CA2731409C - Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers - Google Patents
Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers Download PDFInfo
- Publication number
- CA2731409C CA2731409C CA2731409A CA2731409A CA2731409C CA 2731409 C CA2731409 C CA 2731409C CA 2731409 A CA2731409 A CA 2731409A CA 2731409 A CA2731409 A CA 2731409A CA 2731409 C CA2731409 C CA 2731409C
- Authority
- CA
- Canada
- Prior art keywords
- target tissue
- illumination
- imaging
- tissue
- acoustic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000090 biomarker Substances 0.000 title claims abstract description 72
- 238000003325 tomography Methods 0.000 title claims abstract description 10
- 238000005286 illumination Methods 0.000 claims abstract description 145
- 238000003384 imaging method Methods 0.000 claims abstract description 113
- 238000000034 method Methods 0.000 claims abstract description 58
- 238000009826 distribution Methods 0.000 claims abstract description 42
- 230000003595 spectral effect Effects 0.000 claims abstract description 28
- 238000012545 processing Methods 0.000 claims abstract description 26
- 230000004044 response Effects 0.000 claims abstract description 15
- 210000001519 tissue Anatomy 0.000 claims description 210
- 238000010521 absorption reaction Methods 0.000 claims description 47
- 230000003287 optical effect Effects 0.000 claims description 39
- 238000001514 detection method Methods 0.000 claims description 26
- 241001465754 Metazoa Species 0.000 claims description 15
- 210000004204 blood vessel Anatomy 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 102000034287 fluorescent proteins Human genes 0.000 claims description 8
- 108091006047 fluorescent proteins Proteins 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 241000282414 Homo sapiens Species 0.000 claims description 6
- 238000000862 absorption spectrum Methods 0.000 claims description 6
- 210000000056 organ Anatomy 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 4
- 239000013307 optical fiber Substances 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 229910000510 noble metal Inorganic materials 0.000 claims description 2
- 210000001367 artery Anatomy 0.000 claims 1
- 230000009102 absorption Effects 0.000 description 31
- 208000037516 chromosome inversion disease Diseases 0.000 description 25
- 238000013459 approach Methods 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 239000003147 molecular marker Substances 0.000 description 11
- 239000000975 dye Substances 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 230000001419 dependent effect Effects 0.000 description 8
- 238000001727 in vivo Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 238000009792 diffusion process Methods 0.000 description 7
- 238000001228 spectrum Methods 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000005855 radiation Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000003550 marker Substances 0.000 description 5
- 238000011002 quantification Methods 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 230000008033 biological extinction Effects 0.000 description 4
- 229910052729 chemical element Inorganic materials 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 238000002604 ultrasonography Methods 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000006096 absorbing agent Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 238000012984 biological imaging Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000004422 calculation algorithm Methods 0.000 description 3
- 238000012512 characterization method Methods 0.000 description 3
- 238000000701 chemical imaging Methods 0.000 description 3
- 239000002872 contrast media Substances 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 238000000151 deposition Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000002059 diagnostic imaging Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000003068 molecular probe Substances 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000002105 nanoparticle Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 238000006213 oxygenation reaction Methods 0.000 description 3
- 238000012800 visualization Methods 0.000 description 3
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 108010002255 deoxyhemoglobin Proteins 0.000 description 2
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 1
- 239000012118 Alexa Fluor 750 Substances 0.000 description 1
- 239000012099 Alexa Fluor family Substances 0.000 description 1
- 101150115442 CKM gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
- 108050008072 Cytochrome c oxidase subunit IV Proteins 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 238000000342 Monte Carlo simulation Methods 0.000 description 1
