CA2736353A1 - Mesenchymal stromal cell populations and methods of isolating and using same - Google Patents

Mesenchymal stromal cell populations and methods of isolating and using same Download PDF

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Publication number
CA2736353A1
CA2736353A1 CA2736353A CA2736353A CA2736353A1 CA 2736353 A1 CA2736353 A1 CA 2736353A1 CA 2736353 A CA2736353 A CA 2736353A CA 2736353 A CA2736353 A CA 2736353A CA 2736353 A1 CA2736353 A1 CA 2736353A1
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CA
Canada
Prior art keywords
population
cells
mesenchymal stromal
mscs
stromal cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2736353A
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English (en)
French (fr)
Inventor
Claudia Lange
Christopher Westenfelder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALLOCURE Inc
Original Assignee
ALLOCURE
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Filing date
Publication date
Application filed by ALLOCURE filed Critical ALLOCURE
Publication of CA2736353A1 publication Critical patent/CA2736353A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • C12N2500/84Undefined extracts from animals from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2736353A 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same Abandoned CA2736353A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8603308P 2008-08-04 2008-08-04
US61/086,033 2008-08-04
PCT/US2009/052733 WO2010017216A2 (en) 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same

Publications (1)

Publication Number Publication Date
CA2736353A1 true CA2736353A1 (en) 2010-02-11

Family

ID=41664170

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2736353A Abandoned CA2736353A1 (en) 2008-08-04 2009-08-04 Mesenchymal stromal cell populations and methods of isolating and using same

Country Status (6)

Country Link
US (1) US20110293576A1 (cg-RX-API-DMAC7.html)
EP (1) EP2321408A4 (cg-RX-API-DMAC7.html)
JP (1) JP2011529706A (cg-RX-API-DMAC7.html)
AU (1) AU2009279736A1 (cg-RX-API-DMAC7.html)
CA (1) CA2736353A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010017216A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12410405B2 (en) 2010-10-08 2025-09-09 Mesoblast International Sàrl Enhanced MSC preparations
US12473547B2 (en) 2017-11-22 2025-11-18 Mesoblast International Sàrl Use of mesenchymal lineage precursor cells or stem cells (MLPSCs) for delivery of oligonucleotides in the treatment of cancer

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EP3266453A1 (en) 2008-07-03 2018-01-10 Mayo Foundation for Medical Education and Research Treating cancer
WO2010033605A2 (en) 2008-09-16 2010-03-25 Mayo Foundation For Medical Education And Research Compositions containing platelet contents
US20120269779A1 (en) * 2009-10-30 2012-10-25 Allocure, Inc. Mesenchymal stromal cell populations and methods of using same
ES2897598T3 (es) * 2009-11-27 2022-03-01 Stempeutics Res Pvt Ltd Métodos de preparación de células madre mesenquimales, composiciones y kit de las mismas
US20130121972A1 (en) 2010-06-01 2013-05-16 Rouzbeh R. Taghizadeh Native wharton's jelly stem cells and their purification
AU2012253571A1 (en) 2011-05-09 2014-01-09 Mayo Foundation For Medical Education And Research Cancer treatments
CN107746830A (zh) 2011-07-06 2018-03-02 细胞治疗有限公司 从富血小板血浆制备血小板裂解物的方法
EP2776578A1 (en) 2011-11-09 2014-09-17 Allocure, Inc. Assay for the prediction of therapeutic effectiveness or potency of mesenchymal stem cells, and methods of using same
CN104136034B (zh) * 2011-11-30 2018-04-24 安斯泰来再生医药协会 间充质基质细胞及其相关用途
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
WO2013166026A1 (en) 2012-04-30 2013-11-07 Allocure, Inc. Methods of treating acute kidney injury using mesenchymal stem cells
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
AU2013327638B2 (en) 2012-10-01 2018-06-14 Mayo Foundation For Medical Education And Research Cancer treatments
WO2014193895A1 (en) 2013-05-29 2014-12-04 Allocure, Inc. Ex vivo perfusion of donor organs prior to transplantation using mesenchymal stem cells
EP3028052B1 (en) * 2013-08-01 2017-11-01 Fundación Pública Andaluza Progreso Y Salud Method for predicting treatment response and test for safe use of mesenchymal stem cells on inflammatory diseases.
CA3138143A1 (en) 2014-05-16 2015-11-19 Mayo Foundation For Medical Education And Research Cell culture media compositions for primary cells
AU2015274408A1 (en) 2014-06-13 2017-01-12 Mayo Foundation For Medical Education And Research Treating lymphomas
EA201692502A1 (ru) 2014-06-16 2017-09-29 Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч Лечение миелом
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
TW201707725A (zh) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 載體-抗體組合物及其製造及使用方法
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
WO2017120501A1 (en) 2016-01-07 2017-07-13 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon
WO2017139698A1 (en) 2016-02-12 2017-08-17 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
CA3018341A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for reducing toxicity of a chemotherapeutic drug
US11878061B2 (en) 2016-03-21 2024-01-23 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
US11160876B2 (en) 2016-09-01 2021-11-02 Mayo Foundation For Medical Education And Research Methods and compositions for targeting t-cell cancers
AU2017318668A1 (en) 2016-09-01 2019-03-21 Mayo Foundation For Medical Education And Research Carrier-PD-L1 binding agent compositions for treating cancers
WO2018048815A1 (en) 2016-09-06 2018-03-15 Nantibodyfc, Llc Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
MX2019002564A (es) 2016-09-06 2019-09-18 Mayo Found Medical Education & Res Composiciones de agente de unión de albúmina-paclitaxel y métodos de uso y elaboración de las mismas.
KR102486057B1 (ko) 2016-09-06 2023-01-10 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 Pd-l1 발현 암의 치료 방법
US20190060365A1 (en) * 2017-08-25 2019-02-28 Meridigen Biotech Co., Ltd. Pharmaceutical composition for treating chronic obstructive pulmonary disease and method thereof
TWI894151B (zh) 2019-06-11 2025-08-21 美商阿克松根股份有限公司 組織之濕式保存
WO2021065971A1 (ja) * 2019-09-30 2021-04-08 テルモ株式会社 凍結保存細胞の希釈用緩衝液
US20230270791A1 (en) * 2020-07-31 2023-08-31 Rainbow (Rainbow Inc.) Platelet lysate derived from autologous platelets
EP4316498A4 (en) 2021-03-30 2025-03-26 Kaneka Corporation Trypsin inhibition method, and method for producing cell preparation in which same is used

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0501462L (sv) * 2005-06-23 2006-09-26 Proliff Ab Förfarande för framställning av blodplättslysat
EP2069479A1 (en) * 2006-09-18 2009-06-17 Medizinische Universität Graz Plasma-free platelet lysate for use as a supplement in cell cultures and for the preparation of cell therapeutics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12410405B2 (en) 2010-10-08 2025-09-09 Mesoblast International Sàrl Enhanced MSC preparations
US12473547B2 (en) 2017-11-22 2025-11-18 Mesoblast International Sàrl Use of mesenchymal lineage precursor cells or stem cells (MLPSCs) for delivery of oligonucleotides in the treatment of cancer

Also Published As

Publication number Publication date
WO2010017216A8 (en) 2010-09-30
WO2010017216A2 (en) 2010-02-11
WO2010017216A3 (en) 2010-06-17
AU2009279736A1 (en) 2010-02-11
EP2321408A2 (en) 2011-05-18
JP2011529706A (ja) 2011-12-15
EP2321408A4 (en) 2013-04-17
US20110293576A1 (en) 2011-12-01

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Effective date: 20150804