CA2752854A1 - Quenched dendrimeric dyes for bright detection - Google Patents
Quenched dendrimeric dyes for bright detection Download PDFInfo
- Publication number
- CA2752854A1 CA2752854A1 CA2752854A CA2752854A CA2752854A1 CA 2752854 A1 CA2752854 A1 CA 2752854A1 CA 2752854 A CA2752854 A CA 2752854A CA 2752854 A CA2752854 A CA 2752854A CA 2752854 A1 CA2752854 A1 CA 2752854A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- activator
- dye
- dyedron
- acceptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/02—Diaryl- or thriarylmethane dyes derived from diarylmethanes
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- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
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- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- Chemical & Material Sciences (AREA)
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- Immunology (AREA)
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- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
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- Biotechnology (AREA)
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- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
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| US20792909P | 2009-02-18 | 2009-02-18 | |
| US61/207,929 | 2009-02-18 | ||
| PCT/US2010/024320 WO2010096388A2 (en) | 2009-02-18 | 2010-02-16 | Quenched dendrimeric dyes for bright detection |
Publications (1)
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| CA2752854A1 true CA2752854A1 (en) | 2010-08-26 |
Family
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|---|---|---|---|
| CA2752854A Abandoned CA2752854A1 (en) | 2009-02-18 | 2010-02-16 | Quenched dendrimeric dyes for bright detection |
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| US (1) | US9249306B2 (https=) |
| EP (1) | EP2398860B1 (https=) |
| JP (2) | JP2012518072A (https=) |
| CA (1) | CA2752854A1 (https=) |
| WO (1) | WO2010096388A2 (https=) |
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| WO2011150079A1 (en) * | 2010-05-25 | 2011-12-01 | Carnegie Mellon University | Targeted probes of cellular physiology |
| US9023998B2 (en) * | 2013-02-25 | 2015-05-05 | Carnegie Mellon University | Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing |
| CN104250380B (zh) * | 2013-06-25 | 2017-02-01 | 中国石油化工股份有限公司 | 一种树枝状聚合物和树枝状聚合物单体及其制备方法和应用 |
| US9475894B2 (en) | 2013-06-25 | 2016-10-25 | China Petroleum & Chemical Corporation | Dendritic polymer, dendritic polymer monomer, and hyperbranched copolymer |
| CN107429075B (zh) | 2014-11-17 | 2022-11-01 | 卡内基梅隆大学 | 可激活的双组份光敏剂 |
| US20180318454A1 (en) * | 2015-11-04 | 2018-11-08 | Duke University | Conjugated polycationic polymers, methods of using the same and methods of treating autoimmune diseases, infectious diseases and acute radiation exposure |
| CN106867970B (zh) * | 2017-01-22 | 2020-08-18 | 杭州市农业科学研究院 | 一种分泌抗孔雀石绿单克隆抗体的杂交瘤细胞株及其应用 |
| IL271386B2 (en) * | 2017-06-16 | 2025-02-01 | Univ Duke | Enhanced resonator networks for label detection, computation, analyte sensing, and tunable random number generation |
| US11058675B2 (en) | 2018-03-29 | 2021-07-13 | Carnegie Mellon University | Cell-based screening and compounds that modulate GaINAc-transferases |
| CN110208441A (zh) * | 2019-01-17 | 2019-09-06 | 广西科技大学 | 淡水鱼中隐性孔雀石绿的快速提取和检测方法 |
| EP4185643A4 (en) * | 2020-07-23 | 2024-09-11 | Enzo Biochem, Inc. | FLUORESCENCE QUENCHER POLYMER CONJUGATES AND USES THEREOF |
| EP4666071A2 (en) * | 2023-02-13 | 2025-12-24 | Nautilus Subsidiary, Inc. | Affinity reagents having artificial polymer scaffolds |
| CN119119767B (zh) * | 2024-03-15 | 2025-09-05 | 浙江大学杭州国际科创中心 | 一种复杂基质中细胞荧光染色用的复方染料 |
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| US421505A (en) | 1890-02-18 | For axle journals | ||