- 206010061309 Neoplasm progression Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 229910052774 Proactinium Inorganic materials 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 208000036366 Sensation of pressure Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 208000004064 acoustic neuroma Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940046545 animal allergen extract Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940077731 carbohydrate nutrients Drugs 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009543 diffuse optical tomography Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 238000012912 drug discovery process Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000000695 excitation spectrum Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000010358 mechanical oscillation Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940031182 nanoparticles iron oxide Drugs 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000002496 oximetry Methods 0.000 description 1
- 229960003903 oxygen Drugs 0.000 description 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000004867 photoacoustic spectroscopy Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000020004 porter Nutrition 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 229910052704 radon Inorganic materials 0.000 description 1
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 1
- 102000012498 secondary active transmembrane transporter activity proteins Human genes 0.000 description 1
- 108040003878 secondary active transmembrane transporter activity proteins Proteins 0.000 description 1
- 238000003375 selectivity assay Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000012911 target assessment Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2008/006142 WO2010009747A1 (en) | 2008-07-25 | 2008-07-25 | Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2731409A1 CA2731409A1 (en) | 2010-01-28 |
| CA2731409C true CA2731409C (en) | 2016-01-05 |
Family
ID=40568503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2731409A Active CA2731409C (en) | 2008-07-25 | 2008-07-25 | Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9572497B2 (enExample) |
| EP (1) | EP2344019B1 (enExample) |
| JP (1) | JP5749164B2 (enExample) |
| CN (1) | CN102137618B (enExample) |
| CA (1) | CA2731409C (enExample) |
| WO (1) | WO2010009747A1 (enExample) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7520860B2 (en) | 2005-04-13 | 2009-04-21 | Marie G. Johnson | Detection of coronary artery disease using an electronic stethoscope |
| EP2527815B1 (en) | 2008-07-25 | 2014-05-14 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Thermoacoustic imaging with quantitative extraction of an absorption image |
| CN102137618B (zh) | 2008-07-25 | 2015-06-17 | 健康与环境慕尼黑德国研究中心赫姆霍茨中心(有限公司) | 组织生物标志物的定量多光谱光声断层摄影(msot) |
| CN102223840B (zh) * | 2008-09-10 | 2015-03-18 | 安德拉有限公司 | 光声成像设备 |
| US9271654B2 (en) | 2009-06-29 | 2016-03-01 | Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Thermoacoustic imaging with quantitative extraction of absorption map |
| EP2459987A1 (en) * | 2009-07-27 | 2012-06-06 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Imaging device and method for optoacoustic imaging of small animals |
| EP2359745A1 (en) | 2010-02-12 | 2011-08-24 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Method and device for multi-spectral photonic imaging |
| JP5693043B2 (ja) * | 2010-04-28 | 2015-04-01 | キヤノン株式会社 | 被検体情報取得装置、被検体情報取得方法 |
| US9047659B2 (en) * | 2010-04-30 | 2015-06-02 | The Trustees Of Columbia University In The City Of New York | System, method and computer-accessible medium for performing attenuation-corrected multispectral luminescence tomography of cerenkov and bioluminescent light sources |
| EP2575604B1 (en) * | 2010-05-28 | 2023-07-05 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for analyzing information regarding cardiovascular disease(s) and function(s) |
| JP5627360B2 (ja) * | 2010-09-14 | 2014-11-19 | キヤノン株式会社 | 光音響イメージング装置およびその制御方法 |
| US8686335B2 (en) | 2011-12-31 | 2014-04-01 | Seno Medical Instruments, Inc. | System and method for adjusting the light output of an optoacoustic imaging system |
| US20130109950A1 (en) * | 2011-11-02 | 2013-05-02 | Seno Medical Instruments, Inc. | Handheld optoacoustic probe |
| US9330452B2 (en) | 2012-03-09 | 2016-05-03 | Seno Medical Instruments, Inc. | Statistical mapping in an optoacoustic imaging system |
| US9289191B2 (en) | 2011-10-12 | 2016-03-22 | Seno Medical Instruments, Inc. | System and method for acquiring optoacoustic data and producing parametric maps thereof |
| JP5875242B2 (ja) * | 2010-10-05 | 2016-03-02 | キヤノン株式会社 | 光音響イメージング用造影剤、及び、それを用いた光音響イメージング方法 |
| CN102175617A (zh) * | 2011-01-28 | 2011-09-07 | 华南理工大学 | 一种光强可控光纤耦合光声检测探头 |
| JP5744557B2 (ja) | 2011-02-10 | 2015-07-08 | キヤノン株式会社 | 音響波取得装置 |
| JP5850633B2 (ja) | 2011-04-12 | 2016-02-03 | キヤノン株式会社 | 被検体情報取得装置 |
| JP2016209725A (ja) * | 2011-05-12 | 2016-12-15 | キヤノン株式会社 | 被検体情報取得装置及び被検体情報取得方法 |
