005252 hepatitis A Diseases 0.000 description 2
• 210000003630 histaminocyte Anatomy 0.000 description 2
• 230000002962 histologic effect Effects 0.000 description 2
• 229940088597 hormone Drugs 0.000 description 2
• 239000005556 hormone Substances 0.000 description 2
• 239000000017 hydrogel Substances 0.000 description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
• 238000012872 hydroxylapatite chromatography Methods 0.000 description 2
• 230000003345 hyperglycaemic effect Effects 0.000 description 2
• 230000003451 hyperinsulinaemic effect Effects 0.000 description 2
• 201000008980 hyperinsulinism Diseases 0.000 description 2
• 230000002218 hypoglycaemic effect Effects 0.000 description 2
• FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
• 210000002865 immune cell Anatomy 0.000 description 2
• 230000036039 immunity Effects 0.000 description 2
• 230000003053 immunization Effects 0.000 description 2
• 238000002649 immunization Methods 0.000 description 2
• 230000005847 immunogenicity Effects 0.000 description 2
• 230000001771 impaired effect Effects 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 230000004968 inflammatory condition Effects 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 150000002484 inorganic compounds Chemical class 0.000 description 2
• 229910010272 inorganic material Inorganic materials 0.000 description 2
• 230000003914 insulin secretion Effects 0.000 description 2
• 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 2
• 108040006732 interleukin-1 receptor activity proteins Proteins 0.000 description 2
• 102000014909 interleukin-1 receptor activity proteins Human genes 0.000 description 2
• 208000036971 interstitial lung disease 2 Diseases 0.000 description 2
• 230000003834 intracellular effect Effects 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 238000005304 joining Methods 0.000 description 2
• 230000000366 juvenile effect Effects 0.000 description 2
• 239000002523 lectin Substances 0.000 description 2
• 208000032839 leukemia Diseases 0.000 description 2
• RGLRXNKKBLIBQS-XNHQSDQCSA-N leuprolide acetate Chemical compound CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 RGLRXNKKBLIBQS-XNHQSDQCSA-N 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 201000007270 liver cancer Diseases 0.000 description 2
• 210000005229 liver cell Anatomy 0.000 description 2
• 208000019423 liver disease Diseases 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 206010025135 lupus erythematosus Diseases 0.000 description 2
• 230000000527 lymphocytic effect Effects 0.000 description 2
• 210000005004 lymphoid follicle Anatomy 0.000 description 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 2
• 230000003211 malignant effect Effects 0.000 description 2
• 239000011159 matrix material Substances 0.000 description 2
• 208000030159 metabolic disease Diseases 0.000 description 2
• 230000009401 metastasis Effects 0.000 description 2
• XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 2
• 229960003105 metformin Drugs 0.000 description 2
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 2
• 206010072221 mevalonate kinase deficiency Diseases 0.000 description 2
• 239000004005 microsphere Substances 0.000 description 2
• 235000013336 milk Nutrition 0.000 description 2
• 239000008267 milk Substances 0.000 description 2
• 210000004080 milk Anatomy 0.000 description 2
• 238000001823 molecular biology technique Methods 0.000 description 2
• 238000010369 molecular cloning Methods 0.000 description 2
• 210000001616 monocyte Anatomy 0.000 description 2
• 238000010172 mouse model Methods 0.000 description 2
• 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 description 2
• 238000002703 mutagenesis Methods 0.000 description 2
• 231100000350 mutagenesis Toxicity 0.000 description 2
• 230000007823 neuropathy Effects 0.000 description 2
• 201000001119 neuropathy Diseases 0.000 description 2
• 210000000440 neutrophil Anatomy 0.000 description 2
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
• 235000015097 nutrients Nutrition 0.000 description 2
• 239000002751 oligonucleotide probe Substances 0.000 description 2
• 210000001672 ovary Anatomy 0.000 description 2
• 210000000496 pancreas Anatomy 0.000 description 2
• 238000004091 panning Methods 0.000 description 2
• 244000052769 pathogen Species 0.000 description 2
• 230000001717 pathogenic effect Effects 0.000 description 2
• AQIXEPGDORPWBJ-UHFFFAOYSA-N pentan-3-ol Chemical compound CCC(O)CC AQIXEPGDORPWBJ-UHFFFAOYSA-N 0.000 description 2
• 208000025487 periodic fever syndrome Diseases 0.000 description 2
• 208000033808 peripheral neuropathy Diseases 0.000 description 2
• 239000000546 pharmaceutical excipient Substances 0.000 description 2
• 239000012071 phase Substances 0.000 description 2
• ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 description 2
• 229960003243 phenformin Drugs 0.000 description 2
• 229920003023 plastic Polymers 0.000 description 2
• 239000004033 plastic Substances 0.000 description 2
• 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
• 230000008488 polyadenylation Effects 0.000 description 2
• 206010036067 polydipsia Diseases 0.000 description 2
• 208000005987 polymyositis Diseases 0.000 description 2
• 201000009104 prediabetes syndrome Diseases 0.000 description 2
• 230000000770 proinflammatory effect Effects 0.000 description 2
• QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
• 125000006239 protecting group Chemical group 0.000 description 2
• 230000022558 protein metabolic process Effects 0.000 description 2
• ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
• 238000002708 random mutagenesis Methods 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 229920005989 resin Polymers 0.000 description 2
• 239000011347 resin Substances 0.000 description 2
• GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
• 210000001525 retina Anatomy 0.000 description 2
• 210000003583 retinal pigment epithelium Anatomy 0.000 description 2
• 239000000523 sample Substances 0.000 description 2
• 208000010157 sclerosing cholangitis Diseases 0.000 description 2
• 238000000926 separation method Methods 0.000 description 2
• 230000011664 signaling Effects 0.000 description 2
• 238000002741 site-directed mutagenesis Methods 0.000 description 2
• JJGWLCLUQNFDIS-GTSONSFRSA-M sodium;1-[6-[5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCNC(=O)CCCC[C@H]1[C@H]2NC(=O)N[C@H]2CS1 JJGWLCLUQNFDIS-GTSONSFRSA-M 0.000 description 2
• 201000005671 spondyloarthropathy Diseases 0.000 description 2
• 230000006641 stabilisation Effects 0.000 description 2
• 238000011105 stabilization Methods 0.000 description 2
• 239000003381 stabilizer Substances 0.000 description 2
• 238000010186 staining Methods 0.000 description 2
• 208000026082 sterile multifocal osteomyelitis with periostitis and pustulosis Diseases 0.000 description 2
• ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 2
• 239000006228 supernatant Substances 0.000 description 2
• 238000003786 synthesis reaction Methods 0.000 description 2
• 230000002194 synthesizing effect Effects 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 208000020408 systemic-onset juvenile idiopathic arthritis Diseases 0.000 description 2
• 206010043207 temporal arteritis Diseases 0.000 description 2
• 150000001467 thiazolidinediones Chemical class 0.000 description 2
• FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
• 229940104230 thymidine Drugs 0.000 description 2
• 206010043778 thyroiditis Diseases 0.000 description 2
• 101150065732 tir gene Proteins 0.000 description 2
• 238000001890 transfection Methods 0.000 description 2
• 230000009466 transformation Effects 0.000 description 2
• 230000008733 trauma Effects 0.000 description 2
• 229960004791 tropicamide Drugs 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 150000003668 tyrosines Chemical class 0.000 description 2
• 238000000108 ultra-filtration Methods 0.000 description 2
• 238000011144 upstream manufacturing Methods 0.000 description 2
• 239000011782 vitamin Substances 0.000 description 2
• 229940088594 vitamin Drugs 0.000 description 2
• 235000013343 vitamin Nutrition 0.000 description 2
• 229930003231 vitamin Natural products 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N &alpha;-D-glucopyranosyl-&alpha;-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
• WZUVPPKBWHMQCE-XJKSGUPXSA-N (+)-haematoxylin Chemical compound C12=CC(O)=C(O)C=C2C[C@]2(O)[C@H]1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-XJKSGUPXSA-N 0.000 description 1
• JKHVDAUOODACDU-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCN1C(=O)C=CC1=O JKHVDAUOODACDU-UHFFFAOYSA-N 0.000 description 1
• PVGATNRYUYNBHO-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O PVGATNRYUYNBHO-UHFFFAOYSA-N 0.000 description 1
• BQWBEDSJTMWJAE-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-[(2-iodoacetyl)amino]benzoate Chemical compound C1=CC(NC(=O)CI)=CC=C1C(=O)ON1C(=O)CCC1=O BQWBEDSJTMWJAE-UHFFFAOYSA-N 0.000 description 1
• PMJWDPGOWBRILU-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-[4-(2,5-dioxopyrrol-1-yl)phenyl]butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCC(C=C1)=CC=C1N1C(=O)C=CC1=O PMJWDPGOWBRILU-UHFFFAOYSA-N 0.000 description 1
• VLARLSIGSPVYHX-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCN1C(=O)C=CC1=O VLARLSIGSPVYHX-UHFFFAOYSA-N 0.000 description 1
• WCMOHMXWOOBVMZ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCNC(=O)CCN1C(=O)C=CC1=O WCMOHMXWOOBVMZ-UHFFFAOYSA-N 0.000 description 1
