CA2798518A1 - Pegylated c-peptide - Google Patents
Pegylated c-peptide Download PDFInfo
- Publication number
- CA2798518A1 CA2798518A1 CA2798518A CA2798518A CA2798518A1 CA 2798518 A1 CA2798518 A1 CA 2798518A1 CA 2798518 A CA2798518 A CA 2798518A CA 2798518 A CA2798518 A CA 2798518A CA 2798518 A1 CA2798518 A1 CA 2798518A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- pegylated
- patient
- insulin
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims abstract 104
- 108010075254 C-Peptide Proteins 0.000 claims abstract 99
- 238000000034 method Methods 0.000 claims abstract 19
- 230000004071 biological effect Effects 0.000 claims abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 50
- 102000004877 Insulin Human genes 0.000 claims 25
- 108090001061 Insulin Proteins 0.000 claims 25
- 229940125396 insulin Drugs 0.000 claims 25
- 238000011287 therapeutic dose Methods 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 208000033808 peripheral neuropathy Diseases 0.000 claims 9
- 206010012601 diabetes mellitus Diseases 0.000 claims 8
- 125000003277 amino group Chemical group 0.000 claims 7
- 230000007774 longterm Effects 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 230000007830 nerve conduction Effects 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- 208000013016 Hypoglycemia Diseases 0.000 claims 3
- 230000002218 hypoglycaemic effect Effects 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- 206010061666 Autonomic neuropathy Diseases 0.000 claims 2
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000008363 phosphate buffer Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 238000002983 circular dichroism Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 238000009256 replacement therapy Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34529310P | 2010-05-17 | 2010-05-17 | |
| US61/345,293 | 2010-05-17 | ||
| US201161448402P | 2011-03-02 | 2011-03-02 | |
| US61/448,402 | 2011-03-02 | ||
| PCT/US2011/036858 WO2011146518A2 (en) | 2010-05-17 | 2011-05-17 | Pegylated c-peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2798518A1 true CA2798518A1 (en) | 2011-11-24 |
Family
ID=44992295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2798518A Abandoned CA2798518A1 (en) | 2010-05-17 | 2011-05-17 | Pegylated c-peptide |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8927488B2 (https=) |
| EP (1) | EP2571896A4 (https=) |
| JP (1) | JP2013533217A (https=) |
| KR (1) | KR20130115086A (https=) |
| CN (1) | CN103119055A (https=) |
| CA (1) | CA2798518A1 (https=) |
| MX (1) | MX2012013375A (https=) |
| NZ (1) | NZ603399A (https=) |
| WO (1) | WO2011146518A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0511269D0 (en) * | 2005-06-02 | 2005-07-13 | Creative Peptides Sweden Ab | Sustained release preparation of pro-insulin C-peptide |
| EP2552967A4 (en) * | 2010-04-02 | 2014-10-08 | Amunix Operating Inc | BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE |
| CA2798518A1 (en) | 2010-05-17 | 2011-11-24 | Cebix, Inc. | Pegylated c-peptide |
| EP2755675B1 (en) * | 2011-09-12 | 2018-06-06 | Amunix Operating Inc. | Glucagon-like peptide-2 compositions and methods of making and using same |
| US8962553B2 (en) | 2011-11-17 | 2015-02-24 | Cebix Ab | Method of treating a diabetic subject having a microvascular impairment disorder by a pegylated C-peptide |
| US20130288973A1 (en) * | 2011-12-14 | 2013-10-31 | Edmund Burke | Decellularized small particle tissue |
| US9988433B2 (en) * | 2013-03-14 | 2018-06-05 | Mosaic Biosciences, Inc. | Covalent modification of biological macromolecules |
| WO2013116791A1 (en) | 2012-02-02 | 2013-08-08 | Mosaic Biosciences, Inc. | Biomaterials for delivery of blood extracts and methods of using same |
| US20150087586A1 (en) * | 2012-03-29 | 2015-03-26 | Cebix, Inc. | Pegylated c-peptide |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| MX375448B (es) * | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| RU2733495C2 (ru) * | 2013-09-24 | 2020-10-02 | Аллерган Фармасьютикалз Интернэшнл Лимитед | Способ экстракции белка |
| RU2017131285A (ru) * | 2015-02-09 | 2019-03-11 | Мозеик Байосайенсиз, Инк. | Биоразлагаемые тиол-ен-полимеры и способы их получения |
| EP3265479A4 (en) * | 2015-03-03 | 2018-11-14 | Avalon Biologics Limited | Compositions and methods for pegylated il-11 |
| CA2979397A1 (en) | 2015-03-12 | 2016-09-15 | Board Of Trustees Of Michigan State University | Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases |
| SG11201802180TA (en) * | 2015-09-18 | 2018-04-27 | Univ Miyazaki | Long-acting adrenomedullin derivative |
| CN108265044B (zh) * | 2016-12-31 | 2021-05-11 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 |
