CA2777734A1 - Antimicrobial compounds and methods of making and using the same - Google Patents

Antimicrobial compounds and methods of making and using the same Download PDF

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Publication number
CA2777734A1
CA2777734A1 CA2777734A CA2777734A CA2777734A1 CA 2777734 A1 CA2777734 A1 CA 2777734A1 CA 2777734 A CA2777734 A CA 2777734A CA 2777734 A CA2777734 A CA 2777734A CA 2777734 A1 CA2777734 A1 CA 2777734A1
Authority
CA
Canada
Prior art keywords
cr6r6
unsaturated
alkyl
group
member saturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2777734A
Other languages
English (en)
French (fr)
Inventor
Erin M. Duffy
Ashoke Bhattacharjee
Hardwin O'dowd
Marco Devivo
Zoltan F. Kanyo
Jacek G. Martinow
Ik-Hyeon Paik
Sandra Sinishtaj
Brian T. Wimberly
Yusheng Wu
Matthew H. Scheideman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melinta Subsidiary Corp
Original Assignee
Rib X Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rib X Pharmaceuticals Inc filed Critical Rib X Pharmaceuticals Inc
Publication of CA2777734A1 publication Critical patent/CA2777734A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
CA2777734A 2009-10-16 2010-10-15 Antimicrobial compounds and methods of making and using the same Abandoned CA2777734A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US25247809P 2009-10-16 2009-10-16
US61/252,478 2009-10-16
US31428710P 2010-03-16 2010-03-16
US61/314,287 2010-03-16
US35820110P 2010-06-24 2010-06-24
US61/358,201 2010-06-24
PCT/US2010/052922 WO2011047319A2 (en) 2009-10-16 2010-10-15 Antimicrobial compounds and methods of making and using the same

Publications (1)

Publication Number Publication Date
CA2777734A1 true CA2777734A1 (en) 2011-04-21

Family

ID=44343888

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2777734A Abandoned CA2777734A1 (en) 2009-10-16 2010-10-15 Antimicrobial compounds and methods of making and using the same

Country Status (15)

Country Link
US (2) US9193731B2 (https=)
EP (2) EP3406613A1 (https=)
JP (1) JP6267863B2 (https=)
KR (2) KR101972992B1 (https=)
CN (1) CN102712647B (https=)
AU (3) AU2010306646B2 (https=)
CA (1) CA2777734A1 (https=)
DK (1) DK2488525T3 (https=)
EA (1) EA201270566A1 (https=)
ES (1) ES2675798T3 (https=)
IL (2) IL219133A (https=)
MX (2) MX349718B (https=)
NZ (1) NZ599291A (https=)
PH (1) PH12016502092A1 (https=)
WO (1) WO2011047319A2 (https=)

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KR20140065378A (ko) 2011-04-15 2014-05-29 멜린타 테라퓨틱스, 인크. 항미생물 화합물 및 그의 제조 방법과 사용 방법
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EP3038623A4 (en) 2013-09-09 2017-04-19 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
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US10934295B2 (en) * 2016-05-06 2021-03-02 BioVersys AG Antimicrobials and methods of making and using same
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WO2018119221A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Pyridine derivatives as immunomodulators
LT3558990T (lt) 2016-12-22 2022-12-27 Incyte Corporation Tetrahidroimidazo[4,5-c]piridino dariniai kaip pd-l1 internalizavimo induktoriai
JP7101678B2 (ja) 2016-12-22 2022-07-15 インサイト・コーポレイション 免疫調節剤としての複素環式化合物
US20180179202A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
AU2018288665A1 (en) 2017-06-19 2019-12-19 Ashoke Bhattacharjee Antimicrobials and methods of making and using same
US20210403473A1 (en) * 2018-02-21 2021-12-30 BioVersys AG Antimicrobial compounds and methods of making and using the same
SMT202500157T1 (it) 2018-03-30 2025-05-12 Incyte Corp Composti eterociclici come immunomodulatori
HUE061503T2 (hu) 2018-05-11 2023-07-28 Incyte Corp Tetrahidro-imidazo[4,5-C]piridin-származékok mint PD-L1 immunmodulátorok
US12152031B2 (en) 2018-06-06 2024-11-26 BioVersys AG Biodefense agents
WO2019234509A2 (en) 2018-06-06 2019-12-12 BioVersys AG Aminomethylamidine and methylamidine antimicrobial compounds
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Also Published As

Publication number Publication date
ES2675798T3 (es) 2018-07-12
US20120220566A1 (en) 2012-08-30
MX2012004340A (es) 2012-11-23
IL219133A0 (en) 2012-06-28
AU2016266048B2 (en) 2018-07-19
JP2013508297A (ja) 2013-03-07
WO2011047319A8 (en) 2011-10-27
JP6267863B2 (ja) 2018-01-24
PH12016502092A1 (en) 2017-08-30
IL255097A0 (en) 2017-12-31
IL219133A (en) 2017-10-31
CN102712647A (zh) 2012-10-03
US20160031893A1 (en) 2016-02-04
KR101972992B1 (ko) 2019-04-29
WO2011047319A3 (en) 2011-08-18
NZ599291A (en) 2014-06-27
KR20170132900A (ko) 2017-12-04
DK2488525T3 (en) 2018-08-06
WO2011047319A2 (en) 2011-04-21
AU2018204628A1 (en) 2018-07-12
AU2010306646B2 (en) 2016-09-01
EP3406613A1 (en) 2018-11-28
AU2010306646A1 (en) 2012-05-03
AU2016266048A1 (en) 2016-12-22
KR20190044136A (ko) 2019-04-29
US9193731B2 (en) 2015-11-24
EP2488525B1 (en) 2018-04-25
EP2488525A2 (en) 2012-08-22
EA201270566A1 (ru) 2012-11-30
EP2488525A4 (en) 2013-07-03
CN102712647B (zh) 2018-04-24
MX349718B (es) 2017-08-10

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Effective date: 20151007

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Effective date: 20200128