• IHVODYOQUSEYJJ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCNC(=O)C(CC1)CCC1CN1C(=O)C=CC1=O IHVODYOQUSEYJJ-UHFFFAOYSA-N 0.000 description 1
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 description 1
• XMQUEQJCYRFIQS-YFKPBYRVSA-N (2s)-2-amino-5-ethoxy-5-oxopentanoic acid Chemical compound CCOC(=O)CC[C@H](N)C(O)=O XMQUEQJCYRFIQS-YFKPBYRVSA-N 0.000 description 1
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
• ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 description 1
• VILFTWLXLYIEMV-UHFFFAOYSA-N 1,5-difluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC([N+]([O-])=O)=C(F)C=C1F VILFTWLXLYIEMV-UHFFFAOYSA-N 0.000 description 1
• BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 1
• DIYPCWKHSODVAP-UHFFFAOYSA-N 1-[3-(2,5-dioxopyrrol-1-yl)benzoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1=CC=CC(N2C(C=CC2=O)=O)=C1 DIYPCWKHSODVAP-UHFFFAOYSA-N 0.000 description 1
• CULQNACJHGHAER-UHFFFAOYSA-N 1-[4-[(2-iodoacetyl)amino]benzoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1=CC=C(NC(=O)CI)C=C1 CULQNACJHGHAER-UHFFFAOYSA-N 0.000 description 1
• PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• YBBNVCVOACOHIG-UHFFFAOYSA-N 2,2-diamino-1,4-bis(4-azidophenyl)-3-butylbutane-1,4-dione Chemical compound C=1C=C(N=[N+]=[N-])C=CC=1C(=O)C(N)(N)C(CCCC)C(=O)C1=CC=C(N=[N+]=[N-])C=C1 YBBNVCVOACOHIG-UHFFFAOYSA-N 0.000 description 1
• KGLPWQKSKUVKMJ-UHFFFAOYSA-N 2,3-dihydrophthalazine-1,4-dione Chemical class C1=CC=C2C(=O)NNC(=O)C2=C1 KGLPWQKSKUVKMJ-UHFFFAOYSA-N 0.000 description 1
• NHJVRSWLHSJWIN-UHFFFAOYSA-N 2,4,6-trinitrobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O NHJVRSWLHSJWIN-UHFFFAOYSA-N 0.000 description 1
• FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• FZDFGHZZPBUTGP-UHFFFAOYSA-N 2-[[2-[bis(carboxymethyl)amino]-3-(4-isothiocyanatophenyl)propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound OC(=O)CN(CC(O)=O)C(C)CN(CC(O)=O)CC(N(CC(O)=O)CC(O)=O)CC1=CC=C(N=C=S)C=C1 FZDFGHZZPBUTGP-UHFFFAOYSA-N 0.000 description 1
• FBUTXZSKZCQABC-UHFFFAOYSA-N 2-amino-1-methyl-7h-purine-6-thione Chemical compound S=C1N(C)C(N)=NC2=C1NC=N2 FBUTXZSKZCQABC-UHFFFAOYSA-N 0.000 description 1
• AXAVXPMQTGXXJZ-UHFFFAOYSA-N 2-aminoacetic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol Chemical compound NCC(O)=O.OCC(N)(CO)CO AXAVXPMQTGXXJZ-UHFFFAOYSA-N 0.000 description 1
• XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 description 1
• NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
• VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
• OBWSOTREAMFOCQ-UHFFFAOYSA-N 4-(4-amino-3,5-dimethylphenyl)-2,6-dimethylaniline;hydrochloride Chemical compound Cl.CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 OBWSOTREAMFOCQ-UHFFFAOYSA-N 0.000 description 1
• XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
• QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 1
• ZMRMMAOBSFSXLN-UHFFFAOYSA-N 4-[4-(2,5-dioxopyrrol-1-yl)phenyl]butanehydrazide Chemical compound C1=CC(CCCC(=O)NN)=CC=C1N1C(=O)C=CC1=O ZMRMMAOBSFSXLN-UHFFFAOYSA-N 0.000 description 1
• YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 description 1
• TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
• 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
• 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
• 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
• 239000013607 AAV vector Substances 0.000 description 1
• 101150102803 ATG16L1 gene Proteins 0.000 description 1
• 208000035657 Abasia Diseases 0.000 description 1
• 108010066676 Abrin Proteins 0.000 description 1
• 208000029483 Acquired immunodeficiency Diseases 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
• 102100036664 Adenosine deaminase Human genes 0.000 description 1
• 241000256118 Aedes aegypti Species 0.000 description 1
• 241000256173 Aedes albopictus Species 0.000 description 1
• 101710187573 Alcohol dehydrogenase 2 Proteins 0.000 description 1
• 101710133776 Alcohol dehydrogenase class-3 Proteins 0.000 description 1
• 206010027654 Allergic conditions Diseases 0.000 description 1
• 208000024827 Alzheimer disease Diseases 0.000 description 1
• QGZKDVFQNNGYKY-OUBTZVSYSA-N Ammonia-15N Chemical compound [15NH3] QGZKDVFQNNGYKY-OUBTZVSYSA-N 0.000 description 1
• 208000003343 Antiphospholipid Syndrome Diseases 0.000 description 1
• 108091023037 Aptamer Proteins 0.000 description 1
• 241000203069 Archaea Species 0.000 description 1
• 206010003210 Arteriosclerosis Diseases 0.000 description 1
• 206010003267 Arthritis reactive Diseases 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 241000228212 Aspergillus Species 0.000 description 1
• 241000351920 Aspergillus nidulans Species 0.000 description 1
• 241000228245 Aspergillus niger Species 0.000 description 1
• 101000669426 Aspergillus restrictus Ribonuclease mitogillin Proteins 0.000 description 1
• 206010003645 Atopy Diseases 0.000 description 1
• 229930003347 Atropine Natural products 0.000 description 1
• 241001367049 Autographa Species 0.000 description 1
• 206010055128 Autoimmune neutropenia Diseases 0.000 description 1
• 108010082399 Autophagy-Related Proteins Proteins 0.000 description 1
• 241000713842 Avian sarcoma virus Species 0.000 description 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 1
• 230000003844 B-cell-activation Effects 0.000 description 1
• 235000014469 Bacillus subtilis Nutrition 0.000 description 1
• 108090000363 Bacterial Luciferases Proteins 0.000 description 1
• 208000023328 Basedow disease Diseases 0.000 description 1
• 208000027496 Behcet disease Diseases 0.000 description 1
• 208000009137 Behcet syndrome Diseases 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 241000255789 Bombyx mori Species 0.000 description 1
• 241000409811 Bombyx mori nucleopolyhedrovirus Species 0.000 description 1
• 208000020084 Bone disease Diseases 0.000 description 1
• ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 201000006474 Brain Ischemia Diseases 0.000 description 1
• 206010055113 Breast cancer metastatic Diseases 0.000 description 1
• 208000026310 Breast neoplasm Diseases 0.000 description 1
• 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
• 108010041884 CD4 Immunoadhesins Proteins 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• QCMYYKRYFNMIEC-UHFFFAOYSA-N COP(O)=O Chemical class COP(O)=O QCMYYKRYFNMIEC-UHFFFAOYSA-N 0.000 description 1
• 101100298998 Caenorhabditis elegans pbs-3 gene Proteins 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 241000282832 Camelidae Species 0.000 description 1
• 206010058019 Cancer Pain Diseases 0.000 description 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 241000282465 Canis Species 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 101710158575 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase Proteins 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
• OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 description 1
• 206010007559 Cardiac failure congestive Diseases 0.000 description 1
• 206010007710 Cartilage injury Diseases 0.000 description 1
• 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
• 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 1
• 206010008120 Cerebral ischaemia Diseases 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• 241000606161 Chlamydia Species 0.000 description 1
• 241000282552 Chlorocebus aethiops Species 0.000 description 1
• 102000011413 Chondroitinases and Chondroitin Lyases Human genes 0.000 description 1
• 108010023736 Chondroitinases and Chondroitin Lyases Proteins 0.000 description 1
• 208000017667 Chronic Disease Diseases 0.000 description 1
• 206010008909 Chronic Hepatitis Diseases 0.000 description 1
• 208000008818 Chronic Mucocutaneous Candidiasis Diseases 0.000 description 1
• 208000030939 Chronic inflammatory demyelinating polyneuropathy Diseases 0.000 description 1
• 108090000746 Chymosin Proteins 0.000 description 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
• 208000015943 Coeliac disease Diseases 0.000 description 1
• 206010052358 Colorectal cancer metastatic Diseases 0.000 description 1
• 201000003874 Common Variable Immunodeficiency Diseases 0.000 description 1
• 108020004635 Complementary DNA Proteins 0.000 description 1
• 206010053547 Congenital generalised lipodystrophy Diseases 0.000 description 1
• 201000006705 Congenital generalized lipodystrophy Diseases 0.000 description 1
• 206010056370 Congestive cardiomyopathy Diseases 0.000 description 1
• 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
• 201000000054 Coronary Restenosis Diseases 0.000 description 1
• 206010056489 Coronary artery restenosis Diseases 0.000 description 1
• 229920000742 Cotton Polymers 0.000 description 1
• 208000014997 Crohn colitis Diseases 0.000 description 1
• 239000004971 Cross linker Substances 0.000 description 1
• 108700032819 Croton tiglium crotin II Proteins 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 108050003414 DNA primase large subunit PriL Proteins 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 101100285402 Danio rerio eng1a gene Proteins 0.000 description 1
• WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 description 1
• CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
• 208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
• 208000016192 Demyelinating disease Diseases 0.000 description 1
• 241000702421 Dependoparvovirus Species 0.000 description 1
• 206010012442 Dermatitis contact Diseases 0.000 description 1
• 239000004375 Dextrin Substances 0.000 description 1
• 229920001353 Dextrin Polymers 0.000 description 1
