CA2756801A1 - Tissue kallikrein for the treatment of pancreatic .beta.-cell dysfunction - Google Patents

Tissue kallikrein for the treatment of pancreatic .beta.-cell dysfunction Download PDF

Info

Publication number
CA2756801A1
CA2756801A1 CA2756801A CA2756801A CA2756801A1 CA 2756801 A1 CA2756801 A1 CA 2756801A1 CA 2756801 A CA2756801 A CA 2756801A CA 2756801 A CA2756801 A CA 2756801A CA 2756801 A1 CA2756801 A1 CA 2756801A1
Authority
CA
Canada
Prior art keywords
seq
purified
isolated
beta
klk1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2756801A
Other languages
English (en)
French (fr)
Inventor
Mark Williams
Kevin Richardson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diamedica Therapeutics Inc
Original Assignee
Diamedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diamedica Inc filed Critical Diamedica Inc
Publication of CA2756801A1 publication Critical patent/CA2756801A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4853Kallikrein (3.4.21.34 or 3.4.21.35)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2756801A 2009-03-25 2010-03-25 Tissue kallikrein for the treatment of pancreatic .beta.-cell dysfunction Abandoned CA2756801A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16317309P 2009-03-25 2009-03-25
US61/163,173 2009-03-25
PCT/CA2010/000413 WO2010108262A1 (en) 2009-03-25 2010-03-25 TISSUE KALLIKREIN FOR THE TREATMENT OF PANCREATIC β-CELL DYSFUNCTION

Publications (1)

Publication Number Publication Date
CA2756801A1 true CA2756801A1 (en) 2010-09-30

Family

ID=42780097

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2756801A Abandoned CA2756801A1 (en) 2009-03-25 2010-03-25 Tissue kallikrein for the treatment of pancreatic .beta.-cell dysfunction

Country Status (8)

Country Link
US (1) US20120070425A1 (enExample)
EP (1) EP2411042A4 (enExample)
JP (1) JP2012521366A (enExample)
CN (1) CN102438648A (enExample)
AU (1) AU2010228068A1 (enExample)
CA (1) CA2756801A1 (enExample)
NZ (1) NZ595364A (enExample)
WO (1) WO2010108262A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12329805B2 (en) 2017-03-09 2025-06-17 Diamedica Inc. Dosage forms of tissue kallikrein 1
EP4435099A4 (en) * 2021-11-16 2025-08-06 Zonhon Biopharma Inst Inc UNDERGLYCOSYLATED KALLIKREIN I, ITS MODIFIER POLYETHYLENE GLYCOL AND ITS PHARMACEUTICAL USE

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ582930A (en) 2007-07-20 2012-11-30 Diamedica Inc Tissue kallikrein for the treatment of diseases associated with amyloid protein
JP2014520119A (ja) * 2011-06-17 2014-08-21 ザ・ジョンズ・ホプキンス・ユニバーシティー インスリン感受性を増大させる方法および糖尿病を処置するための方法
WO2013173923A1 (en) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
PT2854841T (pt) 2012-06-04 2017-05-15 Diamedica Inc Isoformas de glicosilação da calicreína 1 em tecido humano
CN104073482A (zh) 2013-12-30 2014-10-01 江苏众红生物工程创药研究院有限公司 聚乙二醇化的组织激肽释放酶及其制备方法和应用
CN112481268B (zh) * 2021-01-25 2024-01-30 河南大学 一种棉花启动子PGhPGF及其重组载体和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
JP2002516261A (ja) * 1998-05-22 2002-06-04 エンターメッド インコーポレイテッド セリンプロテアーゼを利用して内皮細胞増殖を阻害し血管新生を調節するための組成物と方法
CN1228447C (zh) * 2001-02-20 2005-11-23 深圳市人民医院 一种含有人胰腺组织激肽释放酶成熟蛋白基因的重组表达载体
CN100338212C (zh) * 2003-01-29 2007-09-19 中国科学院大连化学物理研究所 人组织激肽释放酶的微囊化细胞及其微囊化方法和应用
JP2008515774A (ja) * 2004-08-03 2008-05-15 ダイアックス コーポレイション hK1結合タンパク質
CN101094869A (zh) * 2004-08-03 2007-12-26 戴埃克斯有限公司 Hk1结合蛋白
EP2051732A4 (en) * 2006-07-26 2009-10-21 Diamedica Inc DIAGNOSIS AND TREATMENT OF METABOLIC DISORDERS AND METHODS THEREFOR
JP5322935B2 (ja) * 2006-07-31 2013-10-23 アクティベサイト ファーマシューティカルズ インコーポレイティッド 血漿カリクレインの阻害薬
CN101134953B (zh) * 2007-07-02 2011-02-09 广东天普生化医药股份有限公司 重组人胰激肽原酶
CN101255438B (zh) * 2008-04-11 2012-01-25 深圳大学 表达人组织激肽释放酶的转基因莱茵衣藻的构建方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12329805B2 (en) 2017-03-09 2025-06-17 Diamedica Inc. Dosage forms of tissue kallikrein 1
EP4435099A4 (en) * 2021-11-16 2025-08-06 Zonhon Biopharma Inst Inc UNDERGLYCOSYLATED KALLIKREIN I, ITS MODIFIER POLYETHYLENE GLYCOL AND ITS PHARMACEUTICAL USE

Also Published As

Publication number Publication date
JP2012521366A (ja) 2012-09-13
WO2010108262A1 (en) 2010-09-30
AU2010228068A1 (en) 2011-10-20
US20120070425A1 (en) 2012-03-22
NZ595364A (en) 2013-09-27
EP2411042A1 (en) 2012-02-01
CN102438648A (zh) 2012-05-02
EP2411042A4 (en) 2012-12-12

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20160329