| JP5743957B2 (ja) * | 2011-06-07 | 2015-07-01 | 富士フイルム株式会社 | 光音響画像生成装置及び方法 |
| US9445786B2 (en) | 2011-11-02 | 2016-09-20 | Seno Medical Instruments, Inc. | Interframe energy normalization in an optoacoustic imaging system |
| US20140005544A1 (en) | 2011-11-02 | 2014-01-02 | Seno Medical Instruments, Inc. | System and method for providing selective channel sensitivity in an optoacoustic imaging system |
| US11287309B2 (en) | 2011-11-02 | 2022-03-29 | Seno Medical Instruments, Inc. | Optoacoustic component utilization tracking |
| US9814394B2 (en) | 2011-11-02 | 2017-11-14 | Seno Medical Instruments, Inc. | Noise suppression in an optoacoustic system |
| US10433732B2 (en) | 2011-11-02 | 2019-10-08 | Seno Medical Instruments, Inc. | Optoacoustic imaging system having handheld probe utilizing optically reflective material |
| US9733119B2 (en) | 2011-11-02 | 2017-08-15 | Seno Medical Instruments, Inc. | Optoacoustic component utilization tracking |
| US20130289381A1 (en) | 2011-11-02 | 2013-10-31 | Seno Medical Instruments, Inc. | Dual modality imaging system for coregistered functional and anatomical mapping |
| US9743839B2 (en) | 2011-11-02 | 2017-08-29 | Seno Medical Instruments, Inc. | Playback mode in an optoacoustic imaging system |
| AU2012332233B2 (en) * | 2011-11-02 | 2017-08-31 | Seno Medical Instruments, Inc. | Dual modality imaging system for coregistered functional and anatomical mapping |
| US9730587B2 (en) | 2011-11-02 | 2017-08-15 | Seno Medical Instruments, Inc. | Diagnostic simulator |
| US20130338475A1 (en) | 2012-06-13 | 2013-12-19 | Seno Medical Instruments, Inc. | Optoacoustic imaging system with fiber optic cable |
| US20130116538A1 (en) | 2011-11-02 | 2013-05-09 | Seno Medical Instruments, Inc. | Optoacoustic imaging systems and methods with enhanced safety |
| US11191435B2 (en) | 2013-01-22 | 2021-12-07 | Seno Medical Instruments, Inc. | Probe with optoacoustic isolator |
| TWI435712B (zh) * | 2011-12-14 | 2014-05-01 | Univ Nat Chiao Tung | 擴散式光學斷層掃描裝置及擴散式光學斷層掃描方法 |
| JP5943598B2 (ja) * | 2011-12-26 | 2016-07-05 | キヤノン株式会社 | 被検体情報取得装置 |
| WO2013154012A1 (ja) | 2012-04-10 | 2013-10-17 | 株式会社国際電気通信基礎技術研究所 | 物体観測装置、物体観測方法、および記録媒体 |
| KR101974580B1 (ko) * | 2012-05-03 | 2019-05-02 | 삼성전자주식회사 | 레이저 유도 초음파 장치 및 이를 이용한 영상 생성 방법 |
| EP2847574A1 (en) | 2012-05-07 | 2015-03-18 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Apparatus and method for frequency-domain thermo-acoustic tomographic imaging |
| EP2742854B1 (en) | 2012-12-11 | 2021-03-10 | iThera Medical GmbH | Handheld device and method for tomographic optoacoustic imaging of an object |
| EP2754388B1 (en) * | 2013-01-15 | 2020-09-09 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | System and method for quality-enhanced high-rate optoacoustic imaging of an object |
| US9398893B2 (en) | 2013-03-15 | 2016-07-26 | Seno Medical Instruments, Inc. | System and method for diagnostic vector classification support |
| JP2015000288A (ja) * | 2013-06-18 | 2015-01-05 | キヤノン株式会社 | 被検体情報取得装置およびその制御方法ならびに音響信号取得装置およびその制御方法 |
| JP2015029550A (ja) * | 2013-07-31 | 2015-02-16 | 船井電機株式会社 | 光音響画像化装置 |
| CN103393408B (zh) * | 2013-08-20 | 2015-12-02 | 中国科学院自动化研究所 | 一种光声和荧光循环互提升成像方法 |
| US9953417B2 (en) | 2013-10-04 | 2018-04-24 | The University Of Manchester | Biomarker method |
| US9519823B2 (en) * | 2013-10-04 | 2016-12-13 | The University Of Manchester | Biomarker method |
| WO2015054688A2 (en) | 2013-10-11 | 2015-04-16 | Seno Medical Instruments, Inc. | Systems and methods for component separation in medical imaging |
| JP2015092914A (ja) * | 2013-11-08 | 2015-05-18 | キヤノン株式会社 | 被検体情報取得装置および音響波受信装置 |
| EP3076860B1 (en) * | 2013-12-06 | 2019-04-24 | Agency for Science, Technology And Research | Method of imaging living tissue |
| US9670522B2 (en) * | 2014-01-08 | 2017-06-06 | University Of South Carolina | Quantitative acoustic contrast tomography for studying fungal growth and toxicity |
| WO2015131098A1 (en) | 2014-02-27 | 2015-09-03 | Seno Medical Instruments, Inc. | Probe adapted to control blood flow through vessels during imaging and method of use of same |
| US9959477B2 (en) | 2014-03-03 | 2018-05-01 | The Board Of Trustees Of The Leland Stanford Junior University | Mapping of blood vessels for biometric authentication |
| JP6545190B2 (ja) * | 2014-05-14 | 2019-07-17 | キヤノン株式会社 | 光音響装置、信号処理装置、信号処理方法、プログラム |
| JP6587410B2 (ja) * | 2014-05-19 | 2019-10-09 | キヤノン株式会社 | 被検体情報取得装置および信号処理方法 |
| US9092691B1 (en) * | 2014-07-18 | 2015-07-28 | Median Technologies | System for computing quantitative biomarkers of texture features in tomographic images |
| JP6152079B2 (ja) * | 2014-08-29 | 2017-06-21 | プレキシオン株式会社 | 光音響画像化装置用プローブ |
| EP3212065B1 (en) | 2014-10-30 | 2022-03-30 | Seno Medical Instruments, Inc. | Opto-acoustic imaging system with detection of relative orientation of light source and acoustic receiver using acoustic waves |
