CA2736177A1 - Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases - Google Patents
Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases Download PDFInfo
- Publication number
- CA2736177A1 CA2736177A1 CA2736177A CA2736177A CA2736177A1 CA 2736177 A1 CA2736177 A1 CA 2736177A1 CA 2736177 A CA2736177 A CA 2736177A CA 2736177 A CA2736177 A CA 2736177A CA 2736177 A1 CA2736177 A1 CA 2736177A1
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- CA
- Canada
- Prior art keywords
- substituted
- heterocycle
- alkyl
- aryl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 21
- 201000011510 cancer Diseases 0.000 title claims abstract 17
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 6
- 108091000080 Phosphotransferase Proteins 0.000 title claims abstract 3
- 102000020233 phosphotransferase Human genes 0.000 title claims abstract 3
- 239000000203 mixture Substances 0.000 title claims 3
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 120
- 238000000034 method Methods 0.000 claims abstract 39
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 22
- 230000002401 inhibitory effect Effects 0.000 claims abstract 12
- 102000001253 Protein Kinase Human genes 0.000 claims abstract 8
- 108060006633 protein kinase Proteins 0.000 claims abstract 8
- 210000000130 stem cell Anatomy 0.000 claims abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 186
- 229910052739 hydrogen Inorganic materials 0.000 claims 123
- 239000001257 hydrogen Substances 0.000 claims 123
- 125000003118 aryl group Chemical group 0.000 claims 98
- 125000000217 alkyl group Chemical group 0.000 claims 88
- 125000003107 substituted aryl group Chemical group 0.000 claims 83
- 125000000547 substituted alkyl group Chemical group 0.000 claims 77
- 150000002431 hydrogen Chemical group 0.000 claims 67
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 66
- 125000000753 cycloalkyl group Chemical group 0.000 claims 56
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 56
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 55
- 125000003342 alkenyl group Chemical group 0.000 claims 33
- 125000000304 alkynyl group Chemical group 0.000 claims 33
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 33
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 33
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 125000004093 cyano group Chemical group *C#N 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 150000002367 halogens Chemical group 0.000 claims 18
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 18
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 18
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 9
- 125000002877 alkyl aryl group Chemical group 0.000 claims 8
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 229910052698 phosphorus Inorganic materials 0.000 claims 8
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- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 6
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- 238000011319 anticancer therapy Methods 0.000 claims 3
- 230000003467 diminishing effect Effects 0.000 claims 3
- 150000003222 pyridines Chemical class 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 claims 2
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 claims 2
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- 210000004027 cell Anatomy 0.000 claims 2
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- 239000003795 chemical substances by application Substances 0.000 claims 2
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- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 102000037979 non-receptor tyrosine kinases Human genes 0.000 claims 2
- 108091008046 non-receptor tyrosine kinases Proteins 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
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- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 2
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- FMCAFXHLMUOIGG-IWFBPKFRSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-formamido-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,5-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoic acid Chemical compound O=CN[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(O)=O)CC1=CC(C)=C(O)C=C1C FMCAFXHLMUOIGG-IWFBPKFRSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
