KR20120127580A - 저메틸화제 및 히스톤 데아세틸라아제 저해제를 함유하는 약학 조성물 - Google Patents

저메틸화제 및 히스톤 데아세틸라아제 저해제를 함유하는 약학 조성물 Download PDF

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KR20120127580A
KR20120127580A KR1020127017074A KR20127017074A KR20120127580A KR 20120127580 A KR20120127580 A KR 20120127580A KR 1020127017074 A KR1020127017074 A KR 1020127017074A KR 20127017074 A KR20127017074 A KR 20127017074A KR 20120127580 A KR20120127580 A KR 20120127580A
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KR
South Korea
Prior art keywords
hdaci
composition
cladribine
transdermal patch
transdermal
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Ceased
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KR1020127017074A
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English (en)
Korean (ko)
Inventor
엘리어트 엠. 에프너
루크 엠. 본
Original Assignee
님블 에피테크, 엘엘씨
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Publication of KR20120127580A publication Critical patent/KR20120127580A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
KR1020127017074A 2009-12-02 2010-04-30 저메틸화제 및 히스톤 데아세틸라아제 저해제를 함유하는 약학 조성물 Ceased KR20120127580A (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US28330509P 2009-12-02 2009-12-02
US61/283,305 2009-12-02
US30195610P 2010-02-05 2010-02-05
US61/301,956 2010-02-05
US32008310P 2010-04-01 2010-04-01
US61/320,083 2010-04-01
US12/769,913 US8491927B2 (en) 2009-12-02 2010-04-29 Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
US12/769,913 2010-04-29
US13/513,327 US10434090B2 (en) 2009-12-02 2010-04-30 Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor
PCT/US2010/001287 WO2011068522A1 (en) 2009-12-02 2010-04-30 Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor

Publications (1)

Publication Number Publication Date
KR20120127580A true KR20120127580A (ko) 2012-11-22

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Family Applications (1)

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KR1020127017074A Ceased KR20120127580A (ko) 2009-12-02 2010-04-30 저메틸화제 및 히스톤 데아세틸라아제 저해제를 함유하는 약학 조성물

Country Status (9)

Country Link
US (3) US8491927B2 (enExample)
EP (1) EP2506814A4 (enExample)
JP (1) JP6002040B2 (enExample)
KR (1) KR20120127580A (enExample)
CN (1) CN102711686A (enExample)
AU (1) AU2010326699B2 (enExample)
CA (1) CA2782205A1 (enExample)
MX (1) MX2012006128A (enExample)
WO (1) WO2011068522A1 (enExample)

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Also Published As

Publication number Publication date
US20120310183A1 (en) 2012-12-06
CN102711686A (zh) 2012-10-03
US8491927B2 (en) 2013-07-23
US20200222379A1 (en) 2020-07-16
CA2782205A1 (en) 2011-06-09
WO2011068522A1 (en) 2011-06-09
MX2012006128A (es) 2012-09-07
EP2506814A4 (en) 2013-05-22
US20110129521A1 (en) 2011-06-02
AU2010326699B2 (en) 2016-01-07
EP2506814A1 (en) 2012-10-10
JP6002040B2 (ja) 2016-10-05
US10434090B2 (en) 2019-10-08
JP2013512898A (ja) 2013-04-18
AU2010326699A1 (en) 2012-07-19

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