CA2743753A1 - Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus - Google Patents
Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus Download PDFInfo
- Publication number
- CA2743753A1 CA2743753A1 CA2743753A CA2743753A CA2743753A1 CA 2743753 A1 CA2743753 A1 CA 2743753A1 CA 2743753 A CA2743753 A CA 2743753A CA 2743753 A CA2743753 A CA 2743753A CA 2743753 A1 CA2743753 A1 CA 2743753A1
- Authority
- CA
- Canada
- Prior art keywords
- granule
- active ingredients
- sucrose
- group
- macrogolglycerides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008187 granular material Substances 0.000 title claims abstract 13
- 238000000034 method Methods 0.000 title claims 6
- 239000004480 active ingredient Substances 0.000 claims abstract 9
- 239000011248 coating agent Substances 0.000 claims abstract 5
- 239000007787 solid Substances 0.000 claims abstract 4
- 238000000576 coating method Methods 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 239000000419 plant extract Substances 0.000 claims abstract 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
- 229930006000 Sucrose Natural products 0.000 claims 5
- 239000005720 sucrose Substances 0.000 claims 5
- 229920005862 polyol Polymers 0.000 claims 4
- 150000003077 polyols Chemical group 0.000 claims 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- 229920001800 Shellac Polymers 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 229920002678 cellulose Polymers 0.000 claims 3
- 235000010980 cellulose Nutrition 0.000 claims 3
- 238000010410 dusting Methods 0.000 claims 3
- 125000005456 glyceride group Chemical group 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 239000004208 shellac Substances 0.000 claims 3
- 235000013874 shellac Nutrition 0.000 claims 3
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 3
- 229940113147 shellac Drugs 0.000 claims 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 2
- 239000001506 calcium phosphate Substances 0.000 claims 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 2
- 229940038472 dicalcium phosphate Drugs 0.000 claims 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 229960001375 lactose Drugs 0.000 claims 2
- 239000000845 maltitol Substances 0.000 claims 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 2
- 235000010449 maltitol Nutrition 0.000 claims 2
- 229940035436 maltitol Drugs 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 150000004760 silicates Chemical class 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 235000010356 sorbitol Nutrition 0.000 claims 2
- 229960002920 sorbitol Drugs 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000000811 xylitol Substances 0.000 claims 2
- 235000010447 xylitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 2
- 229960002675 xylitol Drugs 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Chemical class 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 241000978776 Senegalia senegal Species 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 235000015778 magnesium gluconate Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 125000005395 methacrylic acid group Chemical group 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 229920001223 polyethylene glycol Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- Glanulating (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0857764 | 2008-11-14 | ||
| FR0857764A FR2938432B1 (fr) | 2008-11-14 | 2008-11-14 | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus |
| PCT/FR2009/052180 WO2010055268A1 (fr) | 2008-11-14 | 2009-11-13 | Nouveau procédé de préparation de granulés de principes actifs, et granulés tels qu'obtenus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2743753A1 true CA2743753A1 (fr) | 2010-05-20 |
Family
ID=40348849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2743753A Abandoned CA2743753A1 (fr) | 2008-11-14 | 2009-11-13 | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20110280945A1 (https=) |
