CA2800569A1 - Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities - Google Patents
Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities Download PDFInfo
- Publication number
- CA2800569A1 CA2800569A1 CA2800569A CA2800569A CA2800569A1 CA 2800569 A1 CA2800569 A1 CA 2800569A1 CA 2800569 A CA2800569 A CA 2800569A CA 2800569 A CA2800569 A CA 2800569A CA 2800569 A1 CA2800569 A1 CA 2800569A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- fluorophenyl
- dicarboxamide
- cyclopropane
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000001747 exhibiting effect Effects 0.000 title description 4
- 230000001093 anti-cancer Effects 0.000 title description 3
- 230000001028 anti-proliverative effect Effects 0.000 title description 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 203
- 150000003839 salts Chemical class 0.000 claims abstract description 55
- 238000000034 method Methods 0.000 claims abstract description 29
- 239000012453 solvate Substances 0.000 claims abstract description 29
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 63
- 125000000217 alkyl group Chemical group 0.000 claims description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 29
- 230000000694 effects Effects 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 23
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 21
- 108091000080 Phosphotransferase Proteins 0.000 claims description 21
- 102000020233 phosphotransferase Human genes 0.000 claims description 21
- 125000002947 alkylene group Chemical group 0.000 claims description 15
- 229910052736 halogen Inorganic materials 0.000 claims description 15
- 125000000623 heterocyclic group Chemical group 0.000 claims description 15
- 150000002367 halogens Chemical class 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 13
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 150000004677 hydrates Chemical class 0.000 claims description 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 11
- 125000001072 heteroaryl group Chemical group 0.000 claims description 11
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 8
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- WOVFQJQCMLCIDS-UHFFFAOYSA-N 1-n'-[4-(2-acetamidopyridin-4-yl)oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 WOVFQJQCMLCIDS-UHFFFAOYSA-N 0.000 claims description 5
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- AXIPFEYBCCZPJU-AWEZNQCLSA-N [(2s)-1-[[4-[2,5-difluoro-4-[[1-[(4-fluorophenyl)carbamoyl]cyclopropanecarbonyl]amino]phenoxy]pyridin-2-yl]amino]-1-oxopropan-2-yl] acetate Chemical compound C1=NC(NC(=O)[C@@H](OC(C)=O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 AXIPFEYBCCZPJU-AWEZNQCLSA-N 0.000 claims description 5
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- WLSYPGHMVDFQRN-UHFFFAOYSA-N 1-n'-[4-[2-[(2-cyanoacetyl)amino]pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CC(F)=CC=C1NC(=O)C1(C(=O)NC=2C(=CC(OC=3C=C(NC(=O)CC#N)N=CC=3)=C(F)C=2)F)CC1 WLSYPGHMVDFQRN-UHFFFAOYSA-N 0.000 claims description 4
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- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 4
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 4
- 125000001624 naphthyl group Chemical group 0.000 claims description 4
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 4
- YIPSLILFBXVKMU-UHFFFAOYSA-N 1-n'-[2,5-difluoro-4-[2-(propanoylamino)pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)CC)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 YIPSLILFBXVKMU-UHFFFAOYSA-N 0.000 claims description 3
- YHZMFCIQHCKQGJ-AWEZNQCLSA-N 1-n'-[2,5-difluoro-4-[2-[[(2s)-2-methoxypropanoyl]amino]pyridin-4-yl]oxyphenyl]-1-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)[C@H](C)OC)=CC(OC=2C(=CC(=C(F)C=2)N(C(=O)C2(CC2)C(N)=O)C=2C=CC(F)=CC=2)F)=C1 YHZMFCIQHCKQGJ-AWEZNQCLSA-N 0.000 claims description 3
- QSMBNJYWRFZRLZ-UHFFFAOYSA-N 1-n'-[4-[2-(azetidine-3-carbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CC(F)=CC=C1NC(=O)C1(C(=O)NC=2C(=CC(OC=3C=C(NC(=O)C4CNC4)N=CC=3)=C(F)C=2)F)CC1 QSMBNJYWRFZRLZ-UHFFFAOYSA-N 0.000 claims description 3
- GNNDEPIMDAZHRQ-UHFFFAOYSA-N 1-n'-[4-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CC(F)=CC=C1NC(=O)C1(C(=O)NC=2C(=CC(OC=3C=C(NC(=O)C4CC4)N=CC=3)=C(F)C=2)F)CC1 GNNDEPIMDAZHRQ-UHFFFAOYSA-N 0.000 claims description 3
