CA2750035C - Treatment for obesity - Google Patents
Treatment for obesity Download PDFInfo
- Publication number
- CA2750035C CA2750035C CA2750035A CA2750035A CA2750035C CA 2750035 C CA2750035 C CA 2750035C CA 2750035 A CA2750035 A CA 2750035A CA 2750035 A CA2750035 A CA 2750035A CA 2750035 C CA2750035 C CA 2750035C
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- Prior art keywords
- peptide
- seq
- amino acid
- acid sequence
- calcitonin
- Prior art date
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Classifications
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1706—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
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- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Marine Sciences & Fisheries (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20575009P | 2009-01-22 | 2009-01-22 | |
| US61/205,750 | 2009-01-22 | ||
| PCT/US2010/021872 WO2010085700A2 (en) | 2009-01-22 | 2010-01-22 | Treatment for obesity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2750035A1 CA2750035A1 (en) | 2010-07-29 |
| CA2750035C true CA2750035C (en) | 2018-02-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2750035A Expired - Fee Related CA2750035C (en) | 2009-01-22 | 2010-01-22 | Treatment for obesity |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US8076291B2 (enExample) |
| EP (1) | EP2389388B1 (enExample) |
| JP (1) | JP5753097B2 (enExample) |
| KR (1) | KR20110119707A (enExample) |
| CN (1) | CN102292346B (enExample) |
| AU (1) | AU2010206614B2 (enExample) |
| BR (1) | BRPI1006943A2 (enExample) |
| CA (1) | CA2750035C (enExample) |
| DK (1) | DK2389388T3 (enExample) |
| ES (1) | ES2622877T3 (enExample) |
| WO (1) | WO2010085700A2 (enExample) |
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| BRPI1006943A2 (pt) * | 2009-01-22 | 2021-06-15 | Unigene Laboratories Inc. | peptídeo, composição farmacêutica que compreende o peptídeo e método para supressão do apetite, prevenção ou tratamento de uma condição de sobrepeso ou obesidade, ou para tratar diabetes |
| EA024507B1 (ru) | 2010-09-28 | 2016-09-30 | Амилин Фармасьютикалс, Ллк | Хорошо растворимые лептины |
| HUE039105T2 (hu) * | 2011-11-02 | 2018-12-28 | Keybioscience Ag | Kalcitonin mimetikumok betegségek és rendellenességek kezelésére |
| US9533022B2 (en) * | 2011-11-02 | 2017-01-03 | KeyBioscience A/S | Peptide analogs for treating diseases and disorders |
| MX351092B (es) | 2011-11-02 | 2017-10-02 | Keybioscience Ag | Analogos peptidicos para tratar enfermedades y trastornos. |
| WO2013156594A1 (en) * | 2012-04-19 | 2013-10-24 | Novo Nordisk A/S | Human amylin analogues |
| CN102965327B (zh) * | 2012-12-12 | 2014-06-11 | 黑龙江大学 | msCT-rhLeptin融合蛋白转基因工程菌株 |
| CN102964452B (zh) * | 2012-12-12 | 2015-09-09 | 黑龙江大学 | 用于治骨质疏松症和肥胖的msCT-rhLeptin融合蛋白及编码该融合蛋白的核酸 |
| CN106687474A (zh) | 2014-09-04 | 2017-05-17 | 诺和诺德股份有限公司 | 新型胰淀素和降钙素受体激动剂 |
| GB201500263D0 (en) * | 2015-01-08 | 2015-02-25 | Keybioscience Ag | Calcitonin analogues for treating diseases and disorders |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| KR102317480B1 (ko) | 2017-03-23 | 2021-10-25 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| WO2020063760A1 (en) | 2018-09-26 | 2020-04-02 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| BR112021006823A2 (pt) | 2018-10-11 | 2021-07-27 | Intarcia Therapeutics, Inc. | polipeptídeos análogos de amilina humana e métodos de uso |
| AR124295A1 (es) | 2020-12-18 | 2023-03-15 | Lilly Co Eli | Agonistas duales del receptor de amilina y calcitonina y usos de los mismos |
| PE20251068A1 (es) | 2022-08-29 | 2025-04-09 | Lilly Co Eli | Composiciones para suministro oral |
| WO2025240893A1 (en) | 2024-05-17 | 2025-11-20 | Eli Lilly And Company | 4-phenyl-1h-pyrazolo[3,4-b]pyridine-5-carboxamide derivatives as amylin and/or calcitonin receptor agonists for the treatment of type 2 diabetes, obesity or overweight |
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| US4708934A (en) | 1984-09-27 | 1987-11-24 | Unigene Laboratories, Inc. | α-amidation enzyme |
| US6319685B1 (en) | 1984-09-27 | 2001-11-20 | Unigene Laboratories, Inc. | Alpha-amidating enzyme compositions and processes for their production and use |
| US4764589A (en) | 1987-05-26 | 1988-08-16 | Rorer Pharmaceutical Corporation | [N-alpha-acyl,8-glycine, des-19-leucine]-calcitonin |
| US5789234A (en) | 1987-08-14 | 1998-08-04 | Unigene Laboratories, Inc. | Expression systems for amidating enzyme |