| EP (1) | EP2349226A1 (https=) |
| JP (1) | JP5608681B2 (https=) |
| KR (1) | KR101585705B1 (https=) |
| CN (1) | CN102223879A (https=) |
| AR (1) | AR074330A1 (https=) |
| AU (1) | AU2009315449B2 (https=) |
| BR (1) | BRPI0916019A2 (https=) |
| CA (1) | CA2743753A1 (https=) |
| CL (1) | CL2011001115A1 (https=) |
| CO (1) | CO6382108A2 (https=) |
| CU (1) | CU20110107A7 (https=) |
| EA (1) | EA201100757A1 (https=) |
| FR (1) | FR2938432B1 (https=) |
| IL (1) | IL212850A0 (https=) |
| MA (1) | MA32789B1 (https=) |
| MX (1) | MX2011005072A (https=) |
| NZ (1) | NZ592857A (https=) |
| PE (1) | PE20110945A1 (https=) |
| SG (1) | SG195651A1 (https=) |
| TN (1) | TN2011000235A1 (https=) |
| TW (1) | TWI522113B (https=) |
| UA (1) | UA103781C2 (https=) |
| WO (1) | WO2010055268A1 (https=) |
| ZA (1) | ZA201103543B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2971422B1 (fr) * | 2011-02-11 | 2016-05-20 | Debregeas Et Associes Pharma | Granules d'acide gamma-hydroxybutyrique |
| US9241956B2 (en) * | 2012-11-05 | 2016-01-26 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
| US20140127296A1 (en) * | 2012-11-05 | 2014-05-08 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
| US11058635B1 (en) * | 2020-10-15 | 2021-07-13 | King Abdulaziz University | Oral administration of 5-FU in a gelling nanosuspension for targeted delivery to treat colorectal cancers |
| KR20240157168A (ko) * | 2023-04-24 | 2024-11-01 | 주식회사 케이티앤지 | 바인더를 사용하는 파우치 충진 물질의 제조 방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6327424A (ja) * | 1986-07-17 | 1988-02-05 | Shionogi & Co Ltd | 徐放性製剤およびその製造法 |
| JP2820829B2 (ja) * | 1991-03-07 | 1998-11-05 | 武田薬品工業株式会社 | 有核散剤およびその製造方法 |
| JPH08310969A (ja) * | 1995-05-22 | 1996-11-26 | Lion Corp | 固形薬品組成物及びその製造方法 |
| FR2790668B1 (fr) * | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
| BR0010649A (pt) * | 1999-05-17 | 2002-02-19 | D B F | Grãnulos que contêm pelo menos uma substância vegetal e processo de preparação dos mesmos |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| US9247765B2 (en) * | 2004-01-14 | 2016-02-02 | Omniactive Health Technologies Limited | Stable beadlets of lipophilic nutrients |
| FR2880541B1 (fr) * | 2005-01-10 | 2008-02-22 | Amalric Veret | Une nouvelle formule de plantes sous forme de micro-granules de xilitol pour renforcer les effets des plantes et leurs proprietes par une meilleure assimilation |
| US20060182796A1 (en) * | 2005-02-03 | 2006-08-17 | Abrika Pharmaceuticals, Inc. | Taste masked pharmaceutical compositions |
| RU2434630C2 (ru) * | 2006-08-31 | 2011-11-27 | Юранд, Инк. | Системы доставки лекарственных средств, включающие в себя твердые растворы слабоосновных лекарственных средств |
| JP5215684B2 (ja) * | 2007-02-14 | 2013-06-19 | 大日精化工業株式会社 | 有機顔料の分散剤およびその使用 |
| US20090004281A1 (en) * | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
-
2008
- 2008-11-14 FR FR0857764A patent/FR2938432B1/fr not_active Expired - Fee Related
-
2009
- 2009-11-13 UA UAA201105988A patent/UA103781C2/uk unknown
- 2009-11-13 EA EA201100757A patent/EA201100757A1/ru unknown
- 2009-11-13 BR BRPI0916019A patent/BRPI0916019A2/pt not_active Application Discontinuation
- 2009-11-13 EP EP09768187A patent/EP2349226A1/fr not_active Withdrawn
- 2009-11-13 NZ NZ592857A patent/NZ592857A/xx not_active IP Right Cessation
- 2009-11-13 SG SG2013082482A patent/SG195651A1/en unknown
- 2009-11-13 MX MX2011005072A patent/MX2011005072A/es active IP Right Grant
- 2009-11-13 CA CA2743753A patent/CA2743753A1/fr not_active Abandoned
- 2009-11-13 US US13/129,028 patent/US20110280945A1/en not_active Abandoned
- 2009-11-13 JP JP2011543800A patent/JP5608681B2/ja not_active Expired - Fee Related
- 2009-11-13 KR KR1020117013588A patent/KR101585705B1/ko not_active Expired - Fee Related
- 2009-11-13 CN CN2009801457596A patent/CN102223879A/zh active Pending
- 2009-11-13 AR ARP090104388A patent/AR074330A1/es unknown
- 2009-11-13 WO PCT/FR2009/052180 patent/WO2010055268A1/fr not_active Ceased