- JPEGWEXLPVMJEI-UHFFFAOYSA-N 1-n'-[4-[2-[[2-(dimethylamino)acetyl]amino]pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)CN(C)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 JPEGWEXLPVMJEI-UHFFFAOYSA-N 0.000 claims description 3
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- 241000124008 Mammalia Species 0.000 claims description 3
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- HVVMMAOQONKVON-UHFFFAOYSA-N 1-n'-[2,5-difluoro-4-[2-[(2-fluoro-2-methylpropanoyl)amino]pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C(C)(F)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 HVVMMAOQONKVON-UHFFFAOYSA-N 0.000 claims description 2
- UTBXIRBUAUMOFR-UHFFFAOYSA-N 1-n'-[2,5-difluoro-4-[2-[(2-methoxyacetyl)amino]pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)COC)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 UTBXIRBUAUMOFR-UHFFFAOYSA-N 0.000 claims description 2
- WLBRCFBAWZUERA-CYBMUJFWSA-N 1-n'-[2,5-difluoro-4-[2-[[(2r)-2-hydroxypropanoyl]amino]pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)[C@H](O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 WLBRCFBAWZUERA-CYBMUJFWSA-N 0.000 claims description 2
- CIVOREZLHOQUQB-CQSZACIVSA-N 1-n'-[2,5-difluoro-4-[2-[[(2r)-2-methoxypropanoyl]amino]pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)[C@@H](C)OC)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 CIVOREZLHOQUQB-CQSZACIVSA-N 0.000 claims description 2
- BAEOIAVGXBJPQH-UHFFFAOYSA-N 1-n'-[4-(2-acetamidopyrimidin-4-yl)oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound CC(=O)NC1=NC=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=N1 BAEOIAVGXBJPQH-UHFFFAOYSA-N 0.000 claims description 2
- ASBXOTJHWOHLPN-UHFFFAOYSA-N 1-n'-[4-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C(C)(C)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 ASBXOTJHWOHLPN-UHFFFAOYSA-N 0.000 claims description 2
- PRXXUUDSMHUXSS-UHFFFAOYSA-N 1-n'-[4-[2-(cyclobutanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CC(F)=CC=C1NC(=O)C1(C(=O)NC=2C(=CC(OC=3C=C(NC(=O)C4CCC4)N=CC=3)=C(F)C=2)F)CC1 PRXXUUDSMHUXSS-UHFFFAOYSA-N 0.000 claims description 2
- DPOPAJRDYZGTIR-UHFFFAOYSA-N Tetrazine Chemical compound C1=CN=NN=N1 DPOPAJRDYZGTIR-UHFFFAOYSA-N 0.000 claims description 2
- 125000005843 halogen group Chemical group 0.000 claims description 2
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- PORMSSHVBFZGAT-UHFFFAOYSA-N 1-n'-[4-(2-acetamidopyridin-4-yl)oxy-2,5-difluorophenyl]-1-n-phenylcyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC=CC=3)=C(F)C=2)F)=C1 PORMSSHVBFZGAT-UHFFFAOYSA-N 0.000 claims 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
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- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
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- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32954810P | 2010-04-29 | 2010-04-29 | |
| US61/329,548 | 2010-04-29 | ||
| PCT/US2011/034556 WO2011137342A1 (en) | 2010-04-29 | 2011-04-29 | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activites |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2800569A1 true CA2800569A1 (en) | 2011-11-03 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2800569A Abandoned CA2800569A1 (en) | 2010-04-29 | 2011-04-29 | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities |
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| RU (1) | RU2012151012A (enExample) |
| SG (2) | SG10201503394PA (enExample) |
| WO (1) | WO2011137342A1 (enExample) |
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| EP2365752B1 (en) * | 2008-10-29 | 2014-09-24 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| PH12012502142A1 (en) * | 2010-04-29 | 2017-04-21 | Deciphera Pharmaceuticals Llc | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities |
| CN102702121B (zh) * | 2012-04-06 | 2016-04-13 | 浙江工业大学 | 一种化合物间羟基苯基四嗪二甲酰胺及制备和应用 |
| CN102702120A (zh) * | 2012-04-06 | 2012-10-03 | 浙江工业大学 | 一种新化合物邻羟基苯基四嗪二甲酰胺及制备和应用 |
