CA2783740C - Monoclonal antibodies that bind b7h6 and uses thereof - Google Patents
Monoclonal antibodies that bind b7h6 and uses thereof Download PDFInfo
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- CA2783740C CA2783740C CA2783740A CA2783740A CA2783740C CA 2783740 C CA2783740 C CA 2783740C CA 2783740 A CA2783740 A CA 2783740A CA 2783740 A CA2783740 A CA 2783740A CA 2783740 C CA2783740 C CA 2783740C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28501809P | 2009-12-09 | 2009-12-09 | |
| US61/285,018 | 2009-12-09 | ||
| PCT/IB2010/003411 WO2011070443A1 (en) | 2009-12-09 | 2010-12-08 | Monoclonal antibodies that bind b7h6 and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2783740A1 CA2783740A1 (en) | 2011-06-16 |
| CA2783740C true CA2783740C (en) | 2020-03-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2783740A Active CA2783740C (en) | 2009-12-09 | 2010-12-08 | Monoclonal antibodies that bind b7h6 and uses thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8822652B2 (en:Method) |
| EP (1) | EP2510011B2 (en:Method) |
| JP (2) | JP2013513380A (en:Method) |
| CN (2) | CN104926942B (en:Method) |
| BR (1) | BR112012013975B8 (en:Method) |
| CA (1) | CA2783740C (en:Method) |
| DK (1) | DK2510011T3 (en:Method) |
| EA (1) | EA024629B1 (en:Method) |
| ES (1) | ES2523472T3 (en:Method) |
| HR (1) | HRP20141170T1 (en:Method) |
| IN (1) | IN2012DN04908A (en:Method) |
| MX (1) | MX2012006443A (en:Method) |
| PL (1) | PL2510011T3 (en:Method) |
| PT (1) | PT2510011E (en:Method) |
| RS (1) | RS53667B1 (en:Method) |
| SI (1) | SI2510011T1 (en:Method) |
| SM (1) | SMT201400184B (en:Method) |
| WO (1) | WO2011070443A1 (en:Method) |
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| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US12492376B2 (en) | 2009-10-29 | 2025-12-09 | The Trustees Of Dartmouth College | T-cell receptor-deficient T cell compositions |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| PL2510011T3 (pl) | 2009-12-09 | 2015-02-27 | Inst Nat Sante Rech Med | Przeciwciała monoklonalne, które wiążą B7H6 i ich zastosowania |
| WO2013033626A2 (en) | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| KR20140069125A (ko) * | 2011-09-13 | 2014-06-09 | 도이체스 크렙스포르슝스첸트룸 | B7-h6 폴리펩티드에 대한 b7-h6 치료학적인 활성 단일클론 항체 |
| ES2719495T5 (en) * | 2012-05-07 | 2025-09-10 | Dartmouth College | Anti-b7-h6 antibody, fusion proteins, and methods of using the same |
| EP2711707A1 (en) | 2012-09-21 | 2014-03-26 | Institut Gustave Roussy | Methods and kits for predicting the sensitivity of a subject to chemotherapy |
| WO2014044799A1 (en) * | 2012-09-21 | 2014-03-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for the diagnosing of inflammatory conditions involving detecting, identifying or assaying for soluble b7-h6 polypeptides |
| CN109310764B (zh) * | 2016-04-15 | 2022-01-14 | 达特茅斯大学理事会 | 高亲和力b7-h6抗体和抗体片段 |
| US11191771B2 (en) * | 2016-06-09 | 2021-12-07 | Seagen Inc. | Combinations of PBD-based antibody drug conjugates with FLT3 inhibitors |
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| ES2523472T3 (es) | 2014-11-26 |
| US20130004432A1 (en) | 2013-01-03 |
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| JP2017031147A (ja) | 2017-02-09 |
| EP2510011B2 (en) | 2021-03-31 |
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| WO2011070443A1 (en) | 2011-06-16 |
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| US20150056214A1 (en) | 2015-02-26 |
| EA024629B1 (ru) | 2016-10-31 |
| EP2510011A1 (en) | 2012-10-17 |
| EA201270654A1 (ru) | 2013-02-28 |
| US9663577B2 (en) | 2017-05-30 |
| CA2783740A1 (en) | 2011-06-16 |
| JP6212181B2 (ja) | 2017-10-11 |
| BR112012013975B1 (pt) | 2021-01-12 |
| CN102741290B (zh) | 2015-04-22 |
| PT2510011E (pt) | 2014-12-12 |
| HRP20141170T1 (hr) | 2015-01-30 |
| BR112012013975A2 (pt) | 2017-01-10 |
| SMT201400184B (it) | 2015-01-15 |
| JP2013513380A (ja) | 2013-04-22 |
| MX2012006443A (es) | 2012-06-28 |
| CN104926942A (zh) | 2015-09-23 |
| IN2012DN04908A (en:Method) | 2015-09-25 |
| PL2510011T3 (pl) | 2015-02-27 |
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