CA2747760C - Engrailed-2 (en2) biomarker for bladder cancer - Google Patents

Engrailed-2 (en2) biomarker for bladder cancer Download PDF

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Publication number
CA2747760C
CA2747760C CA2747760A CA2747760A CA2747760C CA 2747760 C CA2747760 C CA 2747760C CA 2747760 A CA2747760 A CA 2747760A CA 2747760 A CA2747760 A CA 2747760A CA 2747760 C CA2747760 C CA 2747760C
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Canada
Prior art keywords
biomarker
bladder cancer
patient
determining
stage
Prior art date
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Active
Application number
CA2747760A
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English (en)
French (fr)
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CA2747760A1 (en
Inventor
Richard Morgan
Hardev S. Pandha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Surrey
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University of Surrey
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Publication of CA2747760A1 publication Critical patent/CA2747760A1/en
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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA2747760A 2008-12-23 2009-12-21 Engrailed-2 (en2) biomarker for bladder cancer Active CA2747760C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0823445.2 2008-12-23
GBGB0823445.2A GB0823445D0 (en) 2008-12-23 2008-12-23 Biomarker
PCT/GB2009/002926 WO2010073001A1 (en) 2008-12-23 2009-12-21 Biomarker

Publications (2)

Publication Number Publication Date
CA2747760A1 CA2747760A1 (en) 2010-07-01
CA2747760C true CA2747760C (en) 2020-01-21

Family

ID=40344114

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2747760A Active CA2747760C (en) 2008-12-23 2009-12-21 Engrailed-2 (en2) biomarker for bladder cancer

Country Status (15)

Country Link
US (1) US9624548B2 (enExample)
EP (1) EP2382327B1 (enExample)
JP (1) JP5947040B2 (enExample)
CN (1) CN102301006B (enExample)
AU (1) AU2009332712B2 (enExample)
BR (1) BRPI0923525A2 (enExample)
CA (1) CA2747760C (enExample)
ES (1) ES2725150T3 (enExample)
GB (1) GB0823445D0 (enExample)
IL (1) IL213510A (enExample)
MX (1) MX343251B (enExample)
NZ (1) NZ593392A (enExample)
RU (1) RU2573925C2 (enExample)
WO (1) WO2010073001A1 (enExample)
ZA (1) ZA201105184B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
EP3508498A1 (en) 2011-01-19 2019-07-10 Cantargia AB Novel agents and uses thereof
US11371941B2 (en) * 2016-07-04 2022-06-28 Celltool Gmbh Device and method for the determination of transfection
KR101777085B1 (ko) * 2017-02-23 2017-09-11 주식회사 성균바이오텍 En2 단백질의 면역원성 단편 펩타이드 또는 이를 특이적으로 인식하는 항체 조성물
KR101923199B1 (ko) 2018-04-25 2018-11-28 주식회사 무진메디 펩스타틴 a를 함유하는 소변 내 en2 진단용 조성물
EP4043583A4 (en) 2019-10-02 2023-11-08 Kyushu University, National University Corporation Biomarker, method, kit and array for predicting therapeutic effects of bcg intravesical infusion therapy in treating bladder cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2469089A1 (en) 2003-07-08 2005-01-08 Institut De Recherches Cliniques De Montreal En-2 gene, disgnostic and therapeutic uses thereof
EP2295601A1 (en) * 2005-02-10 2011-03-16 Oncotherapy Science, Inc. Method of diagnosing bladder cancer
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
ES2384071T3 (es) * 2007-01-19 2012-06-29 Epigenomics Ag Métodos y ácidos nucleicos para análisis de trastornos proliferativos celulares
JP5694776B2 (ja) 2007-12-11 2015-04-01 エピゲノミクス アーゲー 細胞増殖性障害の解析のための方法及び核酸

Also Published As

Publication number Publication date
CA2747760A1 (en) 2010-07-01
MX2011006773A (es) 2011-08-03
US20120020888A1 (en) 2012-01-26
NZ593392A (en) 2013-05-31
IL213510A0 (en) 2011-07-31
ES2725150T3 (es) 2019-09-19
CN102301006B (zh) 2015-07-15
AU2009332712B2 (en) 2015-05-28
ZA201105184B (en) 2012-02-29
US9624548B2 (en) 2017-04-18
AU2009332712A1 (en) 2011-07-07
GB0823445D0 (en) 2009-01-28
JP5947040B2 (ja) 2016-07-06
JP2012513584A (ja) 2012-06-14
WO2010073001A1 (en) 2010-07-01
EP2382327B1 (en) 2019-02-13
MX343251B (es) 2016-10-31
CN102301006A (zh) 2011-12-28
RU2573925C2 (ru) 2016-01-27
BRPI0923525A2 (pt) 2020-08-11
IL213510A (en) 2016-04-21
EP2382327A1 (en) 2011-11-02
RU2011130795A (ru) 2013-01-27

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Effective date: 20141208