| AU2013259583A1 (en) | 2012-05-08 | 2014-11-13 | The Regents Of The University Of California | Alpha 7 nicotinic acetylcholine allosteric modulators, their derivatives and uses thereof |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| ES2798899T3 (es) | 2013-02-25 | 2020-12-14 | Novartis Ag | Mutación novedosa del receptor de andrógenos |
| WO2014145023A1 (en) * | 2013-03-15 | 2014-09-18 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| WO2016061231A1 (en) * | 2014-10-14 | 2016-04-21 | Deciphera Pharmaceuticals, Llc | Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression |
| EP3206752A1 (en) * | 2014-10-14 | 2017-08-23 | Deciphera Pharmaceuticals, LLC | Inhibition of trk kinase mediated tumor growth and disease progression |
| US20170079966A1 (en) * | 2014-10-14 | 2017-03-23 | Deciphera Pharmaceuticals, Llc | Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression |
| BR112018068681A2 (pt) | 2016-03-16 | 2019-01-15 | Bayer Cropscience Ag | derivados de n-(cianobenzil)-6-(ciclopropil-carbonilamino)-4-(fenil)-piridina-2-carboxamida e compostos relacionados como pesticidas e agentes de proteção de plantas |
| CN106349158B (zh) * | 2016-08-03 | 2020-02-28 | 杭州市西溪医院 | 一种c-Met小分子抑制剂、含其的药物组合物及其药学应用 |
| CN107793363B (zh) * | 2016-09-06 | 2021-02-26 | 上海医药工业研究院 | 一种取代芳胺基芳杂环类化合物及其作为抗肿瘤药物的应用 |
| CN106831707B (zh) * | 2016-12-28 | 2019-09-20 | 杭州市西溪医院 | 作为c-Met激酶抑制剂的苯并杂环类衍生物及其医疗用途 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| CN109988108B (zh) * | 2017-12-29 | 2022-04-29 | 江苏豪森药业集团有限公司 | 一种卡博替尼的制备方法 |
| AU2019215081B2 (en) | 2018-01-31 | 2024-07-25 | Deciphera Pharmaceuticals, Llc. | Combination therapy for the treatment of gastrointestinal stromal tumors |
| CN111886006B (zh) | 2018-01-31 | 2024-07-09 | 德西费拉制药有限责任公司 | 治疗肥大细胞增多症的组合疗法 |
| PT3902547T (pt) | 2018-12-28 | 2023-12-04 | Deciphera Pharmaceuticals Llc | Inibidores de csf1r para utilização no tratamento do cancro |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| SI3966206T1 (sl) | 2019-05-10 | 2023-12-29 | Deciphera Pharmaceuticals, Llc | Heteroarilaminopirimidinski amidni zaviralci avtofagije in načini njihove uporabe |
| HRP20231730T1 (hr) | 2019-05-10 | 2024-05-10 | Deciphera Pharmaceuticals, Llc | Fenilaminopirimidin amidni inhibitori autofagije i postupci njihove primjene |
| CA3143489A1 (en) | 2019-06-17 | 2020-12-24 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| MX2022001863A (es) | 2019-08-12 | 2022-05-30 | Deciphera Pharmaceuticals Llc | Metodos para tratar los tumores del estroma gastrointestinal. |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| CN119970649A (zh) | 2019-12-30 | 2025-05-13 | 德西费拉制药有限责任公司 | 非晶型激酶抑制剂制剂及其使用方法 |
| FI4084779T3 (fi) | 2019-12-30 | 2024-12-16 | Deciphera Pharmaceuticals Llc | 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia |
| WO2022109001A1 (en) | 2020-11-18 | 2022-05-27 | Deciphera Pharmaceuticals, Llc | Gcn2 and perk kinase inhibitors and methods of use thereof |
| EP4444429A1 (en) | 2021-12-09 | 2024-10-16 | Deciphera Pharmaceuticals, LLC | Raf kinase inhibitors and methods of use thereof |
| CN114394940B (zh) * | 2022-01-26 | 2024-01-16 | 武汉工程大学 | 一种环丙基-1,1二酰胺类化合物及其制备方法和应用 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| WO2025122952A1 (en) | 2023-12-08 | 2025-06-12 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| WO2025231106A1 (en) | 2024-05-01 | 2025-11-06 | Deciphera Pharmaceuticals, Llc | Csf-1r inhibitors and methods of use thereof |
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| US20070270421A1 (en) * | 2004-02-27 | 2007-11-22 | Tomohiro Matsushima | Novel pyridine Derivative and Pyrimidine Derivative (1) |
| US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| DK1889836T3 (da) * | 2005-08-24 | 2013-08-19 | Eisai R&D Man Co Ltd | Hidtil ukendt pyridinderivat og pyrimidinderivat |
| US8003662B2 (en) | 2006-01-30 | 2011-08-23 | Array Biopharma, Inc. | Heterobicyclic thiophene compounds and methods of use |
| CA2661333C (en) | 2006-08-23 | 2014-08-05 | Eisai R&D Management Co., Ltd. | Salt of phenoxypyridine derivative or crystal thereof and process for producing the same |
| US7790885B2 (en) | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| US20080255155A1 (en) | 2006-10-18 | 2008-10-16 | Stephane Raeppel | Kinase inhibitors and uses thereof |
