CN102438648A - 用于治疗胰腺β细胞功能障碍的组织激肽释放酶 - Google Patents

用于治疗胰腺β细胞功能障碍的组织激肽释放酶 Download PDF

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Publication number
CN102438648A
CN102438648A CN2010800181825A CN201080018182A CN102438648A CN 102438648 A CN102438648 A CN 102438648A CN 2010800181825 A CN2010800181825 A CN 2010800181825A CN 201080018182 A CN201080018182 A CN 201080018182A CN 102438648 A CN102438648 A CN 102438648A
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CN
China
Prior art keywords
purified
seq
klk1
isolated
variant
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Pending
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CN2010800181825A
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English (en)
Chinese (zh)
Inventor
M·威廉姆斯
K·理查德森
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Diamedica Therapeutics Inc
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Diamedica Inc
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Publication of CN102438648A publication Critical patent/CN102438648A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4853—Kallikrein (3.4.21.34 or 3.4.21.35)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN2010800181825A 2009-03-25 2010-03-25 用于治疗胰腺β细胞功能障碍的组织激肽释放酶 Pending CN102438648A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16317309P 2009-03-25 2009-03-25
US61/163,173 2009-03-25
PCT/CA2010/000413 WO2010108262A1 (en) 2009-03-25 2010-03-25 TISSUE KALLIKREIN FOR THE TREATMENT OF PANCREATIC β-CELL DYSFUNCTION

Publications (1)

Publication Number Publication Date
CN102438648A true CN102438648A (zh) 2012-05-02

Family

ID=42780097

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800181825A Pending CN102438648A (zh) 2009-03-25 2010-03-25 用于治疗胰腺β细胞功能障碍的组织激肽释放酶

Country Status (8)

Country Link
US (1) US20120070425A1 (enExample)
EP (1) EP2411042A4 (enExample)
JP (1) JP2012521366A (enExample)
CN (1) CN102438648A (enExample)
AU (1) AU2010228068A1 (enExample)
CA (1) CA2756801A1 (enExample)
NZ (1) NZ595364A (enExample)
WO (1) WO2010108262A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2693921A1 (en) 2007-07-20 2009-01-29 Genesys Venture Inc. Tissue kallikrein for the treatment of diseases associated with amyloid protein
EP2720703A4 (en) * 2011-06-17 2015-07-22 Univ Johns Hopkins METHOD FOR INCREASING INSULIN SENSITIVITY AND TREATING DIABETES
WO2013173923A1 (en) 2012-05-25 2013-11-28 Diamedica, Inc. Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
HUE032613T2 (en) 2012-06-04 2017-10-30 Diamedica Therapeutics Inc Human tissue kallikrein 1 is glycosylated isoforms
CN109498815B (zh) 2013-12-30 2022-07-22 江苏众红生物工程创药研究院有限公司 重组人激肽释放酶的化学修饰物及其应用
WO2018165551A1 (en) 2017-03-09 2018-09-13 Diamedica Inc. Dosage forms of tissue kallikrein 1
CN112481268B (zh) * 2021-01-25 2024-01-30 河南大学 一种棉花启动子PGhPGF及其重组载体和应用
CN116135973A (zh) * 2021-11-16 2023-05-19 江苏众红生物工程创药研究院有限公司 低糖基化修饰的激肽原酶及其聚乙二醇修饰物和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1384199A (zh) * 2001-02-20 2002-12-11 深圳市人民医院 一种表达人胰腺组织激肽释放酶基因的重组表达载体及重组人胰腺组织激肽释放酶的制备
CN1521257A (zh) * 2003-01-29 2004-08-18 中国科学院大连化学物理研究所 人组织激肽释放酶的微囊化细胞及其微囊化方法和应用
CN101094869A (zh) * 2004-08-03 2007-12-26 戴埃克斯有限公司 Hk1结合蛋白
CN101134953A (zh) * 2007-07-02 2008-03-05 广东天普生化医药股份有限公司 重组人胰激肽原酶
CN101255438A (zh) * 2008-04-11 2008-09-03 深圳大学 表达人组织激肽释放酶的转基因莱茵衣藻的构建方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
WO1999060984A2 (en) * 1998-05-22 1999-12-02 Entremed, Inc. Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using serine proteases
WO2006017538A2 (en) * 2004-08-03 2006-02-16 Dyax Corp. Hk1-binding proteins
EP2051732A4 (en) * 2006-07-26 2009-10-21 Diamedica Inc DIAGNOSIS AND TREATMENT OF METABOLIC DISORDERS AND METHODS THEREFOR
CA2658523C (en) * 2006-07-31 2012-06-12 Activesite Pharmaceuticals, Inc. Inhibitors of plasma kallikrein

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1384199A (zh) * 2001-02-20 2002-12-11 深圳市人民医院 一种表达人胰腺组织激肽释放酶基因的重组表达载体及重组人胰腺组织激肽释放酶的制备
CN1521257A (zh) * 2003-01-29 2004-08-18 中国科学院大连化学物理研究所 人组织激肽释放酶的微囊化细胞及其微囊化方法和应用
CN101094869A (zh) * 2004-08-03 2007-12-26 戴埃克斯有限公司 Hk1结合蛋白
CN101134953A (zh) * 2007-07-02 2008-03-05 广东天普生化医药股份有限公司 重组人胰激肽原酶
CN101255438A (zh) * 2008-04-11 2008-09-03 深圳大学 表达人组织激肽释放酶的转基因莱茵衣藻的构建方法

Also Published As

Publication number Publication date
CA2756801A1 (en) 2010-09-30
US20120070425A1 (en) 2012-03-22
WO2010108262A1 (en) 2010-09-30
EP2411042A4 (en) 2012-12-12
AU2010228068A1 (en) 2011-10-20
EP2411042A1 (en) 2012-02-01
NZ595364A (en) 2013-09-27
JP2012521366A (ja) 2012-09-13

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