- 2009-11-13 AU AU2009315449A patent/AU2009315449B2/en not_active Ceased
- 2009-11-13 PE PE2011001032A patent/PE20110945A1/es not_active Application Discontinuation
- 2009-11-16 TW TW098138860A patent/TWI522113B/zh not_active IP Right Cessation
-
2011
- 2011-05-12 IL IL212850A patent/IL212850A0/en unknown
- 2011-05-12 TN TN2011000235A patent/TN2011000235A1/fr unknown
- 2011-05-13 CO CO11059023A patent/CO6382108A2/es not_active Application Discontinuation
- 2011-05-13 CU CU20110107A patent/CU20110107A7/es unknown
- 2011-05-13 CL CL2011001115A patent/CL2011001115A1/es unknown
- 2011-05-13 MA MA33837A patent/MA32789B1/fr unknown
- 2011-05-13 ZA ZA2011/03543A patent/ZA201103543B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR074330A1 (es) | 2011-01-05 |
| JP2012508786A (ja) | 2012-04-12 |
| EP2349226A1 (fr) | 2011-08-03 |
| JP5608681B2 (ja) | 2014-10-15 |
| IL212850A0 (en) | 2011-07-31 |
| CN102223879A (zh) | 2011-10-19 |
| AU2009315449B2 (en) | 2015-03-26 |
| PE20110945A1 (es) | 2012-02-01 |
| KR101585705B1 (ko) | 2016-01-15 |
| AU2009315449A1 (en) | 2010-05-20 |
| TW201029667A (en) | 2010-08-16 |
| TWI522113B (zh) | 2016-02-21 |
| CU20110107A7 (es) | 2012-01-31 |
| ZA201103543B (en) | 2012-01-25 |
| MA32789B1 (fr) | 2011-11-01 |
| BRPI0916019A2 (pt) | 2015-11-10 |
| MX2011005072A (es) | 2011-10-03 |
| TN2011000235A1 (fr) | 2012-12-17 |
| CL2011001115A1 (es) | 2011-11-11 |
| UA103781C2 (uk) | 2013-11-25 |
| WO2010055268A1 (fr) | 2010-05-20 |
| NZ592857A (en) | 2013-07-26 |
| US20110280945A1 (en) | 2011-11-17 |
| FR2938432A1 (fr) | 2010-05-21 |
| CO6382108A2 (es) | 2012-02-15 |
| EA201100757A1 (ru) | 2011-12-30 |
| FR2938432B1 (fr) | 2011-05-20 |
| SG195651A1 (en) | 2013-12-30 |
| KR20110095888A (ko) | 2011-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2743767A1 (fr) | Nouvelle composition a base d'acide gamma-hydroxybutyrique | |
| CA2743753A1 (fr) | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus | |
| EP2568974B1 (fr) | Forme pharmaceutique orale alcoolo-resistante | |
| CA2771053C (fr) | Microgranules flottants | |
| EP1126829B1 (fr) | Particules enrobees d'ibuprofene cristallin granule | |
| CA2375600A1 (fr) | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif | |
| JP5954890B2 (ja) | ２−オキソ−１−ピロリジン誘導体を含む持続放出製剤 | |
| CA2367755A1 (en) | Dimeric compounds and their use as inhibitors of neuraminidase | |
| JP2026027401A (ja) | フェニル酪酸ナトリウムを含む口当たりの良い組成物及びその使用 | |
| EP0937085A1 (fr) | Le (-)hydroxycitrate de magnesium, procede de preparation, applications, et compositions notamment pharmaceutiques le renfermant | |
| RS61239B1 (sr) | Inhibitori aldozne reduktaze i postupci korišćenja | |
| FR2557878A1 (fr) | Compose antibiotique, procede pour le preparer et compositions le contenant | |
| MA29554B1 (fr) | Nouveaux derives d'amide d'acide piperidine carboxylique | |
| US5424301A (en) | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents | |
| CN109415400A (zh) | (+)表儿茶素及其类似物的用途 | |
| JP2015143256A (ja) | ２−オキソ−１−ピロリジン誘導体を含む持続放出製剤 | |
| FR2821745A1 (fr) | Granules et granules enrobes au gout masque | |
| WO2005097763A3 (en) | 1,3,4-oxadiazol-2-ones as ppar delta | |
| CA2622822A1 (en) | Controlled release pharmaceutical composition of venlafaxine hydrochloride, and process for preparation thereof | |
| CN119504753A (zh) | 一种芳香稠环亚胺类化合物及其制备方法和应用 | |
| HUT75962A (en) | A ranitidine tablet having a hydroxypropylmethycellulose containing coating and a method for producing said coating | |
| US20070123568A1 (en) | Therapeutic methods using prostaglandin EP4 agonist components | |
| AU2020368463A1 (en) | Compositions comprising quinone and/or quinol and methods of preparations and use thereof | |
| FR2821747A1 (fr) | Suspension de telithromycine a gout masque | |
| KR20190131792A (ko) | 퓨라노칼 콘을 유효성분으로 포함하는 신경 질환의 예방 또는 치료용 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20141029 |
|
| FZDE | Discontinued |
Effective date: 20180419 |