| KR20090090365A (ko) | 2007-02-23 | 2009-08-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Ｈｇｆｒ 유전자 증폭 세포주에 대하여 우수한 세포 증식 억제 효과 및 항종양 효과를 나타내는 피리딘 유도체 또는 피리미딘 유도체 |
| WO2009033084A1 (en) | 2007-09-06 | 2009-03-12 | Array Biopharma Inc. | Pyrazolo-pyridines as tyrosine kinase inhibitors |
| JP2009132660A (ja) | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
| US20090227556A1 (en) * | 2008-01-31 | 2009-09-10 | Eisai R&D Management Co., Ltd. | Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives |
| JPWO2009104520A1 (ja) | 2008-02-18 | 2011-06-23 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | フェノキシピリジン誘導体の製造方法（２） |
| TW201035017A (en) * | 2008-09-26 | 2010-10-01 | Smithkline Beecham Corp | Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide |
| EP2365752B1 (en) * | 2008-10-29 | 2014-09-24 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| WO2010064300A1 (ja) | 2008-12-02 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 食道癌治療用組成物 |
| JP2010178651A (ja) | 2009-02-04 | 2010-08-19 | Eisai R & D Management Co Ltd | Ｈｇｆｒ阻害物質の作用検定方法 |
| PH12012502142A1 (en) * | 2010-04-29 | 2017-04-21 | Deciphera Pharmaceuticals Llc | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities |
-
2011
- 2011-04-29 PH PH1/2012/502142A patent/PH12012502142A1/en unknown
- 2011-04-29 CN CN201180031486.XA patent/CN103068384B/zh not_active Expired - Fee Related
- 2011-04-29 BR BR112012027743A patent/BR112012027743A2/pt active Search and Examination
- 2011-04-29 RU RU2012151012/04A patent/RU2012151012A/ru not_active Application Discontinuation
- 2011-04-29 PT PT117194217T patent/PT2563362E/pt unknown
- 2011-04-29 WO PCT/US2011/034556 patent/WO2011137342A1/en not_active Ceased
- 2011-04-29 CA CA2800569A patent/CA2800569A1/en not_active Abandoned
- 2011-04-29 MX MX2012012571A patent/MX2012012571A/es active IP Right Grant
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- 2011-04-29 AU AU2011245248A patent/AU2011245248B2/en not_active Ceased
- 2011-04-29 JP JP2013508280A patent/JP5795630B2/ja not_active Expired - Fee Related
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- 2011-04-29 EP EP11719421.7A patent/EP2563362B1/en not_active Not-in-force
- 2011-04-29 SG SG2012079760A patent/SG185073A1/en unknown
- 2011-04-29 US US13/098,243 patent/US20120058985A1/en not_active Abandoned
- 2011-04-29 DK DK11719421.7T patent/DK2563362T3/da active
- 2011-04-29 KR KR1020127031316A patent/KR20130109943A/ko not_active Ceased
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2012
- 2012-05-24 US US13/480,108 patent/US20120252849A1/en not_active Abandoned
- 2012-07-26 US US13/559,170 patent/US8637672B2/en not_active Expired - Fee Related
- 2012-10-28 IL IL222728A patent/IL222728A0/en unknown
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2013
- 2013-12-20 US US14/136,295 patent/US20140194405A1/en not_active Abandoned
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2015
- 2015-01-22 US US14/602,781 patent/US20150218130A1/en not_active Abandoned
Also Published As
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|---|---|
| US8637672B2 (en) | 2014-01-28 |
| SG10201503394PA (en) | 2015-06-29 |
| JP2013525458A (ja) | 2013-06-20 |
| RU2012151012A (ru) | 2014-06-10 |
| EP2563362A1 (en) | 2013-03-06 |
| MX2012012571A (es) | 2013-04-05 |
| US20140194405A1 (en) | 2014-07-10 |
| SG185073A1 (en) | 2012-12-28 |
| ES2475741T3 (es) | 2014-07-11 |
| AU2011245248B2 (en) | 2016-01-07 |
| US20150218130A1 (en) | 2015-08-06 |
| BR112012027743A2 (pt) | 2017-03-14 |
| WO2011137342A1 (en) | 2011-11-03 |
| CN103068384A (zh) | 2013-04-24 |
| IL222728A0 (en) | 2012-12-31 |
| US20120322834A1 (en) | 2012-12-20 |
| JP5795630B2 (ja) | 2015-10-14 |
| AU2011245248A1 (en) | 2012-12-20 |
| HK1184392A1 (zh) | 2014-01-24 |
| DK2563362T3 (da) | 2014-06-23 |
| US20120252849A1 (en) | 2012-10-04 |
| KR20130109943A (ko) | 2013-10-08 |
| PH12012502142A1 (en) | 2017-04-21 |
| US20120058985A1 (en) | 2012-03-08 |
| PT2563362E (pt) | 2014-07-11 |
| CN103068384B (zh) | 2015-03-11 |
| EP2563362B1 (en) | 2014-03-12 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20160426 |
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| FZDE | Discontinued |
Effective date: 20190320 |