CA2757866A1 - Novel amide and amidine derivatives and uses thereof - Google Patents
Novel amide and amidine derivatives and uses thereof Download PDFInfo
- Publication number
- CA2757866A1 CA2757866A1 CA2757866A CA2757866A CA2757866A1 CA 2757866 A1 CA2757866 A1 CA 2757866A1 CA 2757866 A CA2757866 A CA 2757866A CA 2757866 A CA2757866 A CA 2757866A CA 2757866 A1 CA2757866 A1 CA 2757866A1
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- Prior art keywords
- cyano
- amino
- methyl
- adamantane
- carboxamide
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- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
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- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
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- C07C2603/95—Spiro compounds containing "not free" spiro atoms
- C07C2603/96—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members
- C07C2603/97—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members containing five-membered rings
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Applications Claiming Priority (3)
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US17094309P | 2009-04-20 | 2009-04-20 | |
US61/170,943 | 2009-04-20 | ||
PCT/US2010/031660 WO2010123838A2 (en) | 2009-04-20 | 2010-04-20 | Novel amide and amidine derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
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CA2757866A1 true CA2757866A1 (en) | 2010-10-28 |
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CA2757866A Abandoned CA2757866A1 (en) | 2009-04-20 | 2010-04-20 | Novel amide and amidine derivatives and uses thereof |
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JP (2) | JP5848698B2 (ja) |
CN (2) | CN102459158B (ja) |
CA (1) | CA2757866A1 (ja) |
MX (1) | MX2011011082A (ja) |
WO (1) | WO2010123838A2 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2010123838A2 (en) * | 2009-04-20 | 2010-10-28 | Abbott Laboratories | Novel amide and amidine derivatives and uses thereof |
MX2015005739A (es) * | 2012-11-06 | 2015-09-16 | Lilly Co Eli | Compuestos novedosos de bencil sulfonamida utiles como inhibidores de mogat-2. |
CN104672166A (zh) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | 一种含脒结构的腈基苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104672164A (zh) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | 一类含苯基脒结构的sglt2/sglt1双靶点抑制剂、其制备方法及用途 |
CN104910097A (zh) * | 2015-02-10 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 一类含苯基脒结构的卤代苯基噻唑羧酸酰胺类化合物、其制备方法及用途 |
CN104672165B (zh) * | 2015-02-10 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104710382A (zh) * | 2015-02-10 | 2015-06-17 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构的卤代苯基噻唑羧酸酰胺类化合物及用途 |
CN104628672A (zh) * | 2015-02-10 | 2015-05-20 | 佛山市赛维斯医药科技有限公司 | 一类含苯基脒结构的烷氧苯基噻唑羧酸酰胺类化合物及用途 |
CN104628673A (zh) * | 2015-02-10 | 2015-05-20 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构的腈基苯噻唑羧酸酰胺类化合物及用途 |
CN104592152A (zh) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一种含脒结构的硝基苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
CN104557766A (zh) * | 2015-02-10 | 2015-04-29 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途 |
CN104592148A (zh) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构的硝基苯噻唑羧酸酰胺类化合物及用途 |
CN104592150A (zh) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构的腈基苯噻唑羧酸酰胺类化合物及用途 |
CN110850012B (zh) * | 2018-08-21 | 2022-07-08 | 四川弘远药业有限公司 | 一种1-(2,3-二氯苯基)哌嗪盐酸盐及其有关物质的检测方法 |
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US2450386A (en) * | 1945-09-04 | 1948-09-28 | Boots Pure Drug Co Ltd | Manufacture of compounds containing amidine groups |
GB1306139A (ja) * | 1970-08-06 | 1973-02-07 | ||
US4156014A (en) * | 1977-03-21 | 1979-05-22 | The Upjohn Company | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression |
FR2387977A1 (fr) * | 1977-04-19 | 1978-11-17 | Hoechst France | Procede de fabrication de l'acide thienyl-2 acetique |
JPS562957A (en) * | 1979-06-18 | 1981-01-13 | Otsuka Pharmaceut Factory Inc | N-adamantylthioamide derivative |
CA1157774A (en) * | 1980-07-30 | 1983-11-29 | Anthony Cerami | Method for the reduction of mucin viscosity |
NZ228329A (en) * | 1988-03-18 | 1991-12-23 | Mitsui Toatsu Chemicals | Catechol derivatives and pharmaceutical compositions thereof |
JPH0660141B2 (ja) * | 1989-09-12 | 1994-08-10 | 三井東圧化学株式会社 | ジヒドロカフェイン酸誘導体およびそれを有効成分として含有する治療剤 |
WO1992002490A1 (en) * | 1990-08-10 | 1992-02-20 | Mitsui Toatsu Chemicals, Incorporated | Dihydrocaffeic acid amide derivative and application thereof as medicine |
AU671071B2 (en) * | 1990-08-30 | 1996-08-15 | State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon, Johnson Hall, | Substituted amidines having high binding to the sigma receptor and the use thereof |
DE19921886A1 (de) * | 1999-05-12 | 2000-11-16 | Bayer Ag | Substituierte N-Cyano-amidine |
EP1341773A2 (en) * | 2000-12-07 | 2003-09-10 | Cv Therapeutics, Inc. | Substituted 1,3,5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis |
WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
CN1227010C (zh) * | 2003-04-22 | 2005-11-16 | 中国药科大学 | 取代的四氢异喹啉衍生物的用途 |
US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
EP1786774B1 (en) * | 2004-08-30 | 2009-10-14 | Janssen Pharmaceutica N.V. | Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
UA87328C2 (en) * | 2004-08-30 | 2009-07-10 | Янссен Фармацевтика Н.В. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
CN101137616A (zh) * | 2005-01-05 | 2008-03-05 | 艾博特公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
BRPI0606228A2 (pt) * | 2005-01-05 | 2009-06-09 | Abbott Lab | inibidores de enzima 11-beta-hidroxiesteróide desidrogenase tipo 1 |
CN101243074A (zh) * | 2005-06-08 | 2008-08-13 | 日本烟草产业株式会社 | 杂环化合物 |
EP1801098A1 (en) * | 2005-12-16 | 2007-06-27 | Merck Sante | 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors |
EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
JP2010526777A (ja) * | 2007-04-24 | 2010-08-05 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 置換アミドの医薬用途 |
JP5736098B2 (ja) * | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
WO2010123838A2 (en) * | 2009-04-20 | 2010-10-28 | Abbott Laboratories | Novel amide and amidine derivatives and uses thereof |
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2010
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- 2010-04-20 CA CA2757866A patent/CA2757866A1/en not_active Abandoned
- 2010-04-20 CN CN201080026472.4A patent/CN102459158B/zh not_active Expired - Fee Related
- 2010-04-20 CN CN201310652121.XA patent/CN103772239B/zh not_active Expired - Fee Related
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- 2010-04-20 JP JP2012507294A patent/JP5848698B2/ja not_active Expired - Fee Related
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2015
- 2015-08-27 JP JP2015167599A patent/JP2016026165A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN103772239B (zh) | 2017-04-12 |
JP5848698B2 (ja) | 2016-01-27 |
WO2010123838A3 (en) | 2011-03-03 |
MX2011011082A (es) | 2011-11-04 |
WO2010123838A2 (en) | 2010-10-28 |
JP2012524121A (ja) | 2012-10-11 |
CN102459158A (zh) | 2012-05-16 |
JP2016026165A (ja) | 2016-02-12 |
CN103772239A (zh) | 2014-05-07 |
CN102459158B (zh) | 2015-11-25 |
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