• 206010012692 Diabetic uveitis Diseases 0.000 description 1
• 206010051392 Diapedesis Diseases 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
• 201000010046 Dilated cardiomyopathy Diseases 0.000 description 1
• 235000017274 Diospyros sandwicensis Nutrition 0.000 description 1
• 102000016607 Diphtheria Toxin Human genes 0.000 description 1
• 108010053187 Diphtheria Toxin Proteins 0.000 description 1
• 208000006926 Discoid Lupus Erythematosus Diseases 0.000 description 1
• 241000255601 Drosophila melanogaster Species 0.000 description 1
• 206010059866 Drug resistance Diseases 0.000 description 1
• 208000032928 Dyslipidaemia Diseases 0.000 description 1
• 206010014733 Endometrial cancer Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 201000009273 Endometriosis Diseases 0.000 description 1
• 241000588914 Enterobacter Species 0.000 description 1
• 241000588921 Enterobacteriaceae Species 0.000 description 1
• 101800003838 Epidermal growth factor Proteins 0.000 description 1
• 102400001368 Epidermal growth factor Human genes 0.000 description 1
• YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
• 208000001351 Epiretinal Membrane Diseases 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 241000588698 Erwinia Species 0.000 description 1
• 206010015218 Erythema multiforme Diseases 0.000 description 1
• 241000588722 Escherichia Species 0.000 description 1
• 241001522878 Escherichia coli B Species 0.000 description 1
• 241001302584 Escherichia coli str. K-12 substr. W3110 Species 0.000 description 1
• 229910052693 Europium Inorganic materials 0.000 description 1
• 208000004332 Evans syndrome Diseases 0.000 description 1
• 101710082714 Exotoxin A Proteins 0.000 description 1
• 108010087819 Fc receptors Proteins 0.000 description 1
• 102000009109 Fc receptors Human genes 0.000 description 1
• 108091006020 Fc-tagged proteins Proteins 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 208000007984 Female Infertility Diseases 0.000 description 1
• 208000001640 Fibromyalgia Diseases 0.000 description 1
• 108090000331 Firefly luciferases Proteins 0.000 description 1
• BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• 238000009017 Fluorometric Assay Kit Methods 0.000 description 1
• 208000004262 Food Hypersensitivity Diseases 0.000 description 1
• 206010016946 Food allergy Diseases 0.000 description 1
• 241000700662 Fowlpox virus Species 0.000 description 1
• PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
• 229910052688 Gadolinium Inorganic materials 0.000 description 1
• 108010015133 Galactose oxidase Proteins 0.000 description 1
• 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 108700004714 Gelonium multiflorum GEL Proteins 0.000 description 1
• 108700023863 Gene Components Proteins 0.000 description 1
• 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
• 229930182566 Gentamicin Natural products 0.000 description 1
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
• 241001416183 Ginglymostomatidae Species 0.000 description 1
• 102000030595 Glucokinase Human genes 0.000 description 1
• 108010021582 Glucokinase Proteins 0.000 description 1
• 239000004366 Glucose oxidase Substances 0.000 description 1
• 108010015776 Glucose oxidase Proteins 0.000 description 1
• 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 206010018473 Glycosuria Diseases 0.000 description 1
• 241000219146 Gossypium Species 0.000 description 1
• 201000005569 Gout Diseases 0.000 description 1
• 206010018634 Gouty Arthritis Diseases 0.000 description 1
• 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
• 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
• 239000007995 HEPES buffer Substances 0.000 description 1
• 208000031886 HIV Infections Diseases 0.000 description 1
• 208000037357 HIV infectious disease Diseases 0.000 description 1
• WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Natural products C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 1
• 208000031856 Haemosiderosis Diseases 0.000 description 1
• 208000001204 Hashimoto Disease Diseases 0.000 description 1
• 101710121697 Heat-stable enterotoxin Proteins 0.000 description 1
• 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 241000700721 Hepatitis B virus Species 0.000 description 1
• 208000005331 Hepatitis D Diseases 0.000 description 1
• 206010019755 Hepatitis chronic active Diseases 0.000 description 1
• 208000037319 Hepatitis infectious Diseases 0.000 description 1
• 208000009889 Herpes Simplex Diseases 0.000 description 1
• 102000005548 Hexokinase Human genes 0.000 description 1
• 108700040460 Hexokinases Proteins 0.000 description 1
• 102100035108 High affinity nerve growth factor receptor Human genes 0.000 description 1
• 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 1
• 101001041117 Homo sapiens Hyaluronidase PH-20 Proteins 0.000 description 1
• 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 description 1
• 101001033233 Homo sapiens Interleukin-10 Proteins 0.000 description 1
• 101000582546 Homo sapiens Methylosome protein 50 Proteins 0.000 description 1
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 1
• 101000648012 Homo sapiens Signal transducing adapter molecule 1 Proteins 0.000 description 1
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
• 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• 241000701109 Human adenovirus 2 Species 0.000 description 1
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
• 208000023105 Huntington disease Diseases 0.000 description 1
• 108010003272 Hyaluronate lyase Proteins 0.000 description 1
• 102000001974 Hyaluronidases Human genes 0.000 description 1
• RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
• 208000004454 Hyperalgesia Diseases 0.000 description 1
• 208000035154 Hyperesthesia Diseases 0.000 description 1
• 208000013016 Hypoglycemia Diseases 0.000 description 1
• 208000000038 Hypoparathyroidism Diseases 0.000 description 1
• UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
• 102000039996 IL-1 family Human genes 0.000 description 1
• 108091069196 IL-1 family Proteins 0.000 description 1
• 208000016300 Idiopathic chronic eosinophilic pneumonia Diseases 0.000 description 1
• 208000010159 IgA glomerulonephritis Diseases 0.000 description 1
• 206010021263 IgA nephropathy Diseases 0.000 description 1
• 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
• 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 206010061598 Immunodeficiency Diseases 0.000 description 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
• 108700005091 Immunoglobulin Genes Proteins 0.000 description 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
• 206010021928 Infertility female Diseases 0.000 description 1
• 102000003781 Inhibitor of growth protein 1 Human genes 0.000 description 1
• 108090000191 Inhibitor of growth protein 1 Proteins 0.000 description 1
• 206010022491 Insulin resistant diabetes Diseases 0.000 description 1
• 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 description 1
• 108010064600 Intercellular Adhesion Molecule-3 Proteins 0.000 description 1
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 1
• 102100037872 Intercellular adhesion molecule 2 Human genes 0.000 description 1
• 101710148794 Intercellular adhesion molecule 2 Proteins 0.000 description 1
• 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 description 1
• 238000012695 Interfacial polymerization Methods 0.000 description 1
• 108050006617 Interleukin-1 receptor Proteins 0.000 description 1
• 102000019223 Interleukin-1 receptor Human genes 0.000 description 1
• 108010065805 Interleukin-12 Proteins 0.000 description 1
• 102000013462 Interleukin-12 Human genes 0.000 description 1
• 102000017761 Interleukin-33 Human genes 0.000 description 1
• 108010067003 Interleukin-33 Proteins 0.000 description 1
• 108090001005 Interleukin-6 Proteins 0.000 description 1
• ZCYVEMRRCGMTRW-AHCXROLUSA-N Iodine-123 Chemical compound [123I] ZCYVEMRRCGMTRW-AHCXROLUSA-N 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• 241000588748 Klebsiella Species 0.000 description 1
• 241000235058 Komagataella pastoris Species 0.000 description 1
• LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• 241000481961 Lachancea thermotolerans Species 0.000 description 1
• 241000235651 Lachancea waltii Species 0.000 description 1
• 102100038609 Lactoperoxidase Human genes 0.000 description 1
• 108010023244 Lactoperoxidase Proteins 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 241000282838 Lama Species 0.000 description 1
• 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 description 1
• 208000035369 Leprechaunism Diseases 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 201000001779 Leukocyte adhesion deficiency Diseases 0.000 description 1
• 206010024453 Ligament sprain Diseases 0.000 description 1
• 208000012309 Linear IgA disease Diseases 0.000 description 1
• 240000006240 Linum usitatissimum Species 0.000 description 1
• 208000017170 Lipid metabolism disease Diseases 0.000 description 1
• 206010024604 Lipoatrophy Diseases 0.000 description 1
• 108060001084 Luciferase Proteins 0.000 description 1
• DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
• 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
• 102000008072 Lymphokines Human genes 0.000 description 1
• 108010074338 Lymphokines Proteins 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 241000282553 Macaca Species 0.000 description 1
• 239000004907 Macro-emulsion Substances 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• 102000013460 Malate Dehydrogenase Human genes 0.000 description 1
