CA2730804A1 - Amyloid .beta. peptide analogues, oligomers thereof, processes for preparing and compositions comprising said analogues or oligomers, and their uses - Google Patents
Amyloid .beta. peptide analogues, oligomers thereof, processes for preparing and compositions comprising said analogues or oligomers, and their uses Download PDFInfo
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- CA2730804A1 CA2730804A1 CA2730804A CA2730804A CA2730804A1 CA 2730804 A1 CA2730804 A1 CA 2730804A1 CA 2730804 A CA2730804 A CA 2730804A CA 2730804 A CA2730804 A CA 2730804A CA 2730804 A1 CA2730804 A1 CA 2730804A1
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- amino acid
- acid residue
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- amyloid
- peptide
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8358908P | 2008-07-25 | 2008-07-25 | |
| US61/083,589 | 2008-07-25 | ||
| PCT/US2009/051721 WO2010011947A2 (en) | 2008-07-25 | 2009-07-24 | AMYLOID ß PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PROCESSES FOR PREPARING AND COMPOSITIONS COMPRISING SAID ANALOGUES OR OLIGOMERS, AND THEIR USES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2730804A1 true CA2730804A1 (en) | 2010-01-28 |
Family
ID=41570887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2730804A Abandoned CA2730804A1 (en) | 2008-07-25 | 2009-07-24 | Amyloid .beta. peptide analogues, oligomers thereof, processes for preparing and compositions comprising said analogues or oligomers, and their uses |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110092445A1 (enExample) |
| EP (1) | EP2303920A4 (enExample) |
| JP (1) | JP2011529084A (enExample) |
| CN (1) | CN102203124A (enExample) |
| CA (1) | CA2730804A1 (enExample) |
| MX (1) | MX2011000975A (enExample) |
| WO (1) | WO2010011947A2 (enExample) |
Families Citing this family (36)
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| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008104386A2 (en) | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| CN102065881B (zh) * | 2008-04-14 | 2014-03-12 | 埃尔奇诺瓦公司 | 稳定的淀粉样beta单体和寡聚体 |
| ES2397641T3 (es) * | 2008-07-01 | 2013-03-08 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Vacuna contra el intermediario de plegado amiloide |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| RU2644335C2 (ru) * | 2010-03-03 | 2018-02-08 | Зе Юниверсити Оф Бритиш Коламбия | Эпитоп, специфичный к олигомеру амилоида бета, и антитела |
| AU2013205000B2 (en) * | 2010-03-03 | 2015-05-28 | The University Of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
| EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
| WO2011156003A2 (en) | 2010-06-09 | 2011-12-15 | New York University | Peptoid and synthetic oligomers, pharmaceutical compositions and methods of using same |
| US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| US20120089291A1 (en) * | 2010-10-12 | 2012-04-12 | Halder Bibhrajit | Autonomous machine control system |
| WO2012072611A1 (de) * | 2010-11-29 | 2012-06-07 | Philipps-Universität Marburg | SYNTHETISCHE LIGANDEN FÜR HUMANE ANTI-Aβ-ANTIKÖRPER |
| DK2646462T3 (en) * | 2010-11-29 | 2017-07-03 | Akershus Univ | METHODS AND COMPOSITIONS FOR MONITORING PHAGOCYTIC ACTIVITY |
| EP2785364B1 (en) * | 2011-11-29 | 2019-01-09 | Proclara Biosciences, Inc. | Use of p3 of bacteriophage as amyloid binding agents |
| US20130164217A1 (en) * | 2011-12-21 | 2013-06-27 | Meso Scale Technologies, Llc | Method of diagnosing, preventing and/or treating dementia & related disorders |
| DE102012021222B4 (de) * | 2012-10-27 | 2015-02-05 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung einer nanoporösen Schicht auf einem Substrat |
| EP2746402A1 (en) * | 2013-03-12 | 2014-06-25 | Academisch Medisch Centrum | Method of prognosis of Alzheimers disease and substrates for use therein |
| EP2787347A1 (en) * | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting Aß-specific antibodies in a biological sample |
