CA2736243A1 - Multi-stage, regression-based pcr analysis system - Google Patents

Multi-stage, regression-based pcr analysis system Download PDF

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Publication number
CA2736243A1
CA2736243A1 CA2736243A CA2736243A CA2736243A1 CA 2736243 A1 CA2736243 A1 CA 2736243A1 CA 2736243 A CA2736243 A CA 2736243A CA 2736243 A CA2736243 A CA 2736243A CA 2736243 A1 CA2736243 A1 CA 2736243A1
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Prior art keywords
function
derivative
amplification
data
baseline
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Abandoned
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CA2736243A
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English (en)
French (fr)
Inventor
Jeffrey Lerner
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Bio Rad Laboratories Inc
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Bio Rad Laboratories Inc
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Publication of CA2736243A1 publication Critical patent/CA2736243A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Data Mining & Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Computational Mathematics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Algebra (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2736243A 2008-09-09 2009-09-09 Multi-stage, regression-based pcr analysis system Abandoned CA2736243A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9541008P 2008-09-09 2008-09-09
US61/095,410 2008-09-09
PCT/US2009/056384 WO2010030686A1 (en) 2008-09-09 2009-09-09 Multi-stage, regression-based pcr analysis system

Publications (1)

Publication Number Publication Date
CA2736243A1 true CA2736243A1 (en) 2010-03-18

Family

ID=42005454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2736243A Abandoned CA2736243A1 (en) 2008-09-09 2009-09-09 Multi-stage, regression-based pcr analysis system

Country Status (6)

Country Link
US (3) US8285489B2 (https=)
EP (1) EP2326949A1 (https=)
JP (1) JP5166608B2 (https=)
CN (1) CN102187215A (https=)
CA (1) CA2736243A1 (https=)
WO (1) WO2010030686A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3926636A2 (de) 2020-06-18 2021-12-22 Analytik Jena GmbH Verfahren zum erkennen einer amplifikationsphase in einer amplifikation
US20220082550A1 (en) * 2017-10-12 2022-03-17 Carrot, Inc. Breath sensor apparatus and methods of use
US11957451B2 (en) 2019-12-31 2024-04-16 Pivot Health Technologies Inc. Breath sensor calibration methods and apparatus

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WO2010030686A1 (en) * 2008-09-09 2010-03-18 Bio-Rad Laboratories, Inc. Multi-stage, regression-based pcr analysis system
EP2475987B1 (en) 2009-09-12 2021-12-15 Azure Vault Ltd Identifying transition points in chemical reactions
EP2558971B1 (en) * 2010-04-11 2021-02-17 Life Technologies Corporation SYSTEMS AND METHODS FOR MODEL-BASED qPCR
US8666673B2 (en) 2010-05-14 2014-03-04 Biomerieux, Inc Identification and/or characterization of a microbial agent using taxonomic hierarchical classification
US9988675B2 (en) 2011-03-15 2018-06-05 Azure Vault Ltd. Rate based identification of reaction points
AU2013203281A1 (en) * 2012-02-03 2013-08-22 Axxin Pty Ltd Nucleic acid amplification and detection apparatus and method
US10475527B2 (en) 2012-03-22 2019-11-12 Biomerieux, Inc. Method and system for detection of microbial growth in a specimen container
US9932629B2 (en) 2012-06-26 2018-04-03 Axxin Pty Ltd Nucleic acid amplification and detection kit
US9607128B2 (en) 2013-12-30 2017-03-28 Roche Molecular Systems, Inc. Detection and correction of jumps in real-time PCR signals
KR20160039529A (ko) * 2014-10-01 2016-04-11 주식회사 씨젠 증폭곡선을 보정하는 방법 및 시료 분석을 위한 정보를 획득하는 방법, 그 기록매체, 그 컴퓨터 프로그램, 컴퓨터 장치
EP3218698B1 (en) 2014-11-14 2020-05-13 Axxin Pty Ltd Biological sample collection and storage assembly
US10470090B2 (en) * 2014-11-14 2019-11-05 Qualcomm Incorporated Data compression techniques for handover and radio link failure recovery
EP3325156A4 (en) 2015-07-17 2019-01-16 Axxin Pty Ltd DIAGNOSTIC TEST ASSEMBLY, APPARATUS, METHOD
EP3353697B1 (en) * 2015-09-24 2025-11-05 Seegene, Inc. Multiple dataset analysis for determining the presence or absence of target analyte
WO2017135756A1 (en) 2016-02-05 2017-08-10 Seegene, Inc. Method for reducing noise level of data set for a target analyte
CN105755159A (zh) * 2016-05-13 2016-07-13 苏州国科闻普生物科技有限公司 自动快速判别荧光定量pcr结果的方法
CN106908655B (zh) * 2017-03-06 2019-06-14 广东顺德工业设计研究院(广东顺德创新设计研究院) 光电信号峰值检测方法与系统
EP3688465B1 (en) 2017-09-27 2025-11-12 Axxin Pty Ltd Diagnostic test system and method
ES2993027T3 (en) * 2017-09-28 2024-12-20 Seegene Inc Method and device for analyzing target analyte in sample
EP3697927B1 (en) * 2017-10-19 2022-12-14 Bio-Rad Laboratories, Inc. Digital amplification assays with unconventional and/or inverse changes in photoluminescence
CN113966535A (zh) 2019-06-14 2022-01-21 Seegene 株式会社 用于协同开发用于检测靶核酸的试剂的计算机实施的方法
CN111931118A (zh) * 2020-08-25 2020-11-13 杭州博日科技股份有限公司 荧光定量熔解实验中熔解曲线测量方法
CN112257754B (zh) * 2020-09-24 2023-07-28 北京航天测控技术有限公司 航天器运行状态的分析方法和装置
EP4421814A4 (en) 2021-10-21 2025-11-12 Seegene Inc APPROVAL AND METHOD FOR READING A POSITIVE/NEGATIVE RESULT WITH RESPECT TO A TARGET TEST SUBSTANCE IN A SAMPLE
CN114058683B (zh) * 2021-11-17 2022-09-30 杭州优思达生物技术有限公司 一种核酸扩增结果判定方法
CN114065120B (zh) * 2022-01-14 2022-04-19 深圳市刚竹医疗科技有限公司 测定pcr的直线-s形生长曲线的循环阈值的方法
KR20250020611A (ko) 2022-07-05 2025-02-11 주식회사 씨젠 복수의 표적 분석물 각각에 대한 근사 신호의 획득 방법 및 이를 수행하는 컴퓨터 장치
IL320357A (en) 2022-10-20 2025-06-01 Seegene Inc Method of guiding multiple detailed performance experiments required for developing reagent for detecting target nucleic acid molecule, and organizing experiment result record sheets
KR20250124154A (ko) 2023-01-05 2025-08-19 주식회사 씨젠 분자진단 분석 결과의 획득 방법, 분자진단 분석 결과를 추정하는 모델의 획득 방법 및 이를 수행하는 컴퓨터 장치
CN117106862A (zh) * 2023-01-19 2023-11-24 江苏普瑞悉恩生物科技有限公司 核酸样本检测定量方法及装置、存储介质及电子设备
CN116564411B (zh) * 2023-07-12 2023-09-29 广州普世君安生物科技有限公司 等温扩增核酸的结果判定方法、系统、设备及存储介质
WO2026005528A1 (ko) * 2024-06-28 2026-01-02 주식회사 씨젠 시료 내 타겟 분석물에 대한 데이터 세트의 보정 방법 및 장치

