DK2389388T3 - TREATMENT FOR Obesity - Google Patents
TREATMENT FOR Obesity Download PDFInfo
- Publication number
- DK2389388T3 DK2389388T3 DK10733943.4T DK10733943T DK2389388T3 DK 2389388 T3 DK2389388 T3 DK 2389388T3 DK 10733943 T DK10733943 T DK 10733943T DK 2389388 T3 DK2389388 T3 DK 2389388T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- residue
- amino acid
- seq
- calcitonin
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
Landscapes
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- Chemical & Material Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20575009P | 2009-01-22 | 2009-01-22 | |
| PCT/US2010/021872 WO2010085700A2 (en) | 2009-01-22 | 2010-01-22 | Treatment for obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2389388T3 true DK2389388T3 (en) | 2017-05-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10733943.4T DK2389388T3 (en) | 2009-01-22 | 2010-01-22 | TREATMENT FOR Obesity |
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| Country | Link |
|---|---|
| US (6) | US8076291B2 (enExample) |
| EP (1) | EP2389388B1 (enExample) |
| JP (1) | JP5753097B2 (enExample) |
| KR (1) | KR20110119707A (enExample) |
| CN (1) | CN102292346B (enExample) |
| AU (1) | AU2010206614B2 (enExample) |
| BR (1) | BRPI1006943A2 (enExample) |
| CA (1) | CA2750035C (enExample) |
| DK (1) | DK2389388T3 (enExample) |
| ES (1) | ES2622877T3 (enExample) |
| WO (1) | WO2010085700A2 (enExample) |
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| JP5753097B2 (ja) | 2009-01-22 | 2015-07-22 | ユニジーン・ラボラトリーズ・インコーポレーテッド | 肥満の治療 |
| CA2813087C (en) | 2010-09-28 | 2020-07-21 | Amylin Pharmaceuticals, Llc | Engineered polypeptides having enhanced duration of action |
| US9533022B2 (en) | 2011-11-02 | 2017-01-03 | KeyBioscience A/S | Peptide analogs for treating diseases and disorders |
| HUE039105T2 (hu) * | 2011-11-02 | 2018-12-28 | Keybioscience Ag | Kalcitonin mimetikumok betegségek és rendellenességek kezelésére |
| MX351092B (es) * | 2011-11-02 | 2017-10-02 | Keybioscience Ag | Analogos peptidicos para tratar enfermedades y trastornos. |
| WO2013156594A1 (en) * | 2012-04-19 | 2013-10-24 | Novo Nordisk A/S | Human amylin analogues |
| CN102965327B (zh) * | 2012-12-12 | 2014-06-11 | 黑龙江大学 | msCT-rhLeptin融合蛋白转基因工程菌株 |
| CN102964452B (zh) * | 2012-12-12 | 2015-09-09 | 黑龙江大学 | 用于治骨质疏松症和肥胖的msCT-rhLeptin融合蛋白及编码该融合蛋白的核酸 |
| TW201625671A (zh) | 2014-09-04 | 2016-07-16 | 諾佛 儂迪克股份有限公司 | 新穎澱粉素及降鈣素受體促效劑 |
| GB201500263D0 (en) * | 2015-01-08 | 2015-02-25 | Keybioscience Ag | Calcitonin analogues for treating diseases and disorders |
| HUE057838T2 (hu) | 2016-06-07 | 2022-06-28 | Jacobio Pharmaceuticals Co Ltd | SHP2 inhibitorokként hasznos új heterociklusos származékok |
| TWI664175B (zh) | 2017-03-23 | 2019-07-01 | 大陸商北京加科思新藥研發有限公司 | 用於作為shp2抑制劑之新穎雜環衍生物 |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| AU2019357621B2 (en) | 2018-10-11 | 2025-04-03 | Intarcia Therapeutics, Inc. | Human amylin analog polypeptides and methods of use |
| TWI790850B (zh) | 2020-12-18 | 2023-01-21 | 美商美國禮來大藥廠 | 雙重澱粉素及降鈣素受體促效劑及其用途 |
| JP2025530743A (ja) | 2022-08-29 | 2025-09-17 | イーライ リリー アンド カンパニー | 経口投与のための組成物 |
| WO2025240893A1 (en) | 2024-05-17 | 2025-11-20 | Eli Lilly And Company | 4-phenyl-1h-pyrazolo[3,4-b]pyridine-5-carboxamide derivatives as amylin and/or calcitonin receptor agonists for the treatment of type 2 diabetes, obesity or overweight |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708934A (en) | 1984-09-27 | 1987-11-24 | Unigene Laboratories, Inc. | α-amidation enzyme |
| US6319685B1 (en) | 1984-09-27 | 2001-11-20 | Unigene Laboratories, Inc. | Alpha-amidating enzyme compositions and processes for their production and use |
| US4764589A (en) | 1987-05-26 | 1988-08-16 | Rorer Pharmaceutical Corporation | [N-alpha-acyl,8-glycine, des-19-leucine]-calcitonin |