| EP2787349A1 (en) | 2013-04-03 | 2014-10-08 | Affiris AG | Method for detecting proteinopathy-specific antibodies in a biological sample |
| JP6517827B2 (ja) | 2014-01-31 | 2019-05-22 | コグニション セラピューティクス，インコーポレイテッド | イソインドリン組成物および神経変性疾患の治療方法 |
| RU2750268C2 (ru) * | 2014-07-07 | 2021-06-25 | Эббви Дойчланд Гмбх Унд Ко. Кг | ИММУНОГЕННЫЕ ПРОДУКТЫ, ПОЛУЧЕННЫЕ НА ОСНОВЕ АМИНОКИСЛОТНЫХ ПОСЛЕДОВАТЕЛЬНОСТЕЙ МУТЕИНОВОГО АМИЛОИДА β (Aβ), И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| CA2960193C (en) * | 2014-09-05 | 2022-10-18 | System Of Systems Analytics, Inc. | Methods for detecting amyloid beta oligomers |
| ES2571055B1 (es) * | 2016-02-15 | 2016-12-28 | Araclon Biotech, S.L. | Conjugado amiloide y usos y procedimientos del mismo |
| WO2018005980A1 (en) * | 2016-07-01 | 2018-01-04 | The Scripps Research Institute | Compositions and diagnostic methods related to transthyretin amyloid diseases |
| CA3061787A1 (en) | 2017-05-15 | 2018-11-22 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| CN108148115A (zh) * | 2018-01-30 | 2018-06-12 | 中国药科大学 | 一种环肽合成新方法及其在药物开发中的应用 |
| WO2019246140A1 (en) * | 2018-06-18 | 2019-12-26 | Emory University | Parallel enzyme digestion for protein biomarker detection |
| CN109851660A (zh) * | 2019-03-20 | 2019-06-07 | 横琴欣健生物科技研究院有限公司 | 一种治疗老年痴呆症的多肽及其疫苗 |
| CN109912687A (zh) * | 2019-03-20 | 2019-06-21 | 横琴欣健生物科技研究院有限公司 | 一种治疗老年痴呆症的多肽药物 |
| JP7357354B2 (ja) * | 2020-02-04 | 2023-10-06 | 国立大学法人京都大学 | アミロイドβ４２架橋アナログペプチド |
| KR102767892B1 (ko) * | 2021-12-30 | 2025-02-14 | 고려대학교 산학협력단 | 신규한 단백질 변이체 및 이를 이용한 신경퇴행성 질환 치료용 조성물 |
| US12037375B2 (en) * | 2021-12-30 | 2024-07-16 | Korea University Research And Business Foundation | Protein variant and composition for treating neurodegenerative disease using the same |
Family Cites Families (9)
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|---|---|---|---|---|
| WO1994017197A1 (fr) * | 1993-01-25 | 1994-08-04 | Takeda Chemical Industries, Ltd. | ANTICORPS DIRIGE CONTRE LE β-AMYLOIDE OU UN DERIVE DE CE DERNIER ET SON UTILISATION |
| DE10101430B4 (de) * | 2001-01-13 | 2008-10-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Lösliche cyclische Analoga zur Modulation der Amyloidogenese |
| US20020132758A1 (en) * | 2001-01-18 | 2002-09-19 | Shell John W. | Method for identifying compounds to treat medical pathologies associated with molecular crystallization |
| US20070213512A1 (en) * | 2002-10-01 | 2007-09-13 | Krafft Grant A | Amyloid beta peptide analogs and assemblies thereof |
| DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| EP1676859A1 (en) * | 2004-12-30 | 2006-07-05 | Pevion Biotech Ltd. | Immunogenic compositions of cyclic peptides derived from the beta-amyloid peptide |
| KR20080021585A (ko) * | 2005-03-05 | 2008-03-07 | 애보트 게엠베하 운트 콤파니 카게 | 스크리닝 방법, 비확산성 ａ-베타 올리고머의 정제 방법,당해 비확산성 ａ-베타 올리고머에 대한 선택적 항체 및당해 항체의 제조 방법 |
| MX2008006957A (es) * | 2005-11-30 | 2008-10-20 | Abbott Lab | Metodos para la preparacion de formas recombinantes de proteina beta-amiloide humana y usos de estas proteinas. |
| EP2091948B1 (en) * | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
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- 2009-07-24 US US12/509,325 patent/US20110092445A1/en not_active Abandoned
- 2009-07-24 JP JP2011520233A patent/JP2011529084A/ja active Pending
- 2009-07-24 EP EP09801088A patent/EP2303920A4/en not_active Withdrawn
- 2009-07-24 WO PCT/US2009/051721 patent/WO2010011947A2/en not_active Ceased
- 2009-07-24 MX MX2011000975A patent/MX2011000975A/es not_active Application Discontinuation
- 2009-07-24 CN CN200980137576XA patent/CN102203124A/zh active Pending
- 2009-07-24 CA CA2730804A patent/CA2730804A1/en not_active Abandoned
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| WO2010011947A2 (en) | 2010-01-28 |
| MX2011000975A (es) | 2011-05-25 |
| CN102203124A (zh) | 2011-09-28 |
| US20110092445A1 (en) | 2011-04-21 |
| EP2303920A4 (en) | 2011-11-09 |
| EP2303920A2 (en) | 2011-04-06 |
| WO2010011947A3 (en) | 2010-04-29 |
| JP2011529084A (ja) | 2011-12-01 |
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