CA2732786A1 - Method and apparatus for non-invasive analysis of saliva - Google Patents
Method and apparatus for non-invasive analysis of saliva Download PDFInfo
- Publication number
- CA2732786A1 CA2732786A1 CA2732786A CA2732786A CA2732786A1 CA 2732786 A1 CA2732786 A1 CA 2732786A1 CA 2732786 A CA2732786 A CA 2732786A CA 2732786 A CA2732786 A CA 2732786A CA 2732786 A1 CA2732786 A1 CA 2732786A1
- Authority
- CA
- Canada
- Prior art keywords
- reagent
- stem
- saliva sample
- head
- color
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003296 saliva Anatomy 0.000 title claims abstract description 81
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000004458 analytical method Methods 0.000 title claims abstract description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 86
- 239000000470 constituent Substances 0.000 claims abstract description 46
- 230000008859 change Effects 0.000 claims abstract description 20
- 230000004044 response Effects 0.000 claims description 27
- 239000000126 substance Substances 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 17
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 14
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 10
- 239000003086 colorant Substances 0.000 claims description 10
- 230000000007 visual effect Effects 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- 239000008103 glucose Substances 0.000 claims description 7
- 229960000890 hydrocortisone Drugs 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 230000035935 pregnancy Effects 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 150000002576 ketones Chemical group 0.000 claims description 5
- 229960001860 salicylate Drugs 0.000 claims description 5
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims description 3
- 235000012000 cholesterol Nutrition 0.000 claims 4
- 125000003158 alcohol group Chemical group 0.000 claims 2
- 238000005452 bending Methods 0.000 claims 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 2
- 150000003873 salicylate salts Chemical group 0.000 claims 2
- 239000012530 fluid Substances 0.000 abstract description 8
- 238000010276 construction Methods 0.000 abstract description 7
- 238000012544 monitoring process Methods 0.000 abstract description 6
- 230000036541 health Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 25
- 108090000790 Enzymes Proteins 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 102000003992 Peroxidases Human genes 0.000 description 3
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 229940060367 inert ingredients Drugs 0.000 description 3
- 230000002452 interceptive effect Effects 0.000 description 3
- -1 potassium ferricyanide Chemical compound 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 241000897241 Acinetobacter sp. ADP1 Species 0.000 description 2
- 101710088194 Dehydrogenase Proteins 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000002117 illicit drug Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- FPFSGDXIBUDDKZ-UHFFFAOYSA-N 3-decyl-2-hydroxycyclopent-2-en-1-one Chemical compound CCCCCCCCCCC1=C(O)C(=O)CC1 FPFSGDXIBUDDKZ-UHFFFAOYSA-N 0.000 description 1
- 108010025188 Alcohol oxidase Proteins 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010071238 Binge Drinking Diseases 0.000 description 1
- 108010089254 Cholesterol oxidase Proteins 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- 102000002268 Hexosaminidases Human genes 0.000 description 1
- 108010000540 Hexosaminidases Proteins 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 108010055297 Sterol Esterase Proteins 0.000 description 1
- 102000000019 Sterol Esterase Human genes 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- GPRSOIDYHMXAGW-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopentanecarboxylic acid iron Chemical compound [CH-]1[CH-][CH-][C-]([CH-]1)C(=O)O.[CH-]1C=CC=C1.[Fe] GPRSOIDYHMXAGW-UHFFFAOYSA-N 0.000 description 1