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- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 claims 1
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- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
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- 230000003197 catalytic effect Effects 0.000 claims 1
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- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
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- 230000004761 fibrosis Effects 0.000 claims 1
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
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- Diabetes (AREA)
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- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97041007P | 2007-09-06 | 2007-09-06 | |
| US60/970,410 | 2007-09-06 | ||
| US1338907P | 2007-12-13 | 2007-12-13 | |
| US61/013,389 | 2007-12-13 | ||
| US7429508P | 2008-06-20 | 2008-06-20 | |
| US61/074,295 | 2008-06-20 | ||
| PCT/US2008/075418 WO2009033033A2 (en) | 2007-09-06 | 2008-09-05 | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2736177A1 true CA2736177A1 (en) | 2009-03-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2736177A Abandoned CA2736177A1 (en) | 2007-09-06 | 2008-09-05 | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
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| EP (2) | EP2197878B1 (show.php) |
| JP (5) | JP5452490B2 (show.php) |
| CN (1) | CN101848908B (show.php) |
| CA (1) | CA2736177A1 (show.php) |
| CY (1) | CY1118012T1 (show.php) |
| DK (1) | DK2197878T3 (show.php) |
| ES (2) | ES2591028T3 (show.php) |
| HR (1) | HRP20161114T1 (show.php) |
| HU (1) | HUE030774T2 (show.php) |
| LT (1) | LT2197878T (show.php) |
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| PT (1) | PT2197878T (show.php) |
| SI (1) | SI2197878T1 (show.php) |
| WO (1) | WO2009033033A2 (show.php) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5452490B2 (ja) * | 2007-09-06 | 2014-03-26 | ボストン バイオメディカル， インコーポレイテッド | キナーゼ阻害剤の組成物ならびに癌およびキナーゼに関連する他の疾患の治療のためのそれらの使用 |
| JP5754942B2 (ja) * | 2007-12-10 | 2015-07-29 | インターデイジタル パテント ホールディングス インコーポレイテッド | 無線リンク制御パケットの破棄および無線リンク制御の再確立をトリガする方法および装置 |
| JP2014509323A (ja) | 2011-02-28 | 2014-04-17 | マックマスター ユニヴァーシティ | ドーパミン受容体遮断薬による癌の処置 |
| US9550764B2 (en) | 2012-08-23 | 2017-01-24 | The Institute Of Cancer Research: Royal Cancer Hospital | Fused heterocyclic compounds and their use |
| US9227962B2 (en) | 2013-03-13 | 2016-01-05 | Boston Biomedical, Inc. | Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative |
| US9187454B2 (en) | 2013-03-13 | 2015-11-17 | Boston Biomedical, Inc. | Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof |
| WO2014160401A1 (en) * | 2013-03-13 | 2014-10-02 | Boston Biomedical, Inc. | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
| WO2014202528A1 (en) * | 2013-06-20 | 2014-12-24 | Boehringer Ingelheim International Gmbh | Olefin substituted oxindoles having ampk activity |
| CN106132412A (zh) * | 2014-01-27 | 2016-11-16 | 北京强新生物科技有限公司 | 治疗癌症的新方法 |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| AU2016255034A1 (en) * | 2015-04-27 | 2017-11-02 | Boston Biomedical, Inc. | Methods for treating cancer with a STAT3 pathway inhibitor and kinase inhibitor |
| US10377749B2 (en) | 2015-08-10 | 2019-08-13 | Sumitomo Dainippon Pharma Co., Ltd. | Purification method for 5-(thiazol-4-yl)indolin-2-one derivative |
| WO2017160978A1 (en) | 2016-03-15 | 2017-09-21 | Boston Biomedical, Inc. | Cell cultures and use thereof |
| JP2019519573A (ja) | 2016-06-28 | 2019-07-11 | ボストン バイオメディカル， インコーポレイテッド | がんを処置するための方法 |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| CA3045306A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| JP7589949B2 (ja) * | 2018-09-18 | 2024-11-26 | １グローブ バイオメディカル カンパニー， リミテッド | 肥満に対する処置 |
| US12318381B2 (en) * | 2018-09-18 | 2025-06-03 | 1Globe Biomedical Co., Ltd. | Treatment for non-alcoholic fatty liver disease |
| CA3237696A1 (en) | 2021-11-08 | 2023-05-11 | Progentos Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
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| JP2829451B2 (ja) * | 1990-11-30 | 1998-11-25 | 大塚製薬株式会社 | 活性酸素抑制剤 |