| EP3056137B1 (en) * | 2015-02-13 | 2017-11-01 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Device and method for multispectral optoacoustic imaging |
| EP3265823B1 (en) | 2015-03-06 | 2020-05-06 | Micromass UK Limited | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
| JP6783240B2 (ja) | 2015-03-06 | 2020-11-11 | マイクロマス ユーケー リミテッド | 生体内内視鏡的組織同定機器 |
| EP3570315B1 (en) | 2015-03-06 | 2024-01-31 | Micromass UK Limited | Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples |
| GB2554181B (en) | 2015-03-06 | 2021-09-08 | Micromass Ltd | Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device |
| JP6753862B2 (ja) | 2015-03-06 | 2020-09-09 | マイクロマス ユーケー リミテッド | 気体サンプルの改良されたイオン化 |
| JP6845148B2 (ja) | 2015-03-06 | 2021-03-17 | マイクロマス ユーケー リミテッド | 電気外科的応用のための液体トラップ又は分離器 |
| US11289320B2 (en) | 2015-03-06 | 2022-03-29 | Micromass Uk Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| US10777398B2 (en) | 2015-03-06 | 2020-09-15 | Micromass Uk Limited | Spectrometric analysis |
| GB2552430B (en) | 2015-03-06 | 2022-05-11 | Micromass Ltd | Collision surface for improved ionisation |
| EP3265819B1 (en) | 2015-03-06 | 2020-10-14 | Micromass UK Limited | Chemically guided ambient ionisation mass spectrometry |
| EP4365928A3 (en) | 2015-03-06 | 2024-07-24 | Micromass UK Limited | Spectrometric analysis of microbes |
| WO2016142674A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Cell population analysis |
| GB2554202B (en) * | 2015-03-06 | 2021-08-18 | Micromass Ltd | Imaging guided ambient ionisation mass spectrometry |
| WO2016142669A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Physically guided rapid evaporative ionisation mass spectrometry ("reims") |
| JP6404451B2 (ja) | 2015-03-13 | 2018-10-10 | 富士フイルム株式会社 | 光音響計測装置及びプローブ |
| JP2017012485A (ja) * | 2015-07-01 | 2017-01-19 | キヤノン株式会社 | 生体マーカおよび被検体情報取得装置 |
| WO2017014167A1 (en) * | 2015-07-21 | 2017-01-26 | Canon Kabushiki Kaisha | Object information acquiring apparatus and object information acquiring method |
| JP6824636B2 (ja) * | 2015-07-21 | 2021-02-03 | キヤノン株式会社 | 被検体情報取得装置および被検体情報取得方法 |
| JP2017055838A (ja) * | 2015-09-14 | 2017-03-23 | プレキシオン株式会社 | 光音響画像化装置 |
| GB201517195D0 (en) | 2015-09-29 | 2015-11-11 | Micromass Ltd | Capacitively coupled reims technique and optically transparent counter electrode |
| US20200297313A1 (en) * | 2016-03-30 | 2020-09-24 | Koninklijke Philips N.V. | Tissue and vascular pathway mapping utilizing photoacoustic and ultrasound techniques |
| EP3443354B1 (en) | 2016-04-14 | 2025-08-20 | Micromass UK Limited | Spectrometric analysis of plants |
| US12036000B2 (en) * | 2016-05-27 | 2024-07-16 | The Regents Of The University Of Michigan | Method of photoacoustic imaging intraocular tumors including back-projection reconstruction to measure heterogeneity |
| US10709333B2 (en) * | 2016-07-25 | 2020-07-14 | PhotoSound Technologies, Inc. | Instrument for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections of tissue and methods of its use |
| US9976997B2 (en) * | 2016-10-17 | 2018-05-22 | Shimadzu Corporation | Data processing device for quantitation |
| RU2649048C1 (ru) * | 2016-11-25 | 2018-03-29 | Самсунг Электроникс Ко., Лтд. | Система компактного спектрометра, предназначенного для неинвазивного измерения спектров поглощения и пропускания образцов биологической ткани |
| EP3375353A1 (en) | 2017-03-16 | 2018-09-19 | Universität Zürich | Photoacoustic imaging of inflamed tissue |
| EP3413235A1 (en) * | 2017-06-08 | 2018-12-12 | Moqi Inc. | System and method for fingerprint recognition |
| CN111587365B (zh) * | 2018-01-11 | 2023-11-03 | 澳大利亚眼科研究中心有限公司 | 用于量化组织的生物标志物的方法和系统 |
| CN108375547B (zh) * | 2018-01-12 | 2020-08-18 | 华南师范大学 | 多光谱光声和光学相干层析双模态成像装置及方法 |
| US11666225B2 (en) | 2018-01-25 | 2023-06-06 | Muhannad N. Fadhel | Method and system for fluence matching in photoacoustic imaging |
| CA3096206A1 (en) * | 2018-04-04 | 2019-10-10 | Tomowave Laboratories, Inc. | Quantitative imaging system and uses thereof |
| EP3840664B1 (en) * | 2018-08-24 | 2023-07-26 | Digital Harmonic LLC | System and method for measuring vibrational spectra in living cells and tissue over time |
| CN115917369A (zh) * | 2020-04-23 | 2023-04-04 | 加利福尼亚大学董事会 | 超快光场断层摄影 |
| EP3932295A1 (en) * | 2020-06-30 | 2022-01-05 | Universität Zürich | Optoacoustic tomography method of a living organism, 2d- or 3d opotacoustic images, 2d- or 3d blood flow and light fluence images and a photoabsorbing agent for the use in an optoacoustic method |
| US20240023813A1 (en) * | 2020-09-14 | 2024-01-25 | Research Development Foundation | Systems and methods for ultrasound and photoacoustic guidance of coronary procedures |
| CN112200883B (zh) * | 2020-11-03 | 2023-03-24 | 华北电力大学（保定） | 一种定量血管内光学相干层析成像方法及系统 |
| CN115137358B (zh) * | 2021-03-29 | 2024-05-14 | 上海近观科技有限责任公司 | 一种皮下无创检测装置、信号收集系统及方法 |
