CA2782205A1 - Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor - Google Patents
Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor Download PDFInfo
- Publication number
- CA2782205A1 CA2782205A1 CA2782205A CA2782205A CA2782205A1 CA 2782205 A1 CA2782205 A1 CA 2782205A1 CA 2782205 A CA2782205 A CA 2782205A CA 2782205 A CA2782205 A CA 2782205A CA 2782205 A1 CA2782205 A1 CA 2782205A1
- Authority
- CA
- Canada
- Prior art keywords
- hdaci
- composition
- cladribine
- transdermal
- hypomethylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (9)
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| US28330509P | 2009-12-02 | 2009-12-02 | |
| US61/283,305 | 2009-12-02 | ||
| US30195610P | 2010-02-05 | 2010-02-05 | |
| US61/301,956 | 2010-02-05 | ||
| US32008310P | 2010-04-01 | 2010-04-01 | |
| US61/320,083 | 2010-04-01 | ||
| US12/769,913 | 2010-04-29 | ||
| US12/769,913 US8491927B2 (en) | 2009-12-02 | 2010-04-29 | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| PCT/US2010/001287 WO2011068522A1 (en) | 2009-12-02 | 2010-04-30 | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
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| CA2782205A1 true CA2782205A1 (en) | 2011-06-09 |
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| CA2782205A Abandoned CA2782205A1 (en) | 2009-12-02 | 2010-04-30 | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
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| US (3) | US8491927B2 (enExample) |
| EP (1) | EP2506814A4 (enExample) |
| JP (1) | JP6002040B2 (enExample) |
| KR (1) | KR20120127580A (enExample) |
| CN (1) | CN102711686A (enExample) |
| AU (1) | AU2010326699B2 (enExample) |
| CA (1) | CA2782205A1 (enExample) |
| MX (1) | MX2012006128A (enExample) |
| WO (1) | WO2011068522A1 (enExample) |
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| US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| CA2868302A1 (en) | 2012-03-23 | 2013-09-26 | Dennis M. Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| WO2013162054A1 (ja) * | 2012-04-24 | 2013-10-31 | 公立大学法人首都大学東京 | クロマチン構造を制御する組成物 |
| JP6243102B2 (ja) * | 2012-05-01 | 2017-12-06 | 株式会社ジェムインターナショナル | 貼付剤 |
| FR2993461B1 (fr) | 2012-07-19 | 2014-08-08 | Genethon | Utilisation de composes modifiant l'epigenome pour le traitement des maladies genetiques musculaires liees a une anomalie de conformation proteique |
| WO2014022524A1 (en) * | 2012-07-31 | 2014-02-06 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| US20140142522A1 (en) * | 2012-11-16 | 2014-05-22 | NU Technology, LLC | Moist dressing with honeycomb pattern and drain channels |
| JP6626085B2 (ja) * | 2014-07-15 | 2019-12-25 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 骨髄由来抑制細胞の抑制及び免疫チェックポイント阻害の方法 |
| US9962340B2 (en) | 2015-06-09 | 2018-05-08 | Life Tech Global, Llc | Device and method for the transdermal delivery of cannabidiol |
| US10272125B2 (en) * | 2015-09-14 | 2019-04-30 | Life Tech Global, Llc | Transdermal delivery of cannabidiol with other active moieties including cannabinoids |
| GB2567093A (en) | 2016-07-15 | 2019-04-03 | Viracta Therapeutics Inc | Histone deacetylase inhibitors for use in immunotherapy |
| US20180353446A1 (en) * | 2017-06-07 | 2018-12-13 | Ranedis Pharmaceuticals, Llc | Compositions and methods of treating and/or preventing cancer |
| EP3976198A4 (en) | 2019-05-31 | 2023-07-19 | Viracta Subsidiary, Inc. | METHODS OF TREATING VIRUS-ASSOCIATED CANCERS WITH HISTONE DEACETYLASE INHIBITORS |
| TW202128169A (zh) * | 2019-10-07 | 2021-08-01 | 美商維拉克塔治療公司 | 具有降低副作用之hdac治療劑量 |
| US20220087948A1 (en) * | 2020-09-18 | 2022-03-24 | Nanovibronix, Inc. | Transdermal patch of a portable ultrasound-generating system for improved delivery of therapeutic agents and associated methods of treatment |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| EP0052322B1 (de) | 1980-11-10 | 1985-03-27 | Gersonde, Klaus, Prof. Dr. | Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3474511D1 (en) | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
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- 2010-04-30 CN CN2010800617444A patent/CN102711686A/zh active Pending
- 2010-04-30 EP EP10834854.1A patent/EP2506814A4/en not_active Withdrawn
- 2010-04-30 CA CA2782205A patent/CA2782205A1/en not_active Abandoned
- 2010-04-30 KR KR1020127017074A patent/KR20120127580A/ko not_active Ceased
- 2010-04-30 JP JP2012541988A patent/JP6002040B2/ja not_active Expired - Fee Related
- 2010-04-30 US US13/513,327 patent/US10434090B2/en not_active Expired - Fee Related
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- 2019-08-23 US US16/549,442 patent/US20200222379A1/en not_active Abandoned
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|---|---|
| US20110129521A1 (en) | 2011-06-02 |
| KR20120127580A (ko) | 2012-11-22 |
| AU2010326699A1 (en) | 2012-07-19 |
| AU2010326699B2 (en) | 2016-01-07 |
| MX2012006128A (es) | 2012-09-07 |
| US20120310183A1 (en) | 2012-12-06 |
| CN102711686A (zh) | 2012-10-03 |
| US8491927B2 (en) | 2013-07-23 |
| US20200222379A1 (en) | 2020-07-16 |
| JP2013512898A (ja) | 2013-04-18 |
| EP2506814A1 (en) | 2012-10-10 |
| US10434090B2 (en) | 2019-10-08 |
| JP6002040B2 (ja) | 2016-10-05 |
| EP2506814A4 (en) | 2013-05-22 |
| WO2011068522A1 (en) | 2011-06-09 |
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