| BR112019026711A2 (pt) | 2017-06-16 | 2020-06-30 | Zealand Pharma A/S | regimes de dosagem para a administração de análogos de peptídeo semelhante a glucagon- 2 (glp-2) |
| JP7058857B2 (ja) * | 2017-08-30 | 2022-04-25 | クラシエホームプロダクツ株式会社 | 毛髪タンパク質の水との相互作用測定方法 |
| EP3449935A1 (en) * | 2017-08-31 | 2019-03-06 | Erytech Pharma | Arginine deiminase encapsulated inside erythrocytes and their use in treating cancer and arginase-1 deficiency |
| WO2019067676A1 (en) * | 2017-09-28 | 2019-04-04 | The Regents Of The University Of California | HYDROGELS OF POLYIONIC POLYPEPTIDE COMPLEXES AND USES THEREOF |
| US11357861B2 (en) | 2017-09-29 | 2022-06-14 | Hanmi Pharm. Co., Ltd | Protein complex comprising non-peptidyl polymer-coupled fatty acid derivative compound as linker and preparation method therefor |
| CA3084013A1 (en) | 2017-12-01 | 2019-06-06 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| PT3716998T (pt) * | 2017-12-01 | 2024-04-09 | Csl Behring Llc | A1at para reduzir risco de início de doença do enxerto contra hospedeiro aguda após transplante de células hematopoiéticas |
| SI3793586T1 (sl) * | 2018-05-16 | 2024-07-31 | Csl Limited | Različice receptorja za topni komplement tipa 1 in njihova uporaba |
| EP3628683A1 (en) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| EP3628682A1 (en) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| WO2020085506A1 (ja) * | 2018-10-25 | 2020-04-30 | 国立大学法人大阪大学 | 軟骨疾患の治療薬 |
| BR112021008098A2 (pt) | 2018-11-15 | 2021-08-10 | Quantum-Si Incorporated | métodos e composições para o sequenciamento de proteínas |
| US20220177704A1 (en) * | 2019-03-27 | 2022-06-09 | The Regents Of Theuniversity Of California | Mixtures of synthetic copolypeptide hydrogels |
| US12390534B2 (en) | 2019-03-29 | 2025-08-19 | Nof Corporation | Branched degradable polyethylene glycol binder |
| EP3950776A4 (en) * | 2019-03-29 | 2023-01-04 | NOF Corporation | BRANCHED AND DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE |
| CN111939244B (zh) * | 2019-05-14 | 2024-08-06 | 阿莫生命科学有限公司 | 用于预防或治疗糖尿病并发症的药物组合物 |
| KR102456958B1 (ko) | 2019-05-14 | 2022-10-21 | 강원대학교 산학협력단 | 당뇨병성 합병증의 예방 또는 치료용 약제학적 조성물 |
| EP4147711A4 (en) * | 2020-04-20 | 2024-04-24 | Shionogi & Co., Ltd | FORMULATION WITH A HMGB1 PARTIAL PEPTIDE |
| US12090206B2 (en) | 2020-04-23 | 2024-09-17 | The Regents Of The University Of California | Compositions comprising tri- and penta-block synthetic copolypeptide hydrogels |
| WO2021236983A2 (en) * | 2020-05-20 | 2021-11-25 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| CN114137094A (zh) * | 2020-09-03 | 2022-03-04 | 北京渼颜空间生物医药有限公司 | 一种聚左旋乳酸中有关物质的检测方法 |
| WO2022119563A1 (en) * | 2020-12-02 | 2022-06-09 | Shih Chun Che | Composition and method for treatment of ischemic disease |
| US20220401525A1 (en) * | 2021-06-16 | 2022-12-22 | Biocell Technology, Llc | Use of collagen compositions for increasing telomere length |
| CN116554267A (zh) * | 2022-01-30 | 2023-08-08 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇修饰的激肽或其变体和药物应用 |
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| CH650679A5 (de) * | 1981-08-27 | 1985-08-15 | Lilly Co Eli | Gegen diabetes mellitus wirksames pharmazeutisches mittel. |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| FR2686759B1 (fr) | 1992-01-29 | 1994-04-22 | Sgs Thomson Microelectronics | Dispositif de regulation de puissance pour un haut-parleur de poste de telephone pendant une sonnerie . |
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-
2011
- 2011-05-17 CA CA2798518A patent/CA2798518A1/en not_active Abandoned
- 2011-05-17 EP EP11784109.8A patent/EP2571896A4/en not_active Withdrawn
- 2011-05-17 MX MX2012013375A patent/MX2012013375A/es not_active Application Discontinuation
- 2011-05-17 NZ NZ603399A patent/NZ603399A/en not_active IP Right Cessation
- 2011-05-17 KR KR1020127031723A patent/KR20130115086A/ko not_active Withdrawn
- 2011-05-17 CN CN2011800350917A patent/CN103119055A/zh active Pending
- 2011-05-17 WO PCT/US2011/036858 patent/WO2011146518A2/en not_active Ceased
- 2011-05-17 JP JP2013511302A patent/JP2013533217A/ja active Pending
- 2011-05-17 US US13/109,522 patent/US8927488B2/en not_active Expired - Fee Related
-
2012
- 2012-05-04 US US13/463,887 patent/US8691755B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011146518A9 (en) | 2012-04-19 |
| WO2011146518A2 (en) | 2011-11-24 |
| EP2571896A4 (en) | 2014-01-08 |
| EP2571896A2 (en) | 2013-03-27 |
| US8691755B2 (en) | 2014-04-08 |
| NZ603399A (en) | 2014-09-26 |
| MX2012013375A (es) | 2013-04-11 |
| KR20130115086A (ko) | 2013-10-21 |
| US20120178676A1 (en) | 2012-07-12 |
| US8927488B2 (en) | 2015-01-06 |
| US20120220542A1 (en) | 2012-08-30 |
| WO2011146518A3 (en) | 2012-03-08 |
| JP2013533217A (ja) | 2013-08-22 |
| CN103119055A (zh) | 2013-05-22 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20160519 |