| CN114027802A (zh) * | 2022-01-10 | 2022-02-11 | 杭州纬壹医疗科技有限公司 | 一种扩散光学层析成像系统 |
| CN115128010B (zh) * | 2022-07-21 | 2025-04-29 | 清华大学 | 一种物质成分比例确定方法及装置 |
| CN115479927B (zh) * | 2022-08-24 | 2025-09-30 | 中国科学院宁波材料技术与工程研究所 | 一种内窥镜用荧光校色卡片及其制备方法和应用 |
| CN115607108B (zh) * | 2022-09-30 | 2024-10-29 | 西北大学 | 一种基于表面测量信号盲源分离的多目标重建方法 |
| CN117017280B (zh) * | 2023-07-24 | 2024-03-19 | 西南交通大学 | 基于可穿戴柔性近红外光声/超声双模态成像系统及方法 |
Family Cites Families (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4255971A (en) | 1978-11-01 | 1981-03-17 | Allan Rosencwaig | Thermoacoustic microscopy |
| CH643397A5 (de) | 1979-09-20 | 1984-05-30 | Ibm | Raster-tunnelmikroskop. |
| US4385634A (en) | 1981-04-24 | 1983-05-31 | University Of Arizona Foundation | Radiation-induced thermoacoustic imaging |
| DE3374522D1 (enExample) | 1982-10-26 | 1987-12-23 | University Of Aberdeen | |
| FR2550678B1 (fr) | 1983-08-11 | 1989-02-17 | Cit Alcatel | Centre satellite numerique de raccordement d'abonnes |
| US4770183A (en) | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| DE3844672C2 (de) | 1987-08-05 | 1997-01-30 | Toshiba Kawasaki Kk | Ultraschall-Therapiegerät |
| DE69131528T2 (de) | 1990-05-30 | 2000-05-04 | Hitachi, Ltd. | Verfahren und Vorrichtung zur Behandlung eines sehr kleinen Bereichs einer Probe |
| US6263221B1 (en) | 1991-01-24 | 2001-07-17 | Non-Invasive Technology | Quantitative analyses of biological tissue using phase modulation spectroscopy |
| US5411730A (en) | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| US5840023A (en) * | 1996-01-31 | 1998-11-24 | Oraevsky; Alexander A. | Optoacoustic imaging for medical diagnosis |
| JPH09219563A (ja) | 1996-02-09 | 1997-08-19 | Hitachi Ltd | 半導体光素子とそれを用いた応用システム |
| US6173604B1 (en) | 1996-09-20 | 2001-01-16 | The Regents Of The University Of California | Scanning evanescent electro-magnetic microscope |
| US5713356A (en) | 1996-10-04 | 1998-02-03 | Optosonics, Inc. | Photoacoustic breast scanner |
| EP1011446A1 (en) | 1997-02-28 | 2000-06-28 | Electro-Optical Sciences, Inc. | Systems and methods for the multispectral imaging and characterization of skin tissue |
| WO1998051993A1 (fr) * | 1997-05-16 | 1998-11-19 | Olympus Optical Co., Ltd. | Dispositif servant a mesurer une hauteur |
| GB9712524D0 (en) | 1997-06-16 | 1997-08-20 | Nycomed Imaging As | Method |
| US5928151A (en) | 1997-08-22 | 1999-07-27 | Acuson Corporation | Ultrasonic system and method for harmonic imaging in three dimensions |
| US6477398B1 (en) | 1997-11-13 | 2002-11-05 | Randell L. Mills | Resonant magnetic susceptibility imaging (ReMSI) |
| US6070093A (en) * | 1997-12-02 | 2000-05-30 | Abbott Laboratories | Multiplex sensor and method of use |
| US6526298B1 (en) * | 1998-05-18 | 2003-02-25 | Abbott Laboratories | Method for the non-invasive determination of analytes in a selected volume of tissue |
| US6662030B2 (en) * | 1998-05-18 | 2003-12-09 | Abbott Laboratories | Non-invasive sensor having controllable temperature feature |
| US6216025B1 (en) | 1999-02-02 | 2001-04-10 | Optosonics, Inc. | Thermoacoustic computed tomography scanner |
| US6760609B2 (en) | 1999-07-14 | 2004-07-06 | Providence Health System - Oregon | Adaptive calibration pulsed oximetry method and device |
| TW579435B (en) | 1999-08-02 | 2004-03-11 | Zetetic Inst | Scanning interferometric near-field confocal microscopy |
| US6567688B1 (en) | 1999-08-19 | 2003-05-20 | The Texas A&M University System | Methods and apparatus for scanning electromagnetically-induced thermoacoustic tomography |
| US6424410B1 (en) * | 1999-08-27 | 2002-07-23 | Maui Innovative Peripherals, Inc. | 3D navigation system using complementary head-mounted and stationary infrared beam detection units |
| US6834063B2 (en) | 2000-01-06 | 2004-12-21 | Raytheon Company | Efficient angle tunable output from a monolithic serial KTA optical parametric oscillator |
| US20020163735A1 (en) | 2000-01-11 | 2002-11-07 | Gunther Detlef | Radially homogeneous high energy density UV sample ablating laser radiation in "pure" solid to gas sample preparation , for analysis by ICP-MS and ICP-OES |
| US6180087B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Tunable indocyanine dyes for biomedical applications |
| US6751490B2 (en) * | 2000-03-01 | 2004-06-15 | The Board Of Regents Of The University Of Texas System | Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit |
| US6847168B1 (en) | 2000-08-01 | 2005-01-25 | Calabazas Creek Research, Inc. | Electron gun for a multiple beam klystron using magnetic focusing with a magnetic field corrector |
| US6754519B1 (en) | 2000-11-24 | 2004-06-22 | Elgems Ltd. | Multimodality imaging system |
| US6615063B1 (en) | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| US20020073717A1 (en) | 2000-12-19 | 2002-06-20 | Dean David E. | MR scanner including liquid cooled RF coil and method |