- 239000011928 denatured alcohol Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 239000012954 diazonium Substances 0.000 description 1
- 150000001989 diazonium salts Chemical class 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000010556 emulsion polymerization method Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 108010046301 glucose peroxidase Proteins 0.000 description 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Substances NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 1
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229960002460 nitroprusside Drugs 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/528—Atypical element structures, e.g. gloves, rods, tampons, toilet paper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B2010/0003—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements including means for analysis by an unskilled person
- A61B2010/0006—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements including means for analysis by an unskilled person involving a colour change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B2010/0009—Testing for drug or alcohol abuse
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Plasma & Fusion (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Pulmonology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/218,950 | 2008-07-18 | ||
| US12/218,950 US7824344B1 (en) | 2007-07-23 | 2008-07-18 | Method and apparatus for non-invasive analysis of saliva |
| US12/380,939 US7993283B1 (en) | 2007-07-23 | 2009-03-04 | Method and apparatus for non-invasive analysis of saliva |
| US12/380,939 | 2009-03-04 | ||
| PCT/US2009/050009 WO2010008989A2 (en) | 2008-07-18 | 2009-07-09 | Method and apparatus for non-invasive analysis of saliva |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2732786A1 true CA2732786A1 (en) | 2010-01-21 |
Family
ID=43759580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2732786A Pending CA2732786A1 (en) | 2008-07-18 | 2009-07-09 | Method and apparatus for non-invasive analysis of saliva |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7993283B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2347257A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011528786A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102159946A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2732786A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010008989A2 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4410198A1 (en) | 2023-01-31 | 2024-08-07 | Nutrix Poland Sp. z o.o. | Read-out device and carrier for analyte detection |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013009797A2 (pt) * | 2010-10-23 | 2020-06-09 | Pop Test LLC | método de produção de um dispositivo para condução de uma análise não invasiva e dispositivo para conduzir uma análise não invasiva |
| WO2012106514A2 (en) | 2011-02-03 | 2012-08-09 | Pop Test Cortisol Llc | System and method for diagnosis and treatment |
| GB2491807B (en) | 2011-05-27 | 2018-07-04 | Ge Healthcare Uk Ltd | Biological sample collection device |
| CN102620953B (zh) * | 2012-03-14 | 2015-07-15 | 杭州安旭科技有限公司 | 一种唾液收集检测装置 |
| GB2521119A (en) * | 2013-10-30 | 2015-06-17 | Surescreen Diagnostics Ltd | Indication device |
| ITUB20155324A1 (it) | 2015-11-03 | 2017-05-03 | Copan Italia Spa | Dispositivo per il prelievo, il trasferimento e la conservazione di campioni di materiale biologico e/o chimico |
| CN105954271A (zh) * | 2016-04-27 | 2016-09-21 | 樊福好 | 一种检测体质的溶液及检测方法 |
| CN105954270A (zh) * | 2016-04-27 | 2016-09-21 | 樊福好 | 一种通过唾液学方法评估葡萄糖代谢的溶液及评估方法 |
| IL268793B2 (en) | 2017-02-21 | 2025-07-01 | Medicortex Finland Oy | Non-invasive brain injury diagnostic device |
| GB201703383D0 (en) | 2017-03-02 | 2017-04-19 | Gargle Tech Ltd | Testing for particulates |
