CA2778493A1 - Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide - Google Patents

Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide Download PDF

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Publication number
CA2778493A1
CA2778493A1 CA2778493A CA2778493A CA2778493A1 CA 2778493 A1 CA2778493 A1 CA 2778493A1 CA 2778493 A CA2778493 A CA 2778493A CA 2778493 A CA2778493 A CA 2778493A CA 2778493 A1 CA2778493 A1 CA 2778493A1
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peak
hcl
degrees
ppm
disease
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CA2778493A
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English (en)
French (fr)
Inventor
Beili Zhang
Mariusz Krawiec
Brian Luisi
Ales Medek
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CA2778493A1 publication Critical patent/CA2778493A1/en
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4748Quinolines; Isoquinolines forming part of bridged ring systems
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
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    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
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    • C07B2200/13Crystalline forms, e.g. polymorphs

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CA2778493A 2009-10-23 2010-10-21 Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide Abandoned CA2778493A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25461409P 2009-10-23 2009-10-23
US61/254,614 2009-10-23
PCT/US2010/053633 WO2011050220A1 (en) 2009-10-23 2010-10-21 Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Publications (1)

Publication Number Publication Date
CA2778493A1 true CA2778493A1 (en) 2011-04-28

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ID=43334525

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Application Number Title Priority Date Filing Date
CA2778493A Abandoned CA2778493A1 (en) 2009-10-23 2010-10-21 Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide

Country Status (18)

Country Link
US (2) US8389727B2 (cg-RX-API-DMAC7.html)
EP (1) EP2491042A1 (cg-RX-API-DMAC7.html)
JP (1) JP5877157B2 (cg-RX-API-DMAC7.html)
KR (1) KR20120102645A (cg-RX-API-DMAC7.html)
CN (1) CN102666546B (cg-RX-API-DMAC7.html)
AR (1) AR078766A1 (cg-RX-API-DMAC7.html)
AU (1) AU2010310617A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012009584A2 (cg-RX-API-DMAC7.html)
CA (1) CA2778493A1 (cg-RX-API-DMAC7.html)
CL (1) CL2012001007A1 (cg-RX-API-DMAC7.html)
IL (1) IL219327A0 (cg-RX-API-DMAC7.html)
MX (1) MX2012004791A (cg-RX-API-DMAC7.html)
NZ (1) NZ599703A (cg-RX-API-DMAC7.html)
RU (1) RU2568608C2 (cg-RX-API-DMAC7.html)
TW (1) TWI507409B (cg-RX-API-DMAC7.html)
UA (1) UA108087C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011050220A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201202919B (cg-RX-API-DMAC7.html)

Families Citing this family (46)

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EP1664006A2 (en) 2003-09-06 2006-06-07 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
BR122018075478B8 (pt) 2004-06-24 2023-10-31 Vertex Pharma moduladores de transportadores de cassete de ligação de atp
EP1912983B1 (en) 2005-08-11 2011-06-08 Vertex Pharmaceuticals, Inc. Modulators of cystic fibrosis transmembrane conductance regulator
ES2778846T3 (es) 2005-11-08 2020-08-12 Vertex Pharma Moduladores heterocíclicos de transportadores de casete de unión a ATP
AU2006336504C9 (en) 2005-12-28 2015-05-14 Vertex Pharmaceuticals Incorporated 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
HUE032813T2 (en) 2005-12-28 2017-11-28 Vertex Pharma Solid forms of N- [2,4-bis (1,1-dimethyl ethyl) -5-hydroxyphenyl] -1,4-dihydro-4-oxoquinoline-3-carboxamide
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
ES2580803T3 (es) 2006-04-07 2016-08-26 Vertex Pharmaceuticals Incorporated Moduladores de transportadores del casete de unión a ATP
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
CA2686838C (en) 2007-05-09 2017-03-14 Vertex Pharmaceuticals Incorporated Modulators of cftr
CN101827593B (zh) 2007-08-24 2013-07-24 沃泰克斯药物股份有限公司 用于治疗(特别是)囊性纤维化的异噻唑并吡啶酮
SI2217572T1 (sl) 2007-11-16 2014-05-30 Vertex Pharmaceuticals Incorporated Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto
MX364936B (es) 2007-12-07 2019-05-15 Vertex Pharma Procesos para producir acidos cicloalquilcarboxamido-piridin benzoicos.
US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
CN101910156B (zh) 2007-12-07 2013-12-04 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式
JP2011506331A (ja) * 2007-12-07 2011-03-03 バーテックス ファーマシューティカルズ インコーポレイテッド 3−(6−(1−(2,2−ジフルオロベンゾ[d][1,3]ジオキソール−5−イル)シクロプロパンカルボキサミド)−3−メチルピリジン−2−イル)安息香酸の処方物
NZ703814A (en) 2008-02-28 2016-06-24 Vertex Pharma Heteroaryl derivatives as cftr modulators
SI2615085T1 (sl) 2008-03-31 2015-11-30 Vertex Pharmaceuticals Incorporated Piridilni derivati kot cftr-modulatorji
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
EP2349223A2 (en) 2008-09-29 2011-08-03 Vertex Pharmaceuticals Incorporated Dosage units of 3-(6-(1-(2,2-difluorobenzo [d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
MX2011004374A (es) * 2008-10-23 2011-05-23 Vertex Pharma Formas solidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluo rometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolin-3-car boxamida.
EA018891B1 (ru) * 2008-10-23 2013-11-29 Вертекс Фармасьютикалз, Инкорпорейтед Модуляторы регулятора трансмембранной проводимости при муковисцидозе
HUE035160T2 (en) 2009-03-20 2018-05-02 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
MX2012003343A (es) * 2009-09-17 2012-08-17 Vertex Pharma Proceso para preparar compuestos azabiciclicos.
AU2010310617A1 (en) * 2009-10-23 2012-05-24 Vertex Pharmaceuticals Incorporated Solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
CN102648182A (zh) * 2009-10-23 2012-08-22 沃泰克斯药物股份有限公司 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法
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AR081760A1 (es) 2010-04-07 2012-10-17 Vertex Pharma Una composicion farmaceutica para administracion oral que comprende acido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico, un metodo para producir la misma, una tableta y una forma unitaria de dosificacion oral que la comprende y el uso de la misma para la fabricacion de un medicamento
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