• 108010026217 Malate Dehydrogenase Proteins 0.000 description 1
• 208000007466 Male Infertility Diseases 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 201000009906 Meningitis Diseases 0.000 description 1
• UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 1
• 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
• 208000003250 Mixed connective tissue disease Diseases 0.000 description 1
• 244000302512 Momordica charantia Species 0.000 description 1
• 235000009811 Momordica charantia Nutrition 0.000 description 1
• 206010028080 Mucocutaneous candidiasis Diseases 0.000 description 1
• 208000034578 Multiple myelomas Diseases 0.000 description 1
• 108010014251 Muramidase Proteins 0.000 description 1
• 102000016943 Muramidase Human genes 0.000 description 1
• 241000699660 Mus musculus Species 0.000 description 1
• 101001076419 Mus musculus Interleukin-1 receptor type 1 Proteins 0.000 description 1
• 102000008934 Muscle Proteins Human genes 0.000 description 1
• 108010074084 Muscle Proteins Proteins 0.000 description 1
• 208000021642 Muscular disease Diseases 0.000 description 1
• 206010028424 Myasthenic syndrome Diseases 0.000 description 1
• 201000009623 Myopathy Diseases 0.000 description 1
• 201000002481 Myositis Diseases 0.000 description 1
• 206010028665 Myxoedema Diseases 0.000 description 1
• 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
• WTBIAPVQQBCLFP-UHFFFAOYSA-N N.N.N.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O Chemical compound N.N.N.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O WTBIAPVQQBCLFP-UHFFFAOYSA-N 0.000 description 1
• 108091008099 NLRP3 inflammasome Proteins 0.000 description 1
• 206010029113 Neovascularisation Diseases 0.000 description 1
• 206010029164 Nephrotic syndrome Diseases 0.000 description 1
• 206010029240 Neuritis Diseases 0.000 description 1
• 241000221960 Neurospora Species 0.000 description 1
• 241000221961 Neurospora crassa Species 0.000 description 1
• 206010029350 Neurotoxicity Diseases 0.000 description 1
• 244000061176 Nicotiana tabacum Species 0.000 description 1
• 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
• 239000000020 Nitrocellulose Substances 0.000 description 1
• 101710163270 Nuclease Proteins 0.000 description 1
• 102100029441 Nucleotide-binding oligomerization domain-containing protein 2 Human genes 0.000 description 1
• 208000008589 Obesity Diseases 0.000 description 1
• 206010029888 Obliterative bronchiolitis Diseases 0.000 description 1
• 206010030113 Oedema Diseases 0.000 description 1
• 102100021079 Ornithine decarboxylase Human genes 0.000 description 1
• 108700005126 Ornithine decarboxylases Proteins 0.000 description 1
• 208000001132 Osteoporosis Diseases 0.000 description 1
• 206010033128 Ovarian cancer Diseases 0.000 description 1
• 206010033165 Ovarian failure Diseases 0.000 description 1
• 206010061535 Ovarian neoplasm Diseases 0.000 description 1
• 108010016731 PPAR gamma Proteins 0.000 description 1
• 229930012538 Paclitaxel Natural products 0.000 description 1
• 208000002193 Pain Diseases 0.000 description 1
• 208000016222 Pancreatic disease Diseases 0.000 description 1
• 108010067372 Pancreatic elastase Proteins 0.000 description 1
• 102000016387 Pancreatic elastase Human genes 0.000 description 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
• 206010033645 Pancreatitis Diseases 0.000 description 1
• 206010033647 Pancreatitis acute Diseases 0.000 description 1
• 108090000526 Papain Proteins 0.000 description 1
• 208000030852 Parasitic disease Diseases 0.000 description 1
• 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 description 1
• 241000721454 Pemphigus Species 0.000 description 1
• 208000027086 Pemphigus foliaceus Diseases 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 108010087702 Penicillinase Proteins 0.000 description 1
• 241000228143 Penicillium Species 0.000 description 1
• 108010067902 Peptide Library Proteins 0.000 description 1
• 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 description 1
• 240000007377 Petunia x hybrida Species 0.000 description 1
• 206010057249 Phagocytosis Diseases 0.000 description 1
• 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 description 1
• 102000001105 Phosphofructokinases Human genes 0.000 description 1
• 108010069341 Phosphofructokinases Proteins 0.000 description 1
• 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
• 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
• ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
• 108091000080 Phosphotransferase Proteins 0.000 description 1
• 108010004729 Phycoerythrin Proteins 0.000 description 1
• 101100413173 Phytolacca americana PAP2 gene Proteins 0.000 description 1
• 101710194982 Platelet glycoprotein VI Proteins 0.000 description 1
• 102100038394 Platelet glycoprotein VI Human genes 0.000 description 1
• 229920000805 Polyaspartic acid Polymers 0.000 description 1
• 206010036105 Polyneuropathy Diseases 0.000 description 1
• 241001505332 Polyomavirus sp. Species 0.000 description 1
• 206010057244 Post viral fatigue syndrome Diseases 0.000 description 1
• 102100025067 Potassium voltage-gated channel subfamily H member 4 Human genes 0.000 description 1
• 101710163352 Potassium voltage-gated channel subfamily H member 4 Proteins 0.000 description 1
• 208000006399 Premature Obstetric Labor Diseases 0.000 description 1
• 208000002500 Primary Ovarian Insufficiency Diseases 0.000 description 1
• 241000677647 Proba Species 0.000 description 1
• KCLANYCVBBTKTO-UHFFFAOYSA-N Proparacaine Chemical compound CCCOC1=CC=C(C(=O)OCCN(CC)CC)C=C1N KCLANYCVBBTKTO-UHFFFAOYSA-N 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
• 206010060862 Prostate cancer Diseases 0.000 description 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 108010001267 Protein Subunits Proteins 0.000 description 1
• 102000002067 Protein Subunits Human genes 0.000 description 1
• 241000588769 Proteus <enterobacteria> Species 0.000 description 1
• 241000589516 Pseudomonas Species 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 101100084022 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) lapA gene Proteins 0.000 description 1
• 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 description 1
• 108010011939 Pyruvate Decarboxylase Proteins 0.000 description 1
• 102000013009 Pyruvate Kinase Human genes 0.000 description 1
• 108020005115 Pyruvate Kinase Proteins 0.000 description 1
• 102000004879 Racemases and epimerases Human genes 0.000 description 1
• 108090001066 Racemases and epimerases Proteins 0.000 description 1
• 208000032056 Radiation Fibrosis Syndrome Diseases 0.000 description 1
• 206010067953 Radiation fibrosis Diseases 0.000 description 1
• 241000700157 Rattus norvegicus Species 0.000 description 1
• 230000010799 Receptor Interactions Effects 0.000 description 1
• 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 description 1
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 1
• 208000001647 Renal Insufficiency Diseases 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 208000006265 Renal cell carcinoma Diseases 0.000 description 1
• 206010063837 Reperfusion injury Diseases 0.000 description 1
• 108700008625 Reporter Genes Proteins 0.000 description 1
• 208000002367 Retinal Perforations Diseases 0.000 description 1
• 241000219061 Rheum Species 0.000 description 1
• 206010039085 Rhinitis allergic Diseases 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• 241000714474 Rous sarcoma virus Species 0.000 description 1
• 229910006124 SOCl2 Inorganic materials 0.000 description 1
• 241000235070 Saccharomyces Species 0.000 description 1
• 206010061934 Salivary gland cancer Diseases 0.000 description 1
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
• 206010039491 Sarcoma Diseases 0.000 description 1
• 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
• 241000311088 Schwanniomyces Species 0.000 description 1
• 241001123650 Schwanniomyces occidentalis Species 0.000 description 1
• 239000012507 Sephadex™ Substances 0.000 description 1
• 229920002684 Sepharose Polymers 0.000 description 1
• 206010053879 Sepsis syndrome Diseases 0.000 description 1
• 108010071390 Serum Albumin Proteins 0.000 description 1
• 102000007562 Serum Albumin Human genes 0.000 description 1
• 241000607768 Shigella Species 0.000 description 1
• 102100025245 Signal transducing adapter molecule 1 Human genes 0.000 description 1
• 102100025265 Signal transducing adapter molecule 2 Human genes 0.000 description 1
• 101710191637 Signal transducing adapter molecule 2 Proteins 0.000 description 1
• BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
• 241000700584 Simplexvirus Species 0.000 description 1
• 206010041067 Small cell lung cancer Diseases 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 240000003768 Solanum lycopersicum Species 0.000 description 1
• 244000061456 Solanum tuberosum Species 0.000 description 1
• 235000002595 Solanum tuberosum Nutrition 0.000 description 1
• 208000010040 Sprains and Strains Diseases 0.000 description 1
• 108010088160 Staphylococcal Protein A Proteins 0.000 description 1
• 206010072148 Stiff-Person syndrome Diseases 0.000 description 1
• 108010090804 Streptavidin Proteins 0.000 description 1
• 241000187747 Streptomyces Species 0.000 description 1
• QTENRWWVYAAPBI-YZTFXSNBSA-N Streptomycin sulfate Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@H]1[C@H](N=C(N)N)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]1O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@H]1[C@H](N=C(N)N)[C@@H](O)[C@H](N=C(N)N)[C@@H](O)[C@@H]1O QTENRWWVYAAPBI-YZTFXSNBSA-N 0.000 description 1
• ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 206010042742 Sympathetic ophthalmia Diseases 0.000 description 1
• 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 1
• 208000004732 Systemic Vasculitis Diseases 0.000 description 1
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
• 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 description 1
• 229940123237 Taxane Drugs 0.000 description 1
• 241000255588 Tephritidae Species 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
• 102000002933 Thioredoxin Human genes 0.000 description 1
• 108010034949 Thyroglobulin Proteins 0.000 description 1
• 102000009843 Thyroglobulin Human genes 0.000 description 1
• 208000024770 Thyroid neoplasm Diseases 0.000 description 1
• 241001149964 Tolypocladium Species 0.000 description 1
• 206010044221 Toxic encephalopathy Diseases 0.000 description 1
• 206010044248 Toxic shock syndrome Diseases 0.000 description 1
• 231100000650 Toxic shock syndrome Toxicity 0.000 description 1
• 101710120037 Toxin CcdB Proteins 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
• 241000223259 Trichoderma Species 0.000 description 1
• 102000005924 Triose-Phosphate Isomerase Human genes 0.000 description 1
• 108700015934 Triose-phosphate isomerases Proteins 0.000 description 1
• 229940122618 Trypsin inhibitor Drugs 0.000 description 1
• 101710162629 Trypsin inhibitor Proteins 0.000 description 1
• 206010048302 Tubulointerstitial nephritis Diseases 0.000 description 1
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
• 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
• 208000025865 Ulcer Diseases 0.000 description 1
• 108091023045 Untranslated Region Proteins 0.000 description 1
• 108010092464 Urate Oxidase Proteins 0.000 description 1
• 108010046334 Urease Proteins 0.000 description 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
• 208000024780 Urticaria Diseases 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 244000000188 Vaccinium ovalifolium Species 0.000 description 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
• 240000001866 Vernicia fordii Species 0.000 description 1
• 108020005202 Viral DNA Proteins 0.000 description 1
• 206010047642 Vitiligo Diseases 0.000 description 1
• 206010047741 Vulval cancer Diseases 0.000 description 1
• 201000011032 Werner Syndrome Diseases 0.000 description 1
• 208000027207 Whipple disease Diseases 0.000 description 1
• 102100033220 Xanthine oxidase Human genes 0.000 description 1
• 108010093894 Xanthine oxidase Proteins 0.000 description 1
• 241000235013 Yarrowia Species 0.000 description 1
• 241000607734 Yersinia <bacteria> Species 0.000 description 1
• 240000008042 Zea mays Species 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 description 1
• 229960000446 abciximab Drugs 0.000 description 1
• 201000010390 abdominal obesity-metabolic syndrome 1 Diseases 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 201000010272 acanthosis nigricans Diseases 0.000 description 1
• 239000008351 acetate buffer Substances 0.000 description 1
• 239000002253 acid Substances 0.000 description 1
• 239000003929 acidic solution Substances 0.000 description 1
• 150000007513 acids Chemical class 0.000 description 1
• 208000033017 acquired idiopathic inflammatory myopathy Diseases 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 201000003229 acute pancreatitis Diseases 0.000 description 1
• 208000018254 acute transverse myelitis Diseases 0.000 description 1
• 125000002015 acyclic group Chemical group 0.000 description 1
• 230000033289 adaptive immune response Effects 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 229960005305 adenosine Drugs 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 230000009824 affinity maturation Effects 0.000 description 1
• 238000001261 affinity purification Methods 0.000 description 1
• 230000004931 aggregating effect Effects 0.000 description 1
• 230000002776 aggregation Effects 0.000 description 1
• 238000004220 aggregation Methods 0.000 description 1
• 230000001270 agonistic effect Effects 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 125000003342 alkenyl group Chemical group 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• 239000013566 allergen Substances 0.000 description 1
• 208000002205 allergic conjunctivitis Diseases 0.000 description 1
• 230000000172 allergic effect Effects 0.000 description 1
• 201000010105 allergic rhinitis Diseases 0.000 description 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
• 108010001818 alpha-sarcin Proteins 0.000 description 1
• 229940037003 alum Drugs 0.000 description 1
• 229940059260 amidate Drugs 0.000 description 1
• 150000001412 amines Chemical group 0.000 description 1
• 229960003896 aminopterin Drugs 0.000 description 1
• 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
• 229960000723 ampicillin Drugs 0.000 description 1
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 238000002583 angiography Methods 0.000 description 1
• 239000003957 anion exchange resin Substances 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 208000022531 anorexia Diseases 0.000 description 1
• 230000008485 antagonism Effects 0.000 description 1
• 229940045799 anthracyclines and related substance Drugs 0.000 description 1
• 230000003466 anti-cipated effect Effects 0.000 description 1
• 230000036436 anti-hiv Effects 0.000 description 1
• 238000011091 antibody purification Methods 0.000 description 1
• 238000009175 antibody therapy Methods 0.000 description 1
• 239000003963 antioxidant agent Substances 0.000 description 1
• 235000006708 antioxidants Nutrition 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
• 208000011775 arteriosclerosis disease Diseases 0.000 description 1
• 206010003246 arthritis Diseases 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 239000012131 assay buffer Substances 0.000 description 1
• 238000003149 assay kit Methods 0.000 description 1
• 208000010927 atrophic thyroiditis Diseases 0.000 description 1
• RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
• 229960000396 atropine Drugs 0.000 description 1
• 108010044540 auristatin Proteins 0.000 description 1
• 229940090047 auto-injector Drugs 0.000 description 1
• 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
• 201000004988 autoimmune vasculitis Diseases 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 239000008228 bacteriostatic water for injection Substances 0.000 description 1
• 210000004082 barrier epithelial cell Anatomy 0.000 description 1
• 210000003651 basophil Anatomy 0.000 description 1
• 229960000686 benzalkonium chloride Drugs 0.000 description 1
• 229960001950 benzethonium chloride Drugs 0.000 description 1
• UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
• 229960000397 bevacizumab Drugs 0.000 description 1
• 230000000975 bioactive effect Effects 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 230000008236 biological pathway Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• HUTDDBSSHVOYJR-UHFFFAOYSA-H bis[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphaplumbetan-2-yl)oxy]lead Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O HUTDDBSSHVOYJR-UHFFFAOYSA-H 0.000 description 1
• 201000000053 blastoma Diseases 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• 229910052796 boron Inorganic materials 0.000 description 1
• 108010006025 bovine growth hormone Proteins 0.000 description 1
• 208000029028 brain injury Diseases 0.000 description 1
• 210000000069 breast epithelial cell Anatomy 0.000 description 1
• 201000003848 bronchiolitis obliterans Diseases 0.000 description 1
• 208000023367 bronchiolitis obliterans with obstructive pulmonary disease Diseases 0.000 description 1
• 208000019748 bullous skin disease Diseases 0.000 description 1
• LRHPLDYGYMQRHN-UHFFFAOYSA-N butyl alcohol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 244000309466 calf Species 0.000 description 1
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 description 1
• 229930195731 calicheamicin Natural products 0.000 description 1
• 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 125000002837 carbocyclic group Chemical group 0.000 description 1
• 230000023852 carbohydrate metabolic process Effects 0.000 description 1
• 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
• 125000004432 carbon atom Chemical group C* 0.000 description 1
• 239000003729 cation exchange resin Substances 0.000 description 1
• 230000020411 cell activation Effects 0.000 description 1
• 238000000423 cell based assay Methods 0.000 description 1
• 239000006143 cell culture medium Substances 0.000 description 1
• 230000006727 cell loss Effects 0.000 description 1
• 239000008004 cell lysis buffer Substances 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 206010008118 cerebral infarction Diseases 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• 208000019065 cervical carcinoma Diseases 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• 229940044683 chemotherapy drug Drugs 0.000 description 1
• 210000000038 chest Anatomy 0.000 description 1
• 210000003161 choroid Anatomy 0.000 description 1
• 238000011098 chromatofocusing Methods 0.000 description 1
• 239000013611 chromosomal DNA Substances 0.000 description 1
• 230000002759 chromosomal effect Effects 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• 201000009323 chronic eosinophilic pneumonia Diseases 0.000 description 1