| EP0929520B1 (en) * | 1996-08-23 | 2005-11-02 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| GB9716557D0 (en) * | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| WO1999015524A1 (en) * | 1997-09-23 | 1999-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives |
| ATE369359T1 (de) * | 2000-02-15 | 2007-08-15 | Sugen Inc | Pyrrol substituierte indolin-2-on protein kinase inhibitoren |
| US6465507B2 (en) * | 2000-02-28 | 2002-10-15 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
| EP1294688A2 (en) * | 2000-06-02 | 2003-03-26 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
| JP4343534B2 (ja) * | 2001-03-02 | 2009-10-14 | ゲーペーツェー バイオテック アクチェンゲゼルシャフト | ３ハイブリッド・アッセイ・システム |
| WO2002081466A1 (en) | 2001-04-09 | 2002-10-17 | Sugen, Inc. | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| US20030119839A1 (en) | 2001-12-13 | 2003-06-26 | Nan-Horng Lin | Protein kinase inhibitors |
| SE0200979D0 (sv) * | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| US20050032871A1 (en) * | 2002-09-03 | 2005-02-10 | Sugen, Inc. | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors |
| JP2007509173A (ja) * | 2003-10-24 | 2007-04-12 | シエーリング アクチエンゲゼルシャフト | インドリノン誘導体類及び疾病状態、例えば癌の処理へのそれらの使用 |
| BRPI0707312B1 (pt) * | 2006-01-27 | 2022-06-07 | Shanghai Hengrui Pharmacetical Co., Ltd | Inibidores de pirrolo [3,2-c] piridina-4-ona 2-indolinona proteína cinase, seu uso e seu processo de fabricação, intermediário e seus processos de fabricação, composição farmacêutica e seu uso |
| BRPI0811978A2 (pt) * | 2007-06-01 | 2014-11-18 | Hoffmann La Roche | Compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de l-cpt1 e uso dos compostos |
| JP5452490B2 (ja) * | 2007-09-06 | 2014-03-26 | ボストン バイオメディカル， インコーポレイテッド | キナーゼ阻害剤の組成物ならびに癌およびキナーゼに関連する他の疾患の治療のためのそれらの使用 |
| US9187454B2 (en) * | 2013-03-13 | 2015-11-17 | Boston Biomedical, Inc. | Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof |
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2008
- 2008-09-05 JP JP2010524187A patent/JP5452490B2/ja not_active Expired - Fee Related
- 2008-09-05 PL PL08829600T patent/PL2197878T3/pl unknown
- 2008-09-05 LT LTEP08829600.9T patent/LT2197878T/lt unknown
- 2008-09-05 ES ES08829600.9T patent/ES2591028T3/es active Active
- 2008-09-05 HU HUE08829600A patent/HUE030774T2/hu unknown
- 2008-09-05 CN CN200880114705.9A patent/CN101848908B/zh active Active
- 2008-09-05 SI SI200831667A patent/SI2197878T1/sl unknown
- 2008-09-05 DK DK08829600.9T patent/DK2197878T3/en active
- 2008-09-05 ES ES16156340T patent/ES2759347T3/es active Active
- 2008-09-05 EP EP08829600.9A patent/EP2197878B1/en active Active
- 2008-09-05 CA CA2736177A patent/CA2736177A1/en not_active Abandoned
- 2008-09-05 PT PT88296009T patent/PT2197878T/pt unknown
- 2008-09-05 WO PCT/US2008/075418 patent/WO2009033033A2/en not_active Ceased
- 2008-09-05 EP EP16156340.8A patent/EP3037419B1/en active Active
- 2008-09-05 US US12/676,869 patent/US8299106B2/en not_active Expired - Fee Related
- 2008-09-05 HR HRP20161114TT patent/HRP20161114T1/hr unknown
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2012
- 2012-08-27 US US13/595,708 patent/US20120321622A1/en not_active Abandoned
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2013
- 2013-12-27 JP JP2013272195A patent/JP5701372B2/ja not_active Expired - Fee Related
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2014
- 2014-07-29 US US14/445,783 patent/US9725444B2/en not_active Expired - Fee Related
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2015
- 2015-02-17 JP JP2015028165A patent/JP5974124B2/ja not_active Expired - Fee Related
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2016
- 2016-07-15 JP JP2016140101A patent/JP6495868B2/ja not_active Expired - Fee Related
- 2016-09-13 CY CY20161100904T patent/CY1118012T1/el unknown
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2017
- 2017-07-07 US US15/643,608 patent/US20180022743A1/en not_active Abandoned
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2018
- 2018-11-14 US US16/190,669 patent/US20190248781A1/en not_active Abandoned
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2019
- 2019-02-08 JP JP2019021397A patent/JP2019070051A/ja active Pending
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