| US20180355405A1 (en) * | 2017-06-09 | 2018-12-13 | Accessible Diagnostics, LLC | System and Method for Determining Glucose Oxidase in an Analyte |
| CN115430471A (zh) | 2018-09-05 | 2022-12-06 | 英雄科学有限公司 | 微粒测试的设备及方法 |
| WO2021181339A1 (en) | 2020-03-11 | 2021-09-16 | Hero Scientific Ltd. | Testing devices |
| CA3202405A1 (en) | 2021-01-06 | 2022-07-14 | Zvi Feldman | Filtration sampling devices |
| EP4201343A1 (en) | 2021-12-24 | 2023-06-28 | Happy Innova SL | A saliva monitoring oral device for collecting and monitoring a saliva sample |
| JP2025056803A (ja) * | 2022-02-22 | 2025-04-09 | 国立大学法人島根大学 | 検査方法及び検査装置 |
| FR3158871A1 (fr) * | 2024-02-01 | 2025-08-08 | Lp23 | Dispositif de mesure biochimique par test salivaire au moyen de couples vecteur de prélèvement – capteur |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1967557A (en) | 1931-10-13 | 1934-07-24 | John Robert | Device for testing acidity in oral secretions |
| US5182191A (en) | 1988-10-14 | 1993-01-26 | Pacific Biotech, Inc. | Occult blood sampling device and assay |
| US5306623A (en) * | 1989-08-28 | 1994-04-26 | Lifescan, Inc. | Visual blood glucose concentration test strip |
| JPH0610862U (ja) * | 1991-03-07 | 1994-02-10 | 南越ケミカル株式会社 | 簡易検査用試験紙 |
| US5211182A (en) * | 1991-10-23 | 1993-05-18 | Deutsch Marshall E | Home ovulation test kit and method |
| US6409680B1 (en) * | 1994-08-25 | 2002-06-25 | James C. Caillouette | pH measurement of body fluid |
| JPH08145992A (ja) * | 1994-11-17 | 1996-06-07 | Besutekusu Kk | 唾液による妊娠可能期間の検査方法 |
| US5747351A (en) * | 1995-06-07 | 1998-05-05 | Smithkline Diagnostics, Inc. | Immunochemical-based test device with lift and twist specimen full tab |
| WO1997018036A1 (en) * | 1995-11-13 | 1997-05-22 | Cortecs (Uk) Limited | Diagnostic test apparatus |
| US5910122A (en) | 1996-06-04 | 1999-06-08 | Americare Health Scan Inc. | Saliva collector with an aspirating pipette |
| DE69724515T2 (de) * | 1996-06-07 | 2004-04-01 | Oxoid Ltd., Basingstoke | Vorrichtung und Testsatz zum Test von Serum und dergleichen |
| US6102872A (en) | 1997-11-03 | 2000-08-15 | Pacific Biometrics, Inc. | Glucose detector and method |
| JP3052290B1 (ja) * | 1999-03-19 | 2000-06-12 | 健次 中島 | 動物用検尿スティック |
| US20030175992A1 (en) | 1999-09-10 | 2003-09-18 | Anthony Toranto | Glucose assay |
| US6391261B1 (en) * | 2000-04-14 | 2002-05-21 | Lifepoint, Inc. | Device for detecting analytes related to sample pH |
| US6623698B2 (en) | 2001-03-12 | 2003-09-23 | Youti Kuo | Saliva-monitoring biosensor electrical toothbrush |
| MX2007002968A (es) | 2004-09-10 | 2008-03-05 | Allan D Pronovost | Monitoreo de glucosa salivar. |
| US20070031914A1 (en) * | 2005-08-05 | 2007-02-08 | Wei Zhu | Devices for analyte assays and methods of use |
-
2009
- 2009-03-04 US US12/380,939 patent/US7993283B1/en not_active Expired - Fee Related
- 2009-07-09 WO PCT/US2009/050009 patent/WO2010008989A2/en not_active Ceased
- 2009-07-09 EP EP09798583.2A patent/EP2347257A4/en not_active Withdrawn
- 2009-07-09 CA CA2732786A patent/CA2732786A1/en active Pending
- 2009-07-09 CN CN2009801361273A patent/CN102159946A/zh active Pending
- 2009-07-09 JP JP2011518800A patent/JP2011528786A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4410198A1 (en) | 2023-01-31 | 2024-08-07 | Nutrix Poland Sp. z o.o. | Read-out device and carrier for analyte detection |
| WO2024160472A1 (en) | 2023-01-31 | 2024-08-08 | Nutrix Poland Sp. Z O.O. | Read-out device and carrier for analyte detection |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010008989A2 (en) | 2010-01-21 |
| CN102159946A (zh) | 2011-08-17 |
| EP2347257A2 (en) | 2011-07-27 |
| WO2010008989A3 (en) | 2010-04-08 |
| US7993283B1 (en) | 2011-08-09 |
| JP2011528786A (ja) | 2011-11-24 |
| EP2347257A4 (en) | 2015-06-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140708 |