CA2802485C - Single chain insulin agonists exhibiting high activity at the insulin receptor - Google Patents
Single chain insulin agonists exhibiting high activity at the insulin receptor Download PDFInfo
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- CA2802485C CA2802485C CA2802485A CA2802485A CA2802485C CA 2802485 C CA2802485 C CA 2802485C CA 2802485 A CA2802485 A CA 2802485A CA 2802485 A CA2802485 A CA 2802485A CA 2802485 C CA2802485 C CA 2802485C
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Zoology (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
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| US35536610P | 2010-06-16 | 2010-06-16 | |
| US61/355,366 | 2010-06-16 | ||
| US201161433500P | 2011-01-17 | 2011-01-17 | |
| US61/433,500 | 2011-01-17 | ||
| PCT/US2011/040699 WO2011159895A2 (en) | 2010-06-16 | 2011-06-16 | Single chain insulin agonists exhibiting high activity at the insulin receptor |
Publications (2)
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| CA2802485A1 CA2802485A1 (en) | 2011-12-22 |
| CA2802485C true CA2802485C (en) | 2019-09-17 |
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|---|---|---|---|
| CA2802485A Expired - Fee Related CA2802485C (en) | 2010-06-16 | 2011-06-16 | Single chain insulin agonists exhibiting high activity at the insulin receptor |
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|---|---|
| US (3) | US8940860B2 (enExample) |
| EP (1) | EP2582719B1 (enExample) |
| JP (1) | JP5969469B2 (enExample) |
| CN (1) | CN103068842B (enExample) |
| AU (1) | AU2011268327B2 (enExample) |
| CA (1) | CA2802485C (enExample) |
| WO (1) | WO2011159895A2 (enExample) |
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| EP2249853A4 (en) | 2008-01-30 | 2012-12-26 | Univ Indiana Res & Tech Corp | ESTER BASED PEPTIDE PRODRUGS |
| US8946147B2 (en) | 2010-06-24 | 2015-02-03 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
| US9573987B2 (en) | 2011-12-20 | 2017-02-21 | Indiana University Research And Technology Corporation | CTP-based insulin analogs for treatment of diabetes |
| CN108383902A (zh) * | 2012-09-26 | 2018-08-10 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
| JP6735561B2 (ja) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｏ−グリコシル化カルボキシ末端部分（ｃｔｐ）ペプチド系のインスリンおよびインスリン類似体 |
| SG11201505615PA (en) * | 2013-02-26 | 2015-09-29 | Hanmi Pharm Ind Co Ltd | Site-specific insulin conjugate |
| WO2014158900A1 (en) | 2013-03-14 | 2014-10-02 | Indiana University Research And Technology Corporation | Insulin-incretin conjugates |
| GB201321489D0 (en) * | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
| US10253082B2 (en) * | 2014-01-20 | 2019-04-09 | Hanmi Pharm. Co., Ltd | Long-acting insulin and use thereof |
| EP3197912B1 (en) | 2014-09-24 | 2023-01-04 | Indiana University Research & Technology Corporation | Lipidated amide-based insulin prodrugs |
| ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
| CN107108716A (zh) | 2014-10-06 | 2017-08-29 | 卡斯西部储备大学 | 双相性单链胰岛素类似物 |
| SG10201809457YA (en) | 2014-11-21 | 2018-11-29 | Merck Sharp & Dohme | Insulin receptor partial agonists |
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| US8940860B2 (en) | 2015-01-27 |
| CN103068842B (zh) | 2016-10-19 |
| US20130203665A1 (en) | 2013-08-08 |
| US10233225B2 (en) | 2019-03-19 |
| AU2011268327B2 (en) | 2016-02-25 |
| CA2802485A1 (en) | 2011-12-22 |
| JP2013533864A (ja) | 2013-08-29 |
| CN103068842A (zh) | 2013-04-24 |
| JP5969469B2 (ja) | 2016-08-17 |
| EP2582719A4 (en) | 2013-12-04 |
| EP2582719B1 (en) | 2016-08-10 |
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