• 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 description 1
• 230000012085 chronic inflammatory response Effects 0.000 description 1
• 229940080701 chymosin Drugs 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 238000011260 co-administration Methods 0.000 description 1
• 238000005354 coacervation Methods 0.000 description 1
• 230000003475 colitic effect Effects 0.000 description 1
• 208000029742 colonic neoplasm Diseases 0.000 description 1
• 238000007398 colorimetric assay Methods 0.000 description 1
• 230000002860 competitive effect Effects 0.000 description 1
• 230000004540 complement-dependent cytotoxicity Effects 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 230000009918 complex formation Effects 0.000 description 1
• 238000010668 complexation reaction Methods 0.000 description 1
• 230000001268 conjugating effect Effects 0.000 description 1
• 208000010247 contact dermatitis Diseases 0.000 description 1
• 239000005289 controlled pore glass Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 238000002586 coronary angiography Methods 0.000 description 1
• 208000029078 coronary artery disease Diseases 0.000 description 1
• 210000004351 coronary vessel Anatomy 0.000 description 1
• 239000007822 coupling agent Substances 0.000 description 1
• 239000013078 crystal Substances 0.000 description 1
• 208000004921 cutaneous lupus erythematosus Diseases 0.000 description 1
• 125000004122 cyclic group Chemical group 0.000 description 1
• 125000000392 cycloalkenyl group Chemical group 0.000 description 1
• 125000000753 cycloalkyl group Chemical group 0.000 description 1
• NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 1
• HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
• 229960003067 cystine Drugs 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 125000001295 dansyl group Chemical group [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])S(*)(=O)=O 0.000 description 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
• 206010061428 decreased appetite Diseases 0.000 description 1
• 230000007123 defense Effects 0.000 description 1
• 230000006735 deficit Effects 0.000 description 1
• 230000003413 degradative effect Effects 0.000 description 1
• 206010061811 demyelinating polyneuropathy Diseases 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000009795 derivation Methods 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• 230000001627 detrimental effect Effects 0.000 description 1
• 235000019425 dextrin Nutrition 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 229930191339 dianthin Natural products 0.000 description 1
• 230000000378 dietary effect Effects 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
• LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
• 125000005442 diisocyanate group Chemical group 0.000 description 1
• 238000007865 diluting Methods 0.000 description 1
• 238000006471 dimerization reaction Methods 0.000 description 1
• ZLFRJHOBQVVTOJ-UHFFFAOYSA-N dimethyl hexanediimidate Chemical compound COC(=N)CCCCC(=N)OC ZLFRJHOBQVVTOJ-UHFFFAOYSA-N 0.000 description 1
• 206010013023 diphtheria Diseases 0.000 description 1
• 150000002016 disaccharides Chemical class 0.000 description 1
• NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• 208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 210000004921 distal colon Anatomy 0.000 description 1
• ZWIBGKZDAWNIFC-UHFFFAOYSA-N disuccinimidyl suberate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O ZWIBGKZDAWNIFC-UHFFFAOYSA-N 0.000 description 1
• 230000006334 disulfide bridging Effects 0.000 description 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-N dithiophosphoric acid Chemical class OP(O)(S)=S NAGJZTKCGNOGPW-UHFFFAOYSA-N 0.000 description 1
• 229960003668 docetaxel Drugs 0.000 description 1
• AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 description 1
• 229930188854 dolastatin Natural products 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 229960004679 doxorubicin Drugs 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 208000011325 dry age related macular degeneration Diseases 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 230000008482 dysregulation Effects 0.000 description 1
• 238000002001 electrophysiology Methods 0.000 description 1
• 230000007831 electrophysiology Effects 0.000 description 1
• 201000008184 embryoma Diseases 0.000 description 1
• 206010014599 encephalitis Diseases 0.000 description 1
• 201000003914 endometrial carcinoma Diseases 0.000 description 1
• 230000002357 endometrial effect Effects 0.000 description 1
• 239000002158 endotoxin Substances 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 108010028531 enomycin Proteins 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
• 230000002327 eosinophilic effect Effects 0.000 description 1
• 201000009580 eosinophilic pneumonia Diseases 0.000 description 1
• 229940116977 epidermal growth factor Drugs 0.000 description 1
• 206010015037 epilepsy Diseases 0.000 description 1
• 230000004890 epithelial barrier function Effects 0.000 description 1
• 210000002919 epithelial cell Anatomy 0.000 description 1
• 239000003797 essential amino acid Substances 0.000 description 1
• 235000020776 essential amino acid Nutrition 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 238000012869 ethanol precipitation Methods 0.000 description 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
• NPUKDXXFDDZOKR-LLVKDONJSA-N etomidate Chemical compound CCOC(=O)C1=CN=CN1[C@H](C)C1=CC=CC=C1 NPUKDXXFDDZOKR-LLVKDONJSA-N 0.000 description 1
• OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
• 208000030533 eye disease Diseases 0.000 description 1
• 235000019197 fats Nutrition 0.000 description 1
• 210000003608 fece Anatomy 0.000 description 1
• 230000003176 fibrotic effect Effects 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 238000013534 fluorescein angiography Methods 0.000 description 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 150000002222 fluorine compounds Chemical class 0.000 description 1
• 238000011010 flushing procedure Methods 0.000 description 1
• 210000000285 follicular dendritic cell Anatomy 0.000 description 1
• 210000001061 forehead Anatomy 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 235000021588 free fatty acids Nutrition 0.000 description 1
• 230000002538 fungal effect Effects 0.000 description 1
• 229930182830 galactose Natural products 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 238000003500 gene array Methods 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 230000002068 genetic effect Effects 0.000 description 1
• BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Natural products O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 description 1
• 229960000346 gliclazide Drugs 0.000 description 1
• 208000005017 glioblastoma Diseases 0.000 description 1
• 108060003196 globin Proteins 0.000 description 1
• 102000018146 globin Human genes 0.000 description 1
• 229940116332 glucose oxidase Drugs 0.000 description 1
• 235000019420 glucose oxidase Nutrition 0.000 description 1
• 229960002989 glutamic acid Drugs 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• 150000002333 glycines Chemical class 0.000 description 1
• 230000002414 glycolytic effect Effects 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 229940084936 gonak Drugs 0.000 description 1
• 201000007192 granulomatous hepatitis Diseases 0.000 description 1
• 229940093915 gynecological organic acid Drugs 0.000 description 1
• 201000009277 hairy cell leukemia Diseases 0.000 description 1
• 201000010536 head and neck cancer Diseases 0.000 description 1
• 208000014829 head and neck neoplasm Diseases 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 230000002440 hepatic effect Effects 0.000 description 1
• 208000002672 hepatitis B Diseases 0.000 description 1
• 201000010284 hepatitis E Diseases 0.000 description 1
• 230000001553 hepatotropic effect Effects 0.000 description 1
• 238000011102 hetero oligomerization reaction Methods 0.000 description 1
• 125000000623 heterocyclic group Chemical group 0.000 description 1
• 239000000833 heterodimer Substances 0.000 description 1
• 238000005734 heterodimerization reaction Methods 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 238000012766 histopathologic analysis Methods 0.000 description 1
• 102000052620 human IL10 Human genes 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
• 229960002773 hyaluronidase Drugs 0.000 description 1
• 238000009396 hybridization Methods 0.000 description 1
• 229920001477 hydrophilic polymer Polymers 0.000 description 1
• 229920001600 hydrophobic polymer Polymers 0.000 description 1
• 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
• 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
• 229940044700 hylenex Drugs 0.000 description 1
• 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
• 238000005286 illumination Methods 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 150000002463 imidates Chemical class 0.000 description 1
• 230000014726 immortalization of host cell Effects 0.000 description 1
• 239000012642 immune effector Substances 0.000 description 1
• 230000007813 immunodeficiency Effects 0.000 description 1
• 238000003364 immunohistochemistry Methods 0.000 description 1
• 229940121354 immunomodulator Drugs 0.000 description 1
• 230000002637 immunotoxin Effects 0.000 description 1
• 229940051026 immunotoxin Drugs 0.000 description 1
• 239000002596 immunotoxin Substances 0.000 description 1
