CA2795261C - Method and apparatus for wound sealant application - Google Patents
Method and apparatus for wound sealant application Download PDFInfo
- Publication number
- CA2795261C CA2795261C CA2795261A CA2795261A CA2795261C CA 2795261 C CA2795261 C CA 2795261C CA 2795261 A CA2795261 A CA 2795261A CA 2795261 A CA2795261 A CA 2795261A CA 2795261 C CA2795261 C CA 2795261C
- Authority
- CA
- Canada
- Prior art keywords
- syringe
- aerosol
- pneumatic
- pressure regulator
- pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000565 sealant Substances 0.000 title abstract description 54
- 238000000034 method Methods 0.000 title abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 123
- 239000000443 aerosol Substances 0.000 claims abstract description 122
- 150000001875 compounds Chemical class 0.000 claims abstract description 41
- 238000007789 sealing Methods 0.000 claims abstract description 38
- 239000002202 Polyethylene glycol Substances 0.000 claims description 29
- 229920001223 polyethylene glycol Polymers 0.000 claims description 29
- 102000009027 Albumins Human genes 0.000 claims description 21
- 108010088751 Albumins Proteins 0.000 claims description 21
- 230000008859 change Effects 0.000 claims description 7
- 230000000994 depressogenic effect Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 36
- 206010052428 Wound Diseases 0.000 abstract description 28
- 208000027418 Wounds and injury Diseases 0.000 abstract description 28
- 230000007246 mechanism Effects 0.000 abstract description 8
- 208000034693 Laceration Diseases 0.000 abstract description 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 59
- 238000011010 flushing procedure Methods 0.000 description 48
- 239000012530 fluid Substances 0.000 description 32
- 239000000499 gel Substances 0.000 description 32
- 239000000243 solution Substances 0.000 description 32
- 239000007921 spray Substances 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 28
- 239000004479 aerosol dispenser Substances 0.000 description 22
- 230000003139 buffering effect Effects 0.000 description 20
- 239000000463 material Substances 0.000 description 16
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 12
- 239000000872 buffer Substances 0.000 description 11
- 238000004132 cross linking Methods 0.000 description 11
- 235000004252 protein component Nutrition 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 238000005507 spraying Methods 0.000 description 9
- 230000004888 barrier function Effects 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 230000009286 beneficial effect Effects 0.000 description 6
- 239000001569 carbon dioxide Substances 0.000 description 6
- 229910002092 carbon dioxide Inorganic materials 0.000 description 6
- 238000004891 communication Methods 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 5
- 239000003431 cross linking reagent Substances 0.000 description 5
- 230000009977 dual effect Effects 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- -1 but not limited to Polymers 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 230000008439 repair process Effects 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 102000008100 Human Serum Albumin Human genes 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000003570 air Substances 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000006073 displacement reaction Methods 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 239000011261 inert gas Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 208000031737 Tissue Adhesions Diseases 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 238000009455 aseptic packaging Methods 0.000 description 2
- 230000003416 augmentation Effects 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000035602 clotting Effects 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000010894 electron beam technology Methods 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 239000003566 sealing material Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- 239000008000 CHES buffer Substances 0.000 description 1