| DE2747824A1 (de) | 1977-10-26 | 1979-05-03 | Bayer Ag | Verfahren zur herstellung von halogenvinyl-gamma-butyrolactonen |
| DE3023787A1 (de) | 1980-06-25 | 1982-01-21 | Studiengesellschaft Kohle mbH, 4330 Mülheim | Verfahren zur erhoehung der inkorporation und der expression von genetischem material in die kerne von intakten zellen mit hilfe von liposomen |
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| JP2627899B2 (ja) | 1987-08-19 | 1997-07-09 | 株式会社 ビタミン研究所 | 遺伝子封入リポソームの製法 |
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| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| EP0452457B1 (en) | 1989-11-03 | 1997-08-20 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
| US5747334A (en) | 1990-02-15 | 1998-05-05 | The University Of North Carolina At Chapel Hill | Random peptide library |
| US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| ES2259800T3 (es) | 1990-06-11 | 2006-10-16 | Gilead Sciences, Inc. | Procedimientos de uso de ligandos de acido nucleico. |
| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5580737A (en) | 1990-06-11 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | High-affinity nucleic acid ligands that discriminate between theophylline and caffeine |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| CA2092323A1 (en) | 1990-10-01 | 1992-04-02 | George Y. Wu | Targeting viruses and cells for selective internalization by cells |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| AU1922092A (en) | 1991-05-03 | 1992-12-21 | Albert Einstein College Of Medicine Of Yeshiva University | Targeted delivery of genes encoding cell surface receptors |
| CA2103064A1 (en) | 1991-05-14 | 1992-11-15 | George Y. Wu | Targeted delivery of genes encoding immunogenic proteins |
| DK0587738T3 (da) | 1991-06-05 | 2000-12-18 | Univ Connecticut | Destineret levering af gener, som koder for sekretionsproteiner |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| EP0666923A1 (en) | 1991-09-05 | 1995-08-16 | The University Of Connecticut | Targeted delivery of poly- or oligonucleotides to cells |
| US6238931B1 (en) * | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
| US5702892A (en) | 1995-05-09 | 1997-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Phage-display of immunoglobulin heavy chain libraries |
| US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
| US6131580A (en) | 1998-04-17 | 2000-10-17 | The University Of Washington | Template imprinted materials by RFGD plasma deposition |
| US6358684B1 (en) | 1999-08-27 | 2002-03-19 | Pe Corporation | UV excitable fluorescent energy transfer dyes |
| GB0119001D0 (en) | 2001-08-03 | 2001-09-26 | Amersham Pharm Biotech Uk Ltd | Use of dendrimers and poly-branched molecules to enhance signal in fluorescent assay systems |
| US20030165918A1 (en) * | 2001-08-17 | 2003-09-04 | Fuji Photo Film Co., Ltd. | Method for detecting nucleic acid |
| EP2061884A4 (en) | 2006-08-11 | 2010-03-24 | Life Technologies Corp | SENSOR PROTEINS AND TEST PROCEDURES THEREFOR |
| EP2629094A1 (en) | 2007-01-24 | 2013-08-21 | Carnegie Mellon University | Optical biosensors |
| WO2011150079A1 (en) * | 2010-05-25 | 2011-12-01 | Carnegie Mellon University | Targeted probes of cellular physiology |
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| US9249306B2 (en) | 2016-02-02 |
| US20120058494A1 (en) | 2012-03-08 |
| EP2398860A2 (en) | 2011-12-28 |
| WO2010096388A3 (en) | 2011-05-19 |
| WO2010096388A4 (en) | 2011-07-21 |
| WO2010096388A2 (en) | 2010-08-26 |
| JP2016014033A (ja) | 2016-01-28 |
| EP2398860B1 (en) | 2013-11-20 |
| JP2012518072A (ja) | 2012-08-09 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
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| FZDE | Discontinued |
Effective date: 20181213 |