| US7498564B2 (en) | 2001-02-06 | 2009-03-03 | University Of Bristol Of Senate House | Resonant scanning near-field optical microscope |
| DE10113661A1 (de) | 2001-03-21 | 2002-09-26 | Philips Corp Intellectual Pty | Katheter zur Anwendung in einem Magnetresonanz-Bildgerät |
| US6498492B1 (en) | 2001-03-23 | 2002-12-24 | Rosemount Analytical Inc. | Process of measuring conductivity using a pH analyzer |
| US6574490B2 (en) * | 2001-04-11 | 2003-06-03 | Rio Grande Medical Technologies, Inc. | System for non-invasive measurement of glucose in humans |
| US6490470B1 (en) | 2001-06-19 | 2002-12-03 | Optosonics, Inc. | Thermoacoustic tissue scanner |
| GB0126804D0 (en) | 2001-11-07 | 2002-01-02 | Univ London | Flow velocity measurement |
| US6700459B2 (en) | 2002-05-29 | 2004-03-02 | Superconductor Technologies, Inc. | Dual-mode bandpass filter with direct capacitive couplings and far-field suppression structures |
| AU2003239968A1 (en) | 2002-06-04 | 2003-12-19 | Visen Medical, Inc. | Imaging volumes with arbitrary geometries in contact and non-contact tomography |
| US7005653B1 (en) | 2002-06-18 | 2006-02-28 | Nanopoint, Inc. | Near-field intra-cellular apertureless tomographic imaging |
| US20040059265A1 (en) * | 2002-09-12 | 2004-03-25 | The Regents Of The University Of California | Dynamic acoustic focusing utilizing time reversal |
| US7774042B2 (en) | 2002-09-26 | 2010-08-10 | Senco Brands, Inc. | Tissue scanner |
| US7245789B2 (en) | 2002-10-07 | 2007-07-17 | Vascular Imaging Corporation | Systems and methods for minimally-invasive optical-acoustic imaging |
| JP2006516207A (ja) | 2003-01-13 | 2006-06-29 | グルコン インク | 光音響分析方法及び装置 |
| US7500953B2 (en) * | 2003-01-25 | 2009-03-10 | Seno Medical Instruments, Inc. | High contrast optoacoustic imaging using nanoparticles |
| US7647091B2 (en) | 2003-02-05 | 2010-01-12 | The General Hospital Corporation | Method and system for free space optical tomography of diffuse media |
| US7551957B2 (en) | 2003-03-06 | 2009-06-23 | Bioelectronics Corp. | Electromagnetic therapy device and methods |
| US7720525B2 (en) * | 2003-03-12 | 2010-05-18 | New Art Advanced Research Technologies Inc. | Method and apparatus for combining continuous wave and time domain optical imaging |
| IES20030396A2 (en) | 2003-05-23 | 2004-11-17 | Univ Dublin City | A method and apparatus for analysis of semiconductor materials using photoacoustic spectroscopy techniques |
| JP2004351023A (ja) | 2003-05-30 | 2004-12-16 | Olympus Corp | 光音響プローブ |
| US7725151B2 (en) | 2003-06-02 | 2010-05-25 | Van Der Weide Daniel Warren | Apparatus and method for near-field imaging of tissue |
| US7298869B1 (en) | 2003-07-21 | 2007-11-20 | Abernathy Donald A | Multispectral data acquisition system and method |
| IL164030A0 (en) | 2003-09-12 | 2005-12-18 | Revital Pery Shechter | Photoacoustic analyzer of a region of interest in a human body |
| US20050107694A1 (en) * | 2003-11-17 | 2005-05-19 | Jansen Floribertus H. | Method and system for ultrasonic tagging of fluorescence |
| US20050154308A1 (en) | 2003-12-30 | 2005-07-14 | Liposonix, Inc. | Disposable transducer seal |
| JP4643153B2 (ja) * | 2004-02-06 | 2011-03-02 | 株式会社東芝 | 非侵襲生体情報映像装置 |
| US7525661B2 (en) | 2004-02-17 | 2009-04-28 | Andreas Mandelis | Laser photo-thermo-acoustic (PTA) frequency swept heterodyned lock-in depth profilometry imaging system |
| US7804075B2 (en) | 2004-03-11 | 2010-09-28 | The General Hospital Corporation | Method and system for tomographic imaging using fluorescent proteins |
| EP2336747B1 (en) | 2004-05-06 | 2017-08-30 | Nippon Telegraph And Telephone Corporation | Component concentration measuring device |
| US7510555B2 (en) | 2004-05-07 | 2009-03-31 | Therm Med, Llc | Enhanced systems and methods for RF-induced hyperthermia |
| US7471975B2 (en) * | 2004-09-22 | 2008-12-30 | The Research Foundation Of State University Of New York | Optical tensor imaging |
| US20060084861A1 (en) | 2004-10-18 | 2006-04-20 | Topspin Medical (Isreal) Ltd. | Magnet and coil configurations for MRI probes |
| WO2006061829A1 (en) * | 2004-12-06 | 2006-06-15 | Glucon Inc. | Photoacoustic intravascular probe |
| JP2008522761A (ja) * | 2004-12-08 | 2008-07-03 | ザ・ゼネラル・ホスピタル・コーポレーション | 規準化された蛍光又は生物発光撮像のためのシステムと方法 |
| IL166408A0 (en) | 2005-01-20 | 2006-01-15 | Ultraview Ltd | Combined 2d pulse-echo ultrasound and optoacousticsignal for glaucoma treatment |
| US20060184042A1 (en) | 2005-01-22 | 2006-08-17 | The Texas A&M University System | Method, system and apparatus for dark-field reflection-mode photoacoustic tomography |
| US20090081122A1 (en) | 2005-05-23 | 2009-03-26 | Universite De Geneve | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant |
| DE102005030151B3 (de) | 2005-06-28 | 2006-11-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Photoakustischer Freifelddetektor |
