CA2790675C - Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps - Google Patents

Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps Download PDF

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Publication number
CA2790675C
CA2790675C CA2790675A CA2790675A CA2790675C CA 2790675 C CA2790675 C CA 2790675C CA 2790675 A CA2790675 A CA 2790675A CA 2790675 A CA2790675 A CA 2790675A CA 2790675 C CA2790675 C CA 2790675C
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CA
Canada
Prior art keywords
tumor
cells
cell
bmp
lif
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CA2790675A
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English (en)
French (fr)
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CA2790675A1 (en
Inventor
Angelo Luigi Vescovi
Brent Allan Reynolds
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STEMGEN SpA
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STEMGEN SpA
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Publication of CA2790675A1 publication Critical patent/CA2790675A1/en
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Publication of CA2790675C publication Critical patent/CA2790675C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2093—Leukaemia inhibitory factor [LIF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2790675A 2005-07-19 2006-07-19 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps Active CA2790675C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70085905P 2005-07-19 2005-07-19
US60/700,859 2005-07-19
CA2615491A CA2615491C (en) 2005-07-19 2006-07-19 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2615491A Division CA2615491C (en) 2005-07-19 2006-07-19 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps

Publications (2)

Publication Number Publication Date
CA2790675A1 CA2790675A1 (en) 2007-01-25
CA2790675C true CA2790675C (en) 2016-12-20

Family

ID=37420973

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2790675A Active CA2790675C (en) 2005-07-19 2006-07-19 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps
CA2615491A Active CA2615491C (en) 2005-07-19 2006-07-19 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2615491A Active CA2615491C (en) 2005-07-19 2006-07-19 Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps

Country Status (13)

Country Link
US (2) US9220756B2 (enExample)
EP (2) EP1904093B1 (enExample)
JP (3) JP5189977B2 (enExample)
KR (2) KR101338533B1 (enExample)
AU (1) AU2006271308B2 (enExample)
CA (2) CA2790675C (enExample)
DK (2) DK3117833T3 (enExample)
ES (2) ES2686093T3 (enExample)
HR (1) HRP20181379T1 (enExample)
HU (2) HUE042197T2 (enExample)
NZ (2) NZ565172A (enExample)
PL (2) PL3117833T3 (enExample)
WO (1) WO2007010394A2 (enExample)

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KR101338533B1 (ko) * 2005-07-19 2013-12-12 스템젠 에스.피.에이. Ｌｉｆ 및 ｂｍｐ에 의한 종양 줄기 세포의 종양발생가능성의 억제
WO2009101012A1 (en) * 2008-02-13 2009-08-20 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts Methods for treating and preventing brain tumors based on bone morphogenetic proteins
US11578110B2 (en) 2015-08-25 2023-02-14 Histide Ag Compounds for inducing tissue formation and uses thereof
DK3349778T3 (da) * 2015-09-17 2021-11-22 Histide Ag Farmaceutisk association af vækstfaktorreceptoragonist og adhæsionsproteininhibitor til omdannelse af en neoplastisk celle til en ikke-neoplastisk celle og anvendelser deraf
WO2017046226A2 (en) * 2015-09-17 2017-03-23 Histide Ag Pharmaceutical association for converting a neoplastic cell into a non-neoplastic cell and uses thereof.
SG10201913355RA (en) * 2015-09-17 2020-02-27 Histide Ag Pharmaceutical association for converting a neoplastic cell into a non-neoplastic cell and uses thereof
AU2016323407A1 (en) * 2015-09-17 2018-04-19 Histide Ag Pharmaceutical association of growth factor receptor agonist and adhesion protein inhibitor for converting a neoplastic cell into a non-neoplastic cell and uses thereof
US20190224279A1 (en) * 2015-09-17 2019-07-25 Histide Ag Pharmaceutical association comprising a growth factor receptor agonist conjugated to a bioactive carrier for converting a neoplastic cell into a non-neoplastic cell and uses thereof
JP7457331B2 (ja) * 2018-12-28 2024-03-28 国立大学法人 東京大学 神経膠腫の治療および予防剤、脳腫瘍の悪性度のマーカーおよび脳腫瘍の予後マーカー、脳腫瘍の悪性度および予後の判定方法並びに腫瘍増殖を抑制する抗体
WO2026022122A1 (en) * 2024-07-23 2026-01-29 Eos Research Sa Checkpoint inhibitors in the treatment of glioblastoma multiforme

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Also Published As

Publication number Publication date
ES2686093T3 (es) 2018-10-16
JP5189977B2 (ja) 2013-04-24
JP2015057452A (ja) 2015-03-26
DK3117833T3 (en) 2019-03-18
JP5891068B2 (ja) 2016-03-22
US20100167999A1 (en) 2010-07-01
NZ565172A (en) 2012-12-21
CA2615491C (en) 2016-11-29
US20160228511A1 (en) 2016-08-11
AU2006271308B2 (en) 2012-12-20
AU2006271308A1 (en) 2007-01-25
WO2007010394A3 (en) 2007-08-30
HUE040063T2 (hu) 2019-02-28
DK1904093T3 (en) 2018-09-03
NZ598031A (en) 2013-11-29
EP1904093A2 (en) 2008-04-02
HRP20181379T1 (hr) 2018-11-16
CA2615491A1 (en) 2007-01-25
PL3117833T3 (pl) 2019-06-28
WO2007010394A2 (en) 2007-01-25
EP3117833A1 (en) 2017-01-18
JP2012107063A (ja) 2012-06-07
KR101311061B1 (ko) 2013-09-25
JP2009502771A (ja) 2009-01-29
HUE042197T2 (hu) 2019-06-28
KR20120125990A (ko) 2012-11-19
EP1904093B1 (en) 2018-06-13
ES2710601T3 (es) 2019-04-26
KR20080082595A (ko) 2008-09-11
PL1904093T3 (pl) 2018-12-31
EP3117833B1 (en) 2019-01-23
US9220756B2 (en) 2015-12-29
CA2790675A1 (en) 2007-01-25
KR101338533B1 (ko) 2013-12-12
US9737589B2 (en) 2017-08-22

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