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 1
- 230000005355 Hall effect Effects 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- QXZUUHYBWMWJHK-UHFFFAOYSA-N [Co].[Ni] Chemical compound [Co].[Ni] QXZUUHYBWMWJHK-UHFFFAOYSA-N 0.000 description 1
- 238000012084 abdominal surgery Methods 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical group OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002684 laminectomy Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920009441 perflouroethylene propylene Polymers 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000012858 resilient material Substances 0.000 description 1
- 239000012812 sealant material Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
- A61B2017/00544—Surgical instruments, devices or methods pneumatically or hydraulically operated pneumatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
- A61B2017/00544—Surgical instruments, devices or methods pneumatically or hydraulically operated pneumatically
- A61B2017/00548—Gas cartridges therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nozzles (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Surgical Instruments (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32087710P | 2010-04-05 | 2010-04-05 | |
| US61/320,877 | 2010-04-05 | ||
| PCT/US2011/031235 WO2011127045A2 (en) | 2010-04-05 | 2011-04-05 | Method and apparatus for wound sealant application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2795261A1 CA2795261A1 (en) | 2011-10-13 |
| CA2795261C true CA2795261C (en) | 2020-08-25 |
Family
ID=44710523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2795261A Active CA2795261C (en) | 2010-04-05 | 2011-04-05 | Method and apparatus for wound sealant application |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10987093B2 (OSRAM) |
| EP (1) | EP2555813B1 (OSRAM) |
| JP (2) | JP2013523336A (OSRAM) |
| CN (1) | CN102933243A (OSRAM) |
| BR (1) | BR112012025498A2 (OSRAM) |
| CA (1) | CA2795261C (OSRAM) |
| WO (1) | WO2011127045A2 (OSRAM) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090038701A1 (en) | 2006-01-17 | 2009-02-12 | Baxter International Inc. | Device, system and method for mixing |
| US7837656B2 (en) * | 2006-03-27 | 2010-11-23 | Tyco Healthcare Group Lp | Dual air regulated spray applicator |
| WO2010033858A1 (en) * | 2008-09-19 | 2010-03-25 | C.R. Bard, Inc. | Medical device securement system |
| WO2010129747A1 (en) * | 2009-05-06 | 2010-11-11 | Synthes Usa, Llc | Method and apparatus for applying a sealant |
| JP2013521984A (ja) * | 2010-03-23 | 2013-06-13 | ハイパーブランチ メディカル テクノロジー， インコーポレイテッド | 多成分配合物のための使い捨ての注射器アプリケータおよびその使用方法 |
| BR112012025500A2 (pt) * | 2010-04-05 | 2016-06-21 | Neomend Inc | sistema automático de purga para liberar uma compisção de hidrogel e método para liberar uma composição de hidrogel |
| KR101458163B1 (ko) | 2012-03-12 | 2014-11-04 | 주식회사 글로원 | 주사약 분사기 및 상기 분사기를 포함하는 주사약 분사장치 |
| US20140121699A1 (en) * | 2012-10-31 | 2014-05-01 | Nordson Corporation | Device and method for dispensing a liquid and a gas |
| AU2013337240A1 (en) * | 2012-11-05 | 2015-05-14 | Smith & Nephew, Inc. | Assemblies and methods for fluid delivery |
| CA2907204C (en) * | 2013-03-15 | 2021-01-19 | Neomend, Inc. | Centrifugal mixing spray nozzle |
| ES2755986T3 (es) * | 2013-05-13 | 2020-04-24 | Univ Arizona | Aerostasis en cirugía pulmonar |
| JP6132404B2 (ja) * | 2013-06-26 | 2017-05-24 | アネスト岩田株式会社 | 塗布器具 |
| US10085729B2 (en) * | 2014-03-06 | 2018-10-02 | Ethicon, Inc. | Methods and devices for forming biomedical coatings using variable mixing ratios of multi-part compositions |
| US10610226B2 (en) * | 2014-06-10 | 2020-04-07 | Ethicon Endo-Surgery, Inc. | Methods and devices for sealing stapled tissue |
| CN106572856A (zh) * | 2014-06-10 | 2017-04-19 | 伊西康内外科有限责任公司 | 用于密封缝合组织的方法和装置 |
| AU2015313794B2 (en) * | 2014-09-11 | 2019-08-29 | Ethicon, Inc. | Addition to a medical applicator |