• 231100000608 immunotoxin Toxicity 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 description 1
• 229940055742 indium-111 Drugs 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 238000001802 infusion Methods 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 230000015788 innate immune response Effects 0.000 description 1
• 238000007689 inspection Methods 0.000 description 1
• 102000006495 integrins Human genes 0.000 description 1
• 108010044426 integrins Proteins 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 229940079322 interferon Drugs 0.000 description 1
• 230000019189 interleukin-1 beta production Effects 0.000 description 1
• 102000044166 interleukin-18 binding protein Human genes 0.000 description 1
• 108010070145 interleukin-18 binding protein Proteins 0.000 description 1
• 108040002014 interleukin-18 receptor activity proteins Proteins 0.000 description 1
• 102000008625 interleukin-18 receptor activity proteins Human genes 0.000 description 1
• 108040007659 interleukin-33 receptor activity proteins Proteins 0.000 description 1
• 201000006334 interstitial nephritis Diseases 0.000 description 1
• 239000001573 invertase Substances 0.000 description 1
• 235000011073 invertase Nutrition 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 229910052742 iron Inorganic materials 0.000 description 1
• 230000002427 irreversible effect Effects 0.000 description 1
• 208000028867 ischemia Diseases 0.000 description 1
• 210000004153 islets of langerhan Anatomy 0.000 description 1
• 229960000318 kanamycin Drugs 0.000 description 1
• 229930027917 kanamycin Natural products 0.000 description 1
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
• 229930182823 kanamycin A Natural products 0.000 description 1
• 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 201000006370 kidney failure Diseases 0.000 description 1
• 238000011813 knockout mouse model Methods 0.000 description 1
• 229940057428 lactoperoxidase Drugs 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 238000011031 large-scale manufacturing process Methods 0.000 description 1
• 229950005692 larotaxel Drugs 0.000 description 1
• SEFGUGYLLVNFIJ-QDRLFVHASA-N larotaxel dihydrate Chemical compound O.O.O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@@]23[C@H]1[C@@]1(CO[C@@H]1C[C@@H]2C3)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 SEFGUGYLLVNFIJ-QDRLFVHASA-N 0.000 description 1
• 230000003902 lesion Effects 0.000 description 1
• 229960004338 leuprorelin Drugs 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 208000022215 lipoatrophic diabetes Diseases 0.000 description 1
• 201000009099 lipoatrophic diabetes mellitus Diseases 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 230000005923 long-lasting effect Effects 0.000 description 1
• 210000003141 lower extremity Anatomy 0.000 description 1
• 201000005249 lung adenocarcinoma Diseases 0.000 description 1
• 210000005265 lung cell Anatomy 0.000 description 1
• 229940087857 lupron Drugs 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 239000004325 lysozyme Substances 0.000 description 1
• 229960000274 lysozyme Drugs 0.000 description 1
• 235000010335 lysozyme Nutrition 0.000 description 1
• 150000002671 lyxoses Chemical class 0.000 description 1
• 208000029233 macular holes Diseases 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 238000002595 magnetic resonance imaging Methods 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 230000036210 malignancy Effects 0.000 description 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
• 229910052748 manganese Inorganic materials 0.000 description 1
• 239000011572 manganese Substances 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 239000012092 media component Substances 0.000 description 1
• 201000001441 melanoma Diseases 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 208000011661 metabolic syndrome X Diseases 0.000 description 1
• 229930182817 methionine Natural products 0.000 description 1
• 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
• 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
• 229960002216 methylparaben Drugs 0.000 description 1
• HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
• 239000004530 micro-emulsion Substances 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 108010029942 microperoxidase Proteins 0.000 description 1
• 230000005012 migration Effects 0.000 description 1
• 238000013508 migration Methods 0.000 description 1
• 229950003063 mitumomab Drugs 0.000 description 1
• 108010010621 modeccin Proteins 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 210000004400 mucous membrane Anatomy 0.000 description 1
• 208000037890 multiple organ injury Diseases 0.000 description 1
• 230000003387 muscular Effects 0.000 description 1
• 206010028417 myasthenia gravis Diseases 0.000 description 1
• 229960000951 mycophenolic acid Drugs 0.000 description 1
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
• 208000025113 myeloid leukemia Diseases 0.000 description 1
• 230000002107 myocardial effect Effects 0.000 description 1
• GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 description 1
• UPSFMJHZUCSEHU-JYGUBCOQSA-N n-[(2s,3r,4r,5s,6r)-2-[(2r,3s,4r,5r,6s)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OC=2C=C3OC(=O)C=C(C)C3=CC=2)O[C@@H]1CO UPSFMJHZUCSEHU-JYGUBCOQSA-N 0.000 description 1
• 239000002088 nanocapsule Substances 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• 210000000822 natural killer cell Anatomy 0.000 description 1
• 230000010807 negative regulation of binding Effects 0.000 description 1
• 230000009826 neoplastic cell growth Effects 0.000 description 1
• 201000008383 nephritis Diseases 0.000 description 1
• 230000004770 neurodegeneration Effects 0.000 description 1
• 230000000926 neurological effect Effects 0.000 description 1
• 230000007135 neurotoxicity Effects 0.000 description 1
• 231100000228 neurotoxicity Toxicity 0.000 description 1
• 230000007935 neutral effect Effects 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• 230000003448 neutrophilic effect Effects 0.000 description 1
• 229920001220 nitrocellulos Polymers 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
• 239000002736 nonionic surfactant Substances 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 239000002777 nucleoside Substances 0.000 description 1
• 150000003833 nucleoside derivatives Chemical class 0.000 description 1
• 235000020824 obesity Nutrition 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 229960000470 omalizumab Drugs 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 239000003538 oral antidiabetic agent Substances 0.000 description 1
• 229940127209 oral hypoglycaemic agent Drugs 0.000 description 1
• 229950007283 oregovomab Drugs 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 150000002894 organic compounds Chemical class 0.000 description 1
• BWKDAMBGCPRVPI-ZQRPHVBESA-N ortataxel Chemical compound O([C@@H]1[C@]23OC(=O)O[C@H]2[C@@H](C(=C([C@@H](OC(C)=O)C(=O)[C@]2(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]21)OC(C)=O)C3(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)CC(C)C)C(=O)C1=CC=CC=C1 BWKDAMBGCPRVPI-ZQRPHVBESA-N 0.000 description 1
• 229950001094 ortataxel Drugs 0.000 description 1
• 230000000399 orthopedic effect Effects 0.000 description 1
• 201000004535 ovarian dysfunction Diseases 0.000 description 1
• 231100000539 ovarian failure Toxicity 0.000 description 1
• 230000001590 oxidative effect Effects 0.000 description 1
• LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
• 229960001592 paclitaxel Drugs 0.000 description 1
• 201000002528 pancreatic cancer Diseases 0.000 description 1
• 208000008443 pancreatic carcinoma Diseases 0.000 description 1
• 210000003134 paneth cell Anatomy 0.000 description 1
• 229940055729 papain Drugs 0.000 description 1
• 235000019834 papain Nutrition 0.000 description 1
• 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 230000008506 pathogenesis Effects 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• 201000001976 pemphigus vulgaris Diseases 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 229950009506 penicillinase Drugs 0.000 description 1
• 238000010647 peptide synthesis reaction Methods 0.000 description 1
• 230000000737 periodic effect Effects 0.000 description 1
• 208000028169 periodontal disease Diseases 0.000 description 1
• 210000001428 peripheral nervous system Anatomy 0.000 description 1
• 201000002628 peritoneum cancer Diseases 0.000 description 1
• 102000013415 peroxidase activity proteins Human genes 0.000 description 1
• 108040007629 peroxidase activity proteins Proteins 0.000 description 1
• 235000020030 perry Nutrition 0.000 description 1
• 230000008782 phagocytosis Effects 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 108010076042 phenomycin Proteins 0.000 description 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
• 101150009573 phoA gene Proteins 0.000 description 1
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
• 150000004713 phosphodiesters Chemical class 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 102000020233 phosphotransferase Human genes 0.000 description 1
• 238000002428 photodynamic therapy Methods 0.000 description 1
• 108091008695 photoreceptors Proteins 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 230000035479 physiological effects, processes and functions Effects 0.000 description 1
• 210000004180 plasmocyte Anatomy 0.000 description 1
