CA2732594C - Monoclonal antibodies for treatment of cancer - Google Patents

Monoclonal antibodies for treatment of cancer Download PDF

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Publication number
CA2732594C
CA2732594C CA2732594A CA2732594A CA2732594C CA 2732594 C CA2732594 C CA 2732594C CA 2732594 A CA2732594 A CA 2732594A CA 2732594 A CA2732594 A CA 2732594A CA 2732594 C CA2732594 C CA 2732594C
Authority
CA
Canada
Prior art keywords
antibody
cancer
cells
dsm
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2732594A
Other languages
English (en)
French (fr)
Other versions
CA2732594A1 (en
Inventor
Ugur Sahin
Oezlem Tuereci
Michael Koslowski
Rita Mitnacht-Kraus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Original Assignee
TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH filed Critical TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Publication of CA2732594A1 publication Critical patent/CA2732594A1/en
Application granted granted Critical
Publication of CA2732594C publication Critical patent/CA2732594C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2732594A 2008-09-16 2009-09-16 Monoclonal antibodies for treatment of cancer Expired - Fee Related CA2732594C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9745308P 2008-09-16 2008-09-16
US61/097,453 2008-09-16
EP08016277.9 2008-09-16
EP08016277A EP2166021A1 (en) 2008-09-16 2008-09-16 Monoclonal antibodies for treatment of cancer
PCT/EP2009/006704 WO2010031551A2 (en) 2008-09-16 2009-09-16 Monoclonal antibodies for treatment of cancer

Publications (2)

Publication Number Publication Date
CA2732594A1 CA2732594A1 (en) 2010-03-25
CA2732594C true CA2732594C (en) 2019-05-28

Family

ID=40589589

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2732594A Expired - Fee Related CA2732594C (en) 2008-09-16 2009-09-16 Monoclonal antibodies for treatment of cancer

Country Status (27)

Country Link
US (1) US8946388B2 (https=)
EP (3) EP2166021A1 (https=)
JP (1) JP2012502938A (https=)
KR (1) KR101818741B1 (https=)
CN (3) CN102164963B (https=)
AU (1) AU2009294896B2 (https=)
BR (1) BRPI0918178B8 (https=)
CA (1) CA2732594C (https=)
CY (1) CY1119956T1 (https=)
DK (1) DK2342234T3 (https=)
ES (1) ES2659718T3 (https=)
HK (1) HK1253579A1 (https=)
HR (1) HRP20180262T1 (https=)
HU (1) HUE036477T2 (https=)
IL (2) IL211010A (https=)
LT (1) LT2342234T (https=)
MX (2) MX357010B (https=)
NO (1) NO2342234T3 (https=)
NZ (2) NZ591004A (https=)
PL (1) PL2342234T3 (https=)
PT (1) PT2342234T (https=)
RS (1) RS56937B1 (https=)
SI (1) SI2342234T1 (https=)
SM (1) SMT201800079T1 (https=)
TR (1) TR201802090T4 (https=)
WO (1) WO2010031551A2 (https=)
ZA (1) ZA201100835B (https=)

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US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
EP2371864A1 (en) 2010-03-23 2011-10-05 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
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CN107556369A (zh) * 2017-08-23 2018-01-09 天津国际生物医药联合研究院 一种抗原肽和用于检测肿瘤细胞的抗体制备方法及其应用
US12208102B2 (en) 2018-04-17 2025-01-28 Endocyte, Inc. Methods of treating cancer
CN109402064B (zh) * 2018-11-05 2021-05-14 湖南省肿瘤医院 杂交瘤细胞株及其产生的单克隆抗体和应用
CN114096264B (zh) 2019-05-20 2025-03-14 因多塞特股份有限公司 制备psma缀合物的方法
KR102266418B1 (ko) * 2019-07-30 2021-06-16 한국생명공학연구원 영여자 추출물을 유효성분으로 함유하는 전립선 질환의 예방 및 치료용 조성물

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Also Published As

Publication number Publication date
SMT201800079T1 (it) 2018-03-08
BRPI0918178A2 (pt) 2015-12-01
EP2166021A1 (en) 2010-03-24
MX357010B (es) 2018-06-22
IL242204B (en) 2020-09-30
BRPI0918178A8 (pt) 2020-05-19
MX2011002856A (es) 2011-06-28
BRPI0918178B1 (pt) 2021-04-06
HK1253579A1 (en) 2019-06-21
BRPI0918178B8 (pt) 2021-05-25
EP2342234B1 (en) 2017-11-15
JP2012502938A (ja) 2012-02-02
NO2342234T3 (https=) 2018-04-14
IL242204A0 (en) 2015-11-30
AU2009294896B2 (en) 2015-04-30
CN102164963B (zh) 2015-07-29
PT2342234T (pt) 2018-02-21
CN104628858B (zh) 2018-11-16
CN104628858A (zh) 2015-05-20
CN102164963A (zh) 2011-08-24
DK2342234T3 (en) 2018-02-26
WO2010031551A2 (en) 2010-03-25
ZA201100835B (en) 2014-04-30
RS56937B1 (sr) 2018-05-31
HRP20180262T1 (hr) 2018-03-23
CY1119956T1 (el) 2018-12-12
IL211010A (en) 2015-11-30
IL211010A0 (en) 2011-04-28
SI2342234T1 (en) 2018-04-30
EP3312198A1 (en) 2018-04-25
NZ591004A (en) 2012-03-30
ES2659718T3 (es) 2018-03-19
LT2342234T (lt) 2018-03-12
TR201802090T4 (tr) 2018-03-21
CN105753988A (zh) 2016-07-13
CA2732594A1 (en) 2010-03-25
NZ596490A (en) 2013-05-31
EP2342234A2 (en) 2011-07-13
KR20110055699A (ko) 2011-05-25
WO2010031551A3 (en) 2010-09-16
KR101818741B1 (ko) 2018-01-15
AU2009294896A1 (en) 2010-03-25
US8946388B2 (en) 2015-02-03
PL2342234T3 (pl) 2018-07-31
HUE036477T2 (hu) 2018-07-30
US20110223182A1 (en) 2011-09-15

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