CA2767014C - Procede pour produire des erythrocytes sans cellules nourricieres - Google Patents
Procede pour produire des erythrocytes sans cellules nourricieres Download PDFInfo
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- CA2767014C CA2767014C CA2767014A CA2767014A CA2767014C CA 2767014 C CA2767014 C CA 2767014C CA 2767014 A CA2767014 A CA 2767014A CA 2767014 A CA2767014 A CA 2767014A CA 2767014 C CA2767014 C CA 2767014C
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/14—Erythropoietin [EPO]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2303—Interleukin-3 (IL-3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2311—Interleukin-11 (IL-11)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
L?invention concerne un procédé pour produire des érythrocytes à partir de cellules hématopoïétiques, en particulier des cellules hématopoïétiques provenant d?un perfusat placentaire combiné à des cellules hématopoïétiques provenant du sang de cordon ombilical, ledit procédé ayant pour résultat une expansion et une différentiation accélérées des cellules hématopoïétiques permettant de produire plus efficacement des érythrocytes administrables. L?invention concerne également un bioréacteur dans lequel s?effectuent l?expansion et la différentiation des cellules hématopoïétiques.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22293009P | 2009-07-02 | 2009-07-02 | |
US61/222,930 | 2009-07-02 | ||
PCT/US2010/040707 WO2011002959A1 (fr) | 2009-07-02 | 2010-07-01 | Procédé pour produire des érythrocytes sans cellules nourricières |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2767014A1 CA2767014A1 (fr) | 2011-01-06 |
CA2767014C true CA2767014C (fr) | 2022-01-25 |
Family
ID=42537451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2767014A Active CA2767014C (fr) | 2009-07-02 | 2010-07-01 | Procede pour produire des erythrocytes sans cellules nourricieres |
Country Status (11)
Country | Link |
---|---|
US (3) | US8586360B2 (fr) |
EP (2) | EP2449095A1 (fr) |
JP (6) | JP2012531916A (fr) |
AR (2) | AR077369A1 (fr) |
AU (5) | AU2010266263B2 (fr) |
CA (1) | CA2767014C (fr) |
IL (2) | IL217257A (fr) |
MX (2) | MX2012000110A (fr) |
NZ (2) | NZ597436A (fr) |
WO (1) | WO2011002959A1 (fr) |
ZA (2) | ZA201200031B (fr) |
Families Citing this family (43)
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US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
ES2444548T3 (es) * | 2001-02-14 | 2014-02-25 | Anthrogenesis Corporation | Renovación y repoblación de tejidos y órganos cadavéricos descelularizados por células madre |
US7682803B2 (en) | 2005-10-13 | 2010-03-23 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
CA2505534A1 (fr) * | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Agents cytotherapeutiques, unites cytotherapeutiques et procedes de traitement dans lesquels ils interviennent |
CN1961283A (zh) * | 2004-03-26 | 2007-05-09 | 细胞基因公司 | 建立干细胞库的系统和方法 |
WO2007047465A1 (fr) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Production d'oligodendrocytes a partir de cellules souches derivees du placenta |
KR20080081088A (ko) * | 2005-12-29 | 2008-09-05 | 안트로제네시스 코포레이션 | 태반 줄기세포와 제2 세포원으로부터 얻은 줄기세포의 공동배양 |
CN103060263B (zh) | 2005-12-29 | 2016-03-16 | 人类起源公司 | 胎盘干细胞群 |
US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
CN103255098A (zh) | 2006-10-23 | 2013-08-21 | 人类起源公司 | 用胎盘细胞群治疗骨缺损的方法和组合物 |
KR20090109127A (ko) * | 2007-02-12 | 2009-10-19 | 안트로제네시스 코포레이션 | 부착성 태반 줄기세포에서 유래한 간세포와 연골세포 및 cd34+, cd45- 태반 줄기세포가 농축된 세포군 |
SI2120977T1 (sl) | 2007-02-12 | 2014-01-31 | Anthrogenesis Coroporation | Zdravljenje vnetnih bolezni z uporabo placentarnih matičnih celic |
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US9200253B1 (en) * | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
JP5703493B2 (ja) * | 2007-09-26 | 2015-04-22 | アンスロジェネシス コーポレーション | ヒト胎盤灌流液由来の血管形成細胞 |
KR20210127819A (ko) * | 2007-09-28 | 2021-10-22 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
CN105766891A (zh) * | 2008-08-20 | 2016-07-20 | 人类起源公司 | 改进的细胞组合物及制备所述组合物的方法 |
CA2743573C (fr) * | 2008-11-21 | 2021-04-27 | Anthrogenesis Corporation | Traitement de maladies, troubles ou etats du poumon utilisant des cellules placentaires |
EP2449095A1 (fr) | 2009-07-02 | 2012-05-09 | Anthrogenesis Corporation | Procédé pour produire des érythrocytes sans cellules nourricières |
WO2011094181A1 (fr) * | 2010-01-26 | 2011-08-04 | Anthrogenesis Corporation | Traitement de cancers associés aux os utilisant des cellules souches placentaires |
PL2556145T3 (pl) | 2010-04-07 | 2017-02-28 | Anthrogenesis Corporation | Angiogeneza z zastosowaniem łożyskowych komórek macierzystych |
WO2011127113A1 (fr) | 2010-04-08 | 2011-10-13 | Anthrogenesis Corporation | Traitement de la sarcoïdose au moyen de cellules souches du sang placentaire |
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MX2012000110A (es) | 2012-04-02 |
JP2018148913A (ja) | 2018-09-27 |
IL256430A (en) | 2018-02-28 |
CA2767014A1 (fr) | 2011-01-06 |
NZ619359A (en) | 2015-07-31 |
JP2017038603A (ja) | 2017-02-23 |
JP2015146816A (ja) | 2015-08-20 |
AR077369A1 (es) | 2011-08-24 |
US20140256042A1 (en) | 2014-09-11 |
US9255248B2 (en) | 2016-02-09 |
AU2023251392A1 (en) | 2023-11-02 |
AU2010266263B2 (en) | 2016-05-19 |
IL217257A (en) | 2017-12-31 |
NZ597436A (en) | 2014-08-29 |
AR111785A2 (es) | 2019-08-21 |
WO2011002959A1 (fr) | 2011-01-06 |
ZA201500754B (en) | 2021-07-28 |
AU2010266263A1 (en) | 2012-02-02 |
JP2020182494A (ja) | 2020-11-12 |
MX353489B (es) | 2018-01-16 |
EP2449095A1 (fr) | 2012-05-09 |
US10041043B2 (en) | 2018-08-07 |
AU2021202607A1 (en) | 2021-05-27 |
AU2016213843A1 (en) | 2016-09-01 |
US8586360B2 (en) | 2013-11-19 |
US20110003387A1 (en) | 2011-01-06 |
JP2022110097A (ja) | 2022-07-28 |
JP2012531916A (ja) | 2012-12-13 |
ZA201200031B (en) | 2015-04-29 |
EP3190179A1 (fr) | 2017-07-12 |
AU2018232905A1 (en) | 2018-10-04 |
IL217257A0 (en) | 2012-02-29 |
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