• 229910052697 platinum Inorganic materials 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 201000006292 polyarteritis nodosa Diseases 0.000 description 1
• 108010064470 polyaspartate Proteins 0.000 description 1
• 229920000728 polyester Polymers 0.000 description 1
• 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
• 238000003752 polymerase chain reaction Methods 0.000 description 1
• 230000007824 polyneuropathy Effects 0.000 description 1
• 229920000136 polysorbate Polymers 0.000 description 1
• 229920002451 polyvinyl alcohol Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 239000011148 porous material Substances 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 206010036601 premature menopause Diseases 0.000 description 1
• 208000017942 premature ovarian failure 1 Diseases 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000003449 preventive effect Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 201000000742 primary sclerosing cholangitis Diseases 0.000 description 1
• 238000004393 prognosis Methods 0.000 description 1
• 208000037821 progressive disease Diseases 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 235000013930 proline Nutrition 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 125000001500 prolyl group Chemical class [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• LFULEKSKNZEWOE-UHFFFAOYSA-N propanil Chemical compound CCC(=O)NC1=CC=C(Cl)C(Cl)=C1 LFULEKSKNZEWOE-UHFFFAOYSA-N 0.000 description 1
• 229960003981 proparacaine Drugs 0.000 description 1
• 238000011321 prophylaxis Methods 0.000 description 1
• 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
• 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
• 229960003415 propylparaben Drugs 0.000 description 1
• 235000019833 protease Nutrition 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 108020001580 protein domains Proteins 0.000 description 1
• 238000001742 protein purification Methods 0.000 description 1
• 230000012743 protein tagging Effects 0.000 description 1
• 231100000654 protein toxin Toxicity 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
• 201000007801 psoriasis 2 Diseases 0.000 description 1
• 208000020016 psychiatric disease Diseases 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 201000009732 pulmonary eosinophilia Diseases 0.000 description 1
• 208000002815 pulmonary hypertension Diseases 0.000 description 1
• 210000001747 pupil Anatomy 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 238000001959 radiotherapy Methods 0.000 description 1
• 229960003876 ranibizumab Drugs 0.000 description 1
• 229910052761 rare earth metal Inorganic materials 0.000 description 1
• 150000002910 rare earth metals Chemical class 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 238000003753 real-time PCR Methods 0.000 description 1
• 238000003259 recombinant expression Methods 0.000 description 1
• 230000006798 recombination Effects 0.000 description 1
• 238000005215 recombination Methods 0.000 description 1
• 230000007115 recruitment Effects 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 230000003362 replicative effect Effects 0.000 description 1
• 230000004243 retinal function Effects 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 201000003068 rheumatic fever Diseases 0.000 description 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 229960004641 rituximab Drugs 0.000 description 1
• 201000003804 salivary gland carcinoma Diseases 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 201000000980 schizophrenia Diseases 0.000 description 1
• 238000003345 scintillation counting Methods 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 210000003786 sclera Anatomy 0.000 description 1
• 150000003341 sedoheptuloses Chemical class 0.000 description 1
• 230000001235 sensitizing effect Effects 0.000 description 1
• 230000036303 septic shock Effects 0.000 description 1
• 238000012163 sequencing technique Methods 0.000 description 1
• 150000003355 serines Chemical class 0.000 description 1
• 210000000717 sertoli cell Anatomy 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 229910052709 silver Inorganic materials 0.000 description 1
• 239000004332 silver Substances 0.000 description 1
• 208000017520 skin disease Diseases 0.000 description 1
• 208000019116 sleep disease Diseases 0.000 description 1
• 208000022925 sleep disturbance Diseases 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• MKNJJMHQBYVHRS-UHFFFAOYSA-M sodium;1-[11-(2,5-dioxopyrrol-1-yl)undecanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCCCCCCN1C(=O)C=CC1=O MKNJJMHQBYVHRS-UHFFFAOYSA-M 0.000 description 1
• ULARYIUTHAWJMU-UHFFFAOYSA-M sodium;1-[4-(2,5-dioxopyrrol-1-yl)butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O ULARYIUTHAWJMU-UHFFFAOYSA-M 0.000 description 1
• VUFNRPJNRFOTGK-UHFFFAOYSA-M sodium;1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 VUFNRPJNRFOTGK-UHFFFAOYSA-M 0.000 description 1
• MIDXXTLMKGZDPV-UHFFFAOYSA-M sodium;1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCN1C(=O)C=CC1=O MIDXXTLMKGZDPV-UHFFFAOYSA-M 0.000 description 1
• 239000007790 solid phase Substances 0.000 description 1
• 210000001082 somatic cell Anatomy 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 238000009987 spinning Methods 0.000 description 1
• 230000002269 spontaneous effect Effects 0.000 description 1
• 208000017572 squamous cell neoplasm Diseases 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
• 238000011146 sterile filtration Methods 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 229960001052 streptozocin Drugs 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 239000007929 subcutaneous injection Substances 0.000 description 1
• 238000010254 subcutaneous injection Methods 0.000 description 1
• 229940014800 succinic anhydride Drugs 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
• YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 238000004114 suspension culture Methods 0.000 description 1
• 230000002459 sustained effect Effects 0.000 description 1
• 201000004595 synovitis Diseases 0.000 description 1
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
• 230000002123 temporal effect Effects 0.000 description 1
• MODVSQKJJIBWPZ-VLLPJHQWSA-N tesetaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3CC[C@@]2(C)[C@H]2[C@@H](C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C(=CC=CN=4)F)C[C@]1(O)C3(C)C)O[C@H](O2)CN(C)C)C(=O)C1=CC=CC=C1 MODVSQKJJIBWPZ-VLLPJHQWSA-N 0.000 description 1
• 229950009016 tesetaxel Drugs 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
• 230000008719 thickening Effects 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• CNHYKKNIIGEXAY-UHFFFAOYSA-N thiolan-2-imine Chemical compound N=C1CCCS1 CNHYKKNIIGEXAY-UHFFFAOYSA-N 0.000 description 1
• 108060008226 thioredoxin Proteins 0.000 description 1
• 229940094937 thioredoxin Drugs 0.000 description 1
• 206010043554 thrombocytopenia Diseases 0.000 description 1
• 229960002175 thyroglobulin Drugs 0.000 description 1
• 201000002510 thyroid cancer Diseases 0.000 description 1
• 208000005057 thyrotoxicosis Diseases 0.000 description 1
• RUELTTOHQODFPA-UHFFFAOYSA-N toluene 2,6-diisocyanate Chemical compound CC1=C(N=C=O)C=CC=C1N=C=O RUELTTOHQODFPA-UHFFFAOYSA-N 0.000 description 1
• 229960005267 tositumomab Drugs 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 238000011830 transgenic mouse model Methods 0.000 description 1
• 230000001052 transient effect Effects 0.000 description 1
• 238000013519 translation Methods 0.000 description 1
• 230000014621 translational initiation Effects 0.000 description 1
• 208000009174 transverse myelitis Diseases 0.000 description 1
• 150000003626 triacylglycerols Chemical class 0.000 description 1
• LZAJKCZTKKKZNT-PMNGPLLRSA-N trichothecene Chemical compound C12([C@@]3(CC[C@H]2OC2C=C(CCC23C)C)C)CO1 LZAJKCZTKKKZNT-PMNGPLLRSA-N 0.000 description 1
• 229930013292 trichothecene Natural products 0.000 description 1
• 239000002753 trypsin inhibitor Substances 0.000 description 1
• 201000008827 tuberculosis Diseases 0.000 description 1
• 230000006433 tumor necrosis factor production Effects 0.000 description 1
• 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
• 108010087967 type I signal peptidase Proteins 0.000 description 1
• 241001430294 unidentified retrovirus Species 0.000 description 1
• 201000005112 urinary bladder cancer Diseases 0.000 description 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
• 206010046766 uterine cancer Diseases 0.000 description 1
• 208000012991 uterine carcinoma Diseases 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 230000003156 vasculitic effect Effects 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• 201000005539 vernal conjunctivitis Diseases 0.000 description 1
• ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 description 1
• 229960003895 verteporfin Drugs 0.000 description 1
• UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
• 229960004355 vindesine Drugs 0.000 description 1
• 239000013603 viral vector Substances 0.000 description 1
• 230000004393 visual impairment Effects 0.000 description 1
• 201000005102 vulva cancer Diseases 0.000 description 1
• 239000011534 wash buffer Substances 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• XLYOFNOQVPJJNP-OUBTZVSYSA-N water-17o Chemical compound [17OH2] XLYOFNOQVPJJNP-OUBTZVSYSA-N 0.000 description 1
• 208000016261 weight loss Diseases 0.000 description 1
• 230000004580 weight loss Effects 0.000 description 1
• 150000003742 xyloses Chemical class 0.000 description 1
• DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1