| US5789234A (en) | 1987-08-14 | 1998-08-04 | Unigene Laboratories, Inc. | Expression systems for amidating enzyme |
| US5364840A (en) * | 1989-12-05 | 1994-11-15 | Vical, Inc. | Synthetic calcitonin peptides |
| US5175146A (en) | 1989-12-05 | 1992-12-29 | Vical, Inc. | Synthetic calcitonin peptides |
| US5527771A (en) * | 1991-01-10 | 1996-06-18 | Amylin Pharmaceuticals, Inc. | Methods and Compositions for treatment of diabetes mellitus, hypoglycemia & other conditions |
| US5580953A (en) * | 1991-08-14 | 1996-12-03 | Amylin Pharmaceuticals, Inc. | Amylin antagonist peptides and uses therefor |
| US5527790A (en) | 1991-09-30 | 1996-06-18 | The University Of British Columbia | Bis(maltolato)oxovanadium compositions for the treatment of elevated blood sugar |
| JPH083196A (ja) * | 1994-06-21 | 1996-01-09 | Sanwa Kagaku Kenkyusho Co Ltd | カルシトニン誘導体及びその用途 |
| EP0726075A1 (en) * | 1995-02-08 | 1996-08-14 | Therapicon Srl | Pharmaceutical non-inorganic saline solutions for endonasal administration |
| US5739106A (en) * | 1995-06-07 | 1998-04-14 | Rink; Timothy J. | Appetite regulating compositions |
| WO1997008133A1 (fr) * | 1995-08-22 | 1997-03-06 | Japan Tobacco Inc. | Composes amide et leur utilisation |
| DK2088188T3 (da) | 1997-04-16 | 2012-01-02 | Unigene Lab Inc | Direkte ekspression af peptider i dyrkningsmedier |
| US6083480A (en) * | 1997-05-01 | 2000-07-04 | Diatide, Inc. | Calcitonin receptor binding reagents |
| US6086018A (en) | 1997-12-09 | 2000-07-11 | Mcdonnell Douglas Corporation | Interlocking assembly system for an aircraft cabin |
| JP2000290295A (ja) * | 1999-03-31 | 2000-10-17 | Asahi Chem Ind Co Ltd | Ｎ−アセチルグルコサミニルカルシトニン |
| CN1274830C (zh) * | 2001-12-14 | 2006-09-13 | 中国农业科学院生物技术研究所 | 一种新型鲑鱼降钙素类似物及其在植物油体中表达的方法 |
| EP2233497A3 (en) * | 2004-02-11 | 2011-01-12 | Amylin Pharmaceuticals, Inc. | Amylin family peptides and methods for making and using them |
| CN1980954A (zh) * | 2004-02-11 | 2007-06-13 | 安米林药品公司 | 胰岛淀粉样多肽家族肽及其制备和使用方法 |
| US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
| GB0422644D0 (en) | 2004-10-12 | 2004-11-10 | Novartis Ag | Organic compounds |
| US8394765B2 (en) * | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| US7445911B2 (en) | 2004-11-24 | 2008-11-04 | Unigene Laboratories Inc. | Enzymatic reactions in the presence of keto acids |
| EP2258382A3 (en) * | 2005-03-31 | 2014-05-14 | Amylin Pharmaceuticals, LLC | Amylin and amylin agonists for treating psychiatric diseases and disorders |
| CN101287840B (zh) | 2005-06-24 | 2013-04-10 | 尤尼基因实验室公司 | 表达在酰胺化产物的制备中有用的酶的细胞系 |
| US8377863B2 (en) | 2007-05-29 | 2013-02-19 | Unigene Laboratories Inc. | Peptide pharmaceutical for oral delivery |
| JP5753097B2 (ja) | 2009-01-22 | 2015-07-22 | ユニジーン・ラボラトリーズ・インコーポレーテッド | 肥満の治療 |
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| EP2389388A4 (en) | 2013-08-21 |
| US9394342B2 (en) | 2016-07-19 |
| US20140073561A1 (en) | 2014-03-13 |
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| EP2389388A2 (en) | 2011-11-30 |
| WO2010085700A3 (en) | 2010-09-23 |
| US8497347B2 (en) | 2013-07-30 |
| JP2012515794A (ja) | 2012-07-12 |
| CA2750035C (en) | 2018-02-27 |
| US8076291B2 (en) | 2011-12-13 |
| US20100311650A1 (en) | 2010-12-09 |
| CN102292346A (zh) | 2011-12-21 |
| US20120142586A1 (en) | 2012-06-07 |
| WO2010085700A2 (en) | 2010-07-29 |
| EP2389388B1 (en) | 2017-03-08 |
| CA2750035A1 (en) | 2010-07-29 |
| US8378067B2 (en) | 2013-02-19 |
| US20120302497A1 (en) | 2012-11-29 |
| KR20110119707A (ko) | 2011-11-02 |
| AU2010206614B2 (en) | 2015-03-26 |
| CN102292346B (zh) | 2015-12-02 |
| AU2010206614A1 (en) | 2011-08-04 |
| US20120149635A1 (en) | 2012-06-14 |
| BRPI1006943A2 (pt) | 2021-06-15 |
| US20160354434A1 (en) | 2016-12-08 |
| US8217139B2 (en) | 2012-07-10 |
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