CA2747760C - Engrailed-2 (en2) biomarker for bladder cancer - Google Patents

Engrailed-2 (en2) biomarker for bladder cancer Download PDF

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Publication number
CA2747760C
CA2747760C CA2747760A CA2747760A CA2747760C CA 2747760 C CA2747760 C CA 2747760C CA 2747760 A CA2747760 A CA 2747760A CA 2747760 A CA2747760 A CA 2747760A CA 2747760 C CA2747760 C CA 2747760C
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CA
Canada
Prior art keywords
biomarker
bladder cancer
patient
determining
stage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2747760A
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English (en)
French (fr)
Other versions
CA2747760A1 (en
Inventor
Richard Morgan
Hardev S. Pandha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Surrey
Original Assignee
University of Surrey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CA2747760A1 publication Critical patent/CA2747760A1/en
Application granted granted Critical
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Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA2747760A 2008-12-23 2009-12-21 Engrailed-2 (en2) biomarker for bladder cancer Active CA2747760C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0823445.2 2008-12-23
GBGB0823445.2A GB0823445D0 (en) 2008-12-23 2008-12-23 Biomarker
PCT/GB2009/002926 WO2010073001A1 (en) 2008-12-23 2009-12-21 Biomarker

Publications (2)

Publication Number Publication Date
CA2747760A1 CA2747760A1 (en) 2010-07-01
CA2747760C true CA2747760C (en) 2020-01-21

Family

ID=40344114

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2747760A Active CA2747760C (en) 2008-12-23 2009-12-21 Engrailed-2 (en2) biomarker for bladder cancer

Country Status (15)

Country Link
US (1) US9624548B2 (enExample)
EP (1) EP2382327B1 (enExample)
JP (1) JP5947040B2 (enExample)
CN (1) CN102301006B (enExample)
AU (1) AU2009332712B2 (enExample)
BR (1) BRPI0923525A2 (enExample)
CA (1) CA2747760C (enExample)
ES (1) ES2725150T3 (enExample)
GB (1) GB0823445D0 (enExample)
IL (1) IL213510A (enExample)
MX (1) MX343251B (enExample)
NZ (1) NZ593392A (enExample)
RU (1) RU2573925C2 (enExample)
WO (1) WO2010073001A1 (enExample)
ZA (1) ZA201105184B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
JP5940093B2 (ja) 2011-01-19 2016-06-29 カンタージア アクチエボラーグ 抗ｉｌ−１ｒａｐ抗体及びヒトを処置するためのそれらの使用
EP3479102A1 (en) * 2016-07-04 2019-05-08 CellTool GmbH Device and method for the determination of transfection
KR101777085B1 (ko) * 2017-02-23 2017-09-11 주식회사 성균바이오텍 En2 단백질의 면역원성 단편 펩타이드 또는 이를 특이적으로 인식하는 항체 조성물
KR101923199B1 (ko) 2018-04-25 2018-11-28 주식회사 무진메디 펩스타틴 a를 함유하는 소변 내 en2 진단용 조성물
US20220389514A1 (en) 2019-10-02 2022-12-08 Kyushu University, National University Corporation Biomarker, method, kit and array for predicting therapeutic effects of bcg intravesical infusion therapy in treating bladder cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2469089A1 (en) * 2003-07-08 2005-01-08 Institut De Recherches Cliniques De Montreal En-2 gene, disgnostic and therapeutic uses thereof
US7998695B2 (en) * 2005-02-10 2011-08-16 Oncotherapy Science, Inc. Method of diagnosing bladder cancer
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
PL2258871T3 (pl) * 2007-01-19 2014-10-31 Epigenomics Ag Sposoby i kwasy nukleinowe do analizy zaburzeń proliferacyjnych komórki
US20110003292A1 (en) 2007-12-11 2011-01-06 Dimo Dietrich Methods and nucleic acids for analyses of cell proliferative disorders

Also Published As

Publication number Publication date
WO2010073001A1 (en) 2010-07-01
GB0823445D0 (en) 2009-01-28
EP2382327A1 (en) 2011-11-02
CN102301006B (zh) 2015-07-15
MX343251B (es) 2016-10-31
IL213510A (en) 2016-04-21
RU2011130795A (ru) 2013-01-27
EP2382327B1 (en) 2019-02-13
RU2573925C2 (ru) 2016-01-27
NZ593392A (en) 2013-05-31
JP2012513584A (ja) 2012-06-14
MX2011006773A (es) 2011-08-03
ZA201105184B (en) 2012-02-29
BRPI0923525A2 (pt) 2020-08-11
US20120020888A1 (en) 2012-01-26
IL213510A0 (en) 2011-07-31
CA2747760A1 (en) 2010-07-01
ES2725150T3 (es) 2019-09-19
US9624548B2 (en) 2017-04-18
JP5947040B2 (ja) 2016-07-06
CN102301006A (zh) 2011-12-28
AU2009332712A1 (en) 2011-07-07
AU2009332712B2 (en) 2015-05-28

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Legal Events

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EEER Examination request

Effective date: 20141208

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20240802