| US10183132B2 (en) * | 2014-09-11 | 2019-01-22 | Ethicon Llc | Methods and devices for co-delivery of liquid and powdered hemostats and sealants |
| WO2017011668A1 (en) * | 2015-07-14 | 2017-01-19 | Boston Scientific Scimed, Inc. | Gel delivery catheters, systems, and methods |
| KR20240050484A (ko) * | 2015-09-29 | 2024-04-18 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 휴대용 스피너 및 사용 방법 |
| US10600299B2 (en) * | 2015-10-15 | 2020-03-24 | Steven Benjamin Faubion | Smoke detector with removable battery compartment |
| AU2016353345B2 (en) | 2015-11-12 | 2021-12-23 | University Of Virginia Patent Foundation | Compositions and methods for vas-occlusive contraception and reversal thereof |
| JP2017176713A (ja) * | 2016-03-31 | 2017-10-05 | テルモ株式会社 | 塗布具 |
| US11040363B2 (en) * | 2016-06-14 | 2021-06-22 | Renovacare Sciences Corp. | Modular device for cell spraying |
| CN106620974A (zh) * | 2016-08-26 | 2017-05-10 | 中国人民解放军军事医学科学院野战输血研究所 | 一种电控气动组织修复喷洒装置及组织修复喷洒方法 |
| CN106362271A (zh) * | 2016-08-29 | 2017-02-01 | 名高医疗器械（昆山）有限公司 | 一种药物喷雾器 |
| US12383421B2 (en) | 2017-01-05 | 2025-08-12 | Contraline, Inc. | Contraceptive devices |
| TWI677359B (zh) * | 2017-02-02 | 2019-11-21 | 黃國倫 | 加壓氣體注射裝置及方法 |
| US12102367B2 (en) * | 2017-06-14 | 2024-10-01 | Osteoagra Llc | Method, composition, and apparatus for stabilization of vertebral bodies |
| MX2020001454A (es) * | 2017-09-08 | 2020-03-24 | Samyang Holdings Corp | Ensamble de jeringa sellante. |
| WO2019090195A1 (en) * | 2017-11-04 | 2019-05-09 | Altaviz, Llc | Gas-powered fluid injection system |
| CN107790332A (zh) * | 2017-11-27 | 2018-03-13 | 深圳市华星光电技术有限公司 | 涂布喷头及涂布机、液晶模组的制造方法 |
| US20210077799A1 (en) * | 2018-04-16 | 2021-03-18 | Renovacare Sciences Corp. | Spray deposition system and its use for treating a living being |
| US11517527B2 (en) * | 2018-11-05 | 2022-12-06 | Ethicon, Inc. | Systems, devices and methods for making and expressing foam used in medical procedures |
| AU2019380413B2 (en) | 2018-11-13 | 2025-04-17 | Contraline, Inc. | Systems and methods for delivering biomaterials |
| CN109528347B (zh) * | 2018-12-14 | 2024-09-10 | 采纳科技股份有限公司 | 电动或气动连续注射器 |
| JP7503067B2 (ja) * | 2019-01-29 | 2024-06-19 | シー・アール・バード・インコーポレーテッド | 生検管路シール剤アプリケータ装置および生検システム |
| NZ779944A (en) * | 2019-03-22 | 2025-09-26 | Bard Inc C R | Sealant delivery apparatus, and system and method for preparing same, for use in a lung procedure |
| CA3150246A1 (en) * | 2019-09-05 | 2021-03-11 | Elizabeth COSSGRIFF-HERNANDEZ | Electrically conductive hydrogels usable as lead extensions, apparatus for delivery of a hydrogel into the vasculasture, and methods of treating ventricular arrhythmia with electrically conductive hydrogels injected in the venous system |
| IT201900016502A1 (it) * | 2019-09-17 | 2021-03-17 | Carlo Cavazzini | Dispositivo medico di ausilio nel trattamento delle varici o trattamenti similari |
| US12207810B2 (en) * | 2019-10-04 | 2025-01-28 | Ethicon, Inc. | Dispensing systems and devices having anti-clogging spray tips for dispensing two or more fluids that react together |
| CA3161744A1 (en) | 2019-11-18 | 2021-05-27 | Boston Scientific Scimed, Inc. | Medical devices for endoscopically dispensing agents and related methods of use |
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2011
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- 2011-04-05 BR BR112012025498A patent/BR112012025498A2/pt not_active Application Discontinuation
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| BR112012025498A2 (pt) | 2016-06-21 |
| EP2555813A2 (en) | 2013-02-13 |
| US20110245866A1 (en) | 2011-10-06 |
| CA2795261A1 (en) | 2011-10-13 |
| EP2555813A4 (en) | 2017-01-11 |
| US10987093B2 (en) | 2021-04-27 |
| JP2017164506A (ja) | 2017-09-21 |
| JP2013523336A (ja) | 2013-06-17 |
| WO2011127045A2 (en) | 2011-10-13 |
| EP2555813B1 (en) | 2019-08-07 |
| WO2011127045A3 (en) | 2012-02-23 |
| JP6585652B2 (ja) | 2019-10-02 |
| CN102933243A (zh) | 2013-02-13 |
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