| US20070015992A1 (en) | 2005-06-30 | 2007-01-18 | General Electric Company | System and method for optoacoustic imaging |
| US7247842B1 (en) | 2005-07-12 | 2007-07-24 | California Institute Of Technology | Method and system for scanning apertureless fluorescence mircroscope |
| US8660631B2 (en) | 2005-09-08 | 2014-02-25 | Bruker Biospin Corporation | Torsional support apparatus and method for craniocaudal rotation of animals |
| US8041409B2 (en) | 2005-09-08 | 2011-10-18 | Carestream Health, Inc. | Method and apparatus for multi-modal imaging |
| WO2007058895A2 (en) | 2005-11-11 | 2007-05-24 | Visualsonics Inc. | Overlay image contrast enhancement |
| DE602006020618D1 (de) | 2005-12-22 | 2011-04-21 | Visen Medical Inc | Kombiniertes röntgen- und optisches tomographie-bildgebungssystem |
| US20090054763A1 (en) | 2006-01-19 | 2009-02-26 | The Regents Of The University Of Michigan | System and method for spectroscopic photoacoustic tomography |
| CA2671101C (en) | 2006-01-20 | 2016-06-14 | Seno Medical Instruments, Inc. | Quantitative optoacoustic tomography with enhanced contrast |
| JP2007307007A (ja) | 2006-05-17 | 2007-11-29 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | 光音響効果を用いたカテーテルシステム |
| WO2008018082A2 (en) | 2006-08-10 | 2008-02-14 | Technion - Research & Development Foundation Ltd | Plasmon resonance bolometer for radiation detection |
| US7741045B2 (en) | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| US20080123083A1 (en) | 2006-11-29 | 2008-05-29 | The Regents Of The University Of Michigan | System and Method for Photoacoustic Guided Diffuse Optical Imaging |
| US20080173093A1 (en) | 2007-01-18 | 2008-07-24 | The Regents Of The University Of Michigan | System and method for photoacoustic tomography of joints |
| WO2008101019A2 (en) | 2007-02-13 | 2008-08-21 | Board Of Regents, The University Of Texas System | Molecular specific photoacoustic imaging |
| US20080221647A1 (en) * | 2007-02-23 | 2008-09-11 | The Regents Of The University Of Michigan | System and method for monitoring photodynamic therapy |
| US20080228073A1 (en) | 2007-03-12 | 2008-09-18 | Silverman Ronald H | System and method for optoacoustic imaging of peripheral tissues |
| WO2009009178A2 (en) | 2007-04-06 | 2009-01-15 | The General Hospital Corporation | Systems and methods for optical imaging using early arriving photons |
| US7894885B2 (en) | 2007-05-02 | 2011-02-22 | Biosense Webster, Inc. | Coherent signal rejection in ECG |
| US8251909B2 (en) | 2007-07-16 | 2012-08-28 | Arnold Stephen C | Acoustic imaging probe incorporating photoacoustic excitation |
| US20090058746A1 (en) | 2007-08-31 | 2009-03-05 | Harris Corporation | Evanescent wave-coupled frequency selective surface |
| CA2740602C (en) | 2007-10-19 | 2017-05-02 | Visen Medical, Inc. | Imaging systems featuring waveguiding compensation |
| WO2010048258A1 (en) | 2008-10-23 | 2010-04-29 | Washington University In St. Louis | Reflection-mode photoacoustic tomography using a flexibly-supported cantilever beam |
| EP2231018A4 (en) | 2007-12-12 | 2012-11-21 | Jeffrey J L Carson | THREE-DIMENSIONAL PHOTOACUSTIC IMAGING APPARATUS AND METHOD FOR CALIBRATING AN IMAGING APPARATUS |
| US9332942B2 (en) | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
| EP2110076A1 (en) | 2008-02-19 | 2009-10-21 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Method and device for near-field dual-wave modality imaging |
| CN102137618B (zh) | 2008-07-25 | 2015-06-17 | 健康与环境慕尼黑德国研究中心赫姆霍茨中心(有限公司) | 组织生物标志物的定量多光谱光声断层摄影(msot) |
| CN102223840B (zh) | 2008-09-10 | 2015-03-18 | 安德拉有限公司 | 光声成像设备 |
| JP2010125260A (ja) | 2008-12-01 | 2010-06-10 | Canon Inc | 生体検査装置 |
| WO2010086861A1 (en) | 2009-01-29 | 2010-08-05 | Noel Axelrod | Multimodal depth-resolving endoscope |
| US9271654B2 (en) | 2009-06-29 | 2016-03-01 | Helmholtz Zentrum Munchen Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Thermoacoustic imaging with quantitative extraction of absorption map |
| JP5574674B2 (ja) | 2009-11-12 | 2014-08-20 | キヤノン株式会社 | 音響波測定装置 |
| EP2332614A1 (en) | 2009-12-10 | 2011-06-15 | Theraclion SAS | Ultrasound treatment device |
| WO2011072198A2 (en) | 2009-12-10 | 2011-06-16 | The Board Of Regents Of The University Of Texas System | Optoacoustic / photoacoustic / acoustic imaging system using probe beam deflection |
| EP2359745A1 (en) | 2010-02-12 | 2011-08-24 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Method and device for multi-spectral photonic imaging |
| JP5448918B2 (ja) | 2010-02-24 | 2014-03-19 | キヤノン株式会社 | 生体情報処理装置 |
| JP5479173B2 (ja) | 2010-03-17 | 2014-04-23 | キヤノン株式会社 | 情報処理装置および情報処理方法 |
| CN103209643A (zh) | 2010-04-30 | 2013-07-17 | 视声公司 | 光声换能器及成像系统 |
| US8930145B2 (en) | 2010-07-28 | 2015-01-06 | Covidien Lp | Light focusing continuous wave photoacoustic spectroscopy and its applications to patient monitoring |