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US5766889A (en) * 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
EP1033411B1 (en) 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
US6783934B1 (en) 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
US7228237B2 (en) 2002-02-07 2007-06-05 Applera Corporation Automatic threshold setting and baseline determination for real-time PCR
EP1335028B1 (en) 2002-02-12 2008-01-16 University of Utah Research Foundation Multi-test analysis of real-time nucleic acid amplifications
US7647187B2 (en) * 2005-05-13 2010-01-12 Bio-Rad Laboratories, Inc. Identifying statistically linear data
JP5091122B2 (ja) * 2005-05-13 2012-12-05 バイオ−ラッド ラボラトリーズ，インコーポレイティド 統計的線形データの同定
US7720611B2 (en) * 2005-05-13 2010-05-18 Bio-Rad Laboratories, Inc. Baselining amplification data
JP5313663B2 (ja) * 2005-05-13 2013-10-09 バイオ−ラッド ラボラトリーズ，インコーポレイティド 増幅データのベースライン化
EP1798650A1 (en) * 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytical method and instrument
US7668663B2 (en) 2005-12-20 2010-02-23 Roche Molecular Systems, Inc. Levenberg-Marquardt outlier spike removal method
WO2010030686A1 (en) * 2008-09-09 2010-03-18 Bio-Rad Laboratories, Inc. Multi-stage, regression-based pcr analysis system

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220082550A1 (en) * 2017-10-12 2022-03-17 Carrot, Inc. Breath sensor apparatus and methods of use
US11796532B2 (en) * 2017-10-12 2023-10-24 Pivot Health Technologies Inc. Breath sensor apparatus and methods of use
US11957451B2 (en) 2019-12-31 2024-04-16 Pivot Health Technologies Inc. Breath sensor calibration methods and apparatus
EP3926636A2 (de) 2020-06-18 2021-12-22 Analytik Jena GmbH Verfahren zum erkennen einer amplifikationsphase in einer amplifikation
DE102020116178A1 (de) 2020-06-18 2021-12-23 Analytik Jena Gmbh Verfahren zum Erkennen einer Amplifikationsphase in einer Amplifikation

Also Published As

Publication number Publication date
US20100070190A1 (en) 2010-03-18
WO2010030686A1 (en) 2010-03-18
JP2012502378A (ja) 2012-01-26
US8560247B2 (en) 2013-10-15
EP2326949A1 (en) 2011-06-01
US8285489B2 (en) 2012-10-09
US20140032126A1 (en) 2014-01-30
US9442891B2 (en) 2016-09-13
JP5166608B2 (ja) 2013-03-21
CN102187215A (zh) 2011-09-14
US20130018593A1 (en) 2013-01-17

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Effective date: 20140627

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