| US5175146A (en) * | 1989-12-05 | 1992-12-29 | Vical, Inc. | Synthetic calcitonin peptides |
| US5364840A (en) * | 1989-12-05 | 1994-11-15 | Vical, Inc. | Synthetic calcitonin peptides |
| US5527771A (en) * | 1991-01-10 | 1996-06-18 | Amylin Pharmaceuticals, Inc. | Methods and Compositions for treatment of diabetes mellitus, hypoglycemia & other conditions |
| US5580953A (en) * | 1991-08-14 | 1996-12-03 | Amylin Pharmaceuticals, Inc. | Amylin antagonist peptides and uses therefor |
| US5527790A (en) * | 1991-09-30 | 1996-06-18 | The University Of British Columbia | Bis(maltolato)oxovanadium compositions for the treatment of elevated blood sugar |
| JPH083196A (ja) * | 1994-06-21 | 1996-01-09 | Sanwa Kagaku Kenkyusho Co Ltd | カルシトニン誘導体及びその用途 |
| EP0726075A1 (en) * | 1995-02-08 | 1996-08-14 | Therapicon Srl | Pharmaceutical non-inorganic saline solutions for endonasal administration |
| US5739106A (en) * | 1995-06-07 | 1998-04-14 | Rink; Timothy J. | Appetite regulating compositions |
| KR100284382B1 (ko) | 1995-08-22 | 2001-03-02 | 미즈노 마사루 | 아미드화합물 및 그의 용도 |
| ATE484572T1 (de) | 1997-04-16 | 2010-10-15 | Unigene Lab Inc | Direkte expression von peptiden ins kulturmedium |
| US6083480A (en) * | 1997-05-01 | 2000-07-04 | Diatide, Inc. | Calcitonin receptor binding reagents |
| US6086018A (en) | 1997-12-09 | 2000-07-11 | Mcdonnell Douglas Corporation | Interlocking assembly system for an aircraft cabin |
| JP2000290295A (ja) * | 1999-03-31 | 2000-10-17 | Asahi Chem Ind Co Ltd | Ｎ−アセチルグルコサミニルカルシトニン |
| CN1274830C (zh) * | 2001-12-14 | 2006-09-13 | 中国农业科学院生物技术研究所 | 一种新型鲑鱼降钙素类似物及其在植物油体中表达的方法 |
| CN1980954A (zh) * | 2004-02-11 | 2007-06-13 | 安米林药品公司 | 胰岛淀粉样多肽家族肽及其制备和使用方法 |
| JP2008500281A (ja) * | 2004-02-11 | 2008-01-10 | アミリン・ファーマシューティカルズ，インコーポレイテッド | アミリンファミリーペプチドおよびそれらを作成し使用するための方法 |
| US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
| GB0422644D0 (en) | 2004-10-12 | 2004-11-10 | Novartis Ag | Organic compounds |
| US8394765B2 (en) * | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| US7445911B2 (en) | 2004-11-24 | 2008-11-04 | Unigene Laboratories Inc. | Enzymatic reactions in the presence of keto acids |
| DK1888094T3 (da) * | 2005-03-31 | 2009-11-09 | Amylin Pharmaceuticals Inc | Amylin og amylinagonister til behandling af psykiatriske sygdomme og forstyrrelser |
| US8815583B2 (en) * | 2005-06-24 | 2014-08-26 | Enteris Biopharma, Inc. | Cell lines for expressing enzyme useful in the preparation of amidated products |
| US8377863B2 (en) | 2007-05-29 | 2013-02-19 | Unigene Laboratories Inc. | Peptide pharmaceutical for oral delivery |
| BRPI1006943A2 (pt) * | 2009-01-22 | 2021-06-15 | Unigene Laboratories Inc. | peptídeo, composição farmacêutica que compreende o peptídeo e método para supressão do apetite, prevenção ou tratamento de uma condição de sobrepeso ou obesidade, ou para tratar diabetes |
-
2010
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- 2010-01-22 KR KR1020117018879A patent/KR20110119707A/ko not_active Ceased
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- 2010-01-22 EP EP10733943.4A patent/EP2389388B1/en not_active Not-in-force
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- 2010-01-22 AU AU2010206614A patent/AU2010206614B2/en not_active Ceased
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2011
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2012
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2013
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2016
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| ES2622877T3 (es) | 2017-07-07 |
| BRPI1006943A2 (pt) | 2021-06-15 |
| EP2389388B1 (en) | 2017-03-08 |
| US8378067B2 (en) | 2013-02-19 |
| WO2010085700A2 (en) | 2010-07-29 |
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| US8217139B2 (en) | 2012-07-10 |
| CA2750035A1 (en) | 2010-07-29 |
| US9833494B2 (en) | 2017-12-05 |
| US20140073561A1 (en) | 2014-03-13 |
| US9394342B2 (en) | 2016-07-19 |
| WO2010085700A3 (en) | 2010-09-23 |
| CN102292346B (zh) | 2015-12-02 |
| EP2389388A4 (en) | 2013-08-21 |
| AU2010206614A1 (en) | 2011-08-04 |
| JP5753097B2 (ja) | 2015-07-22 |
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| CN102292346A (zh) | 2011-12-21 |
| US20100311650A1 (en) | 2010-12-09 |
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| DK2389388T3 (en) | 2017-05-01 |
| AU2010206614B2 (en) | 2015-03-26 |
| US20160354434A1 (en) | 2016-12-08 |
| US8076291B2 (en) | 2011-12-13 |
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