| US9949717B2 (en) | 2011-02-04 | 2018-04-24 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheitund Umwelt (GmbH) | Ultrasound detector and detecting device for optoacoustic or thermoacoustic imaging |
| JP5939786B2 (ja) | 2011-02-10 | 2016-06-22 | キヤノン株式会社 | 音響波取得装置 |
| JP5744557B2 (ja) | 2011-02-10 | 2015-07-08 | キヤノン株式会社 | 音響波取得装置 |
| JP5469113B2 (ja) | 2011-02-24 | 2014-04-09 | 富士フイルム株式会社 | 光音響分析用プローブユニットおよび光音響分析装置 |
| JP5704998B2 (ja) | 2011-04-06 | 2015-04-22 | キヤノン株式会社 | 光音響装置およびその制御方法 |
| JP5762118B2 (ja) | 2011-05-02 | 2015-08-12 | キヤノン株式会社 | 光照射装置およびその制御方法、ならびに被検体情報取得装置 |
| WO2013071942A1 (en) | 2011-11-18 | 2013-05-23 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | System for creating a tomographic object image based on multiple imaging modalities |
| EP2847574A1 (en) | 2012-05-07 | 2015-03-18 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Apparatus and method for frequency-domain thermo-acoustic tomographic imaging |
| WO2013185784A1 (en) | 2012-06-11 | 2013-12-19 | Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Imaging system and method for imaging an object |
| EP2695893A1 (en) | 2012-08-09 | 2014-02-12 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Novel far red fluorescent protein |
| DK2908713T3 (en) | 2012-10-22 | 2019-03-18 | Massachusetts Gen Hospital | HYBRID Catheter System |
| EP2742853B1 (en) | 2012-12-11 | 2022-03-23 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Handheld device and method for volumetric real-time optoacoustic imaging of an object |
| EP2742854B1 (en) | 2012-12-11 | 2021-03-10 | iThera Medical GmbH | Handheld device and method for tomographic optoacoustic imaging of an object |
| EP2754388B1 (en) | 2013-01-15 | 2020-09-09 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | System and method for quality-enhanced high-rate optoacoustic imaging of an object |
-
2008
- 2008-07-25 CN CN200880130942.4A patent/CN102137618B/zh active Active
- 2008-07-25 US US13/055,552 patent/US9572497B2/en active Active
- 2008-07-25 WO PCT/EP2008/006142 patent/WO2010009747A1/en not_active Ceased
- 2008-07-25 CA CA2731409A patent/CA2731409C/en active Active
- 2008-07-25 EP EP08785095.4A patent/EP2344019B1/en active Active
- 2008-07-25 JP JP2011519044A patent/JP5749164B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2731409A1 (en) | 2010-01-28 |
| JP5749164B2 (ja) | 2015-07-15 |
| JP2011528923A (ja) | 2011-12-01 |
| CN102137618A (zh) | 2011-07-27 |
| US20110306857A1 (en) | 2011-12-15 |
| WO2010009747A1 (en) | 2010-01-28 |
| EP2344019A1 (en) | 2011-07-20 |
| EP2344019B1 (en) | 2013-11-27 |
| CN102137618B (zh) | 2015-06-17 |
| US9572497B2 (en) | 2017-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2731409C (en) | Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers | |
| Pogue et al. | Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast | |
| Dhawan et al. | Optical imaging modalities for biomedical applications | |
| JP2011528923A5 (enExample) | ||
| US20220054017A1 (en) | Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use | |
| Hu et al. | Photoacoustic imaging and characterization of the microvasculature | |
| CA2810822C (en) | Systems and methods for virtual index-matching of diffusive media | |
| Lin et al. | Photoacoustic imaging | |
| CA2809798A1 (en) | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique | |
| JP2013519867A (ja) | マルチスペクトルフォトニック画像化方法及び装置 | |
| Turchin | Methods of biomedical optical imaging: from subcellular structures to tissues and organs | |
| Hillman et al. | Sub‐millimeter resolution 3D optical imaging of living tissue using laminar optical tomography | |
| Jiang et al. | Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate Part II: Experimental demonstration | |
| Laufer | Photoacoustic imaging: Principles and applications | |
| Ntziachristos | Clinical translation of optical and optoacoustic imaging | |
| Mireles et al. | Diffuse Optical Tomography | |
| Chen | Skin-equivalent opto-/elastofluidic in-vitro microphysiological vascular models for translational studies of optical biopsies | |
| Attia et al. | Photoacoustic Imaging and Sensing for Biomedical Applications | |
| Wang | Functional photoacoustic tomography of animal brains | |
| Fouladi et al. | Fundamentals of Photoacoustic Imaging | |
| Li | Breast cancer detection with diffuse optical tomography | |
| Buehler et al. | Visualization of mouse kidney perfusion with multispectral optoacoustic tomography (MSOT) at video rate | |
| Intes et al. | Conference 8216: Multimodal Biomedical Imaging VII | |
| Ntziachristos et al. | Revolutionizing Biopharmaceutical Development with Quantitative Multispectral Optoacoustic Tomography (MSOT) | |
| Razansky et al. | Multi-spectral photo-acoustic molecular tomography resolves fluorochrome distribution with high resolution and sensitivity in small animals |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130411 |